2013—2017年南宁市登记肺结核患者HIV感染情况
|
摘要
目的 通过分析2013—2017年南宁市结核病患者中人类免疫缺陷病毒(HIV)感染的流行病学特征,为控制结核杆菌(TB)/HIV双重感染提供理论依据。方法 利用结核病管理信息系统获取南宁市登记肺结核患者中HIV感染情况数据,并对其进行流行病学描述分析。结果 2013—2017年,各年份登记结核病患者HIV感染率分别为2.29%、1.75%、1.24%、1.48%、1.47%,年均感染率为1.64%。2013年登记结核患者HIV感染率最高,差异有统计学意义(χ~2=17.037,P<0.05);各月份均有报告HIV感染阳性病例,感染率无明显季节性;南宁市区HIV感染率均为最低(P<0.05),2013、2015年贫困县和非贫困县HIV感染率比较,差异无统计学意义(P>0.05),其余年份中HIV感染率均为贫困县最高(P<0.05);40～80岁之间结核病患者,无论构成比还是感染率均为各年龄组中最高,而<20岁及≥80岁的结核病患者中HIV感染率较低;男性HIV感染率在各年份均高于女性;农民HIV感染率比非农民更高,两者差异有统计学意义(χ~2=35.262,P<0.05)。结论 重点关注贫困县区、农村患者、中老年患者、男性患者这些群体中的HIV感染干预工作,通过政府主导,经济、发展文化事业,有利于控制HIV感染疫情,对结核病及艾滋病防治工作产生积极影响。
[Objective]B y analyzing the epidemiological characteristics of HIV infection in tuberculosis patients in Nanning City from 2013-2017,provide the theoretical basis for the control of dual infection of Mycobacterium tuberculosis(TB)/HIV.[Methods]The data of HIV infection in registered tuberculosis patients in Nanning City were obtained by using tuberculosis management information system,to conduct an epidemiological analysis.[Results]From 2013 to 2017,the annual HIV infection rate of registered tuberculosis patients was 2.29%,1.75%,1.24%,1.48% and 1.47%,respectively,with an annual average of 1.64%.The registered tuberculosis patients had the highest HIV infection rate in 2013,and the difference was statistically significant(χ~2=17.037,P<0.05). Positive HIV infection was reported in every month,and infection rate showed no obvious seasonality. The HIV infection rate in urban area of Nanning City was the lowest(P<0.05). Except that there was no statistical difference between poor counties and non-poor counties in 2013 and 2015(P>0.05),the HIV infection rate in other years was the highest in poor counties(P<0.05). The tuberculosis patients aged 40-80 years old had the highest infection rate and constituent ratio in all age groups,while HIV infection rate was lower in patients under 20 years old and above 80 years old. HIV infection rate in males was higher than that in females in each year. The HIV infection rate of farmers was higher than that of non-farmers,and the difference was statistically significant(χ~2=35.262,P<0.05).[Conclusion]It is necessary to focus on HIV infection intervention in poor counties,rural patients,middle-aged and elderly patients,and male patients. Government-led efforts to develop economic and cultural programs will help control HIV infection and have a positive impact on tuberculosis and HIV prevention.
[Objective]B y analyzing the epidemiological characteristics of HIV infection in tuberculosis patients in Nanning City from 2013-2017,provide the theoretical basis for the control of dual infection of Mycobacterium tuberculosis(TB)/HIV.[Methods]The data of HIV infection in registered tuberculosis patients in Nanning City were obtained by using tuberculosis management information system,to conduct an epidemiological analysis.[Results]From 2013 to 2017,the annual HIV infection rate of registered tuberculosis patients was 2.29%,1.75%,1.24%,1.48% and 1.47%,respectively,with an annual average of 1.64%.The registered tuberculosis patients had the highest HIV infection rate in 2013,and the difference was statistically significant(χ~2=17.037,P<0.05). Positive HIV infection was reported in every month,and infection rate showed no obvious seasonality. The HIV infection rate in urban area of Nanning City was the lowest(P<0.05). Except that there was no statistical difference between poor counties and non-poor counties in 2013 and 2015(P>0.05),the HIV infection rate in other years was the highest in poor counties(P<0.05). The tuberculosis patients aged 40-80 years old had the highest infection rate and constituent ratio in all age groups,while HIV infection rate was lower in patients under 20 years old and above 80 years old. HIV infection rate in males was higher than that in females in each year. The HIV infection rate of farmers was higher than that of non-farmers,and the difference was statistically significant(χ~2=35.262,P<0.05).[Conclusion]It is necessary to focus on HIV infection intervention in poor counties,rural patients,middle-aged and elderly patients,and male patients. Government-led efforts to develop economic and cultural programs will help control HIV infection and have a positive impact on tuberculosis and HIV prevention.
引文
[1]王超,吴利先.艾滋病与结核病双重感染的流行及相互作用机制的研究进展[J].中国病原生物学杂志,2013,8(8):756-758.
[2]WHO.TB/HIV Facts 2012-2013[EB/OL](2014-12-03)[2018-11-01].http://www.who.int/hiv/topics/tb/tbhiv_facts_2013/en/.
[3]龚震宇,龚训良.全球结核病简报(2018年1月更新报告)[J].疾病监测,2018,33(4):351-352.
[4]周昀,沈宇清.人类免疫缺陷病毒与结核杆菌双重感染致病机制的研究进展[J].病毒学报,2013,29(4):452-456.
[5]李斯斯,农全兴,徐永芳,等.广西南宁市新报告艾滋病患者晚发现影响因素研究[J].现代预防医学,2017,44(16):3028-3031.
[6]吴莉,乔方圆,李源晖,等.2004-2012年全国肺结核流行特征及时空聚集性分析[J].江苏预防医学,2014,45(29):4110-4112.
[7]苏武锦,陈悦,黄茜,等.南宁地区2006-2015年无偿献血者HIV阳性的分布特征[J].重庆医学,2016,44(16):3028-3031.
[8]LIANG S,SHEN Z,YAN J,et al.Low virologic failure and drug resistance among HIV-Infected patients receiving Hospital-BasedART while care and outreach through community in Guangxi,China[J/OL].Frontiers in public health,2015,3:244.[2018-11-01]http://kns.cnki.net/KCMS/detail/detail.aspx?dbcode=SJPD&dbname=SJPD1516_U&filename=SJPD4857B2A4FFF66C8BCD88CD4F10847183&uid=WEEvREdxOWJmbC9oM1NjYkdwUlZXSXFEaGVreGkrbllTMWtFSUZIY3BSMWs=$R1yZ0H6jyaa0en3RxVUd8df-oHi7XMMDo7mtKT6mSmEvTuk11l2gFA!!&v=MjU5NjVucEt4MlJnbmpkMU93dm0yaE0xY2JhVFJMS2NDSlVhRj F1UVVyL1BKbGNTYm1LQ0dZQ0dRbGZDcExRMzV0eGh3TGk4d2FBPU5pZmJhcmV3RzlhK3JmNUJFcDE1Qw-.DOI:10.3389/fpubh.2015.00244.
[9]梁大斌,林玫,崔哲哲,等.2014-2016年广西结核杆菌/艾滋病病毒双重感染检测结果分析[J].现代预防医学,2017,44(14):2628-2631.
[10]胡嘉,邱林西,陈伟,等.江西省6个县(区)结核患者HIV感染现状分析[J].中国防痨杂志,2010,32(12):831-834.
[11]魏静,贺良,赵娜,等.2013-2017年重庆市万州区新发肺结核病例HIV抗体检测结果分析[J].寄生虫病与感染性疾病,2018,16(2):76-77.
[12]何旺瑞,胡嘉江.江西省结核病人中HIV感染现状调查[J].现代预防医学,2009,36(16):3147-3149.
[13]王芸,候景龙,杨蕊,等.云南省2010-2013年结核菌/艾滋病病毒双重感染者流行特征[J].公共卫生与预防医学,2015,26(3):8-11.
[14]林建,魏淑贞,陈求扬,等.福建省2008-2009年结核病患者HIV感染现状调查[J].中国热带医学,2012,12(7):862-863.
[15]黄宝杨,白玉,俸卫东,等.2009-2011年柳州市区TB/HIV双重感染人群资料分析[J].职业与健康,2013,28(4):460-464.
[16]葛宪民,唐振柱,朱秋映,等.广西2010-2015年艾滋病流行特征及趋势分析[J].中国艾滋病性病,2017,23(1):40-43.
[17]延芸.某市2015-2016年艾滋病感染状况及危险行为分析[J].延安大学学报(医学科学版),2017,15(4):66-68.
[18]何静,赵西和,等.2013-2017年四川省绵阳市艾滋病疫情分析[J].寄生虫病与感染性疾病,2018,16(3):119-124.
[19]甄新安.485例住院肺结核病人HIV感染调查[J].中国防痨杂志,2003,25(6):384.
[20]张湘玲,李薇伦.中越边境地区结核菌/艾滋病病毒双重感染人群特征分析[J].中国健康教育,2014,30(1):78-79.
[2]WHO.TB/HIV Facts 2012-2013[EB/OL](2014-12-03)[2018-11-01].http://www.who.int/hiv/topics/tb/tbhiv_facts_2013/en/.
[3]龚震宇,龚训良.全球结核病简报(2018年1月更新报告)[J].疾病监测,2018,33(4):351-352.
[4]周昀,沈宇清.人类免疫缺陷病毒与结核杆菌双重感染致病机制的研究进展[J].病毒学报,2013,29(4):452-456.
[5]李斯斯,农全兴,徐永芳,等.广西南宁市新报告艾滋病患者晚发现影响因素研究[J].现代预防医学,2017,44(16):3028-3031.
[6]吴莉,乔方圆,李源晖,等.2004-2012年全国肺结核流行特征及时空聚集性分析[J].江苏预防医学,2014,45(29):4110-4112.
[7]苏武锦,陈悦,黄茜,等.南宁地区2006-2015年无偿献血者HIV阳性的分布特征[J].重庆医学,2016,44(16):3028-3031.
[8]LIANG S,SHEN Z,YAN J,et al.Low virologic failure and drug resistance among HIV-Infected patients receiving Hospital-BasedART while care and outreach through community in Guangxi,China[J/OL].Frontiers in public health,2015,3:244.[2018-11-01]http://kns.cnki.net/KCMS/detail/detail.aspx?dbcode=SJPD&dbname=SJPD1516_U&filename=SJPD4857B2A4FFF66C8BCD88CD4F10847183&uid=WEEvREdxOWJmbC9oM1NjYkdwUlZXSXFEaGVreGkrbllTMWtFSUZIY3BSMWs=$R1yZ0H6jyaa0en3RxVUd8df-oHi7XMMDo7mtKT6mSmEvTuk11l2gFA!!&v=MjU5NjVucEt4MlJnbmpkMU93dm0yaE0xY2JhVFJMS2NDSlVhRj F1UVVyL1BKbGNTYm1LQ0dZQ0dRbGZDcExRMzV0eGh3TGk4d2FBPU5pZmJhcmV3RzlhK3JmNUJFcDE1Qw-.DOI:10.3389/fpubh.2015.00244.
[9]梁大斌,林玫,崔哲哲,等.2014-2016年广西结核杆菌/艾滋病病毒双重感染检测结果分析[J].现代预防医学,2017,44(14):2628-2631.
[10]胡嘉,邱林西,陈伟,等.江西省6个县(区)结核患者HIV感染现状分析[J].中国防痨杂志,2010,32(12):831-834.
[11]魏静,贺良,赵娜,等.2013-2017年重庆市万州区新发肺结核病例HIV抗体检测结果分析[J].寄生虫病与感染性疾病,2018,16(2):76-77.
[12]何旺瑞,胡嘉江.江西省结核病人中HIV感染现状调查[J].现代预防医学,2009,36(16):3147-3149.
[13]王芸,候景龙,杨蕊,等.云南省2010-2013年结核菌/艾滋病病毒双重感染者流行特征[J].公共卫生与预防医学,2015,26(3):8-11.
[14]林建,魏淑贞,陈求扬,等.福建省2008-2009年结核病患者HIV感染现状调查[J].中国热带医学,2012,12(7):862-863.
[15]黄宝杨,白玉,俸卫东,等.2009-2011年柳州市区TB/HIV双重感染人群资料分析[J].职业与健康,2013,28(4):460-464.
[16]葛宪民,唐振柱,朱秋映,等.广西2010-2015年艾滋病流行特征及趋势分析[J].中国艾滋病性病,2017,23(1):40-43.
[17]延芸.某市2015-2016年艾滋病感染状况及危险行为分析[J].延安大学学报(医学科学版),2017,15(4):66-68.
[18]何静,赵西和,等.2013-2017年四川省绵阳市艾滋病疫情分析[J].寄生虫病与感染性疾病,2018,16(3):119-124.
[19]甄新安.485例住院肺结核病人HIV感染调查[J].中国防痨杂志,2003,25(6):384.
[20]张湘玲,李薇伦.中越边境地区结核菌/艾滋病病毒双重感染人群特征分析[J].中国健康教育,2014,30(1):78-79.