视网膜母细胞瘤的治疗研究进展
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摘要
视网膜母细胞瘤(retinoblastoma,RB)是婴幼儿最常见的眼内恶性肿瘤,其发病与基因突变相关。为提高患儿生存率,降低眼球摘除率,治疗方法不断更新发展。目前主要治疗方法有化学治疗、放射治疗、手术治疗、物理治疗、光化学治疗、基因治疗等。本文就视网膜母细胞瘤的治疗进展进行综述。
Retinoblastoma( RB) is the most common intraocular malignant tumor in infants,the pathogenesis of which,is related to gene mutations. In order to improve the survival rate and eye-protection rate of RB patients,the therapeutic approaches have been constantly updated and developed, mainly including chemotherapy, radiation therapy, surgical treatment, physiotherapy,photochemotherapy, gene therapy at present. In this article,we mainly reviewed the progress of RB treatment.
Retinoblastoma( RB) is the most common intraocular malignant tumor in infants,the pathogenesis of which,is related to gene mutations. In order to improve the survival rate and eye-protection rate of RB patients,the therapeutic approaches have been constantly updated and developed, mainly including chemotherapy, radiation therapy, surgical treatment, physiotherapy,photochemotherapy, gene therapy at present. In this article,we mainly reviewed the progress of RB treatment.
引文
1 Abramson DH.Retinoblastoma in the 20th century:past success and future challenges the Weisenfeld lecture.Invest Ophthalmol Vis Sci 2005;46(8):2683-2691
2 Delhiwala KS,Vadakkal IP,Mulay K,et al.Retinoblastoma:An update.Semin Diagn Pathol 2016;33(3):133-140
3 Cassoux N,Lumbroso L,Levy-Gabriel C,et al.Retinoblastoma:Update on Current Management.Asia Pac J Ophthalmol(Phila)2017;6(3):290-295
4 Shields CL,Mashayekhi A,Cater J,et al.Chemoreduction for retinoblastoma:analysis of tumor control and risks for recurrence in 457tumors.Am J Ophthalmol 2004;138(3):329-337
5 Yanik O,Gündüz K,Yavuz K,et al.Chemotherapy in Retinoblastoma:Current Approaches.Turk J Ophthalmol 2015;45(6):259-267
6 Zhao JY,Zhang CY.The key points in intravenous chemotherapy and intra-arterial chemotherapy on retinoblastoma treatment.Zhonghua Yan Ke Za Zhi 2017;53(8):566-569
7 Reddy MA,Naeem Z,Duncan C,et al.Reduction of severe visual loss and complications following intra-arterial chemotherapy(IAC)for refractory retinoblastoma.Br J Ophthalmol 2017;101(12):1704-1708
8 Shields CL,Lally SE,Leahey AM,et al.Targeted retinoblastoma management:when to use intravenous,intra-arterial,periocular,and intravitreal chemotherapy.Curr Opin Ophthalmol 2014;5(5):374-385
9 惠卉,程翼飞.儿童视网膜母细胞瘤的化学疗法.中国斜视与小儿眼科杂志2014;22(2):34,46-48
10 Smith SJ,Pulido JS,Salom2o DR,et al.Combined intravitreal and subconjunctival carboplatin for retinoblastoma with vitreous seeds.Br J Ophthalmol 2012;96(8):1073-1077
11 Kim JY,Park Y.Treatment of Retinoblastoma:The Role of External Beam Radiotherapy.Yonsei Med J 2015;56(6):1478-1491
12 Manjandavida FP,Honavar SG,Reddy VAP,et al.Management and outcome of retinoblastoma with vitreous seeds.Ophthalmology 2014;121(2):517-524
13 Sethi RV,Shih HA,Yeap BY,et al.Second nonocular tumors among survivors of retinoblastoma treated with contemporary photon and proton radiotherapy.Cancer 2014;120(1):126-133
14 Mouw KW,Yeap BY,Caruso P,et al.Analysis of patient outcomes following proton radiation therapy for retinoblastoma.Adv Radiat Oncol2017;2(1):44-52
15 Chawla B,Singh R.Recent advances and challenges in the management of retinoblastoma.Indian J Ophthalmol 2017;65(2):133-139
16 宋轶鹏,胡立宽,竺鑫丽,等.视网膜母细胞瘤立体定向放射治疗16 例临床分析.癌症进展2009;7(6):669-674
17 Atalar B,Ozyar E,Gunduz K,et al.Intensity modulated radiotherapy(IMRT)in bilateral retinoblastoma.Radiol Oncol 2010;44(3):194-198
18 Seth R,Singh A,Guru V,et al.Long-term follow-up of retinoblastoma survivors:Experience from India.South Asian J Cancer2017;6(4):176-179
19 Chawla B,Jain A,Azad R.Conservative treatment modalities in retinoblastoma.Indian J Ophthalmol 2013;61(9):479-485
20 Hasanreisoglu M,Saktanasate J,Schwendeman R,et al.Indocyanine Green-Enhanced Transpupillary Thermotherapy for Retinoblastoma:Analysis of 42 Tumors.J Pediatr Ophthalmol Strabismus 2015;52(6):348-354
21 Teixo R,Laranjo M,Abrantes AM,et al.Retinoblastoma:might photodynamic therapy be an option?Cancer Metastasis Rev 2015;34(4):563-573
22 Cerman E,Cekic O.Clinical use of photodynamic therapy in ocular tumors.Surv Ophthalmol 2015;60(6):557-574
23 Okura H,Smith CA,Rutka JT.Gene therapy for malignant glioma.Mol Cell Ther 2014;2:21
24 Audo I,Darjatmoko SR,Schlamp CL,et al.Vitamin D analogues increase p53,p21,and apoptosis in a xenograft model of human retinoblastoma.Invest Ophthalmol Vis Sci 2003;44(10):4192-4199
25 罗霁菡,周希瑗.超声微泡介导野生型p53基因转染Y79细胞的实验研究.中国超声医学杂志2008;24(12):1060-1062
26 Wadhwa L,Hurwitz M,Chévez-Barrios P,et al.Treatment of invasive retinoblastoma in a murine model using an oncolytic picornavirus.Cancer Res 2007;67(22):10653-10656
27 Adachi M,Brooks SE,Stein MR,et al.Destruction of human retinoblastoma after treatment by the E variant of encephalomyocarditis virus.J Neurooncol 2006;77(3):233-240
28 Dunkel IJ,Chan HSL,Jubran R,et al.High-dose chemotherapy with autologous hematopoietic stem cell rescue for stage 4B retinoblastoma.Pediatr Blood Cancer 2010;55(1):149-152
29 Zhou Y,Gu H,Xu Y,et al.Targeted antiangiogenesis gene therapy using targeted cationic microbubbles conjugated with CD105 antibody compared with untargeted cationic and neutral microbubbles.Theranostics2015;5(4):399-417
2 Delhiwala KS,Vadakkal IP,Mulay K,et al.Retinoblastoma:An update.Semin Diagn Pathol 2016;33(3):133-140
3 Cassoux N,Lumbroso L,Levy-Gabriel C,et al.Retinoblastoma:Update on Current Management.Asia Pac J Ophthalmol(Phila)2017;6(3):290-295
4 Shields CL,Mashayekhi A,Cater J,et al.Chemoreduction for retinoblastoma:analysis of tumor control and risks for recurrence in 457tumors.Am J Ophthalmol 2004;138(3):329-337
5 Yanik O,Gündüz K,Yavuz K,et al.Chemotherapy in Retinoblastoma:Current Approaches.Turk J Ophthalmol 2015;45(6):259-267
6 Zhao JY,Zhang CY.The key points in intravenous chemotherapy and intra-arterial chemotherapy on retinoblastoma treatment.Zhonghua Yan Ke Za Zhi 2017;53(8):566-569
7 Reddy MA,Naeem Z,Duncan C,et al.Reduction of severe visual loss and complications following intra-arterial chemotherapy(IAC)for refractory retinoblastoma.Br J Ophthalmol 2017;101(12):1704-1708
8 Shields CL,Lally SE,Leahey AM,et al.Targeted retinoblastoma management:when to use intravenous,intra-arterial,periocular,and intravitreal chemotherapy.Curr Opin Ophthalmol 2014;5(5):374-385
9 惠卉,程翼飞.儿童视网膜母细胞瘤的化学疗法.中国斜视与小儿眼科杂志2014;22(2):34,46-48
10 Smith SJ,Pulido JS,Salom2o DR,et al.Combined intravitreal and subconjunctival carboplatin for retinoblastoma with vitreous seeds.Br J Ophthalmol 2012;96(8):1073-1077
11 Kim JY,Park Y.Treatment of Retinoblastoma:The Role of External Beam Radiotherapy.Yonsei Med J 2015;56(6):1478-1491
12 Manjandavida FP,Honavar SG,Reddy VAP,et al.Management and outcome of retinoblastoma with vitreous seeds.Ophthalmology 2014;121(2):517-524
13 Sethi RV,Shih HA,Yeap BY,et al.Second nonocular tumors among survivors of retinoblastoma treated with contemporary photon and proton radiotherapy.Cancer 2014;120(1):126-133
14 Mouw KW,Yeap BY,Caruso P,et al.Analysis of patient outcomes following proton radiation therapy for retinoblastoma.Adv Radiat Oncol2017;2(1):44-52
15 Chawla B,Singh R.Recent advances and challenges in the management of retinoblastoma.Indian J Ophthalmol 2017;65(2):133-139
16 宋轶鹏,胡立宽,竺鑫丽,等.视网膜母细胞瘤立体定向放射治疗16 例临床分析.癌症进展2009;7(6):669-674
17 Atalar B,Ozyar E,Gunduz K,et al.Intensity modulated radiotherapy(IMRT)in bilateral retinoblastoma.Radiol Oncol 2010;44(3):194-198
18 Seth R,Singh A,Guru V,et al.Long-term follow-up of retinoblastoma survivors:Experience from India.South Asian J Cancer2017;6(4):176-179
19 Chawla B,Jain A,Azad R.Conservative treatment modalities in retinoblastoma.Indian J Ophthalmol 2013;61(9):479-485
20 Hasanreisoglu M,Saktanasate J,Schwendeman R,et al.Indocyanine Green-Enhanced Transpupillary Thermotherapy for Retinoblastoma:Analysis of 42 Tumors.J Pediatr Ophthalmol Strabismus 2015;52(6):348-354
21 Teixo R,Laranjo M,Abrantes AM,et al.Retinoblastoma:might photodynamic therapy be an option?Cancer Metastasis Rev 2015;34(4):563-573
22 Cerman E,Cekic O.Clinical use of photodynamic therapy in ocular tumors.Surv Ophthalmol 2015;60(6):557-574
23 Okura H,Smith CA,Rutka JT.Gene therapy for malignant glioma.Mol Cell Ther 2014;2:21
24 Audo I,Darjatmoko SR,Schlamp CL,et al.Vitamin D analogues increase p53,p21,and apoptosis in a xenograft model of human retinoblastoma.Invest Ophthalmol Vis Sci 2003;44(10):4192-4199
25 罗霁菡,周希瑗.超声微泡介导野生型p53基因转染Y79细胞的实验研究.中国超声医学杂志2008;24(12):1060-1062
26 Wadhwa L,Hurwitz M,Chévez-Barrios P,et al.Treatment of invasive retinoblastoma in a murine model using an oncolytic picornavirus.Cancer Res 2007;67(22):10653-10656
27 Adachi M,Brooks SE,Stein MR,et al.Destruction of human retinoblastoma after treatment by the E variant of encephalomyocarditis virus.J Neurooncol 2006;77(3):233-240
28 Dunkel IJ,Chan HSL,Jubran R,et al.High-dose chemotherapy with autologous hematopoietic stem cell rescue for stage 4B retinoblastoma.Pediatr Blood Cancer 2010;55(1):149-152
29 Zhou Y,Gu H,Xu Y,et al.Targeted antiangiogenesis gene therapy using targeted cationic microbubbles conjugated with CD105 antibody compared with untargeted cationic and neutral microbubbles.Theranostics2015;5(4):399-417