不同钙离子浓度透析液预防继发性甲状旁腺功能亢进效果比较
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摘要
目的对不同钙离子浓度透析液预防继发性甲状旁腺功能亢进效果进行比较分析。方法选取2015年3月~2016年3月于我院肾内科收治的120例行血液透析的慢性肾衰竭患者作为研究对象,采取数字表法将其随机分为A、B、C三组,各40例,分别采取不同钙离子浓度透析液(1.25%、1.50%、1.75%)进行透析,比较三组透析后继发性甲状旁腺功能亢进的发生情况,分别于透析前、透析后(3、6、12个月)对其血清全段甲状旁腺激素、血磷、血钙进行检测,并比较三组透析前后收缩压、舒张压、空腹血糖的变化情况。结果 A、B、C组患者出现继发性甲状旁腺功能亢进临床表现的例数分别为15、3、1,影像学检查异常分别为4、1、0,三组比较P<0.05,具有统计学意义;透析前后A、B组血压、血糖无明显变化,C组舒张压、血糖无明显变化,P>0.05,无统计学意义;C组收缩压(96.1±11.1)mmHg相较于透析前(92.1±9.6)mmHg差异具有统计学意义,P<0.05。结论 1.50%钙离子浓度透析液具有较好的预防继发性甲状旁腺功能亢进的作用。
Objective To different calcium concentration dialysate to prevent secondary hyperparathyroidism effect comparative analysis.Methods From March 2015 to March 2016 in our hospital kidney internal medicine department admitted 120 patients underwent hemodialysis in chronic renal failure patients as the research object,take the number table method were randomly divided into a,B and C group,each group of 40 cases,respectively adopt different calcium concentration dialysate(1.25 and 1.50,1.75%) of dialysis and compared among the three groups after dialysis secondary parathyroid hyperfunction,respectively,in pre dialysis,dialysis(3,6 and 12 months) on the serum intact parathyroid hormone and serum phosphorus,serum calcium were detected and compared among the three groups before and after dialysis systolic blood pressure,diastolic blood pressure,fasting blood glucose changes.Results A,B,C groups of patients with several cases of secondary hyperparathyroidism were 15,3,1 clinical manifestations,imaging abnormalities were4,1,0,three groups P<0.05,having statistical significance; before and after dialysis A,Bgroups,blood pressure,blood glucose no significant changes in group C diastolic blood pressure,blood glucose no significant changes,P>0.05,no statistical significance; group C systolic blood pressure(96.1±11.1) mmHg compared to dialysis before(92.1±9.6) mmHg difference was statistically significant,P<0.05.Conclusion 1.50% calcium ion concentration dialysis solution has a good effect on prevention of secondary parathyroid function.
Objective To different calcium concentration dialysate to prevent secondary hyperparathyroidism effect comparative analysis.Methods From March 2015 to March 2016 in our hospital kidney internal medicine department admitted 120 patients underwent hemodialysis in chronic renal failure patients as the research object,take the number table method were randomly divided into a,B and C group,each group of 40 cases,respectively adopt different calcium concentration dialysate(1.25 and 1.50,1.75%) of dialysis and compared among the three groups after dialysis secondary parathyroid hyperfunction,respectively,in pre dialysis,dialysis(3,6 and 12 months) on the serum intact parathyroid hormone and serum phosphorus,serum calcium were detected and compared among the three groups before and after dialysis systolic blood pressure,diastolic blood pressure,fasting blood glucose changes.Results A,B,C groups of patients with several cases of secondary hyperparathyroidism were 15,3,1 clinical manifestations,imaging abnormalities were4,1,0,three groups P<0.05,having statistical significance; before and after dialysis A,Bgroups,blood pressure,blood glucose no significant changes in group C diastolic blood pressure,blood glucose no significant changes,P>0.05,no statistical significance; group C systolic blood pressure(96.1±11.1) mmHg compared to dialysis before(92.1±9.6) mmHg difference was statistically significant,P<0.05.Conclusion 1.50% calcium ion concentration dialysis solution has a good effect on prevention of secondary parathyroid function.
引文
[1]曹艳飞,麦建玲.不同钙离子浓度透析液对血液透析患者的影响[J].现代中西医结合杂志,2011,20(17):2130-2131.
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[3]冼翠华,石晓峰,罗明乾,等.血液透析患者甲状旁腺全切除加上臂移植术后低钙血症的防治[J].临床肾脏病杂志,2014,14(1):32-35.
[4]赵慧萍,王梅.不同钙离子浓度透析液在腹膜透析患者中的应用[J].中华肾脏病杂志,2011,27(10):791-793.
[5]牛欣.不同钙离子浓度透析液对血液透析患者钙平衡及分段甲状旁腺激素的影响[J].山西医药杂志,2009,38(6):560-562.
[6]刘泽梅.透析液钙离子浓度对肾功能衰竭患者血液透析后血压的影响[J].吉林医学,2012,33(30):6515.
[2]张斌.维持性血液透析患者甲状旁腺功能低下影响因素分析[D].山东大学,2015.
[3]冼翠华,石晓峰,罗明乾,等.血液透析患者甲状旁腺全切除加上臂移植术后低钙血症的防治[J].临床肾脏病杂志,2014,14(1):32-35.
[4]赵慧萍,王梅.不同钙离子浓度透析液在腹膜透析患者中的应用[J].中华肾脏病杂志,2011,27(10):791-793.
[5]牛欣.不同钙离子浓度透析液对血液透析患者钙平衡及分段甲状旁腺激素的影响[J].山西医药杂志,2009,38(6):560-562.
[6]刘泽梅.透析液钙离子浓度对肾功能衰竭患者血液透析后血压的影响[J].吉林医学,2012,33(30):6515.