伏隔核内多巴胺在奖赏和强化学习中的作用
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摘要
<正>多巴胺(dopamine,DA)属儿茶酚胺类神经递质,在许多神经精神疾病的发生、发展中扮演重要角色。多巴胺还参与调控奖赏环路中的诸多重要环节,中脑边缘多巴胺系统更被认为是大脑奖赏系统的神经解剖学基础。多巴胺的功能特征主要取决于多巴胺能神经元胞体的所在脑区以及该神经元轴突终末的投射靶区~([1-3])。现重点综述中脑腹侧被盖区多巴胺能神经元的投
引文
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[19]Sugam J A,Day J J,Wightman R M,et al.Phasic nucleus accumbens dopamine encodes risk-based decision-making behavior[J].Biol Psychiatry,2012,71:199-205.
[20]Jones J L,Day J J,Wheeler R A,et al.The basolateral amygdala differentially regulates conditioned neural responses within the nucleus accumbens core and shell[J].Neuroscience,2010,169(3):1186-1198.
[21]Stuber G D,Sparta D R,Stamatakis A M,et al.Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking[J].Nature,2011,475(7356):377-380.
[2]Russo S J,Nestler E J.The brain reward circuitry in mood disorders[J].Nat Rev Neurosci,2013,14(9):609-625.
[3]Jenni N L,Larkin J D,Floresco S B.Prefrontal dopamine D1and D2receptors regulate dissociable aspects of decision making via distinct ventral striatal and amygdalar circuits[J].J Neurosci,2017,37(26):6200-6213.
[4]Hadley J A,Nenert R,Kraguljac N V,et al.Ventral tegmental area/midbrain functional connectivity and response to antipsychotic medication in schizophrenia[J].Neuropsychopharmacology,2014,39(4):1020-1030.
[5]Lammel S,Lim B K,Malenka R C.Reward and aversion in a heterogeneous midbrain dopamine system[J].Neuropharmacology,2014,76Pt B:351-359.
[6]Beyene M,Carelli R M,Wightman R M.Cue-evoked dopamine release in the nucleus accumbens shell tracks reinforcer magnitude during intracranial self-stimulation[J].Neuroscience,2010,169(4):1682-1688.
[7]Cacciapaglia F,Wightman R M,Carelli R M.Rapid dopamine signaling differentially modulates distinct microcircuits within the nucleus accumbens during sucrose-directed behavior[J].JNeurosci,2011,31(39):13860-13869.
[8]张伟国,曹桂范,杜惠莲,等.多巴胺D2受体在创伤后应激障碍样大鼠伏隔核内的表达[J].解剖学杂志,2014,37(2):185-187.
[9]杨春晖,郭德纲,吴曦,等.双侧伏隔核高频脑深部电刺激抑制大鼠成瘾行为消退[J].中华神经科杂志,2017,50(5):342-347.
[10]Wheeler R A,Aragona B J,Fuhrmann K A,et al.Cocaine cues drive opposing context-dependent shifts in reward processing and emotional state[J].Biol Psychiatry,2011,69(11):1067-1074.
[11]Dreyer J K,Herrik K F,Berg R W,et al.Influence of phasic and tonic dopamine release on receptor activation[J].J Neurosci,2010,30(42):14273-14283.
[12]Esber G R,Haselgrove M.Reconciling the influence of predictiveness and uncertainty on stimulus salience:a model of attention in associative learning[J].Proc Biol Sci,2011,278(1718):2553-2561.
[13]McDannald M A,Lucantonio F,Burke K A,et al.Ventral striatum and orbitofrontal cortex are both required for modelbased,but not model-free,reinforcement learning[J].JNeurosci,2011,31(7):2700-2705.
[14]Saddoris M P,Stamatakis A,Carelli R M.Neural correlates of Pavlovian-to-instrumental transfer in the nucleus accumbens shell are selectively potentiated following cocaine self-administration[J].Eur J Neurosci,2011,33(12):2274-2287.
[15]Sackett D A,Saddoris M P,Carelli R M.Nucleus accumbens shell dopamine preferentially tracks information related to outcome value of reward[J].eNeuro,2017,4(3).pii:ENEURO.0058-17.2017.
[16]Ghods-Sharifi S,Floresco S B.Differential effects on effort discounting induced by inactivations of the nucleus accumbens core or shell[J].Behav Neurosci,2010,124(2):179-191.
[17]Stopper C M,Floresco S B.Contributions of the nucleus accumbens and its subregions to different aspects of risk-based decision making[J].Cogn Affect Behav Neurosci,2011,11(1):97-112.
[18]Nasrallah N A,Clark J J,Collins A L,et al.Risk preference following adolescent alcohol use is associated with corrupted encoding of costs but not rewards by mesolimbic dopamine[J].Proc Natl Acad Sci USA,2011,108(13):5466-5471.
[19]Sugam J A,Day J J,Wightman R M,et al.Phasic nucleus accumbens dopamine encodes risk-based decision-making behavior[J].Biol Psychiatry,2012,71:199-205.
[20]Jones J L,Day J J,Wheeler R A,et al.The basolateral amygdala differentially regulates conditioned neural responses within the nucleus accumbens core and shell[J].Neuroscience,2010,169(3):1186-1198.
[21]Stuber G D,Sparta D R,Stamatakis A M,et al.Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking[J].Nature,2011,475(7356):377-380.