石斛免疫调节功能研究进展
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摘要
基于近年来国内外石斛免疫调节功能的研究,从免疫器官、免疫细胞及免疫分子三个层面,综述了石斛多糖、苷类、生物碱类活性物质对机体的免疫调节作用,包括降低炎症、抑制肿瘤以及减缓衰老等作用,以期为石斛开展现代生物技术的深入研究与开发提供理论参考。
Based on the previous studies, the author collected, analyzed and summarized the literature on Dendrobium Sw. at home and abroad in recent 10 years, and systemically reviewed the research advances in immunoregulatory functions in immune organs, immune cell and immune molecile. It is reviewed that the mechanism of immunostimulative function, antiinflammatory and anti-aging activities base on the active substances, such as polysaccharides, glycosides and alkaloid, in order to provide a theoretical reference for further research, reasonable exploitation and utilization of the species.
Based on the previous studies, the author collected, analyzed and summarized the literature on Dendrobium Sw. at home and abroad in recent 10 years, and systemically reviewed the research advances in immunoregulatory functions in immune organs, immune cell and immune molecile. It is reviewed that the mechanism of immunostimulative function, antiinflammatory and anti-aging activities base on the active substances, such as polysaccharides, glycosides and alkaloid, in order to provide a theoretical reference for further research, reasonable exploitation and utilization of the species.
引文
[1]陈心启,吉占和.中国兰花全书[M].2版.北京:中国林业出版社,2003.
[2]包雪声,顺庆生,陈立钻.中国药用石斛彩色图谱[M].上海:上海医科大学出版社,2001.
[3]国家药典委员会.中华人民共和国药典:一部[M].2015年版.北京:中国医药科技出版社,2015.
[4]YAZDANI R,SHARIFI M,SHIRVAN A S,et al.Characteristics of innate lymphoid cells(ILCs)and their role in immunological disorders(an update)[J].Cellular Immunology,2015,298(1-2):66-76.
[5]Zh A X Q,LUO J P,JIANG S T.Induction of immunomodulating cytokines by polysaccharides from Dendrobium huoshanense[J].Pharmaceutical Biology,2008,45(1):71-76.
[6]Zh A X Q,LUO J P,LUO S Z,et al.Structure identifi cation of a new immunostimulating polysaccharide from the stems of Dendrobium huoshanense[J].Carbohydrate Polymers,2007,69(1):86-93.
[7]HSIEH Y,CHIEN C S,LIAO S,et al.Structure and bioactivity of the polysaccharides in medicinal plant Dendrobium huoshanense[J].Bioorganic&Medicinal Chemistry,2008,16(11):6054-6068.
[8]黄民权,黄步汉,蔡体育,等.铁皮石斛多糖的提取、分离和分析[J].中草药,1994,3:128-129.
[9]侯少贞,李焕彬,郭建茹,等.铁皮石斛镇痛与抗炎作用研究[J].动物医学进展,2012,33(10):49-52.
[10]郑晓珂,曹新伟,匡海学,等.金钗石斛的研究进展[J].中国新药杂志,2005,14(7):826-829.
[11]施红,陈玉春,林智诚,等.石斛复方制剂对小鼠免疫功能的影响[J].康复学报,1996,2:24-26.
[12]HUANG M,CAI T,LIU Y.Effects of polysaccharides from D e n d r o b i u m c a n d i d u m on wh it e blo o d c el l s a nd ly m ph c el l moving inhibition factor of mice[J].Natural Product Research&Development,1996,8(3):39-41.
[13]HWANG J S,LEE S A,HONG S S,et al.Phenanthrenes from Dendrobium nobile and their inhibition of the LPS-induced production of nitric oxide in macrophage RAW 264.7 cells[J].Bioorganic&Medicinal Chemistry Letters,2010,20(12):3785-3787.
[14]赵武述.现代临床免疫学[M].北京:人民军医出版社,1994.
[15]ZHAO W,YE Q,TAN X,et al.Three new sesquiterpene glycosides f rom Dendrobium nobile with im mu nomodulator y activit y[J].Journal of Natural Products,2001,64(9):1196-1200.
[16]HAN Y,DING C,ZHOU J,et al.Antifibrotic phenanthrenes of Dendrobium nobile stems[J].Journal of Natural Products,2007,70(12):1925-1929.
[17]高建平,金若敏,吴耀平,等.铁皮石斛原球茎与原药材免疫调节作用的比较研究[J].中药材,2002,25(7):487-489.
[18]MAR?AIS A,VIEL S,GRAU M,et al.Regulation of mouse NK cell development and function by cytokines[J].Frontiers in Immunology,2013,4:450.
[19]黄民权,蔡体育.铁皮石斛多糖对小白鼠白细胞数和淋巴细胞移动抑制因子的影响[J].天然产物研究与开发,1996,3(3):39-41.
[20]李小琼,金徽,葛晓军,等.金钗石斛多糖对脂多糖诱导的小鼠腹腔巨噬细胞分泌TNF-α·NO的影响[J].安徽农业科学,2009,37(28):13634-13635.
[21]张俊青,吴芹,龚其海,等.金钗石斛生物总碱对脂多糖激活星形胶质细胞产生炎症因子的影响[J].中国药理学通报,2011,27(6):824-827.
[22]WANG X,FENG Y,WANG N,et al.Chinese medicines induce cell death:the molecular and cellular mechanisms for cancer therapy[J].Biomed Research International,2014,2014(3):530342.
[23]金丽莎,陈良良.中医药抗肿瘤的生物免疫效应[J].生物技术通讯,2015,2:298-300.
[24]LEE Y H,PARK J D,BAEK N I,et al.In vitro and in vivo antitumoral phenanthrenes from the aerial parts of Dendrobium nobile[J].Planta Medica,1995,61(2):178-180.
[25]鲍丽娟,王军辉,罗建平.4种石斛水提物对人宫颈癌Hela S3细胞和肝癌Hep G2细胞的抑制作用[J].安徽农业科学,2008,36:15968-15970.
[26]罗文娟,王光辉,张雪,等.金钗石斛茎提取物联苄类化合物对人肝癌高侵袭转移细胞株FHCC-98增殖的抑制[J].中国组织工程研究,2006,10(43):150-152.
[27]罗慧玲,黄民权.石斛多糖增强脐带血和肿瘤病人外周血LAK细胞体外杀伤作用的研究[J].癌症,2000,19(12):1124-1126.
[28]WANG J H,LUO J P,ZHA X Q,et al.Comparison of antitumor activities of different polysaccharide fractions from the stems of Dendrobium nobile Lindl.[J].Carbohydrate Polymers,2010,79(1):114-118.
[29]黎英,赵亚平,陈蓓怡,等.5种石斛水提物对活性氧的清除作用[J].中草药,2004,35(11):1240-1242.
[30]LUO A X,HE X J,ZHOU S D,et al.Purification,composition analysis and antioxid ant activit y of the polysaccha r ides f rom Dendrobium nobile Lindl.[J].Carbohydrate Polymers,2010,79(4):1014-1019.
[31]LUO A X,HE X J,ZHOU S D,et al.In vitro antioxidant activities of a wat e r-soluble p olysa ccha r ide de r ive d f rom D e n d robiu m nobile Li nd l.ext r act s[J].I nter nat ional Jou r nal of Biolog ical Macromolecules,2009,45(4):359.
[32]陈祝霞,时雅旻.石斛类药材的红外光谱鉴别研究及其抗氧化活性比较[J].中国现代中药,2007,9(8):22-24.
[33]蔡永萍,于力文.霍山三种石斛茎中抗氧化酶等活性物质的测定[J].中国药学杂志,1996,31(11):649-651.
[34]查学强,王军辉,潘利华,等.石斛多糖体外抗氧化活性的研究[J].食品科学,2007,28(10):90-93.
[35]WANG S.Anti-oxidation activity in vitro of polysaccharides of Dendrobium Huoshanense and Dendrobium moniliforme[J].Agricultural Science&Technology,2009,10(6):121-124.
[36]黄小燕,党翠芝,杨庆雄.金钗石斛的抗氧化活性研究[J].贵州农业科学,2011,39(7):84-86.
[37]施红,黄玲.石斛抗衰老作用的实验研究[J].中华老年医学杂志,1994,13(2):104.
[38]梁颖敏.铁皮石斛对雌性衰老小鼠的抗衰老作用及其机理研究[D].广州:广州中医药大学,2011.
[39]张雪,续洁琨,王乃利,等.金钗石斛中联苄类和酚酸类成分的抗氧化活性研究[J].中国药学杂志,2008,43(11):829-832.
[40]ONO M,ITO Y,MASUOKA C,et al.Antioxidative constituents from Dendrobii Herba(Stems of Dendrobium spp.)[J].Food Science&Technology International Tokyo,1995,1(2):115-120.
[41]ZHANG X.Antioxidant phenanthrenes and lignans from Dendrobium nobile[J].Journal of Chinese Pharmaceutical Sciences,2008,17(4):314-318.
[2]包雪声,顺庆生,陈立钻.中国药用石斛彩色图谱[M].上海:上海医科大学出版社,2001.
[3]国家药典委员会.中华人民共和国药典:一部[M].2015年版.北京:中国医药科技出版社,2015.
[4]YAZDANI R,SHARIFI M,SHIRVAN A S,et al.Characteristics of innate lymphoid cells(ILCs)and their role in immunological disorders(an update)[J].Cellular Immunology,2015,298(1-2):66-76.
[5]Zh A X Q,LUO J P,JIANG S T.Induction of immunomodulating cytokines by polysaccharides from Dendrobium huoshanense[J].Pharmaceutical Biology,2008,45(1):71-76.
[6]Zh A X Q,LUO J P,LUO S Z,et al.Structure identifi cation of a new immunostimulating polysaccharide from the stems of Dendrobium huoshanense[J].Carbohydrate Polymers,2007,69(1):86-93.
[7]HSIEH Y,CHIEN C S,LIAO S,et al.Structure and bioactivity of the polysaccharides in medicinal plant Dendrobium huoshanense[J].Bioorganic&Medicinal Chemistry,2008,16(11):6054-6068.
[8]黄民权,黄步汉,蔡体育,等.铁皮石斛多糖的提取、分离和分析[J].中草药,1994,3:128-129.
[9]侯少贞,李焕彬,郭建茹,等.铁皮石斛镇痛与抗炎作用研究[J].动物医学进展,2012,33(10):49-52.
[10]郑晓珂,曹新伟,匡海学,等.金钗石斛的研究进展[J].中国新药杂志,2005,14(7):826-829.
[11]施红,陈玉春,林智诚,等.石斛复方制剂对小鼠免疫功能的影响[J].康复学报,1996,2:24-26.
[12]HUANG M,CAI T,LIU Y.Effects of polysaccharides from D e n d r o b i u m c a n d i d u m on wh it e blo o d c el l s a nd ly m ph c el l moving inhibition factor of mice[J].Natural Product Research&Development,1996,8(3):39-41.
[13]HWANG J S,LEE S A,HONG S S,et al.Phenanthrenes from Dendrobium nobile and their inhibition of the LPS-induced production of nitric oxide in macrophage RAW 264.7 cells[J].Bioorganic&Medicinal Chemistry Letters,2010,20(12):3785-3787.
[14]赵武述.现代临床免疫学[M].北京:人民军医出版社,1994.
[15]ZHAO W,YE Q,TAN X,et al.Three new sesquiterpene glycosides f rom Dendrobium nobile with im mu nomodulator y activit y[J].Journal of Natural Products,2001,64(9):1196-1200.
[16]HAN Y,DING C,ZHOU J,et al.Antifibrotic phenanthrenes of Dendrobium nobile stems[J].Journal of Natural Products,2007,70(12):1925-1929.
[17]高建平,金若敏,吴耀平,等.铁皮石斛原球茎与原药材免疫调节作用的比较研究[J].中药材,2002,25(7):487-489.
[18]MAR?AIS A,VIEL S,GRAU M,et al.Regulation of mouse NK cell development and function by cytokines[J].Frontiers in Immunology,2013,4:450.
[19]黄民权,蔡体育.铁皮石斛多糖对小白鼠白细胞数和淋巴细胞移动抑制因子的影响[J].天然产物研究与开发,1996,3(3):39-41.
[20]李小琼,金徽,葛晓军,等.金钗石斛多糖对脂多糖诱导的小鼠腹腔巨噬细胞分泌TNF-α·NO的影响[J].安徽农业科学,2009,37(28):13634-13635.
[21]张俊青,吴芹,龚其海,等.金钗石斛生物总碱对脂多糖激活星形胶质细胞产生炎症因子的影响[J].中国药理学通报,2011,27(6):824-827.
[22]WANG X,FENG Y,WANG N,et al.Chinese medicines induce cell death:the molecular and cellular mechanisms for cancer therapy[J].Biomed Research International,2014,2014(3):530342.
[23]金丽莎,陈良良.中医药抗肿瘤的生物免疫效应[J].生物技术通讯,2015,2:298-300.
[24]LEE Y H,PARK J D,BAEK N I,et al.In vitro and in vivo antitumoral phenanthrenes from the aerial parts of Dendrobium nobile[J].Planta Medica,1995,61(2):178-180.
[25]鲍丽娟,王军辉,罗建平.4种石斛水提物对人宫颈癌Hela S3细胞和肝癌Hep G2细胞的抑制作用[J].安徽农业科学,2008,36:15968-15970.
[26]罗文娟,王光辉,张雪,等.金钗石斛茎提取物联苄类化合物对人肝癌高侵袭转移细胞株FHCC-98增殖的抑制[J].中国组织工程研究,2006,10(43):150-152.
[27]罗慧玲,黄民权.石斛多糖增强脐带血和肿瘤病人外周血LAK细胞体外杀伤作用的研究[J].癌症,2000,19(12):1124-1126.
[28]WANG J H,LUO J P,ZHA X Q,et al.Comparison of antitumor activities of different polysaccharide fractions from the stems of Dendrobium nobile Lindl.[J].Carbohydrate Polymers,2010,79(1):114-118.
[29]黎英,赵亚平,陈蓓怡,等.5种石斛水提物对活性氧的清除作用[J].中草药,2004,35(11):1240-1242.
[30]LUO A X,HE X J,ZHOU S D,et al.Purification,composition analysis and antioxid ant activit y of the polysaccha r ides f rom Dendrobium nobile Lindl.[J].Carbohydrate Polymers,2010,79(4):1014-1019.
[31]LUO A X,HE X J,ZHOU S D,et al.In vitro antioxidant activities of a wat e r-soluble p olysa ccha r ide de r ive d f rom D e n d robiu m nobile Li nd l.ext r act s[J].I nter nat ional Jou r nal of Biolog ical Macromolecules,2009,45(4):359.
[32]陈祝霞,时雅旻.石斛类药材的红外光谱鉴别研究及其抗氧化活性比较[J].中国现代中药,2007,9(8):22-24.
[33]蔡永萍,于力文.霍山三种石斛茎中抗氧化酶等活性物质的测定[J].中国药学杂志,1996,31(11):649-651.
[34]查学强,王军辉,潘利华,等.石斛多糖体外抗氧化活性的研究[J].食品科学,2007,28(10):90-93.
[35]WANG S.Anti-oxidation activity in vitro of polysaccharides of Dendrobium Huoshanense and Dendrobium moniliforme[J].Agricultural Science&Technology,2009,10(6):121-124.
[36]黄小燕,党翠芝,杨庆雄.金钗石斛的抗氧化活性研究[J].贵州农业科学,2011,39(7):84-86.
[37]施红,黄玲.石斛抗衰老作用的实验研究[J].中华老年医学杂志,1994,13(2):104.
[38]梁颖敏.铁皮石斛对雌性衰老小鼠的抗衰老作用及其机理研究[D].广州:广州中医药大学,2011.
[39]张雪,续洁琨,王乃利,等.金钗石斛中联苄类和酚酸类成分的抗氧化活性研究[J].中国药学杂志,2008,43(11):829-832.
[40]ONO M,ITO Y,MASUOKA C,et al.Antioxidative constituents from Dendrobii Herba(Stems of Dendrobium spp.)[J].Food Science&Technology International Tokyo,1995,1(2):115-120.
[41]ZHANG X.Antioxidant phenanthrenes and lignans from Dendrobium nobile[J].Journal of Chinese Pharmaceutical Sciences,2008,17(4):314-318.