影响足月新生儿呼吸窘迫综合征的危险因素病例对照研究
|
摘要
目的探讨足月新生儿呼吸窘迫综合征的相关危险因素,为早期干预提供依据。方法选取77例确诊的新生儿呼吸窘迫综合征作为病例组,同期随机选取77例未发生新生儿呼吸窘迫综合征的正常新生儿作为对照组;采用回顾性病例对照的研究方法,使用单因素比较法和多因素logistic回归法分别筛选影响足月新生儿呼吸窘迫综合征发病的危险因素。结果单因素分析显示,两组新生儿的社会因素剖宫产、妊娠高血压疾病、胎膜早破、羊水胎粪污染、胎儿宫内窘迫、羊水吸入、新生儿感染、新生儿窒息、新生儿低血糖、产后使用PS等因素存在统计学差异(P<0.05)。多因素分析显示,足月新生儿呼吸窘迫综合征发病的影响因素包括社会因素剖宫产(OR=5.714)、胎儿宫内窘迫(OR=6.390)、羊水吸入(OR=15.745)、新生儿窒息(OR=12.798)、产后使用肺表面活性物质(OR=0.212)等。结论足月新生儿呼吸窘迫综合征发病的高危因素包括社会因素剖宫产、胎儿宫内窘迫、新生儿窒息、羊水吸入及产后未使用肺表面活性物质,应结合以上高危因素,进行早预防、早诊断、早治疗新生儿呼吸窘迫综合征。
Objective To explore the correlated risk factors of acute respiratory distress syndrome of newborns(NRDS) with full-term, and to provide basis for early intervention for it.Methods Seventy-seven confirmed cases of NRDS were selected as the case group, and 77 cases of normal newborns without NRDS were randomly selected as the control group. With retrospective case-control study method, the risk factors of NRDS were screened by single factor comparison method and multiple factors logistic regression method.Results Single factor analysis showed that there were statistical significances about social factors caesarean section, pregnancy induced hypertension, premature rupture of membranes, meconium pollution in amniotic fluid, fetal intrauterine distress, amniotic fluid inhalation, neonatal infection, asphyxia neonatorum, hypoglycemia in newborns and postpartum use of PS between the two groups(P<0.05). Multiple factors analysis result indicated that the influencing factors of NRDS included social factors caesarean section(OR=5.714), fetal intrauterine distress(OR=6.390), amniotic fluid inhalation(OR=15.745), asphyxia neonatorum(OR=12.798) and postpartum use of PS(OR=0.212).Conclusion The high risk factors of NRDS contain social factors caesarean section, fetal intrauterine distress, amniotic fluid inhalation, asphyxia neonatorum and without use of PS after delivery. To aim directly at these high risk factors, we should early prevent, diagnose and treat NRDS.
Objective To explore the correlated risk factors of acute respiratory distress syndrome of newborns(NRDS) with full-term, and to provide basis for early intervention for it.Methods Seventy-seven confirmed cases of NRDS were selected as the case group, and 77 cases of normal newborns without NRDS were randomly selected as the control group. With retrospective case-control study method, the risk factors of NRDS were screened by single factor comparison method and multiple factors logistic regression method.Results Single factor analysis showed that there were statistical significances about social factors caesarean section, pregnancy induced hypertension, premature rupture of membranes, meconium pollution in amniotic fluid, fetal intrauterine distress, amniotic fluid inhalation, neonatal infection, asphyxia neonatorum, hypoglycemia in newborns and postpartum use of PS between the two groups(P<0.05). Multiple factors analysis result indicated that the influencing factors of NRDS included social factors caesarean section(OR=5.714), fetal intrauterine distress(OR=6.390), amniotic fluid inhalation(OR=15.745), asphyxia neonatorum(OR=12.798) and postpartum use of PS(OR=0.212).Conclusion The high risk factors of NRDS contain social factors caesarean section, fetal intrauterine distress, amniotic fluid inhalation, asphyxia neonatorum and without use of PS after delivery. To aim directly at these high risk factors, we should early prevent, diagnose and treat NRDS.
引文
[1] 代苗英,李少兵,胡金绘,等.不同胎龄新生儿呼吸窘迫综合征高危因素及临床分析[J].临床儿科杂志,2014,9(7):644-648.
[2] 李莲,张晓慧.青海地区足月新生儿急性呼吸窘迫综合征发病的高危因素[J].中国妇幼保健,2015,30(2):232-234.
[3] 邵肖梅,叶鸿瑁,丘小汕.实用新生儿学[M].4版,北京:人民卫生出版社,2011:395-397.
[4] 李敏,刘晓琳. 足月新生儿呼吸窘迫综合征危险因素分析[J].安徽医学,2016,37(3):330-332.
[5] 刘莺,周卫萍.足月新生儿急性呼吸窘迫综合征的高危因素及临床特点分析[J].当代医学,2015,21(20):97-98.
[6] 赵倩,邵勇.新生儿呼吸窘迫综合征高危因素研究进展[J].中国妇产科临床杂志,2013,14(4):375-378.
[7] 麻伟博.新生儿呼吸窘迫综合征发病危险因素的Logistic回归分析[J].中华肺部疾病杂志(电子版),2016,9(2):182-184.
[8] 刘敬.足月新生儿呼吸窘迫综合征的诊断与治疗[J].中华实用儿科临床杂志,2013,28(14):1117-1120.
[9] 李琳琳,娜丽.影响新生儿呼吸窘迫综合征的相关因素调查分析[J].中国妇幼保健,2015,30(34):6094-6096.
[10] 钟炜,周利,刘小松,等.肺表面活性物质治疗新生儿羊水吸入性重症肺炎并呼吸衰竭的疗效[J].实用临床医学,2012,13(3):65-67.
[11] 闫小红,刘云,李宗尚.新生儿急性呼吸窘迫综合征发病相关因素分析[J].中国中西医结合儿科学,2013,5(4):334-336.
[12] 陈才.肺表面活性物质治疗足月新生儿急性呼吸窘迫综合征的效果探析[J].中国社区医师,2016,32(7):71-72.
[2] 李莲,张晓慧.青海地区足月新生儿急性呼吸窘迫综合征发病的高危因素[J].中国妇幼保健,2015,30(2):232-234.
[3] 邵肖梅,叶鸿瑁,丘小汕.实用新生儿学[M].4版,北京:人民卫生出版社,2011:395-397.
[4] 李敏,刘晓琳. 足月新生儿呼吸窘迫综合征危险因素分析[J].安徽医学,2016,37(3):330-332.
[5] 刘莺,周卫萍.足月新生儿急性呼吸窘迫综合征的高危因素及临床特点分析[J].当代医学,2015,21(20):97-98.
[6] 赵倩,邵勇.新生儿呼吸窘迫综合征高危因素研究进展[J].中国妇产科临床杂志,2013,14(4):375-378.
[7] 麻伟博.新生儿呼吸窘迫综合征发病危险因素的Logistic回归分析[J].中华肺部疾病杂志(电子版),2016,9(2):182-184.
[8] 刘敬.足月新生儿呼吸窘迫综合征的诊断与治疗[J].中华实用儿科临床杂志,2013,28(14):1117-1120.
[9] 李琳琳,娜丽.影响新生儿呼吸窘迫综合征的相关因素调查分析[J].中国妇幼保健,2015,30(34):6094-6096.
[10] 钟炜,周利,刘小松,等.肺表面活性物质治疗新生儿羊水吸入性重症肺炎并呼吸衰竭的疗效[J].实用临床医学,2012,13(3):65-67.
[11] 闫小红,刘云,李宗尚.新生儿急性呼吸窘迫综合征发病相关因素分析[J].中国中西医结合儿科学,2013,5(4):334-336.
[12] 陈才.肺表面活性物质治疗足月新生儿急性呼吸窘迫综合征的效果探析[J].中国社区医师,2016,32(7):71-72.