两种苦参碱缓释微粒的释放动力学研究
|
摘要
对比苦参碱的市售粉剂、脂质体及蛋白微囊在实验室静态水与模拟大田实验流动态的水中的释放差异,探究释放规律。设计实验室模拟静态释放和动态释放,并通过Origin 8.0进行模型拟合。结果市售粉剂、脂质体及蛋白微囊在静态和动态释放过程中均符合一级动力学模型(r>0.99),其中市售苦参碱粉剂在Ritger-peppas模型中的药物释放因子n<0.45,脂质体及微囊在Ritger-peppas模型中的药物释放因子0.45 Commercially available powders,liposomes and protein microcapsules of Matrine were compared the difference of release in standing water and flowing water to research the release characteristics.Origin 8.0 was been used to analyzed and fitted the equation.The commercially available powders,liposomes and protein microcapsules were consistent with the first-order kinetic model(r>0.99)both in standing water and flowing water.The pharmacokinetic factor of commercially available Matrine powder in the Ritger-peppas model was less than 0.45,the pharmacokinetic factor of liposomes and protein microcapsules in the Ritger-peppas model was between 0.45 and 0.89.The release of commercially available matrine powder is focused on diffusion within 4 h,while the release of liposomes and protein microcapsules are focused on the couple of diffusion and erosion model.
引文
[1]王玉龙,关扎根,贾学思,等.苦参碱在农业害虫防治中的应用研究进展[J].山西农业科学,2012,40(4):424-428.WANG Yulong,GUAN Zhagen,JIA Xuesi,et al.Study progress of matrine application in farming pest control[J].Journal of Shanxi Agricultural Sciences,2012,40(4):424-428.
[2]吴传万,杜小凤,杨文飞,等.植物源农药苦参碱防治韭蛆实验[J].现代农药,2004,3(1):43-44.WU Chuanwan,DU Xiaofeng,YANG Wenfei,et al.Experiment on the prevention and treatment of leek trees by plant-derived pesticide matrine[J].Modern Agrochemicals,2004,3(1):43-44.
[3]张兴,马志卿,冯俊涛,等.植物源农药研究进展[J].中国生物防治学报,2015,31(5):685-698.ZHANG Xing,MA Zhiqing,FENG Juntao,et al.Review on research and development of botanical pesticides[J].Chinese Journal of Biological Control,2015,31(5):685-698.
[4]付颖,王长波,叶非.我国苦参碱农药研究应用概况[J].农药科学与管理,2005,26(12):30-33.FU Ying,WANG Changbo,YE Fei.The application of aophora flavescens ait alkaloids in China[J].Pesticde Science and Adiministration,2005,26(12):30-33.
[5]蔡伟.植物源农药苦参生物杀虫剂的研究进展[J].中药材,2012,19:51-53.CAI Wei.Research progress of plant-derived pesticide sophora flavescens biological insecticide[J].Journal of Chinese Medicinal Materials,2012,19:51-53.
[6]熊鑫,郭树奇,李琳,等.苦豆子生物碱对番茄生长及果实品质的影响[J].中国农业科学,2015,48(9):1737-1746.XIONG Xin,GUO Shuqi,LI Lin,et al.Effect of sophora alopecuroides alkaloids ontomato growth and fruit quality[J].Scientia Agricultura Sinica,2015,48(9):1737-1746.
[7]夏丽娟,王朝斌,赵霞,等.苦参碱1.5%可溶液剂防治芹菜、苦瓜、西葫芦蚜虫效果研究[J].农药科学与管理,2013,34(10):51-54.XIA Lijuan,WANG Chaobin,ZHAO Xia,et al.The control effect of 1.5%matrine SL against aphids on celery,balsam pear and summer squash[J].Pesticide Science and Administration,2013,34(10):51-54.
[8]李娜娜,杨建平.植物源农药对韭菜迟眼蕈蚊幼虫的室内毒力测定和田间防治效果[J].山东农业科学,2012,44(7):101-103.LI Nana,YANG Jianping.Toxicity determination of botanical pesticide to larvae of Bradysia odoriphagaYang et Zhang in laboratory and its control effect in fields[J].Shandong Agricultural Sciences,2012,44(7):101-103.
[9]李文香,杨玉婷,吴青君,等.韭菜迟眼蕈蚊研究进展[J].植物保护,2015,41(5):8-12.LI Wenxiang,YANG Yuting,WU Qingjun,et al.Research progress on Bradysia odoriphaga Yang et Zhang(Diptera:Sciaridae)[J].Plant Protection,2015,41(5):8-12.
[10]王锐,张泽俊,陈光全,等.紫外分光光度法测定狼牙刺花中生物碱含量[J].广东化工,2015,42(6):166-167.WAN Rui,ZHANG Zejun,CHENG Guangquan,et al.Determinaton of alkaloids in the flowers of sophora viciifolia hance by ultraviolet spectrophotometry[J].Guangdong Chemical Industry,2015,42(6):166-167.
[11]杨毅恒,翟所迪.酸性染料比色法测定鞣苦胶囊中苦参总生物碱的含量[J].北京中医药大学学报,2004,27(6):63-65.YANG Yiheng,ZHAI Suodi.Determination of total alkaloids in sophora flavescens in tannin capsules by acid dye colorimetry[J].Journal of Beijing University of Chinese Medicine,2004,27(6):63-65.
[12]李秀英,曾凡,赵曜.脂质体药物递送系统的研究进展[J].中国新药杂志,2014,23(16):1904-1917.LI Xiuying,ZENG Fan,ZHAO Yao.Advances in the research and development of liposomal drug delivery systems[J].Chinese Journal of New Drugs,2014,23(16):1904-1917.
[2]吴传万,杜小凤,杨文飞,等.植物源农药苦参碱防治韭蛆实验[J].现代农药,2004,3(1):43-44.WU Chuanwan,DU Xiaofeng,YANG Wenfei,et al.Experiment on the prevention and treatment of leek trees by plant-derived pesticide matrine[J].Modern Agrochemicals,2004,3(1):43-44.
[3]张兴,马志卿,冯俊涛,等.植物源农药研究进展[J].中国生物防治学报,2015,31(5):685-698.ZHANG Xing,MA Zhiqing,FENG Juntao,et al.Review on research and development of botanical pesticides[J].Chinese Journal of Biological Control,2015,31(5):685-698.
[4]付颖,王长波,叶非.我国苦参碱农药研究应用概况[J].农药科学与管理,2005,26(12):30-33.FU Ying,WANG Changbo,YE Fei.The application of aophora flavescens ait alkaloids in China[J].Pesticde Science and Adiministration,2005,26(12):30-33.
[5]蔡伟.植物源农药苦参生物杀虫剂的研究进展[J].中药材,2012,19:51-53.CAI Wei.Research progress of plant-derived pesticide sophora flavescens biological insecticide[J].Journal of Chinese Medicinal Materials,2012,19:51-53.
[6]熊鑫,郭树奇,李琳,等.苦豆子生物碱对番茄生长及果实品质的影响[J].中国农业科学,2015,48(9):1737-1746.XIONG Xin,GUO Shuqi,LI Lin,et al.Effect of sophora alopecuroides alkaloids ontomato growth and fruit quality[J].Scientia Agricultura Sinica,2015,48(9):1737-1746.
[7]夏丽娟,王朝斌,赵霞,等.苦参碱1.5%可溶液剂防治芹菜、苦瓜、西葫芦蚜虫效果研究[J].农药科学与管理,2013,34(10):51-54.XIA Lijuan,WANG Chaobin,ZHAO Xia,et al.The control effect of 1.5%matrine SL against aphids on celery,balsam pear and summer squash[J].Pesticide Science and Administration,2013,34(10):51-54.
[8]李娜娜,杨建平.植物源农药对韭菜迟眼蕈蚊幼虫的室内毒力测定和田间防治效果[J].山东农业科学,2012,44(7):101-103.LI Nana,YANG Jianping.Toxicity determination of botanical pesticide to larvae of Bradysia odoriphagaYang et Zhang in laboratory and its control effect in fields[J].Shandong Agricultural Sciences,2012,44(7):101-103.
[9]李文香,杨玉婷,吴青君,等.韭菜迟眼蕈蚊研究进展[J].植物保护,2015,41(5):8-12.LI Wenxiang,YANG Yuting,WU Qingjun,et al.Research progress on Bradysia odoriphaga Yang et Zhang(Diptera:Sciaridae)[J].Plant Protection,2015,41(5):8-12.
[10]王锐,张泽俊,陈光全,等.紫外分光光度法测定狼牙刺花中生物碱含量[J].广东化工,2015,42(6):166-167.WAN Rui,ZHANG Zejun,CHENG Guangquan,et al.Determinaton of alkaloids in the flowers of sophora viciifolia hance by ultraviolet spectrophotometry[J].Guangdong Chemical Industry,2015,42(6):166-167.
[11]杨毅恒,翟所迪.酸性染料比色法测定鞣苦胶囊中苦参总生物碱的含量[J].北京中医药大学学报,2004,27(6):63-65.YANG Yiheng,ZHAI Suodi.Determination of total alkaloids in sophora flavescens in tannin capsules by acid dye colorimetry[J].Journal of Beijing University of Chinese Medicine,2004,27(6):63-65.
[12]李秀英,曾凡,赵曜.脂质体药物递送系统的研究进展[J].中国新药杂志,2014,23(16):1904-1917.LI Xiuying,ZENG Fan,ZHAO Yao.Advances in the research and development of liposomal drug delivery systems[J].Chinese Journal of New Drugs,2014,23(16):1904-1917.