中药抗流感病毒研究进展
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摘要
流感是由流感病毒引起的呼吸道疾病,发病率高、流行广泛、变异性强。中药在抑制流感病毒方面有其独特优势,目前在我国临床已有广泛应用,研究表明其具有多方面确切疗效,具有更广泛的适应性。通过采用文献查阅法,对抗流感病毒中药的有效成分、体内外抗流感病毒作用及其机制进行阐述。
Influenza is a respiratory disease caused by influenza virus, charactered with high incidence, widespread prevalence, and strong variability. Chinese medicine has its unique advantages in suppressing the virus, it has been widely used in clinic in China and a variety of studies showed the herbs exact effect on multiple target sites, has a wider range of adaptability. From the effects of Chinese medicine on anti-influenza virus in effective components, in vitro and in vivo experimental and underlying mechanisms of relevant articles are reviewed.
Influenza is a respiratory disease caused by influenza virus, charactered with high incidence, widespread prevalence, and strong variability. Chinese medicine has its unique advantages in suppressing the virus, it has been widely used in clinic in China and a variety of studies showed the herbs exact effect on multiple target sites, has a wider range of adaptability. From the effects of Chinese medicine on anti-influenza virus in effective components, in vitro and in vivo experimental and underlying mechanisms of relevant articles are reviewed.
引文
[1]张照研,张会敏,周喆,等.银翘散对H1N1流感病毒感染小鼠的保护作用[J].世界中西医结合杂志,2015,10(6):771-773.
[2]张海婴,王雪峰,王思源,等.银翘散提取物对流感病毒性肺炎小鼠组织TLR4及NF-κBp65的影响[J].时珍国医国药,2014,25(10):2321-2323.
[3]刘廷,王海丹,狄留庆,等.基于甲型H1N1流感病毒致MDCK细胞损伤保护作用的双黄连组方HPLC特征图谱谱效关系研究[J].中国中药杂志,2015,40(21):4194-4199.
[4]赵利华,陈全姣.清开灵注射液体对H1N1、H5N1和H7N9流感病毒的作用研究[J].中药新药与临床药理,2015,26(5):644-648.
[5]张波,李玲,卢芳国,等.麻杏石甘汤对流感病毒感染小鼠肺部炎症与神经氨酸酶活性影响的研究[J].中华中医药杂志,2013,28(4):1094-1099.
[6]丁新侃.连花清瘟药物抗流感病毒的药理分析[J].临床合理用药杂志,2012,5(28):32.
[7]陈杲,广慧敏,李立,等.连花清瘟颗粒/胶囊治疗甲型H1N1流感作用机理的网络生物学分析[J].中医杂志,2014,55(8):703-707.
[8]南淑玲,徐顺富,陈许,等.升降散对流感病毒鼠肺适应株FM1感染肺炎小鼠保护作用观察[J].中药药理与临床,2016,32(3):8-12.
[9]南淑玲,徐顺富,陈许,等.升降散对流感病毒鼠肺适应株FM1感染小鼠免疫功能的影响[J].中药药理与临床,2016,32(5):8-13.
[10]Xiao P,Ye W Y,Chen J W,et al.Antiviral activities against influenza virus(FM1)of bioactive fractions and representative compounds extracted from Banlangen(Radix Isatidis)[J].J Tra Chin Med,2016,36(3):369-376.
[11]Zhou B X,Yang Z F,Feng Q T,et al.Aurantiamide acetate from baphicacanthus cusia root exhibits anti-inflammatory and anti-viral effects via inhibition of the NF-κB signaling pathway in Influenza A virus-infected cells[J].J Eth,2017,199(6):60-67.
[12]Wang J,Yan Y T,Gao Z P,et al.Anti-influenza Virus(H5N1)Activity Screening on the Phloroglucinols from Rhizomes of Dryopteris crassirhizoma[J].Molecules,2017,22(3):E431.
[13]Ou C B,Zhang Q,Gao Z P,et al.Dryocrassin ABBA,a novel active substance for use against amantadine-resistant H5N1 avian influenza virus[J].Frontiers in Microbiology,2016,7(6):1464.
[14]Ji S,Li R,Wang Q,et al.Anti-H1N1 virus,cytotoxic and Nrf2 activation activities of chemical constituents from Scutellaria baicalensis[J].J Eth,2015,176(24):475-484.
[15]郭姗姗,包蕾,崔晓兰.黄芩苷对宿主因子PACT干扰后流感病毒RNA聚合酶活性的影响[J].中国药物警戒,2016,13(3):129-131.
[16]刘晓婷,张沂,顾立刚,等.流感病毒H1N1感染A549细胞诱导凋亡及黄芩苷干预作用的研究[J].中国药理学通报,2015,31(7):936-939.
[17]邱玲玲,肖莹,支星,等.Box-Behnken响应曲面法筛选金银花中抗流感病毒活性成分研究[J].中国现代中药,2016,18(11):1454-1457.
[18]朱明珠,毛淑敏,刘玉红,等.金银花水煎液抗流感病毒作用的研究[J].中国中医药现代远程教育,2016,14(9):135-137.
[19]段林建,胡伶清,张清,等.不同连翘制剂对甲型流感病毒NP基因转染后表达的影响[J].中医学报,2015,30(1):71-73.
[20]李莉,王晓东,何光星.鱼腥草挥发油压微型乳口腔喷雾剂体外抗病毒实验研究[J].四川中医,2013,31(6):76-78.
[21]杨斌,杨慧,王农荣,等.鱼腥草及三丫苦对甲型流感病毒NPAG表达的影响[J].江西医药,2014,49(6):495-496.
[22]姚干,王允,刘毅,等.黄芩总黄酮和栀子总环烯醚萜对含药小鼠血清体外抗病毒作用[J].中成药,2014,36(4):698-701.
[23]张耘实,祁贤,卢协勤,等.栀子苷对甲型H1N1流感病毒的抑制作用[J].中国药科大学学报,2016,47(2):204-209.
[24]陈秀秀,周红霞,亓文宝,等.甘草酸联合利巴韦林体内抗甲型H1N1流感病毒作用[J].药学学报,2015,50(8):966-972.
[25]刘宝剑,王存连,徐明举,等.人参皂苷Rb1对H9N2流感病毒诱导急性肺损伤小鼠抗氧化酶的影响[J].中国实验动物学报,2014,22(1):38-43.
[26]吴方,余陈欢,俞文英,等.基于micro RNAs的石荠苧总黄酮抗流感病毒性肺炎作用机制研究[J].中草药,2016,47(7):1149-1154.
[27]Wu Q F,Wang W,Dai X Y,et al.Chemical compositions and anti-influenza activities of essential oils from Mosla dianthera[J].J Eth,2012,139(2):668-671.
[28]许珊丽,蒲秀瑛,杨晓华,等.贯叶连翘提取物对流感病毒感染小鼠免疫功能的影响[J].西部中医药,2016,29(9):23-27.
[29]Yang Z F,Bai L P,Huang W B,et al.Comparison of in vitro antiviral activity of tea polyphenols against influenza A and B viruses and structure–activity relationship analysis[J].Fitoterapia,2014,93(3):47-53.
[30]Theisen L L,Erdelmeier C A,Spoden G A,et al.Tannins from Hamamelis virginiana bark extract:characterization and improvement of the antiviral efficacy against influenza A virus and human papillomavirus[J].PLo S One,2014,9(1):e88062.
[31]Kyoko U,Ryoko K,Takashi I,et al.Inactivation of Pathogenic Viruses by Plant-Derived Tannins:Strong Effects of Extracts from Persimmon(Diospyros kaki)on a Broad Range of Viruses[J].PLo S One,2013,8(1):e55343.
[32]Yu C H,Yu W Y,Fang J,et al.Mosla scabra flavonoids ameliorate the influenza A virus-induced lung injury and water transport abnormality via the inhibition of PRR and AQP signaling pathways in mice[J].J Eth,2016,179(17):146-155.
[33]Patchima S,Martin M,Manfred S Z,et al.Differential antiviral and antiinflammatory mechanisms of the flavonoids biochanin A and baicalein in H5N1 influenza A virus-infected cells[J].Antiviral Res,2013,97(1):41-48.
[34]Hisahiro K,Masatsugu O,Hiroki Y,et al.In vitro and in vivo anti-influenza virus activities of flavonoids and related compounds as components of Brazilian propolis(AF-08)[J].J fun f,2014,8(3):214-223.
[35]刘蓉,武志强,何敏,等.桂枝挥发油与桂皮醛对病毒性肺炎小鼠细胞因子及T细胞亚群的影响[J].中国实验方剂学杂志,2015,21(18):139-143.
[36]何婷,汤奇,曾南,等.荆芥挥发油及其主要成分抗流感病毒作用与机制研究[J].中国中药杂志,2013,38(11):1772-1777.
[37]陈小璇,代剑平,万倩英,等.氧化苦参碱抗流感病毒药效及机制研究[J].癌变.畸变.突变,2014,26(3):175-179.
[38]张贵源,龚莉莉,余跃生,等.刺三甲总生物碱抗流感病毒的鸡胚试验[J].时珍国医国药,2012,23(5):1074-1075.
[39]何立巍,吴晓培,杨婧妍,等.板蓝根总生物碱的提取纯化工艺及其抗病毒药理作用研究[J].中成药,2014,36(12):2611-2614.
[40]李帅,王玉霞,李海霞,等.茯苓总多糖对H1N1流感疫苗和乙肝疫苗抗原的佐剂作用[J].中国药理学与毒理学杂志,2015,29(1):60-64.
[41]董娜,李倩,张贵强,等.淫羊藿多糖对甲型H1N1流感病毒裂解疫苗的免疫佐剂作用[J].国际药学研究杂志,2013,40(1):63-68.
[42]张亚楠,黄生波,李小曼,等.玉竹多糖对流感病毒裂解疫苗的黏膜佐剂效应[J].激光生物学报,2017,26(1):68-72.
[43]Yang Q,Gao L,Si J Y,et al.Inhibition of porcine reproductive and respiratory syndrome virus replication by flavaspidic acid AB[J].Antiviral Res,2013,97(1):66-73.
[44]RYu Y B,Jeong H J,Yoon S Y et al.Influenza virus neuraminidase inhibitory activity of phlorotannins from the Edible Brown Alga Ecklonia cava[J].J agri f chem,2011,59(12):6467-6473.
[2]张海婴,王雪峰,王思源,等.银翘散提取物对流感病毒性肺炎小鼠组织TLR4及NF-κBp65的影响[J].时珍国医国药,2014,25(10):2321-2323.
[3]刘廷,王海丹,狄留庆,等.基于甲型H1N1流感病毒致MDCK细胞损伤保护作用的双黄连组方HPLC特征图谱谱效关系研究[J].中国中药杂志,2015,40(21):4194-4199.
[4]赵利华,陈全姣.清开灵注射液体对H1N1、H5N1和H7N9流感病毒的作用研究[J].中药新药与临床药理,2015,26(5):644-648.
[5]张波,李玲,卢芳国,等.麻杏石甘汤对流感病毒感染小鼠肺部炎症与神经氨酸酶活性影响的研究[J].中华中医药杂志,2013,28(4):1094-1099.
[6]丁新侃.连花清瘟药物抗流感病毒的药理分析[J].临床合理用药杂志,2012,5(28):32.
[7]陈杲,广慧敏,李立,等.连花清瘟颗粒/胶囊治疗甲型H1N1流感作用机理的网络生物学分析[J].中医杂志,2014,55(8):703-707.
[8]南淑玲,徐顺富,陈许,等.升降散对流感病毒鼠肺适应株FM1感染肺炎小鼠保护作用观察[J].中药药理与临床,2016,32(3):8-12.
[9]南淑玲,徐顺富,陈许,等.升降散对流感病毒鼠肺适应株FM1感染小鼠免疫功能的影响[J].中药药理与临床,2016,32(5):8-13.
[10]Xiao P,Ye W Y,Chen J W,et al.Antiviral activities against influenza virus(FM1)of bioactive fractions and representative compounds extracted from Banlangen(Radix Isatidis)[J].J Tra Chin Med,2016,36(3):369-376.
[11]Zhou B X,Yang Z F,Feng Q T,et al.Aurantiamide acetate from baphicacanthus cusia root exhibits anti-inflammatory and anti-viral effects via inhibition of the NF-κB signaling pathway in Influenza A virus-infected cells[J].J Eth,2017,199(6):60-67.
[12]Wang J,Yan Y T,Gao Z P,et al.Anti-influenza Virus(H5N1)Activity Screening on the Phloroglucinols from Rhizomes of Dryopteris crassirhizoma[J].Molecules,2017,22(3):E431.
[13]Ou C B,Zhang Q,Gao Z P,et al.Dryocrassin ABBA,a novel active substance for use against amantadine-resistant H5N1 avian influenza virus[J].Frontiers in Microbiology,2016,7(6):1464.
[14]Ji S,Li R,Wang Q,et al.Anti-H1N1 virus,cytotoxic and Nrf2 activation activities of chemical constituents from Scutellaria baicalensis[J].J Eth,2015,176(24):475-484.
[15]郭姗姗,包蕾,崔晓兰.黄芩苷对宿主因子PACT干扰后流感病毒RNA聚合酶活性的影响[J].中国药物警戒,2016,13(3):129-131.
[16]刘晓婷,张沂,顾立刚,等.流感病毒H1N1感染A549细胞诱导凋亡及黄芩苷干预作用的研究[J].中国药理学通报,2015,31(7):936-939.
[17]邱玲玲,肖莹,支星,等.Box-Behnken响应曲面法筛选金银花中抗流感病毒活性成分研究[J].中国现代中药,2016,18(11):1454-1457.
[18]朱明珠,毛淑敏,刘玉红,等.金银花水煎液抗流感病毒作用的研究[J].中国中医药现代远程教育,2016,14(9):135-137.
[19]段林建,胡伶清,张清,等.不同连翘制剂对甲型流感病毒NP基因转染后表达的影响[J].中医学报,2015,30(1):71-73.
[20]李莉,王晓东,何光星.鱼腥草挥发油压微型乳口腔喷雾剂体外抗病毒实验研究[J].四川中医,2013,31(6):76-78.
[21]杨斌,杨慧,王农荣,等.鱼腥草及三丫苦对甲型流感病毒NPAG表达的影响[J].江西医药,2014,49(6):495-496.
[22]姚干,王允,刘毅,等.黄芩总黄酮和栀子总环烯醚萜对含药小鼠血清体外抗病毒作用[J].中成药,2014,36(4):698-701.
[23]张耘实,祁贤,卢协勤,等.栀子苷对甲型H1N1流感病毒的抑制作用[J].中国药科大学学报,2016,47(2):204-209.
[24]陈秀秀,周红霞,亓文宝,等.甘草酸联合利巴韦林体内抗甲型H1N1流感病毒作用[J].药学学报,2015,50(8):966-972.
[25]刘宝剑,王存连,徐明举,等.人参皂苷Rb1对H9N2流感病毒诱导急性肺损伤小鼠抗氧化酶的影响[J].中国实验动物学报,2014,22(1):38-43.
[26]吴方,余陈欢,俞文英,等.基于micro RNAs的石荠苧总黄酮抗流感病毒性肺炎作用机制研究[J].中草药,2016,47(7):1149-1154.
[27]Wu Q F,Wang W,Dai X Y,et al.Chemical compositions and anti-influenza activities of essential oils from Mosla dianthera[J].J Eth,2012,139(2):668-671.
[28]许珊丽,蒲秀瑛,杨晓华,等.贯叶连翘提取物对流感病毒感染小鼠免疫功能的影响[J].西部中医药,2016,29(9):23-27.
[29]Yang Z F,Bai L P,Huang W B,et al.Comparison of in vitro antiviral activity of tea polyphenols against influenza A and B viruses and structure–activity relationship analysis[J].Fitoterapia,2014,93(3):47-53.
[30]Theisen L L,Erdelmeier C A,Spoden G A,et al.Tannins from Hamamelis virginiana bark extract:characterization and improvement of the antiviral efficacy against influenza A virus and human papillomavirus[J].PLo S One,2014,9(1):e88062.
[31]Kyoko U,Ryoko K,Takashi I,et al.Inactivation of Pathogenic Viruses by Plant-Derived Tannins:Strong Effects of Extracts from Persimmon(Diospyros kaki)on a Broad Range of Viruses[J].PLo S One,2013,8(1):e55343.
[32]Yu C H,Yu W Y,Fang J,et al.Mosla scabra flavonoids ameliorate the influenza A virus-induced lung injury and water transport abnormality via the inhibition of PRR and AQP signaling pathways in mice[J].J Eth,2016,179(17):146-155.
[33]Patchima S,Martin M,Manfred S Z,et al.Differential antiviral and antiinflammatory mechanisms of the flavonoids biochanin A and baicalein in H5N1 influenza A virus-infected cells[J].Antiviral Res,2013,97(1):41-48.
[34]Hisahiro K,Masatsugu O,Hiroki Y,et al.In vitro and in vivo anti-influenza virus activities of flavonoids and related compounds as components of Brazilian propolis(AF-08)[J].J fun f,2014,8(3):214-223.
[35]刘蓉,武志强,何敏,等.桂枝挥发油与桂皮醛对病毒性肺炎小鼠细胞因子及T细胞亚群的影响[J].中国实验方剂学杂志,2015,21(18):139-143.
[36]何婷,汤奇,曾南,等.荆芥挥发油及其主要成分抗流感病毒作用与机制研究[J].中国中药杂志,2013,38(11):1772-1777.
[37]陈小璇,代剑平,万倩英,等.氧化苦参碱抗流感病毒药效及机制研究[J].癌变.畸变.突变,2014,26(3):175-179.
[38]张贵源,龚莉莉,余跃生,等.刺三甲总生物碱抗流感病毒的鸡胚试验[J].时珍国医国药,2012,23(5):1074-1075.
[39]何立巍,吴晓培,杨婧妍,等.板蓝根总生物碱的提取纯化工艺及其抗病毒药理作用研究[J].中成药,2014,36(12):2611-2614.
[40]李帅,王玉霞,李海霞,等.茯苓总多糖对H1N1流感疫苗和乙肝疫苗抗原的佐剂作用[J].中国药理学与毒理学杂志,2015,29(1):60-64.
[41]董娜,李倩,张贵强,等.淫羊藿多糖对甲型H1N1流感病毒裂解疫苗的免疫佐剂作用[J].国际药学研究杂志,2013,40(1):63-68.
[42]张亚楠,黄生波,李小曼,等.玉竹多糖对流感病毒裂解疫苗的黏膜佐剂效应[J].激光生物学报,2017,26(1):68-72.
[43]Yang Q,Gao L,Si J Y,et al.Inhibition of porcine reproductive and respiratory syndrome virus replication by flavaspidic acid AB[J].Antiviral Res,2013,97(1):66-73.
[44]RYu Y B,Jeong H J,Yoon S Y et al.Influenza virus neuraminidase inhibitory activity of phlorotannins from the Edible Brown Alga Ecklonia cava[J].J agri f chem,2011,59(12):6467-6473.