自拟理气和胃汤治疗肝胃不和型慢性胃炎临床观察
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摘要
目的总结自拟理气和胃汤治疗肝胃不和型慢性胃炎的临床疗效,并从临床观察和理论两个方面探讨自拟理气和胃汤治疗肝胃不和型慢性胃炎的作用机理。方法将82例慢性胃炎证属肝胃不和型的患者随机分为两组,治疗组42例,对照组40例,治疗组给予口服理气和胃汤治疗,对照组给予口服奥美拉唑肠溶片、多潘立酮片治疗,两组均以8周为1个疗程,1个疗程后评定疗效。结果治疗后临床疗效比较,治疗组总有效率90. 5%,对照组总有效率72. 5%,治疗组疗效明显优于对照组(P <0. 05);治疗后证候积分比较,两组中医证候积分均降低,治疗组降低更加显著(P <0. 05);治疗后各种症状的改善情况比较,治疗后治疗组较对照组胃痛、恶心呕吐症状积分无明显差别(P> 0. 05),但治疗组较对照组胃部胀满、饮食减少、呃逆、胁肋胀满、胃反酸、嗳气症状积分明显降低(P <0. 05);治疗后胃镜检查比较,治疗组总有效率88. 1%,对照组总有效率70. 0%,治疗组疗效明显优于对照组(P <0. 05)。结论自拟理气和胃汤治疗肝胃不和型慢性胃炎临床疗效显著,可明显改善患者的临床症状,胃镜检查结果等,值得临床推广应用。
Objective To analyze the clinical effects on chronic gastritis of liver-stomach disharmony treated with self-prepared liqi hewei decoction and explore the effect mechanism in the aspects of clinical observation and theoretic study. Methods A total of 82 patients of chronic gastritis of liver-stomach disharmony were randomized into two groups,a treatment group( 42 cases) and a control group( 40 cases). In the treatment group,liqi hewei decoction was taken orally. In the control group,omeprazole enteric-coated tablets and domperidone tablets were prescribed for oral administration. The treatment for 8 weeks was as 1 session and the therapeutic effects were evaluated after 1 session treatment in the two groups. Results The total effective rate was 90. 5% in the treatment group and was 72. 5% in the control group.The effects in the treatment group were better obviously than the control group( P < 0. 05). After treatment,the symptom scores were all reduced in the two groups and the reduction in the treatment was more significant as compared with the control group( P < 0. 05). Regarding the improvements in symptoms,the differences in gastric pain,nausea and vomiting were not significant obviously between the treatment group and the control group( P > 0. 05). Compared with the control group,the score reduction for gastric distention,poor appetite,hiccup,hypochondriac distention and fullness,acid reflux and belching was more obviously as compared with the control group( P < 0. 05). After treatment,in gastroscopic examination,the total effective rate was 88. 1% in the treatment group and was 70% in the control group. The effect in the treatment group was better obviously as compared with the control group( P < 0. 05). Conclusion The self-prepared liqi hewei decoction achieves the significant clinical effects on chronic gastritis of liver-stomach disharmony and has obvious improvements in clinical symptoms and gastroscopic examination. This medication deserves to be promoted in clinical practice.
Objective To analyze the clinical effects on chronic gastritis of liver-stomach disharmony treated with self-prepared liqi hewei decoction and explore the effect mechanism in the aspects of clinical observation and theoretic study. Methods A total of 82 patients of chronic gastritis of liver-stomach disharmony were randomized into two groups,a treatment group( 42 cases) and a control group( 40 cases). In the treatment group,liqi hewei decoction was taken orally. In the control group,omeprazole enteric-coated tablets and domperidone tablets were prescribed for oral administration. The treatment for 8 weeks was as 1 session and the therapeutic effects were evaluated after 1 session treatment in the two groups. Results The total effective rate was 90. 5% in the treatment group and was 72. 5% in the control group.The effects in the treatment group were better obviously than the control group( P < 0. 05). After treatment,the symptom scores were all reduced in the two groups and the reduction in the treatment was more significant as compared with the control group( P < 0. 05). Regarding the improvements in symptoms,the differences in gastric pain,nausea and vomiting were not significant obviously between the treatment group and the control group( P > 0. 05). Compared with the control group,the score reduction for gastric distention,poor appetite,hiccup,hypochondriac distention and fullness,acid reflux and belching was more obviously as compared with the control group( P < 0. 05). After treatment,in gastroscopic examination,the total effective rate was 88. 1% in the treatment group and was 70% in the control group. The effect in the treatment group was better obviously as compared with the control group( P < 0. 05). Conclusion The self-prepared liqi hewei decoction achieves the significant clinical effects on chronic gastritis of liver-stomach disharmony and has obvious improvements in clinical symptoms and gastroscopic examination. This medication deserves to be promoted in clinical practice.
引文
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[12]颜艳.中药砂仁的研究进展[J].中国中医药科技,2007,14(4):304-305.
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[14]王华新,刘文娟.白术在胃肠道疾病方面的药理与临床应用[J].时珍国医国药,2007,18(11):2847-2848.
[15]章斌,金剑,金芝贵,等.枳壳的药理作用与临床应用进展[J].医药导报,2013,32(11):1462-1464.
[16]罗玉梅,王贺振.山楂的化学成分及药理研究进展[J].时珍国医国药,2004,15(1):53-54.
[17]赵婧,霍青,李运伦.莱菔子的现代研究及临床应用[J].长春中医药大学学报,2011,27(2):294-296.
[18]陈红,刘传玉,李承晏.青皮的化学及药理作用研究进展[J].中草药,2001,32(11):1050-1052.
[19]朱自平,张明发,沈雅琴,等.厚朴对消化系统的药理作用[J].中国中药杂志,1997,22(11):686-688.
[2]陈灏珠,林果为.实用内科学[M]. 13版.北京:人民卫生出版社,2009:1976-1980.
[3]徐斌,黄玉凯,周进.慢性萎缩性胃炎的胃镜下表现与病理诊断对照分析[J].中华全科医学,2014,12(9):1388-1390.
[4]周莉,魏文慧,张燕丽.温补通络法治疗慢性萎缩性胃炎脾胃虚弱(寒)证的临床研究[J].中医药信息,2015,32(1):103-105.
[5]魏玮,杨洋.慢性萎缩性胃炎诊治现状及中医药治疗优势[J].中医杂志,2016,57(1):36-40.
[6]周仲瑛.中医内科学[M].北京:中国中医药出版社,2003:196-202.
[7]郑筱萸.中药新药临床研究指导原则[M].北京:中医药科技出版社,2002:124-129.
[8]中国中西医结合学会消化系统疾病专业委员会.胃肠疾病中医症状评分表[J].中国中西医结合消化杂志,2011,19(1):66-68.
[9]李仁国.柴胡有效成分及药理作用分析[J].陕西中医,2013,34(6):750-751.
[10]苏玮,郭群.白芍的现代药理研究概况[J].中医药信息,1996,13(70):9-11.
[11]王绪颖,贾晓斌,陈彦.木香类药材的研究进展[J].中药材,2010,33(1):153-157.
[12]颜艳.中药砂仁的研究进展[J].中国中医药科技,2007,14(4):304-305.
[13]高学敏.中药学[M].北京:中国中医药出版社,2003:58.
[14]王华新,刘文娟.白术在胃肠道疾病方面的药理与临床应用[J].时珍国医国药,2007,18(11):2847-2848.
[15]章斌,金剑,金芝贵,等.枳壳的药理作用与临床应用进展[J].医药导报,2013,32(11):1462-1464.
[16]罗玉梅,王贺振.山楂的化学成分及药理研究进展[J].时珍国医国药,2004,15(1):53-54.
[17]赵婧,霍青,李运伦.莱菔子的现代研究及临床应用[J].长春中医药大学学报,2011,27(2):294-296.
[18]陈红,刘传玉,李承晏.青皮的化学及药理作用研究进展[J].中草药,2001,32(11):1050-1052.
[19]朱自平,张明发,沈雅琴,等.厚朴对消化系统的药理作用[J].中国中药杂志,1997,22(11):686-688.