基于光谱技术的中药质量控制研究进展
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摘要
中药作为中国的民族瑰宝,对医疗保健的潜在影响引起了国际社会越来越多的关注。然而中药化学成分复杂,具有系统性、多靶点和多渠道等特点,运用传统的质量控制方法来识别中药已经不能满足现代中医药发展的需要。近年来光谱技术结合化学计量学的研究方法迅速发展,其凭借可对样本直接分析、对环境友好和操作简单等优点在中药领域的应用越来越广泛。以光谱技术为基础针对近几年中药质量控制的主要研究方法进行总结和概述,以期为中药的质量控制以及中药特色产业走向现代化和国际化提供参考依据。
As a national treasure of China,traditional Chinese medicine(TCM)has attracted more and more attention for its potential impact on health care worldwide.However,traditional Chinese medicine is characterized by complex chemical components,systematicness,multi-target and multi-channel.Traditional quality control methods was not able to meet the demands of modern development of traditional Chinese medicine.In recent years,spectral techniques combined with chemometrics have been developed rapidly.With the advantages of direct analysis,environmental friendliness and simple operation,they have been widely used in quality control of traditional Chinese medicine.Progress of spectral technologies in recent years was summarized,so as to provide references for the quality control of traditional Chinese medicine and the modernization and internationalization of the characteristic industry.
As a national treasure of China,traditional Chinese medicine(TCM)has attracted more and more attention for its potential impact on health care worldwide.However,traditional Chinese medicine is characterized by complex chemical components,systematicness,multi-target and multi-channel.Traditional quality control methods was not able to meet the demands of modern development of traditional Chinese medicine.In recent years,spectral techniques combined with chemometrics have been developed rapidly.With the advantages of direct analysis,environmental friendliness and simple operation,they have been widely used in quality control of traditional Chinese medicine.Progress of spectral technologies in recent years was summarized,so as to provide references for the quality control of traditional Chinese medicine and the modernization and internationalization of the characteristic industry.
引文
[1]刘海新,马浩,黄海娟,等.中药药渣的综合利用研究进展[J].发酵科技通讯,2014,43(1):30-32.
[2]THANIK E,WISNIEWSKI J A,NOWAK-WEGRZYN A,et al.Effect of traditional Chinese medicine on skin lesions and quality of life in patients with moderate to severe eczema[J].Annals of allergy asthma&immunology,2018,121(1):135-136.
[3]LUO H,LI H,WANG Y Y,et al.Clinical practice guidelines for treating headache with traditional Chinese medicine:quality assessment with the appraisal of guidelines for research and evaluation II instrument[J].Journal of traditional chinese medicine,2018,38(3):339-350.
[4]LI W F,JIANG J G,CHEN J.Chinese medicine and its modernization demands[J].Archives of medical research,2008,39(2):246-251.
[5]GUO D A,LU A P,LIU L.Modernization of traditional Chinese medicine[J].Journal of ethnopharmacology,2012,141(2):547-548.
[6]UZUNER H,BAUER R,FAN T P,et al.Traditional Chinese medicine research in the post-genomic era:good practice,priorities,challenges and opportunities[J].Journal of ethnopharmacology,2012,140(3):458-468.
[7]CHEN D D,XIE X F,AO H,et al.Raman spectroscopy in quality control of Chinese herbal medicine[J].Journal of the Chinese medical association,2017,80(5):288-296.
[8]ZHANG C,ZHENG X,NI H,et al.Discovery of quality control markers from traditional Chinese medicines by fingerprint-efficacy modeling:current status and future perspectives[J].Journal of pharmaceutical and biomedical analysis,2018,159:296-304.
[9]CHAN K,HU X Y,RAZMOVSKI-NAUMOVSKI V,et al.Challenges and opportunities of integrating traditional Chinese medicine into mainstream medicine:a review of the current situation[J].European journal of integrative medicine,2015,7(1):67-75.
[10]GUO L,DUAN L,DOU L L,et al.Quality standardization of herbal medicines using effective compounds combination as labeled constituents[J].Journal of pharmaceutical and biomedical analysis,2016,129:320-331.
[11]SHU Y S,LIU Z L,ZHAO S Y,et al.Integrated and global pseudotargeted metabolomics strategy applied to screening for quality control markers of citrus TCMs[J].Analytical and bioanalytical chemistry,2017,409(20):4849-4865.
[12]JING J,REN W C,CHEN S B,et al.Advances in analytical technologies to evaluate the quality of traditional Chinese medicines[J].Trac-trends in analytical chemistry,2013,44:39-45.
[13]LI S,ZHANG B.Traditional Chinese medicine network pharmacology:theory,methodology and application[J].Chinese journal of natural medicines,2013,11(2):110-120.
[14]杨鸣华,孔令义.中药质量标准现代化与国际化的思考[J].世界科学技术-中医药现代化专论,2017,19(10):1619-1622.
[15]JIANG Y,LIU F J,WANG Y M,et al.Dereplicationguided isolation of novel hepatoprotective triterpenoid saponins fromCelosiae Semen by high-performance liquid chromatography coupled with electrospray ionization tandem quadrupole-time-of-flight mass spectrometry[J].Journal of pharmaceutical and biomedical analysis,2017,132:148-155.
[16]唐艳,李晶,吴涛.L-异亮氨酸高效液相色谱检测方法的研究[J].发酵科技通讯,2017,46(4):220-223.
[17]YANG H,CHAO C X,WANG X M,et al.Chromatographic fingerprint investigation for quality evaluation and control of shengui hair-growth tincture[J].Planta medica,2010,76(4):372-377.
[18]SIMION I M,CASONI D,SARBU C.Classification of romanian medicinal plant extracts according to the therapeutic effects using thin layer chromatography and robust chemometrics[J].Journal of pharmaceutical and biomedical analysis,2019,163:137-143.
[19]CHEN T,WANG P,WANG N N,et al.Separation of three polar compounds from rheum tanguticum by high-speed countercurrent chromatography with an ethyl acetate/glacial acetic acid/water system[J].Journal of separation science,2018,41(8):1775-1780.
[20]LI C H,ZUO H L,CHEN C,et al.SDS-PAGE and 2-DEprotein profiles of Ganoderma lucidumfrom different origins[J].Pakistan journal of pharmaceutical sciences,2018,31(2):447-454.
[21]ZHANG H,REN Q C,REN Y,et al.Ajudecumin A from Ajuga ovalifolia var.calantha exhibits anti-inflammatory activity in lipopolysaccharide-activated RAW264.7 murine macrophages and animal models of acute inflammation[J].Pharmaceutical biology,2018,56(1):649-657.
[22]ROCHA F S,GOMES A J,LUNARDI C N,et al.Experimental methods in chemical engineering:ultraviolet visible spectroscopy-UV-Vis[J].Canadian journal of chemical engineering,2018,96(12):2512-2517.
[23]王元忠,钟贵,张霁,等.紫外指纹图谱结合化学计量学对不同产地中药三七的鉴别研究[J].光谱学与光谱分析,2016,36(6):1789-1793.
[24]HUANG H X,LV Y Y,SUN X Y,et al.Rapid determination of tannin in Danshen and Guanxinning injections using UV spectrophotometry for quality control[J].Journal of innovative optical health sciences,2018,11(6):1-10.
[25]YANG L F,MA F,ZHOU Q,et al.Analysis and identification of wild and cultivated Paridis rhizoma by infrared spectroscopy[J].Journal of molecular structure,2018,1165:37-41.
[26]郭宇飞,徐拓,徐庆阳.异亮氨酸发酵过程中浓度近红外预测模型的建立[J].发酵科技通讯,2017,46(3):138-142.
[27]WU Z,PENG Y,CHEN W,et al.NIR spectroscopy as a process analytical technology(PAT)tool for monitoring and understanding of a hydrolysis process[J].Bioresource technology,2013,137:394-399.
[28]CHEN Y,HUANG J F,YEAP Z Q,et al.Rapid authentication and identification of different types of A.roxburghii by tri-step FT-IR spectroscopy[J].Spectrochimica acta part A-molecular and biomolecular spectroscopy,2018,199:271-282.
[29]CHEN H,LIN Z,TAN C.Fast discrimination of the geographical origins of notoginseng by near-infrared spectroscopy and chemometrics[J].Journal of pharmaceutical and biomedical analysis,2018,161:239-245.
[30]李运,张霁,金航,等.FTIR结合化学计量学对三七地下部位鉴别及皂苷含量预测[J].光谱学与光谱分析,2019,39(1):103-108.
[31]WANG W T,ZHANG H,YUAN Y,et al.Research progress of raman spectroscopy in drug analysis[J].AAPSPharmSciTech,2018,19(7):2921-2928.
[32]张凡,陈龙,黄必胜,等.应用X线衍射及拉曼光谱鉴别白石英[J].中国医院药学杂志,2017,37(24):2443-2447.
[33]QI X,ZENG C C,LIU H P,et al.Rapid quantitative analysis of puerarin using raman spectroscopy[J].Spectroscopy,2013,28(4):34-39.
[34]DE LUCA E,REDAELLI M,ZAFFINO C,et al.A SERSand HPLC study of traditional dyes from native Chinese plants[J].Vibrational spectroscopy,2018,95:62-67.
[35]ZHAO J,LIU Y,FALES A M,et al.Direct analysis of traditional Chinese medicines using surface-enhanced raman scattering(SERS)[J].Drug testing and analysis,2014,6(10):1063-1068.
[36]CHEN W W,YU L,HONG S,et al.Study on Drug Groups in Huo-Xue-Hua-Yu Decoction with surfaced-enhanced raman scattering spectroscopic[J].Spectroscopy and spectral analysis,2017,37(4):1134-1138.
[37]SILVA T V,MILORI D M B P,NETO J A G,et al.Prediction of black,immature and sour defective beans in coffee blends by using laser-induced breakdown spectroscopy[J].Food chemistry,2019,278:223-227.
[38]LIU X N,MA Q,LIU S S,et al.Monitoring As and Hg variation in An-Gong-Niu-Huang Wan(AGNH)intermediates in a pilot scale blending process using laser-induced breakdown spectroscopy[J].Spectrochimica acta part A-molecular and biomolecular spectroscopy,2015,151:547-552.
[39]WANG J M,XUE S W,ZHENG P C,et al.Determination of lead and copper in ligusticum wallichii by laser-induced breakdown spectroscopy[J].Analytical letters,2017,50(12):2000-2011.
[40]ZHAO Y Y,ZHU S S,HE J,et al.Identification of Fritillaria thunbergii treated by sulfur fumigation using laser-induced breakdown spectroscopy[J].Spectroscopy and spectral analysis,2018,38(11):3558-3562.
[41]KIANI S,VAN RUTH S M,MINAEI S.Hyperspectral imaging,a non-destructive technique in medicinal and aromatic plant products industry:current status and potential future applications[J].Computers and electronics in agriculture,2018,152:9-18.
[42]SANDASI M,VERMAAK I,CHEN W Y,et al.Skullcap and Germander:preventing potential toxicity through the application of hyperspectral imaging and multivariate image analysis as a novel quality control method[J].Planta medica,2014,80(15):1329-1339.
[43]XIA Z Y,ZHANG C,WENG H Y,et al.Sensitive wavelengths selection in identification of ophiopogon japonicus based on near-infrared hyperspectral imaging technology[J].International journal of analytical chemistry,2017,8:1-11.
[44]SANDASI M,CHEN W Y,VERMAAK I,et al.Non-destructive quality assessment of herbal tea blends using hyperspectral imaging[J].Phytochemistry letters,2018,24:94-101.
[45]HE J,HE Y,ZHANG C.Determination and visualization of Peimine and Peiminine content in Fritillariathunbergiibulbi treated by sulfur fumigation using hyperspectral imaging with chemometrics[J].Molecules,2017,22(9):1-12.
[46]赵峰,李静玲,袁敏杰,等.基于太赫兹透射谱的中药材特征提取方案[J].太赫兹科学与信息电子学报,2018,16(2):212-217.
[47]王潇霖,连艳,郑潇潇,等.太赫兹光谱技术在中药鉴别中的研究概况[J].中药与临床,2017,8(1):14-17.
[48]田珺宏,周俊,郑潇潇,等.基于太赫兹时域光谱仪的中药材鉴定技术研究[J].中国医疗设备,2018,33(7):9-13.
[49]杨帅,左剑,刘尚建,等.太赫兹光谱技术在中药大黄炮制品检测中的应用研究[J].光谱学与光谱分析,2016,36(12):3870-3874.
[50]胡清宇,姚锦平,李德成.太赫兹光谱技术在中药大黄炮制品检测中的应用价值分析[J].世界最新医学信息文摘,2018,18(72):265-267.
[51]周永军,刘劲松,王可嘉,等.基于太赫兹谱分析中药材鉴别[J].光谱学与光谱分析,2014,34(7):1840-1843.
[52]LI P F,HE M X,XU Z,et al.Terahertz spectrum clustering of traditional Chinese medicine based on first derivative characteristics[J].Journal of measurement science and instrumentation,2017,8(4):371-377.
[53]刘薇,戴连奎.中药提取过程在线紫外动态趋势回归分析及终点判定[J].光谱学与光谱分析,2017,37(2):497-502.
[54]WANG J,SHI M,ZHENG P,et al.Quantitative analysis of Ca,Mg,and K in the roots of Angelica pubescens f.biserrata by laser-induced breakdown spectroscopy combined with artificial neural networks[J].Journal of applied spectroscopy,2018,85(1):190-196.
[55]WANG J M,LIAO X Y,ZHENG P C,et al.Classification of Chinese herbal medicine by laser-induced breakdown spectroscopy with principal component analysis and artificial neural network[J].Analytical letters,2018,51(4):575-586.
[56]DJOKAM M,SANDASI M,CHEN W,et al.Hyperspectral imaging as a rapid quality control method for herbal tea blends[J].Applied sciences-basel,2017,7(3):1-16.
[57]TANKEU S,VERMAAK I,CHEN W Y,et al.Differentiation between two“fang ji”herbal medicines,Stephania tetrandraand the nephrotoxic Aristolochia fangchi,using hyperspectral imaging[J].Phytochemistry,2016,122:213-222.
[58]ZHANG H M,WU T X,ZHANG L F,et al.Development of a portable field imaging spectrometer:application for the identification of sun-dried and sulfur-fumigated chinese herbals[J].Applied spectroscopy,2016,70(5):879-887.
[2]THANIK E,WISNIEWSKI J A,NOWAK-WEGRZYN A,et al.Effect of traditional Chinese medicine on skin lesions and quality of life in patients with moderate to severe eczema[J].Annals of allergy asthma&immunology,2018,121(1):135-136.
[3]LUO H,LI H,WANG Y Y,et al.Clinical practice guidelines for treating headache with traditional Chinese medicine:quality assessment with the appraisal of guidelines for research and evaluation II instrument[J].Journal of traditional chinese medicine,2018,38(3):339-350.
[4]LI W F,JIANG J G,CHEN J.Chinese medicine and its modernization demands[J].Archives of medical research,2008,39(2):246-251.
[5]GUO D A,LU A P,LIU L.Modernization of traditional Chinese medicine[J].Journal of ethnopharmacology,2012,141(2):547-548.
[6]UZUNER H,BAUER R,FAN T P,et al.Traditional Chinese medicine research in the post-genomic era:good practice,priorities,challenges and opportunities[J].Journal of ethnopharmacology,2012,140(3):458-468.
[7]CHEN D D,XIE X F,AO H,et al.Raman spectroscopy in quality control of Chinese herbal medicine[J].Journal of the Chinese medical association,2017,80(5):288-296.
[8]ZHANG C,ZHENG X,NI H,et al.Discovery of quality control markers from traditional Chinese medicines by fingerprint-efficacy modeling:current status and future perspectives[J].Journal of pharmaceutical and biomedical analysis,2018,159:296-304.
[9]CHAN K,HU X Y,RAZMOVSKI-NAUMOVSKI V,et al.Challenges and opportunities of integrating traditional Chinese medicine into mainstream medicine:a review of the current situation[J].European journal of integrative medicine,2015,7(1):67-75.
[10]GUO L,DUAN L,DOU L L,et al.Quality standardization of herbal medicines using effective compounds combination as labeled constituents[J].Journal of pharmaceutical and biomedical analysis,2016,129:320-331.
[11]SHU Y S,LIU Z L,ZHAO S Y,et al.Integrated and global pseudotargeted metabolomics strategy applied to screening for quality control markers of citrus TCMs[J].Analytical and bioanalytical chemistry,2017,409(20):4849-4865.
[12]JING J,REN W C,CHEN S B,et al.Advances in analytical technologies to evaluate the quality of traditional Chinese medicines[J].Trac-trends in analytical chemistry,2013,44:39-45.
[13]LI S,ZHANG B.Traditional Chinese medicine network pharmacology:theory,methodology and application[J].Chinese journal of natural medicines,2013,11(2):110-120.
[14]杨鸣华,孔令义.中药质量标准现代化与国际化的思考[J].世界科学技术-中医药现代化专论,2017,19(10):1619-1622.
[15]JIANG Y,LIU F J,WANG Y M,et al.Dereplicationguided isolation of novel hepatoprotective triterpenoid saponins fromCelosiae Semen by high-performance liquid chromatography coupled with electrospray ionization tandem quadrupole-time-of-flight mass spectrometry[J].Journal of pharmaceutical and biomedical analysis,2017,132:148-155.
[16]唐艳,李晶,吴涛.L-异亮氨酸高效液相色谱检测方法的研究[J].发酵科技通讯,2017,46(4):220-223.
[17]YANG H,CHAO C X,WANG X M,et al.Chromatographic fingerprint investigation for quality evaluation and control of shengui hair-growth tincture[J].Planta medica,2010,76(4):372-377.
[18]SIMION I M,CASONI D,SARBU C.Classification of romanian medicinal plant extracts according to the therapeutic effects using thin layer chromatography and robust chemometrics[J].Journal of pharmaceutical and biomedical analysis,2019,163:137-143.
[19]CHEN T,WANG P,WANG N N,et al.Separation of three polar compounds from rheum tanguticum by high-speed countercurrent chromatography with an ethyl acetate/glacial acetic acid/water system[J].Journal of separation science,2018,41(8):1775-1780.
[20]LI C H,ZUO H L,CHEN C,et al.SDS-PAGE and 2-DEprotein profiles of Ganoderma lucidumfrom different origins[J].Pakistan journal of pharmaceutical sciences,2018,31(2):447-454.
[21]ZHANG H,REN Q C,REN Y,et al.Ajudecumin A from Ajuga ovalifolia var.calantha exhibits anti-inflammatory activity in lipopolysaccharide-activated RAW264.7 murine macrophages and animal models of acute inflammation[J].Pharmaceutical biology,2018,56(1):649-657.
[22]ROCHA F S,GOMES A J,LUNARDI C N,et al.Experimental methods in chemical engineering:ultraviolet visible spectroscopy-UV-Vis[J].Canadian journal of chemical engineering,2018,96(12):2512-2517.
[23]王元忠,钟贵,张霁,等.紫外指纹图谱结合化学计量学对不同产地中药三七的鉴别研究[J].光谱学与光谱分析,2016,36(6):1789-1793.
[24]HUANG H X,LV Y Y,SUN X Y,et al.Rapid determination of tannin in Danshen and Guanxinning injections using UV spectrophotometry for quality control[J].Journal of innovative optical health sciences,2018,11(6):1-10.
[25]YANG L F,MA F,ZHOU Q,et al.Analysis and identification of wild and cultivated Paridis rhizoma by infrared spectroscopy[J].Journal of molecular structure,2018,1165:37-41.
[26]郭宇飞,徐拓,徐庆阳.异亮氨酸发酵过程中浓度近红外预测模型的建立[J].发酵科技通讯,2017,46(3):138-142.
[27]WU Z,PENG Y,CHEN W,et al.NIR spectroscopy as a process analytical technology(PAT)tool for monitoring and understanding of a hydrolysis process[J].Bioresource technology,2013,137:394-399.
[28]CHEN Y,HUANG J F,YEAP Z Q,et al.Rapid authentication and identification of different types of A.roxburghii by tri-step FT-IR spectroscopy[J].Spectrochimica acta part A-molecular and biomolecular spectroscopy,2018,199:271-282.
[29]CHEN H,LIN Z,TAN C.Fast discrimination of the geographical origins of notoginseng by near-infrared spectroscopy and chemometrics[J].Journal of pharmaceutical and biomedical analysis,2018,161:239-245.
[30]李运,张霁,金航,等.FTIR结合化学计量学对三七地下部位鉴别及皂苷含量预测[J].光谱学与光谱分析,2019,39(1):103-108.
[31]WANG W T,ZHANG H,YUAN Y,et al.Research progress of raman spectroscopy in drug analysis[J].AAPSPharmSciTech,2018,19(7):2921-2928.
[32]张凡,陈龙,黄必胜,等.应用X线衍射及拉曼光谱鉴别白石英[J].中国医院药学杂志,2017,37(24):2443-2447.
[33]QI X,ZENG C C,LIU H P,et al.Rapid quantitative analysis of puerarin using raman spectroscopy[J].Spectroscopy,2013,28(4):34-39.
[34]DE LUCA E,REDAELLI M,ZAFFINO C,et al.A SERSand HPLC study of traditional dyes from native Chinese plants[J].Vibrational spectroscopy,2018,95:62-67.
[35]ZHAO J,LIU Y,FALES A M,et al.Direct analysis of traditional Chinese medicines using surface-enhanced raman scattering(SERS)[J].Drug testing and analysis,2014,6(10):1063-1068.
[36]CHEN W W,YU L,HONG S,et al.Study on Drug Groups in Huo-Xue-Hua-Yu Decoction with surfaced-enhanced raman scattering spectroscopic[J].Spectroscopy and spectral analysis,2017,37(4):1134-1138.
[37]SILVA T V,MILORI D M B P,NETO J A G,et al.Prediction of black,immature and sour defective beans in coffee blends by using laser-induced breakdown spectroscopy[J].Food chemistry,2019,278:223-227.
[38]LIU X N,MA Q,LIU S S,et al.Monitoring As and Hg variation in An-Gong-Niu-Huang Wan(AGNH)intermediates in a pilot scale blending process using laser-induced breakdown spectroscopy[J].Spectrochimica acta part A-molecular and biomolecular spectroscopy,2015,151:547-552.
[39]WANG J M,XUE S W,ZHENG P C,et al.Determination of lead and copper in ligusticum wallichii by laser-induced breakdown spectroscopy[J].Analytical letters,2017,50(12):2000-2011.
[40]ZHAO Y Y,ZHU S S,HE J,et al.Identification of Fritillaria thunbergii treated by sulfur fumigation using laser-induced breakdown spectroscopy[J].Spectroscopy and spectral analysis,2018,38(11):3558-3562.
[41]KIANI S,VAN RUTH S M,MINAEI S.Hyperspectral imaging,a non-destructive technique in medicinal and aromatic plant products industry:current status and potential future applications[J].Computers and electronics in agriculture,2018,152:9-18.
[42]SANDASI M,VERMAAK I,CHEN W Y,et al.Skullcap and Germander:preventing potential toxicity through the application of hyperspectral imaging and multivariate image analysis as a novel quality control method[J].Planta medica,2014,80(15):1329-1339.
[43]XIA Z Y,ZHANG C,WENG H Y,et al.Sensitive wavelengths selection in identification of ophiopogon japonicus based on near-infrared hyperspectral imaging technology[J].International journal of analytical chemistry,2017,8:1-11.
[44]SANDASI M,CHEN W Y,VERMAAK I,et al.Non-destructive quality assessment of herbal tea blends using hyperspectral imaging[J].Phytochemistry letters,2018,24:94-101.
[45]HE J,HE Y,ZHANG C.Determination and visualization of Peimine and Peiminine content in Fritillariathunbergiibulbi treated by sulfur fumigation using hyperspectral imaging with chemometrics[J].Molecules,2017,22(9):1-12.
[46]赵峰,李静玲,袁敏杰,等.基于太赫兹透射谱的中药材特征提取方案[J].太赫兹科学与信息电子学报,2018,16(2):212-217.
[47]王潇霖,连艳,郑潇潇,等.太赫兹光谱技术在中药鉴别中的研究概况[J].中药与临床,2017,8(1):14-17.
[48]田珺宏,周俊,郑潇潇,等.基于太赫兹时域光谱仪的中药材鉴定技术研究[J].中国医疗设备,2018,33(7):9-13.
[49]杨帅,左剑,刘尚建,等.太赫兹光谱技术在中药大黄炮制品检测中的应用研究[J].光谱学与光谱分析,2016,36(12):3870-3874.
[50]胡清宇,姚锦平,李德成.太赫兹光谱技术在中药大黄炮制品检测中的应用价值分析[J].世界最新医学信息文摘,2018,18(72):265-267.
[51]周永军,刘劲松,王可嘉,等.基于太赫兹谱分析中药材鉴别[J].光谱学与光谱分析,2014,34(7):1840-1843.
[52]LI P F,HE M X,XU Z,et al.Terahertz spectrum clustering of traditional Chinese medicine based on first derivative characteristics[J].Journal of measurement science and instrumentation,2017,8(4):371-377.
[53]刘薇,戴连奎.中药提取过程在线紫外动态趋势回归分析及终点判定[J].光谱学与光谱分析,2017,37(2):497-502.
[54]WANG J,SHI M,ZHENG P,et al.Quantitative analysis of Ca,Mg,and K in the roots of Angelica pubescens f.biserrata by laser-induced breakdown spectroscopy combined with artificial neural networks[J].Journal of applied spectroscopy,2018,85(1):190-196.
[55]WANG J M,LIAO X Y,ZHENG P C,et al.Classification of Chinese herbal medicine by laser-induced breakdown spectroscopy with principal component analysis and artificial neural network[J].Analytical letters,2018,51(4):575-586.
[56]DJOKAM M,SANDASI M,CHEN W,et al.Hyperspectral imaging as a rapid quality control method for herbal tea blends[J].Applied sciences-basel,2017,7(3):1-16.
[57]TANKEU S,VERMAAK I,CHEN W Y,et al.Differentiation between two“fang ji”herbal medicines,Stephania tetrandraand the nephrotoxic Aristolochia fangchi,using hyperspectral imaging[J].Phytochemistry,2016,122:213-222.
[58]ZHANG H M,WU T X,ZHANG L F,et al.Development of a portable field imaging spectrometer:application for the identification of sun-dried and sulfur-fumigated chinese herbals[J].Applied spectroscopy,2016,70(5):879-887.