中药配方颗粒在慢性非细菌性前列腺炎内外兼治中的应用
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摘要
目的:研究与分析中药配方颗粒在慢性非细菌性前列腺炎内外兼治中的应用效果。方法:慢性非细菌性前列腺炎患者78例,按数字表法随机分为对照组38例与观察组40例。对照组患者采用前列康片进行治疗,观察组患者则采用中药配方颗粒进行治疗。对比分析两组患者治疗前后NIH-CPSI积分变化情况、前列腺液中白细胞计数(EPS-WBC)、最大尿流率及临床总有效率。结果:经过治疗后,所有患者均未见明显不良反应出现,观察组患者疼痛不适评分(4.72±2.74)分、尿路刺激征(2.94±1.08)分、生活质量(4.00±2.76)分、前列腺症状严重程度(9.35±5.67)分等评分、EPS-WBC(13.55±5.87)个/HP、最大尿流率(28.56±6.39)ml/s、临床总有效率(95.00%)等均明显优于对照组患者疼痛不适评分(6.99±3.98)分、尿路刺激征(3.97±1.95)分、生活质量(5.88±3.95)分、前列腺症状严重程度(13.28±6.88)分评分、EPS-WBC(16.59±7.32)个/HP、最大尿流率(24.13±5.17)ml/s、临床总有效率(78.95%),差异有统计学意义(P<0.05)。结论:慢性非细菌性前列腺炎经中药配方颗粒进行治疗后,患者前列腺不适症状、排尿困难情况及疼痛等均有显著改善,生活质量明显提升,临床应用效果较优。
Objective: To study and analyze the effect of traditional Chinese medicine dispensing granules in the treatment of the patients with chronic abacterial prostatitis. Methods: 78 cases of chronic abacterial prostatitis were randomly selected and randomly divided into the control group( 38 cases) and the observation group( 40 cases) according to the digital table. The patients in the control group were treated with Qianliekang Tablets while those in the observation group were treated with traditional Chinese medicine granules. The changes of NIH-CPSI scores,the white blood cell count( EPS-WBC),the maximum urinary flow rate and the total clinical efficiency of two groups were compared and analyzed before and after treatment. Results: After treatment,there were no obvious adverse reactions in all patients. The observation group's pain score( 4. 72 ± 2. 74),urinary tract irritation( 2. 94 ± 1. 08),quality of life( 4. 00 ± 2. 76),prostate symptom severity( 9. 35 ± 5. 67),EPS-WBC( 13. 55 ± 5. 87)/HP,maximum urinary flow rate( 28. 56 ± 6. 39) m L/s and the total clinical efficiency( 95%) were significantly better than the control group's pain score( 6. 99 ± 3. 98),urinary tract irritation( 3. 97 ± 1. 95),quality of life( 5. 88 ± 3. 95),anterior column gland symptom severity( 13. 28 ±6. 88) and EPS-WBC( 16. 59 ± 7. 32)/HP,maximum urinary flow rate( 24. 13 ± 5. 17) m L/s and the total clinical efficiency( 78. 95%),and the difference was statistically significant( P < 0. 05). Conclusion: For chronic non bacterial prostatitis,Chinese medicine granule can relieve prostate discomfort and pain and improve dysuria symptoms significantly.The quality of life is improved significantly and the clinical effect is better.
Objective: To study and analyze the effect of traditional Chinese medicine dispensing granules in the treatment of the patients with chronic abacterial prostatitis. Methods: 78 cases of chronic abacterial prostatitis were randomly selected and randomly divided into the control group( 38 cases) and the observation group( 40 cases) according to the digital table. The patients in the control group were treated with Qianliekang Tablets while those in the observation group were treated with traditional Chinese medicine granules. The changes of NIH-CPSI scores,the white blood cell count( EPS-WBC),the maximum urinary flow rate and the total clinical efficiency of two groups were compared and analyzed before and after treatment. Results: After treatment,there were no obvious adverse reactions in all patients. The observation group's pain score( 4. 72 ± 2. 74),urinary tract irritation( 2. 94 ± 1. 08),quality of life( 4. 00 ± 2. 76),prostate symptom severity( 9. 35 ± 5. 67),EPS-WBC( 13. 55 ± 5. 87)/HP,maximum urinary flow rate( 28. 56 ± 6. 39) m L/s and the total clinical efficiency( 95%) were significantly better than the control group's pain score( 6. 99 ± 3. 98),urinary tract irritation( 3. 97 ± 1. 95),quality of life( 5. 88 ± 3. 95),anterior column gland symptom severity( 13. 28 ±6. 88) and EPS-WBC( 16. 59 ± 7. 32)/HP,maximum urinary flow rate( 24. 13 ± 5. 17) m L/s and the total clinical efficiency( 78. 95%),and the difference was statistically significant( P < 0. 05). Conclusion: For chronic non bacterial prostatitis,Chinese medicine granule can relieve prostate discomfort and pain and improve dysuria symptoms significantly.The quality of life is improved significantly and the clinical effect is better.
引文
[1]孙晓慧,张玉刚,曲辑.萆薜、石菖蒲药对治疗慢性非细菌性前列腺炎最佳配伍比例的药效学研究[J].长春中医药大学学报,2017,33(1):16-18.
[2]邹如政,曹继刚,李亚昊,等.慢性非细菌性前列腺炎/慢性盆底疼痛综合征中医药治疗的近况[J].中国男科学杂志,2015,29(11):69-72.
[3]Moayednia A,Haghdani s,Khosrawi s,et al.Long-term effect of extracorporeal shock wave therapy on the treatment of chronic pelvic pain syndrorne due to non bacterial prostatitis[J].Joumal ofResea I in Medical Sciences:The Official Joumal of Isfahan University of Medical sciences,2014,19(4):293.
[4]杨会志,徐吉良,沈智理,等.慢性前列腺炎伴抑郁症的中医证候特征研究[J].湖南中医药大学学报,2016,36(2):72-75.
[5]赵友康,曹宏文,周智恒,等.红鹿合剂联合癃清胶囊治疗湿热瘀阻型慢性非细菌性前列腺炎的临床研究[J].上海中医药杂志,2017,51(3):57.
[6]高喜源,李俊英.利肾逐瘀饮结合温针灸治疗慢性非细菌性前列腺炎的疗效观察[J].中国医药导报,2016,22(2):91-93.
[7]李玉勤,徐少华,郑惠霞,等.中西医结合认知行为干预治疗非细菌性前列腺炎临床对比研究[J].国际泌尿系统杂志,2016,36(2):167-170.
[8]张玉军.中西医结合治疗慢性非细菌性前列腺炎58例临床观察[J].世界中西医结合杂志,2016,11(2):198-200,203.
[9]Ryan W,Sherard A.Tatum Chronic nonbacterial osteomyelitis[J].Curr Opin Otolaryngol Head Neck Surg,2014,22(4):332-335.
[10]王光,袁学明,梁如,等.中药保留灌肠联合微能量体外冲击波治疗慢性非细菌性前列腺炎的临床观察[J].中国性科学,2016,25(3):88-90.
[11]叶章群,蓝儒竹,沈周俊,等.癃清片与左氧氟沙星单药或联合应用治疗非细菌性炎症性前列腺炎的临床研究[J].中华泌尿外科杂志,2016,37(5):363-367.
[12]孙洪福,刘燕,王卫东,等.肝郁与慢性非细菌性前列腺炎的关系[J].中国医药导报,2015,12(23):21-24.
[13]李世林,唐梁,叶海霞.清浊祛毒丸联合针刺治疗慢性非细菌性前列腺炎的临床研究[J].广州中医药大学学报,2015,32(6):1035-1039.
[14]张凯,时荣同,马楠,等.萆菟汤治疗慢性非细菌性前列腺炎110例[J].安徽中医药大学学报,2015,34(4):28-31.
[15]丁劲,张耀圣,闫博,等.除湿通淋颗粒治疗慢性非细菌性前列腺炎临床疗效及对IL-2、IL-6、IL-8影响观察[J].中国性科学,2015,24(5):82-85.
[2]邹如政,曹继刚,李亚昊,等.慢性非细菌性前列腺炎/慢性盆底疼痛综合征中医药治疗的近况[J].中国男科学杂志,2015,29(11):69-72.
[3]Moayednia A,Haghdani s,Khosrawi s,et al.Long-term effect of extracorporeal shock wave therapy on the treatment of chronic pelvic pain syndrorne due to non bacterial prostatitis[J].Joumal ofResea I in Medical Sciences:The Official Joumal of Isfahan University of Medical sciences,2014,19(4):293.
[4]杨会志,徐吉良,沈智理,等.慢性前列腺炎伴抑郁症的中医证候特征研究[J].湖南中医药大学学报,2016,36(2):72-75.
[5]赵友康,曹宏文,周智恒,等.红鹿合剂联合癃清胶囊治疗湿热瘀阻型慢性非细菌性前列腺炎的临床研究[J].上海中医药杂志,2017,51(3):57.
[6]高喜源,李俊英.利肾逐瘀饮结合温针灸治疗慢性非细菌性前列腺炎的疗效观察[J].中国医药导报,2016,22(2):91-93.
[7]李玉勤,徐少华,郑惠霞,等.中西医结合认知行为干预治疗非细菌性前列腺炎临床对比研究[J].国际泌尿系统杂志,2016,36(2):167-170.
[8]张玉军.中西医结合治疗慢性非细菌性前列腺炎58例临床观察[J].世界中西医结合杂志,2016,11(2):198-200,203.
[9]Ryan W,Sherard A.Tatum Chronic nonbacterial osteomyelitis[J].Curr Opin Otolaryngol Head Neck Surg,2014,22(4):332-335.
[10]王光,袁学明,梁如,等.中药保留灌肠联合微能量体外冲击波治疗慢性非细菌性前列腺炎的临床观察[J].中国性科学,2016,25(3):88-90.
[11]叶章群,蓝儒竹,沈周俊,等.癃清片与左氧氟沙星单药或联合应用治疗非细菌性炎症性前列腺炎的临床研究[J].中华泌尿外科杂志,2016,37(5):363-367.
[12]孙洪福,刘燕,王卫东,等.肝郁与慢性非细菌性前列腺炎的关系[J].中国医药导报,2015,12(23):21-24.
[13]李世林,唐梁,叶海霞.清浊祛毒丸联合针刺治疗慢性非细菌性前列腺炎的临床研究[J].广州中医药大学学报,2015,32(6):1035-1039.
[14]张凯,时荣同,马楠,等.萆菟汤治疗慢性非细菌性前列腺炎110例[J].安徽中医药大学学报,2015,34(4):28-31.
[15]丁劲,张耀圣,闫博,等.除湿通淋颗粒治疗慢性非细菌性前列腺炎临床疗效及对IL-2、IL-6、IL-8影响观察[J].中国性科学,2015,24(5):82-85.