硝苯地平联合拉贝洛尔对妊娠期高血压疾病病人心肾功能及血流动力学的影响
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摘要
目的:探讨硝苯地平联合拉贝洛尔对妊娠期高血压疾病病人心肾功能及血流动力学的影响。方法:选取2016-02～2017-04期间我院收治的妊娠期高血压疾病病人134例,随机分为两组,对照组应用拉贝洛尔治疗,研究组联合应用硝苯地平治疗。结果:研究组cTnT及BNP显著低于对照组(P<0.05);研究组24 h尿蛋白及Cys-C低于对照组(P<0.05);研究组疗效高于对照组(P<0.05);研究组各项血流动力学指标低于对照组(P<0.05)。结论:妊娠期高血压疾病病人应用硝苯地平联合拉贝洛尔的疗效更为理想,能显著改善病人的心肾功能及血流动力学水平,有助于改善病人的妊娠结局。
Objective:To investigate the effect of nifedipine combined with labetalol on cardiac and renal function and hemodynamics in patients with gestational hypertension.Methods:134 patients with gestational hypertension admitted to our hospital from February 2016 to April 2017 were selected and randomly divided into two groups.The control group was treated with rabelor and the study group was treated with nifedipine.Results:cTnT and BNP in the study group were significantly lower than those in the control group(P<0.05).Urinary protein and Cys-C in the study group were lower than those in the control group(P<0.05).The efficacy of the study group was higher than that of the control group(P<0.05).The hemodynamic indexes of the study group were lower than those of the control group(P<0.05).Conclusion:The application of nifedipine combined with labetalol in patients with hypertension during pregnancy is more ideal,which can significantly improve the level of cardiac and renal function and hemodynamics,and contribute to improving the pregnancy outcome of patients.
Objective:To investigate the effect of nifedipine combined with labetalol on cardiac and renal function and hemodynamics in patients with gestational hypertension.Methods:134 patients with gestational hypertension admitted to our hospital from February 2016 to April 2017 were selected and randomly divided into two groups.The control group was treated with rabelor and the study group was treated with nifedipine.Results:cTnT and BNP in the study group were significantly lower than those in the control group(P<0.05).Urinary protein and Cys-C in the study group were lower than those in the control group(P<0.05).The efficacy of the study group was higher than that of the control group(P<0.05).The hemodynamic indexes of the study group were lower than those of the control group(P<0.05).Conclusion:The application of nifedipine combined with labetalol in patients with hypertension during pregnancy is more ideal,which can significantly improve the level of cardiac and renal function and hemodynamics,and contribute to improving the pregnancy outcome of patients.
引文
[1]周宇涵,樊伍峰,董金菊.肾损伤分子-1、β2-微球蛋白、内皮素-1和肌配在妊娠期高血压疾病并发急性肾损伤的临床研究[J].生殖与避孕,2016;36(3):189-194
[2]Gomez-arango LF,Barrett HL,Mcintyre HD,et al.Increased systolic and diastolic blood pressure Is associated with altered gut microbiota composition and butyrate production in early pregnancy[J].Hypertension,2016;68(4):974-981
[3]李介岩,张为远,王欣,等.硫酸镁应用对妊娠期高血压疾病患者胎盘中基质金属蛋白酶-9和水通道蛋白-9表达的影响[J].中华医学杂志,2016;96(30):2421-2423
[4]Sergent F,Hoffmann P,Brouillet S,et al.Sustained endoc-rine gland-derived vascular endothelial growth factor levels beyond the first trimester of pregnancy display phenotypic and functional changes associated with the pathogenesis of pregnancy-induced hypertension[J].Hypertension,2016;68(1):148-156
[5]文睿婷,黄琳,于芝颖,等.甲基多巴和拉贝洛尔治疗妊娠期高血压疾病的系统评价[J].中国临床药理学杂志,2017;33(17):1710-1712
[6]Edward antwi,Kerstin klipstein-grobusch,Gloria quansah asare,et al.Measuring regional and district variations in the incidence of pregnancy-induced hypertension in ghana:challenges,Opportunities and implications for maternal and newborn health policy and programmes[J].Tropical Medicine & International Health,2016;21(1):93-100
[7]戴岭,王银瓶,佘广彤,等.血叶酸、同型半胱氨酸及尿酸水平与妊娠期高血压疾病发病的相关性分析[J].中国妇产科临床杂志,2017;21(4):361-362
[8]Tateishi A,Ohira S,Yamamoto Y,et al.Histopathological findings of pregnancy-induced hypertension:histopat-hology of early-onset type reflects two-stage disorder theory[J].Virchows Archiv,2018;(3):1-8
[9]谢桂英,马玉燕.拉贝洛尔对中重度妊娠期高血压疾病患者心肾功能及妊娠结局的影响及机制[J].山东医药,2017;57(21):74-76
[2]Gomez-arango LF,Barrett HL,Mcintyre HD,et al.Increased systolic and diastolic blood pressure Is associated with altered gut microbiota composition and butyrate production in early pregnancy[J].Hypertension,2016;68(4):974-981
[3]李介岩,张为远,王欣,等.硫酸镁应用对妊娠期高血压疾病患者胎盘中基质金属蛋白酶-9和水通道蛋白-9表达的影响[J].中华医学杂志,2016;96(30):2421-2423
[4]Sergent F,Hoffmann P,Brouillet S,et al.Sustained endoc-rine gland-derived vascular endothelial growth factor levels beyond the first trimester of pregnancy display phenotypic and functional changes associated with the pathogenesis of pregnancy-induced hypertension[J].Hypertension,2016;68(1):148-156
[5]文睿婷,黄琳,于芝颖,等.甲基多巴和拉贝洛尔治疗妊娠期高血压疾病的系统评价[J].中国临床药理学杂志,2017;33(17):1710-1712
[6]Edward antwi,Kerstin klipstein-grobusch,Gloria quansah asare,et al.Measuring regional and district variations in the incidence of pregnancy-induced hypertension in ghana:challenges,Opportunities and implications for maternal and newborn health policy and programmes[J].Tropical Medicine & International Health,2016;21(1):93-100
[7]戴岭,王银瓶,佘广彤,等.血叶酸、同型半胱氨酸及尿酸水平与妊娠期高血压疾病发病的相关性分析[J].中国妇产科临床杂志,2017;21(4):361-362
[8]Tateishi A,Ohira S,Yamamoto Y,et al.Histopathological findings of pregnancy-induced hypertension:histopat-hology of early-onset type reflects two-stage disorder theory[J].Virchows Archiv,2018;(3):1-8
[9]谢桂英,马玉燕.拉贝洛尔对中重度妊娠期高血压疾病患者心肾功能及妊娠结局的影响及机制[J].山东医药,2017;57(21):74-76