长期佩戴角膜塑形镜对角膜内皮细胞数量和形态的影响研究
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摘要
目的:探讨长时间佩戴角膜塑形镜对近视眼患者角膜内皮细胞数量以及形态的影响。方法:选取本院2017年1月-2018年1月收治的123例(200只眼)佩戴角膜塑形镜的近视眼患者作为研究对象,分别于戴镜前、戴镜后1 d、1周、1、3及6个月检测其角膜内皮细胞数量、形态,以及角膜厚度改变情况。结果:戴镜后1 d～6个月,患者的角膜内皮细胞六角形比率及细胞密度有轻微下降,变异系数以及平均面积出现轻微上升,但戴镜前及戴镜后各时间段比较,差异均无统计学意义(P>0.05)。戴镜后1 d～1个月,患者旁周边厚度出现轻微减薄,之后又出现轻微增厚,中央厚度在1 d～6个月之后出现轻微减薄,但不同部位的角膜内皮厚度于戴镜前及戴镜后各时间段比较,差异均无统计学意义(P>0.05)。结论:应用角膜塑形镜对青少年近视眼患者进行科学的矫治,戴镜前后角膜内皮细胞数量以及形态无明显变化,对角膜代谢基本无影响,长时间佩戴帮助患者控制近视过快发展,是安全有效的,值得推广及应用。
Objective:To investigate the effect of long-term wearing orthokeratology on the number and morphology of corneal endothelial cells in patients with myopia.Method:A total of 123(200 eyes) myopia patients who underwent orthokeratology in our hospital from January 2017 to January 2018 were selected as the study objects.The number and morphology of corneal endothelial cells and corneal thickness were measured before and after wearing orthokeratology 1 day,1 week,1,3 and 6 months.Result:The hexagonal ratio and cell density of corneal endothelial cells decreased slightly and the coefficient of variation and average area increased slightly from 1 day to after wearing orthokeratology 6 months,but there were no significant differences between before and after wearing orthokeratology(P>0.05).The peripheral thickness decreased slightly after wearing orthokeratology 1 day to 1 month,and then increased slightly.The central thickness decreased slightly after wearing orthokeratology 1 day to 6 months.However,there were no significant differences between the thickness of corneal endothelium in different parts before and after wearing orthokeratology(P>0.05).Conclusion:The orthokeratology is used to scientifically correct the patients with myopia in the adolescents.There are no significant changes in the number and morphology of corneal endothelial cells before and after wearing orthokeratology.There is no effect on corneal metabolism.It is safe and effective to help patients to control myopia for long-term wear.It is worth of promoting and applying.
Objective:To investigate the effect of long-term wearing orthokeratology on the number and morphology of corneal endothelial cells in patients with myopia.Method:A total of 123(200 eyes) myopia patients who underwent orthokeratology in our hospital from January 2017 to January 2018 were selected as the study objects.The number and morphology of corneal endothelial cells and corneal thickness were measured before and after wearing orthokeratology 1 day,1 week,1,3 and 6 months.Result:The hexagonal ratio and cell density of corneal endothelial cells decreased slightly and the coefficient of variation and average area increased slightly from 1 day to after wearing orthokeratology 6 months,but there were no significant differences between before and after wearing orthokeratology(P>0.05).The peripheral thickness decreased slightly after wearing orthokeratology 1 day to 1 month,and then increased slightly.The central thickness decreased slightly after wearing orthokeratology 1 day to 6 months.However,there were no significant differences between the thickness of corneal endothelium in different parts before and after wearing orthokeratology(P>0.05).Conclusion:The orthokeratology is used to scientifically correct the patients with myopia in the adolescents.There are no significant changes in the number and morphology of corneal endothelial cells before and after wearing orthokeratology.There is no effect on corneal metabolism.It is safe and effective to help patients to control myopia for long-term wear.It is worth of promoting and applying.
引文
[1]陈春梅,秦艳,杨川会,等.青少年配戴角膜塑形镜偏心量对眼轴影响的临床研究[J].第三军医大学学报,2018,40(8):728-732.
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[14]裴天序,张佳欢,韩冬,等.夜戴型角膜塑形镜对青少年泪膜的影响[J].眼科新进展,2018,38(6):217-218.
[15]连燕,金婉卿,毛欣杰,等.框架眼镜与角膜塑形镜矫正的近视儿童脉络膜厚度差异比较研究[J].眼科新进展,2017,37(5):431-434.
[16]周佳,林伟平,刘桂华,等.停戴角膜塑形镜期间角膜前表面形态恢复情况观察[J].眼科新进展,2017,37(8):739-742.
[17]沈亚,单彧,程金伟,等.夜戴型角膜塑形镜矫治青少年近视的临床观察研究[J].第二军医大学学报,2017,38(11):1467-1470.
[18]Zimmer C L,Rinker F,Honer Zu Siederdissen C,et al.Increased NK cell function after cessation of long-term nucleos(t)ide analogue treatment in chronic hepatitis B associates with liver damage and HBsAg loss[J].Journal of Infectious Diseases,2018,217(10):1656-1666.
[19]刘桂华,谷天瀑,李颖,等.角膜塑形镜配戴后瞳孔与光学区的大小对视觉质量的影响[J].眼科新进展,2017,37(1):38-41.
[20]唐晓蕾,扶世杰,王晓莉,等.角膜塑形镜控制儿童近视进展的一年综合效果[J].眼科,2016,31(2):98-101.
[2]安阳,李威,郑春晖,等.玻璃酸钠滴眼液在角膜塑形镜配戴中对眼表形态和泪液的影响[J].眼科新进展,2016,36(1):74-77.
[3]Nest T V,Ruysschaert G,Vandecasteele B,et al.The long term use of farmyard manure and compost:Effects on P availability,orthophosphate sorption strength and P leaching[J].Agriculture Ecosystems&Environment,2016,216(11):23-33.
[4]王晓冰,张利科,邱迎红,等.角膜塑形镜对青少年近视眼视力、眼压及生物测量参数的影响[J].重庆医学,2017,46(16):2204-2205.
[5]孙园,周珺,高敬,等.角膜形态及视觉质量对角膜塑形镜试戴结果的影响[J].中国医科大学学报,2017,46(8):742-745.
[6]Santos Soares S M,Brito-Junior M,de Souza F K,et al.Management of cyst-like periapical lesions by orthograde decompression and long-term calcium hydroxide/chlorhexidine intracanal dressing:a case series[J].Journal of Endodontics,2016,42(7):1135-1141.
[7]吕燕云,武晶晶,彭丽,等.青少年近视性屈光参差患者长期配戴角膜塑形镜效果观察[J].眼科,2017,32(2):131-134.
[8]吕天斌,王丽娅,覃建,等.角膜塑形镜配戴矫治高度近视的回顾性队列研究[J].中华实验眼科杂志,2018,11(2):144-149.
[9]Skieresz-Szewczyk K,Jackowiak H,Ratajczak M.Ultrastructural study on the embryonic development of the orthokeratinized epithelium and its cornified layer(lingual nail)on the ventral surface of the lingual apex in the domestic duck(Anas platyrhynchos f.domestica)[J].Zoology,2018,126:36-45.
[10]于军,栗莉.佩戴角膜塑形镜与框架眼镜控制儿童近视效果及安全性比较[J].第二军医大学学报,2018,13(5):227-229.
[11]苗春旭,徐昕涌,张会.儿童夜戴角膜塑形镜角膜并发症分析[J].中华眼科杂志,2017,53(3):198-202.
[12]赵可浩,陆文秀,王文萃,等.配戴一年以上的夜用角膜塑形镜停戴后角膜参数的变化[J].眼科,2016,31(5):306-309.
[13]Deterding K,Mauss S,Pathil A,et al.PS-096-Long-term follow-up after IFN-free therapy of advanced HCV-associated liver cirrhosis:continued improvement of liver function parameters-results from the German Hepatitis C-Registry(DHC-R)[J].Journal of Hepatology,2017,66(1):S55.
[14]裴天序,张佳欢,韩冬,等.夜戴型角膜塑形镜对青少年泪膜的影响[J].眼科新进展,2018,38(6):217-218.
[15]连燕,金婉卿,毛欣杰,等.框架眼镜与角膜塑形镜矫正的近视儿童脉络膜厚度差异比较研究[J].眼科新进展,2017,37(5):431-434.
[16]周佳,林伟平,刘桂华,等.停戴角膜塑形镜期间角膜前表面形态恢复情况观察[J].眼科新进展,2017,37(8):739-742.
[17]沈亚,单彧,程金伟,等.夜戴型角膜塑形镜矫治青少年近视的临床观察研究[J].第二军医大学学报,2017,38(11):1467-1470.
[18]Zimmer C L,Rinker F,Honer Zu Siederdissen C,et al.Increased NK cell function after cessation of long-term nucleos(t)ide analogue treatment in chronic hepatitis B associates with liver damage and HBsAg loss[J].Journal of Infectious Diseases,2018,217(10):1656-1666.
[19]刘桂华,谷天瀑,李颖,等.角膜塑形镜配戴后瞳孔与光学区的大小对视觉质量的影响[J].眼科新进展,2017,37(1):38-41.
[20]唐晓蕾,扶世杰,王晓莉,等.角膜塑形镜控制儿童近视进展的一年综合效果[J].眼科,2016,31(2):98-101.