盐酸米多君原料药含量测定方法的改进
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摘要
目的:建立革除汞盐的氢氧化钠电位滴定法测定盐酸米多君原料药的含量。方法:采用Mettler Toledo DG111-SC(pH 0-14,0-70℃)复合电极,以乙醇为溶剂,采用氢氧化钠滴定液(0.1mol·L~(-1))滴定,并与国家药品试行标准YBH09272004中含量测定原方法进行了比较。结果:空白无干扰,重复性良好,成功革除醋酸汞,两种测定方法含量结果比较无明显差异。结论:建立的新方法革除了醋酸汞,滴定突跃明显,方法简单易行,重复性好。
Objective:To establish a mercury-free sodium hydroxide potentiometric titration method for the assay of midodrine hydrochloride.Methods:Mettler DG111(Ph 0-14,0-70℃)was used as the composite electrode,the ethanol was used as the solvent and sodium hydroxide(0.1 mol· L~(-1))was used as titrating solution.The method was compared with the original methods stated in YBH09272004.Results:The experiments had better repeatability and the blank had no interference.The result showed that there was no significant difference between two kinds of methods.Conclusion:The improved method discards mercuric salt and obtain an abrupt change of the titration cruve.It is simple,reproducible and accurate for the determination of midodrine hydrochloride.
Objective:To establish a mercury-free sodium hydroxide potentiometric titration method for the assay of midodrine hydrochloride.Methods:Mettler DG111(Ph 0-14,0-70℃)was used as the composite electrode,the ethanol was used as the solvent and sodium hydroxide(0.1 mol· L~(-1))was used as titrating solution.The method was compared with the original methods stated in YBH09272004.Results:The experiments had better repeatability and the blank had no interference.The result showed that there was no significant difference between two kinds of methods.Conclusion:The improved method discards mercuric salt and obtain an abrupt change of the titration cruve.It is simple,reproducible and accurate for the determination of midodrine hydrochloride.
引文
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2 张娜,岳志华,牛秀华,等.2010年版中国药典非水滴定中革除汞盐方法的探讨[J].药物分析杂志,2008,28(8):1405-1407.
3 胡猛慎,洪志玲,黄剑英,等.非水电位滴定法测定氢溴酸西酞普兰原料药含量的改进[J].中国现代应用药学,2014,31(3):323-332.
4 游水英,李运群,周小霞,等.非水滴定法与电位滴定法测定金刚烷胺含量比较[J].中国药师,2012,15(1):130-131.
5 姜瑛,吕丽娟,代栾,等.非水滴定法测定帕拉米韦原料药中帕拉米韦[J].现代药物与临床,2013,28(2):200-202.
6 中国药典[S].2010年版二部,附录.
7 中国药典[S].2015年版二部,附录.
8 王桂林,淘淑芸.浅谈自动电位滴定技术发展及在常规检测中的应用[J].水文水资源,2013,(08):35-38.
9 冯俊贤,宋丽英,张如春,等.新的电位滴定终点识别方法[J].理化检验,2007,(05):61-63.
10 俞学炜,丁荣敏.电位滴定法在药物分析中的应用进展[J].理化检验,2014,(03):131-134.