金银花水煎液对放射性食管炎患者的免疫调节作用
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摘要
目的:观察金银花水煎液对放射性食管炎患者的免疫调节作用。方法:选取150例食管癌放射治疗患者,随机分为对照组及观察组,每组各75例,对照组患者根据照射剂量给予相应剂量地塞米松治疗,观察组在对照组患者治疗的基础上给予金银花水煎液,比较两组患者在放射治疗后,放射性食管炎发生率、发病程度、炎性因子(TNF-α、IL-6、TGF-β1)、免疫因子(Ig G、CRP、补体C3及补体C4)、淋巴细胞亚群变化情况。结果:观察组患者放射性食管炎发生率低于对照组(P <0. 05),发病程度低于对照组,两组患者接受放射治疗后各炎性因子水平均升高,观察组患者炎性因子水平低于对照组(P <0. 05);免疫因子CRP水平低于对照组(P <0. 05),Ig G及补体C3水平高于对照组(P <0. 05);观察组患者CD3~+T、CD4~+T及CD4~+/CD8+水平高于对照组(P <0. 05),观察组患者不良反应发生情况优于对照组。结论:金银花水煎液可有效抑制放射治疗引起的患者免疫功能下降情况,增强免疫水平,降低放射性食管炎发生率。
Objective: To observe the immunomodulatory effect of honeysuckle decoction on patients with radiation esophagitis. Methods: 150 cases of esophageal cancer radiotherapy were randomly divided into control group and observation group,75 cases in each group. The control group was given the corresponding dose of dexamethasone. The observation group was treated with honeysuckle decoction on the basis of the treatment of the control group. Incidence of radiation esophagitis,incidence of the disease,inflammatory factors( TNF-α,IL-6,TGF-β1),immune factors( Ig G,CRP,complement C3 and complement C4) and changes of lymphocyte subsets were compared between the two groups after radiotherapy. Results: The incidence of radioactive esophagitis in the observation group was lower than that of the control group( P < 0. 05),and the incidence of the disease was lower than that of the control group. The levels of inflammatory factors increased after radiotherapy in both groups. The levels of inflammatory factors in the observation group were lower than those in the control group( P < 0. 05),and the level of immune factor CRP was lower than that of the control group( P < 0. 05),the level of Ig G and complement C3 was higher than that of the control group( P < 0. 05). The level of CD3~+T,CD4~+T and CD4~+/CD8~+ in the observation group was higher than that of the control group( P < 0. 05). The incidence of adverse reactions in the observation group was better than that of the control group. Conclusion: Honeysuckle decoction can effectively inhibit the decrease of immune function caused by radiotherapy,enhance the level of immunity,and reduce the incidence of radiation esophagitis.
Objective: To observe the immunomodulatory effect of honeysuckle decoction on patients with radiation esophagitis. Methods: 150 cases of esophageal cancer radiotherapy were randomly divided into control group and observation group,75 cases in each group. The control group was given the corresponding dose of dexamethasone. The observation group was treated with honeysuckle decoction on the basis of the treatment of the control group. Incidence of radiation esophagitis,incidence of the disease,inflammatory factors( TNF-α,IL-6,TGF-β1),immune factors( Ig G,CRP,complement C3 and complement C4) and changes of lymphocyte subsets were compared between the two groups after radiotherapy. Results: The incidence of radioactive esophagitis in the observation group was lower than that of the control group( P < 0. 05),and the incidence of the disease was lower than that of the control group. The levels of inflammatory factors increased after radiotherapy in both groups. The levels of inflammatory factors in the observation group were lower than those in the control group( P < 0. 05),and the level of immune factor CRP was lower than that of the control group( P < 0. 05),the level of Ig G and complement C3 was higher than that of the control group( P < 0. 05). The level of CD3~+T,CD4~+T and CD4~+/CD8~+ in the observation group was higher than that of the control group( P < 0. 05). The incidence of adverse reactions in the observation group was better than that of the control group. Conclusion: Honeysuckle decoction can effectively inhibit the decrease of immune function caused by radiotherapy,enhance the level of immunity,and reduce the incidence of radiation esophagitis.
引文
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[15]Li L,Du YW,Kou S,et al.Bioinformatics analysis of the effects of honeysuckle,forsythia on the immune regulatory pathway of influenza H1N1[J].Chinese Journal of Experimental Traditional Medical Formulae,2017,23(10):201-204.[李立,杜雅薇,寇爽,等.金银花、连翘对甲型H1N1流感免疫调节通路影响的生物信息学分析[J].中国实验方剂学杂志,2017,23(10):201-204.]
[16]Du HX,Zhou HF,He Y,et al.Study on the immune mechanism of Yinhua Ping granule and three depression soup in vivo anti influenza A virus[J].China Journal of Chinese Materia Medica,2018,43(5):1028-1033.[杜海霞,周惠芬,何昱,等.银花平感颗粒和三拗汤体内抗甲型流感病毒的免疫机制研究[J].中国中药杂志,2018,43(5):1028-1033.]
[2]Liu Q,Chen PJ.Current status and prospect of tumor radiotherapy combined with immunotherapy[J].Modern Oncology,2017,25(8):1325-1328.[刘倩,陈佩娟.肿瘤放疗联合免疫治疗的发展现状和前景[J].现代肿瘤医学,2017,25(8):1325-1328.]
[3]Xu YY,Hong M,Li GX.Effect of radiotherapy on the mechanism of anti tumor immunity in vivo[J].Modern Oncology,2016,24(24):4023-4025.[胥芸芸,洪梅,李桂香.放疗对机体抗肿瘤免疫效应机制的影响[J].现代肿瘤医学,2016,24(24):4023-4025.]
[4]Zhang Y,Cui MO.Effect of recombinant human interleukin-11containing liquid on prevention and treatment of radiation esophagitis in esophageal cancer patients[J].Journal of Nursing,2014,21(24):46-48.[章艳,崔鸣欧.重组人白介素-11含服液防治食管癌患者放射性食管炎的效果观察[J].护理学报,2014,21(24):46-48.]
[5]Hamilton SR,Aaltonen LA.Tumours of the oesophagus,pathology and genetics of tumours of the digestive system,World Health Organization classification of tumours[M].Lyon:IARC,2004:7-28.
[6]Sui X,Zhao D,Lin HM,et al.Progress in radiotherapy combined with immunotherapy for cancer[J].Chinese Journal of Radiation Oncology,2016,25(10):1135-1138.[隋鑫,赵丹,林红梅,等.放疗联合免疫治疗癌症的研究进展[J].中华放射肿瘤学杂志,2016,25(10):1135-1138.]
[7]Ma M,Liu LH,Yang XX,et al.Effect of Tanreqing Injection on lymphocytes in patients with squamous cell carcinoma of the lung[J].Chinese Journal of Experimental Traditional Medical Formulae,2013,19(2):291-294.[马鸣,刘丽华,杨兴肖,等.痰热清注射液对肺鳞状细胞癌患者放疗后淋巴细胞的影响[J].中国实验方剂学杂志,2013,19(2):291-294.]
[8]Liang YF,Wen QQ,Liang YY,et al.Influence of different radiation dose radiotherapy on survival and lymphocyte subsets of patients with residual cancer after thyroid cancer[J].Chinese Journal of General Surgery,2017,26(11):1485-1488.[梁艳芳,温清泉,梁颖莹,等.不同放射剂量放疗对甲状腺癌术后残余癌患者生存期和淋巴细胞亚群的影响[J].中国普通外科杂志,2017,26(11):1485-1488.]
[9]Wang CG,Jia XJ,Dong LH,et al.Effect of Panax quinquefolium three alcohol group saponins on the expression of immunoglobulin,complement and lymphocyte CD4,CD8 and CD25 in patients with breast cancer radiotherapy[J].Journal of Jilin University(Medicine Edition),2005,31(2):287-289.[王春刚,贾晓晶,董丽华,等.西洋参叶三醇组皂苷对乳腺癌放疗患者外周血免疫球蛋白、补体水平及淋巴细胞CD4、CD8和CD25表达的影响[J].吉林大学学报(医学版),2005,31(2):287-289.]
[10]Lu JZ,Zhang L.Prevention and treatment of acute radiation esophagitis by Chinese medicine[J].China Journal of Traditional Chinese Medicine and Pharmacy,2012,27(12):3019-3023.[路军章,张蕾.中医药防治急性放射性食管炎[J].中华中医药杂志,2012,27(12):3019-3023.]
[11]Yu LL,Xing LG.Prediction of physical and biological factors of radiation esophagitis[J].Chinese Journal of Cancer Prevention and Treatment,2016,23(14):974-978.[余丽娌,邢力刚.预测放射性食管炎的物理及生物学因素研究进展[J].中华肿瘤防治杂志,2016,23(14):974-978.]
[12]Xu J,Deng X,Peng J,et al.Randomized controlled trial of GM-CSF containing liquid to prevent radiation esophagitis in patients with esophageal cancer[J].Modern Oncology,2017,25(17):2737-2740.[徐静,邓雪,彭进,等.GM-CSF含服液防治食管癌患者放射性食管炎的随机对照研究[J].现代肿瘤医学,2017,25(17):2737-2740.]
[13]Wang LD,Chen NN,Li RJ,et al.Progress in clinical research of radiation esophagitis[J].Journal of Practical Oncology,2017,32(5):474-478.[王立东,谌娜娜,李蕊洁,等.放射性食管炎的临床研究进展[J].实用肿瘤杂志,2017,32(5):474-478.]
[14]Hou HN,Ceng YY,Huang XY,et al.Effects of honeysuckle extract on activation and proliferation of mouse lymphocytes in vitro[J].Immunological Journal,2008,24(2):178-180.[侯会娜,曾耀英,黄秀艳,等.金银花提取物对小鼠淋巴细胞体外活化与增殖的影响[J].免疫学杂志,2008,24(2):178-180.]
[15]Li L,Du YW,Kou S,et al.Bioinformatics analysis of the effects of honeysuckle,forsythia on the immune regulatory pathway of influenza H1N1[J].Chinese Journal of Experimental Traditional Medical Formulae,2017,23(10):201-204.[李立,杜雅薇,寇爽,等.金银花、连翘对甲型H1N1流感免疫调节通路影响的生物信息学分析[J].中国实验方剂学杂志,2017,23(10):201-204.]
[16]Du HX,Zhou HF,He Y,et al.Study on the immune mechanism of Yinhua Ping granule and three depression soup in vivo anti influenza A virus[J].China Journal of Chinese Materia Medica,2018,43(5):1028-1033.[杜海霞,周惠芬,何昱,等.银花平感颗粒和三拗汤体内抗甲型流感病毒的免疫机制研究[J].中国中药杂志,2018,43(5):1028-1033.]