酪酸梭菌二联活菌散联合蓝光照射治疗36例新生儿病理性黄疸患儿的疗效观察
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摘要
目的:探究酪酸梭菌二联活菌散联合蓝光照射治疗新生儿病理性黄疸患儿的疗效。方法:选取我院新生儿病理性黄疸108例患儿,依据治疗方案不同分为A、B、C三组,各36例。A组予以蓝光照射治疗,B组给予酪酸梭菌二联活菌散治疗,C组给予蓝光照射+酪酸梭菌二联活菌散治疗。统计对比三组临床疗效及治疗前后血清总胆红素(Tbil)水平。结果:C组临床治疗总有效率94.44%(34/36)高于A组72.22%(26/36)、B组75.00%(27/36),差异有统计学意义(P<0.05);治疗1d、2d、4d时,C组血清Tbil水平低于A组、B组,差异有统计学意义(P<0.05)。结论:联合酪酸梭菌二联活菌散与蓝光照射治疗新生儿病理性黄疸患儿,可明显降低血清Tbil水平,临床效果显著。
Objective: To investigate the efficacy of Clostridium butyricum conjugated live bacillus combined with blue light irradiation in the treatment of neonatal pathological jaundice. Methods: 108 children with neonatal pathological jaundice were enrolled in our hospital. According to different treatment options, they were divided into three groups: A, B and C with 36 cases in each group. Group A was treated with blue light, group B was treated with Clostridium butyricum and live bacteria, and group C was given blue light + Clostridium butyricum treatment. The clinical efficacy of the three groups and the serum total bilirubin(Tbil) levels before and after treatment were statistically compared. Results: The total effective rate of clinical treatment in group C was 94.44%(34/36)), which was significantly higher than 72.22%(26/36) in group A and 75.00%(27/36) in group B. The difference was statistically significant(P<0.05). In 1d, 2 d, and 4 d, serum Tbil levels in group C were significantly lower than those in group A and B, and the difference was statistically significant(P<0.05). Conclusion: Combined with Clostridium butyricum and live blue light irradiation in the treatment of neonatal pathological jaundice, serum Tbil levels can be significantly reduced, and the clinical effect is significant.
Objective: To investigate the efficacy of Clostridium butyricum conjugated live bacillus combined with blue light irradiation in the treatment of neonatal pathological jaundice. Methods: 108 children with neonatal pathological jaundice were enrolled in our hospital. According to different treatment options, they were divided into three groups: A, B and C with 36 cases in each group. Group A was treated with blue light, group B was treated with Clostridium butyricum and live bacteria, and group C was given blue light + Clostridium butyricum treatment. The clinical efficacy of the three groups and the serum total bilirubin(Tbil) levels before and after treatment were statistically compared. Results: The total effective rate of clinical treatment in group C was 94.44%(34/36)), which was significantly higher than 72.22%(26/36) in group A and 75.00%(27/36) in group B. The difference was statistically significant(P<0.05). In 1d, 2 d, and 4 d, serum Tbil levels in group C were significantly lower than those in group A and B, and the difference was statistically significant(P<0.05). Conclusion: Combined with Clostridium butyricum and live blue light irradiation in the treatment of neonatal pathological jaundice, serum Tbil levels can be significantly reduced, and the clinical effect is significant.
引文
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[3]孙洁,林方.酪酸梭菌活菌散剂辅助治疗新生儿高胆红素血症的临床效果分析[J].医学综述,2016,22(3):594-595.
[4]张瑛.酪酸梭菌二联活菌散剂辅助治疗新生儿黄疸的临床效果观察[J].中国实用医药,2016,11(20):8-9.
[5]孟娥,朱彦.不同蓝光照射方式对新生儿黄疸的治疗效果分析[J].中国妇幼保健,2015,30(17):2857-2859.
[6]魏绪霞,徐俊杰,唐运萍,等.酪酸梭菌二联活菌散联合消旋卡多曲治疗婴幼儿病毒性腹泻的疗效[J].实用临床医学,2014,15(9):70.
[7]袁政,陈维.酪酸梭菌二联活菌散预防肺炎婴幼儿抗生素相关性腹泻的临床观察[J].中国基层医药,2014,21(24):3715-3716.
[8]赵林静,张磊,石计朋.酪酸梭菌二联活菌散预防极低出生体质量儿坏死性小肠结肠炎112例[J].医药导报,2015,34(3):350-353.
[9]王卫平.儿科学[M].第8版.北京:人民卫生出版社,2013:119-121.
[10]姚建宏,李小艳,张新华,等.酪酸梭菌活菌散辅助治疗新生儿黄疸的随机多中心临床疗效观察[J].中国微生态学杂志,2016,28(10):1178-1180.
[11]董志巧,程书卿,张辉果,等.口服常乐康早产低出生体重儿的胃肠功能、生长发育情况观察[J].山东医药,2017,57(3):79-81.
[12]李婕,胡燕.蓝光联合茵栀黄颗粒治疗新生儿病理性黄疸的临床研究[J].中国临床药理学杂志,2015,31(18):1809-1811.
[13]王桂梅.蓝光联合茵栀黄颗粒对新生儿病理性黄疸治疗效果及不良反应的影响[J].中国医药导刊,2015,17(9):922-923.
[14]路军.茵栀黄口服液联合蓝光照射治疗新生儿病理性黄疸的临床疗效研究[J].中医药学报,2014,42(5):132-134.
[15]林方,孙洁.单纯蓝光治疗与复合中药联合治疗新生儿黄疸疗效比较[J].医学综述,2016,22(12):2474-2476.
[16]徐拔群,吕海涛,张立春.双歧杆菌三联活菌散辅助治疗足月新生儿黄疸的疗效分析[J].儿科药学杂志,2017,34(1):26-28.
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