涎腺腺样囊性癌发生发展相关基因研究进展
摘要
<正>涎腺腺样囊性癌(salivary adenoid cystic carcinoma,SACC)约占涎腺恶性肿瘤的24%,是对人体危害最大的头颈部恶性肿瘤之一。此肿瘤生长特殊,一般无包膜,侵袭性强,嗜神经生长和远处转移是SACC的两大恶性生物学特性。因放疗及化学药物治疗效果均不理想,临床难以确定其明确的浸润
引文
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[4]柯学平,姚瑶,颜廷元,等.p27及皮层肌动蛋白的表达与涎腺腺样囊性癌嗜神经侵袭的相关性[J].江苏医药,2013,39(3):282-284,封3.
[5]林海升,施更生,王慧明.p27在涎腺腺样囊性癌组织中的表达及其意义[J].实用肿瘤杂志,2008,23(3):252-254.
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[7]范小平.涎腺腺样囊性癌细胞中PTEN基因启动子区甲基化状态的研究[D].重庆医科大学:生物医学工程组织工程与细胞工程.
[8]黄汉,王琳源,关宁,等.整合素连接激酶与磷酸脂酶在人涎腺腺样囊性癌中的表达[J].解剖科学进展,2010,16(1):12-15.
[9]刘晓华,张引成,任文豪,等.涎腺腺样囊性癌SACC-83细胞C-erb B2、PTEN基因表达的研究[J].口腔医学,2010,30(8):477-480.
[10]陈刚,赵春利,翁秀琴,等.CD54、CD44在涎腺腺样囊性癌中的表达及意义[J].中国肿瘤,2001,10(3):159-160.
[11]Rittling SR,Chambers AF.Role of osteopontin in tumour progression[J].Br J Cancer,2004,90(10):1877-1881.
[12]Teramoto H,Castellone MD,Malek RL,et al.Autocrine activation of an osteopontin-CD44-Rac pathway enhances invasion and transformation by H-Ras V12[J].Oncogene,2005,24(3):489-501.
[13]陈垂史,黄志权,王友元,等.骨桥蛋白、CD44v6在涎腺腺样囊性癌转移中的意义[J].分子诊断与治疗杂志,2010,2(3):160-163.
[14]Muller A,Sonkoly E,Eulert C,et al.Chemokine receptors in head and neck cancer:association with metastatic spread and regulation during chemotherapy[J].Int J Cancer,2006,118(9):2147-2157.
[15]王璐,张斌,于涛.趋化因子CXCL12及其受体在涎腺腺样囊性癌组织中表达的意义[J].医学信息(中旬刊),2010,5(6):1404-1405.
[16]罗小龙,孙沫逸,杨连甲,等.雪旺细胞标志物S100蛋白在涎腺腺样囊性癌嗜神经侵袭中的意义[J].实用口腔医学杂志,2003,19(2):173-175.
[17]荆得宝,王丽琴,刘雪阳,等.神经细胞粘附分子在涎腺腺样囊性癌中的表达及其意义[J].现代口腔医学杂志,2010,24(3):191-193.
[18]陈伟,董震,苏寒,等.涎腺腺样囊性癌组织中神经生长因子表达及其临床病理特征的Meta分析[J].医学研究生学报,2012,25(2):143-147.
[19]Wang L,Sun M,Jiang Y,et al.Nerve growth factor and tyrosine kinase A in human salivary adenoid cystic carcinoma:expression patterns and effects on in vitro invasive behavior[J].J Oral Maxillofac Surg,2006,64(4):636-641.
[20]农晓琳,夏勇,杨亦萍,等.酪氨酸激酶A和血管内皮生长因子受体2在涎腺腺样囊性癌侵袭转移中的作用[J].华西口腔医学杂志,2010,28(4):420-424,429.
[21]Nguyen N,Lee SB,Lee YS,et al.Neuroprotection by NGF and BDNF against neurotoxin-exerted apoptotic death in neural stem cells are mediated through Trk receptors,activating PI3-kinase and MAPK pathways[J].Neurochem Res,2009,34(5):942-951.
[22]陈钟,纪晴,郑晓丹.Trk B在口腔鳞癌浸润和淋巴结转移中的功能[J].口腔医学研究,2011,27(1):64-67.
[23]Lam CT,Yang ZF,Lau CK,et al.Brain-derived neurotrophic factor promotes tumorigenesis via induction of neovascularization:implication in hepatocellular carcinoma[J].Clin Cancer Res,2011,17(10):3123-3133.
[24]夏勇,农晓琳,杨亦萍,等.酪氨酸激酶B与VEGF在涎腺腺样囊性癌中的表达及其与侵袭转移相关性的分析[J].临床口腔医学杂志,2012,28(2):67-70.
[25]金善恩,赏金标,王可敬.神经生长因子受体在涎腺腺样囊性癌中的表达及临床意义[J].浙江医学,2010,32(4):471-472,476.
[26]丁林灿,郑斐斐,佘林,等.FZD3基因在涎腺腺样囊性癌转移与复发中的作用[J].福建医科大学学报,2013,2:85-88.
[27]郑斐斐,王锦锋,佘林,等.FZD2基因与涎腺腺样囊性癌增殖及侵袭转移能力的关系[J].福建医科大学学报,2011,45(1):1-4.
[28]Cowell CF,Yan IK,Eiseler T,et al.Loss of cell-cell contacts induces NF-kappa B via Rho A-mediated activation of protein kinase D1[J].J Cell Biochem,2009,106(4):714-728.
[29]胡瑞利,安峰,林媛媛,等.Rho A和Snail在涎腺腺样囊性癌中的表达及意义[J].天津医药,2015,7:759-761.
[30]Bolos V,Mira E,Martínez-Poveda B,et al.Notch activation stimulates migration of breast cancer cells and promotes tumor growth[J].Breast Cancer Res,2013,15(4):R54.
[31]Howard JD,Moriarty WF,Park J,et al.Notch signaling mediates melanoma-endothelial cell communication and melanoma cell migration[J].Pigment Cell Melanoma Res,2013,26(5):697-707.
[32]Ding LC,She L,Zheng DL,et al.Notch-4 contributes to the metastasis of salivary adenoid cystic carcinoma[J].Oncol Rep,2010,24(2):363-368.
[33]Chen W,Zhang H,Wang J,et al.Lentiviral-mediated gene silencing of Notch-4 inhibits in vitro proliferation and perineural invasion of ACC-M cells[J].Oncol Rep,2013,29(5):1797-1804.
[2]Affolter A,Helmbrecht S,Finger S,et al.Altered expression of cell cycle regulators p21,p27,and p53 in tumors of salivary glands and paranasal sinuses[J].Oncol Rep,2005,13(6):1089-1094.
[3]Shahsavari F,Eslami M,Baghaie F,et al.Immunohistochemical evaluation of p27(kip1)in pleomorphic adenomas and adenoid cystic carcinomas of the minor salivary glands[J].Asian Pac J Cancer Prev,2005,6(4):527-530.
[4]柯学平,姚瑶,颜廷元,等.p27及皮层肌动蛋白的表达与涎腺腺样囊性癌嗜神经侵袭的相关性[J].江苏医药,2013,39(3):282-284,封3.
[5]林海升,施更生,王慧明.p27在涎腺腺样囊性癌组织中的表达及其意义[J].实用肿瘤杂志,2008,23(3):252-254.
[6]Ito R,Oue N,Zhu X,et al.Expression of integrin-linked kinase is closely correlated with invasion and metastasis of gastric carcinoma[J].Virchows Arch,2003,442(2):118-123.
[7]范小平.涎腺腺样囊性癌细胞中PTEN基因启动子区甲基化状态的研究[D].重庆医科大学:生物医学工程组织工程与细胞工程.
[8]黄汉,王琳源,关宁,等.整合素连接激酶与磷酸脂酶在人涎腺腺样囊性癌中的表达[J].解剖科学进展,2010,16(1):12-15.
[9]刘晓华,张引成,任文豪,等.涎腺腺样囊性癌SACC-83细胞C-erb B2、PTEN基因表达的研究[J].口腔医学,2010,30(8):477-480.
[10]陈刚,赵春利,翁秀琴,等.CD54、CD44在涎腺腺样囊性癌中的表达及意义[J].中国肿瘤,2001,10(3):159-160.
[11]Rittling SR,Chambers AF.Role of osteopontin in tumour progression[J].Br J Cancer,2004,90(10):1877-1881.
[12]Teramoto H,Castellone MD,Malek RL,et al.Autocrine activation of an osteopontin-CD44-Rac pathway enhances invasion and transformation by H-Ras V12[J].Oncogene,2005,24(3):489-501.
[13]陈垂史,黄志权,王友元,等.骨桥蛋白、CD44v6在涎腺腺样囊性癌转移中的意义[J].分子诊断与治疗杂志,2010,2(3):160-163.
[14]Muller A,Sonkoly E,Eulert C,et al.Chemokine receptors in head and neck cancer:association with metastatic spread and regulation during chemotherapy[J].Int J Cancer,2006,118(9):2147-2157.
[15]王璐,张斌,于涛.趋化因子CXCL12及其受体在涎腺腺样囊性癌组织中表达的意义[J].医学信息(中旬刊),2010,5(6):1404-1405.
[16]罗小龙,孙沫逸,杨连甲,等.雪旺细胞标志物S100蛋白在涎腺腺样囊性癌嗜神经侵袭中的意义[J].实用口腔医学杂志,2003,19(2):173-175.
[17]荆得宝,王丽琴,刘雪阳,等.神经细胞粘附分子在涎腺腺样囊性癌中的表达及其意义[J].现代口腔医学杂志,2010,24(3):191-193.
[18]陈伟,董震,苏寒,等.涎腺腺样囊性癌组织中神经生长因子表达及其临床病理特征的Meta分析[J].医学研究生学报,2012,25(2):143-147.
[19]Wang L,Sun M,Jiang Y,et al.Nerve growth factor and tyrosine kinase A in human salivary adenoid cystic carcinoma:expression patterns and effects on in vitro invasive behavior[J].J Oral Maxillofac Surg,2006,64(4):636-641.
[20]农晓琳,夏勇,杨亦萍,等.酪氨酸激酶A和血管内皮生长因子受体2在涎腺腺样囊性癌侵袭转移中的作用[J].华西口腔医学杂志,2010,28(4):420-424,429.
[21]Nguyen N,Lee SB,Lee YS,et al.Neuroprotection by NGF and BDNF against neurotoxin-exerted apoptotic death in neural stem cells are mediated through Trk receptors,activating PI3-kinase and MAPK pathways[J].Neurochem Res,2009,34(5):942-951.
[22]陈钟,纪晴,郑晓丹.Trk B在口腔鳞癌浸润和淋巴结转移中的功能[J].口腔医学研究,2011,27(1):64-67.
[23]Lam CT,Yang ZF,Lau CK,et al.Brain-derived neurotrophic factor promotes tumorigenesis via induction of neovascularization:implication in hepatocellular carcinoma[J].Clin Cancer Res,2011,17(10):3123-3133.
[24]夏勇,农晓琳,杨亦萍,等.酪氨酸激酶B与VEGF在涎腺腺样囊性癌中的表达及其与侵袭转移相关性的分析[J].临床口腔医学杂志,2012,28(2):67-70.
[25]金善恩,赏金标,王可敬.神经生长因子受体在涎腺腺样囊性癌中的表达及临床意义[J].浙江医学,2010,32(4):471-472,476.
[26]丁林灿,郑斐斐,佘林,等.FZD3基因在涎腺腺样囊性癌转移与复发中的作用[J].福建医科大学学报,2013,2:85-88.
[27]郑斐斐,王锦锋,佘林,等.FZD2基因与涎腺腺样囊性癌增殖及侵袭转移能力的关系[J].福建医科大学学报,2011,45(1):1-4.
[28]Cowell CF,Yan IK,Eiseler T,et al.Loss of cell-cell contacts induces NF-kappa B via Rho A-mediated activation of protein kinase D1[J].J Cell Biochem,2009,106(4):714-728.
[29]胡瑞利,安峰,林媛媛,等.Rho A和Snail在涎腺腺样囊性癌中的表达及意义[J].天津医药,2015,7:759-761.
[30]Bolos V,Mira E,Martínez-Poveda B,et al.Notch activation stimulates migration of breast cancer cells and promotes tumor growth[J].Breast Cancer Res,2013,15(4):R54.
[31]Howard JD,Moriarty WF,Park J,et al.Notch signaling mediates melanoma-endothelial cell communication and melanoma cell migration[J].Pigment Cell Melanoma Res,2013,26(5):697-707.
[32]Ding LC,She L,Zheng DL,et al.Notch-4 contributes to the metastasis of salivary adenoid cystic carcinoma[J].Oncol Rep,2010,24(2):363-368.
[33]Chen W,Zhang H,Wang J,et al.Lentiviral-mediated gene silencing of Notch-4 inhibits in vitro proliferation and perineural invasion of ACC-M cells[J].Oncol Rep,2013,29(5):1797-1804.