甘露醇联合糖皮质激素治疗周围性面神经麻痹的疗效观察
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摘要
目的:观察甘露醇联合糖皮质激素治疗周围性面神经麻痹的临床疗效。方法:周围性面神经麻痹患者120例,随机分为对照组和治疗组,各60例。对照组给予常规治疗加用强的松口服,治疗组在常规治疗基础上加用甘露醇联合强的松口服治疗,比较2组疗效及肌电图改变。结果:治疗7 d时,治疗组总有效率78.33%,对照组总有效率56.67%,差异有统计学意义(P<0.05);治疗14 d时,治疗组总有效率90.33%,对照组总有效率81.67%,差异有统计学意义(P<0.05)。治疗7、14 d后,2组CMAP波幅均较前恢复,R1潜伏期均较前缩短,且治疗组较对照组幅度更为明显(P<0.05)。结论:甘露醇联合地塞米松治疗周围性面神经麻痹临床效果更快更好,值得推广。
Objective: To observe the clinical efficacy of treating peripheral facial paralysis patients with mannitol combined with glucocorticoid. Methods:One hundred and twenty cases with peripheral facial paralysis were enrolled and were randomly divided into treatment group(n=60) and control group(n=60). Cases in the control group were treated with conventional therapy ways and dexamethasone. Besides conventional therapy ways and dexamethasone, mannitol were used to treat the patients in the treatment group. Data of electromyogram and House-Brackmann scales were collected and compared between the two groups. Results:At 7 days after treatment, the total effective rate was 78.33% in the treatment group and 56.67% in the control group(P<0.05). At 14 days after treatment, the total effective rate was 90.33% in the treatment group and 81.67% in the control group(P<0.05). Electromyogram data showed that CMAP amplitude recovered in the both groups and R1 incubation period was shorter than those before. CMAP amplitudes and R1 incubation periods in the treatment group were shorter than those in the control group(P<0.05). Conclusion: It is an effective way to treat peripheral facial paralysis patients with mannitol combined with glucocorticoid.
Objective: To observe the clinical efficacy of treating peripheral facial paralysis patients with mannitol combined with glucocorticoid. Methods:One hundred and twenty cases with peripheral facial paralysis were enrolled and were randomly divided into treatment group(n=60) and control group(n=60). Cases in the control group were treated with conventional therapy ways and dexamethasone. Besides conventional therapy ways and dexamethasone, mannitol were used to treat the patients in the treatment group. Data of electromyogram and House-Brackmann scales were collected and compared between the two groups. Results:At 7 days after treatment, the total effective rate was 78.33% in the treatment group and 56.67% in the control group(P<0.05). At 14 days after treatment, the total effective rate was 90.33% in the treatment group and 81.67% in the control group(P<0.05). Electromyogram data showed that CMAP amplitude recovered in the both groups and R1 incubation period was shorter than those before. CMAP amplitudes and R1 incubation periods in the treatment group were shorter than those in the control group(P<0.05). Conclusion: It is an effective way to treat peripheral facial paralysis patients with mannitol combined with glucocorticoid.
引文
[1]Liu YR,Liu Q.Meta-analysis of m NGF therapy for peripheral nerve injury:a systematic review[J].Chin J Traumatol,2012,15:86-91.
[2]王维治.神经病学[M].第六版.北京:人民卫生出版社,2009:335-337.
[3]Lee HY,Park MS,Byun JY,et al.Agreement between the Facial Nerve Grading System 2.0 and the House-Brackmann Grading System in patients with Bell palsy[J].Clin Exp Oto-rhinolaryngol,2013,6:135-139.
[4]庾建英,刘继新.瞬目反射、面神经电图和面肌肌电图对面神经炎的诊断、治疗和预后的评估[J].精神疾病与精神卫生,2011,11:153-155.
[5]Schecterson LC,Bothwell M.Neurotrophin receptors:old frieds with new partners[J].Dev Neurobiol,2010,70:332-338.
[6]李莉,龙一鸣,林祐成,等.前列地尔注射液联合鼠神经生长因子治疗特发性面神经麻痹的疗效观察[J].数理医药学杂志,2015,28:876-877.
[7]李卫国.糖皮质激素在急性满神经炎定位治疗中的运用[J].医学综述,2011,17:3494-3495.
[8]李瑞娜.恩再适联合糖皮质激素治疗面神经炎的疗效观察[J].实用药物与临床,2013,16:262-263.
[9]屈改艳,夏和平.激素联合甘露醇治疗面神经炎64例疗效分析[J].吉林医学,2014,6:3561-3562.
[10]周春林,夏和平.阿昔洛韦联合糖皮质激素治疗面神经炎34例临床疗效分析[J].现代诊断与治疗,2015,26:2697-2698.
[11]黄以隋.甘露醇联合甲钴胺治疗面神经炎63例临床观察[J].中国医药指南,2010,8:77-77.
[12]王红州,王万华,毛慧慧.复方甘露醇联合糖皮质激素治疗重度面神经炎的疗效分析[J].中西医结合心脑血管杂志,2011,9:1074-1075.
[2]王维治.神经病学[M].第六版.北京:人民卫生出版社,2009:335-337.
[3]Lee HY,Park MS,Byun JY,et al.Agreement between the Facial Nerve Grading System 2.0 and the House-Brackmann Grading System in patients with Bell palsy[J].Clin Exp Oto-rhinolaryngol,2013,6:135-139.
[4]庾建英,刘继新.瞬目反射、面神经电图和面肌肌电图对面神经炎的诊断、治疗和预后的评估[J].精神疾病与精神卫生,2011,11:153-155.
[5]Schecterson LC,Bothwell M.Neurotrophin receptors:old frieds with new partners[J].Dev Neurobiol,2010,70:332-338.
[6]李莉,龙一鸣,林祐成,等.前列地尔注射液联合鼠神经生长因子治疗特发性面神经麻痹的疗效观察[J].数理医药学杂志,2015,28:876-877.
[7]李卫国.糖皮质激素在急性满神经炎定位治疗中的运用[J].医学综述,2011,17:3494-3495.
[8]李瑞娜.恩再适联合糖皮质激素治疗面神经炎的疗效观察[J].实用药物与临床,2013,16:262-263.
[9]屈改艳,夏和平.激素联合甘露醇治疗面神经炎64例疗效分析[J].吉林医学,2014,6:3561-3562.
[10]周春林,夏和平.阿昔洛韦联合糖皮质激素治疗面神经炎34例临床疗效分析[J].现代诊断与治疗,2015,26:2697-2698.
[11]黄以隋.甘露醇联合甲钴胺治疗面神经炎63例临床观察[J].中国医药指南,2010,8:77-77.
[12]王红州,王万华,毛慧慧.复方甘露醇联合糖皮质激素治疗重度面神经炎的疗效分析[J].中西医结合心脑血管杂志,2011,9:1074-1075.