川芎嗪注射液对腹透患者腹透液CA125的影响
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摘要
目的观察川芎嗪注射液对腹透患者腹透液CA125的影响。方法采用盐酸川芎嗪注射液加入腹透液中治疗7天,观察治疗前后患者超滤量、溶质转运参数、D/Pcr、腹透液CA125浓度,以及尿素清除指数(KT/V),肌酐清除率(Ccr)的变化。结果治疗后患者超滤量由治疗前(338±71)ml/d明显提高到(692±90)ml/d,腹透液CA125平均浓度由治疗前的(15.1±2.9)U/ml提高到(17.5±3.4)U/ml;而患者尿量、溶质清除率、D/Pcr等未见明显改变。结论川芎嗪注射液能提高腹透患者的超滤量,安全性良好。
Objective To observe the effect of ligustrazine injection on the CA125 in patients with abdominal dialysis.Methods Ligustrazine hydrochloride injection to join to drain fluid treatment in 7 days,patients before and after treatment was observed ultrafiltration volume,solute transport parameters,D/Pcr,abdominal fluid CA125 concentrations,and KT/V(urea clearance index),the change of Ccr(creatinine clearance).Results After treatment,the ultrafiltration rate of patients increased significantly from(338±71) ml/d to(692±90) ml/d,and the average concentration of CA125 increased from(15.1±2.9) U/ml to(17.5±3.4) U/ml.However,there was no significant change in urine volume,solute clearance rate,D/Pcr.Conclusion Ligustrazine injection can improve the ultrafiltration and safety of patients with ventral dialysis.
Objective To observe the effect of ligustrazine injection on the CA125 in patients with abdominal dialysis.Methods Ligustrazine hydrochloride injection to join to drain fluid treatment in 7 days,patients before and after treatment was observed ultrafiltration volume,solute transport parameters,D/Pcr,abdominal fluid CA125 concentrations,and KT/V(urea clearance index),the change of Ccr(creatinine clearance).Results After treatment,the ultrafiltration rate of patients increased significantly from(338±71) ml/d to(692±90) ml/d,and the average concentration of CA125 increased from(15.1±2.9) U/ml to(17.5±3.4) U/ml.However,there was no significant change in urine volume,solute clearance rate,D/Pcr.Conclusion Ligustrazine injection can improve the ultrafiltration and safety of patients with ventral dialysis.
引文
[1]Hye Eun Yoon,Yoon Kyung Chang,Seok Joon Shin,et al.Benefits of a Continuous Ambulatory Peritoneal Dialysis(CAPD)Technique with One Icodextrin-Containing and Two Biocompatible Glucose-Containing Dialysates for Preservation of Residual Renal Function and Biocompatibility in Incident CAPD Patients[J].JKorean Med Sci,2014,29(9):1217-1225.
[2]Deirisa Lopes Barreto,Tiny Hoekstra,Nynke Halbesma,et al.The Association of Effluent Ca125 with Peritoneal Dialysis Technique Failure[J].Perit Dial Int,2015,35(7):683-690.
[3]Anouk T.N.van Diepen,Sadie van Esch,Dirk G.Struijk,et al.The First Peritonitis Episode Alters the Natural Course of Peritoneal Membrane Characteristics in Peritoneal Dialysis Patients[J].Perit Dial Int,2015,35(3):324-332.
[4]郭林,赵晓光,贺小霞.慢性肾功能不全腹膜透析患者透出液CA125检测的临床意义[J].新乡医学院学报,2014,31(12):1045-1047.
[5]冯婷,梁衍,金刚.腹膜透析患者透出液糖类抗原125浓度变化的观察[J].临床肾脏病杂志,2016,16(7):408-411.
[6]蔡汝超.黄芪注射液对腹膜透析患者透出液CA125影响的临床观察[J].内蒙古中医药,2014,33(34):29.
[7]张小鹿,张丹,王怡.川芎嗪注射液对腹膜透析大鼠腹膜功能及相关蛋白的影响[J].中国中西医结合肾病杂志,2014,15(9):762-766.
[8]沈翊,梁晓平.川芎嗪注射液改善腹膜超滤功能及腹膜纤维化的疗效观察[J].湖南中医杂志,2015,31(1):48-50.
[9]郭林,赵晓光,贺小霞.慢性肾功能不全腹膜透析患者透出液CA125检测的临床意义[J].新乡医学院学报,2014,31(12):1045-1047.
[10]滕兰波,常明,刘书馨,等.不同钙离子浓度透析液对腹膜组织损伤及腹腔炎症标志的影响[J].中国血液净化,2016,15(10):554-558.
[11]李娟,郭志勇,赖学莉,等.腹腔内应用低分子肝素可以提高腹膜透析患者的透析效能[J].中国中西医结合肾病杂志,2015,16(5):430-432.
[12]李卫巍,单炜薇,孙铸兴,等.HMG-Co A还原酶抑制剂对腹膜透析患者腹膜纤维化的影响[J].吉林医学,2016,37(10):2419-2421.
[2]Deirisa Lopes Barreto,Tiny Hoekstra,Nynke Halbesma,et al.The Association of Effluent Ca125 with Peritoneal Dialysis Technique Failure[J].Perit Dial Int,2015,35(7):683-690.
[3]Anouk T.N.van Diepen,Sadie van Esch,Dirk G.Struijk,et al.The First Peritonitis Episode Alters the Natural Course of Peritoneal Membrane Characteristics in Peritoneal Dialysis Patients[J].Perit Dial Int,2015,35(3):324-332.
[4]郭林,赵晓光,贺小霞.慢性肾功能不全腹膜透析患者透出液CA125检测的临床意义[J].新乡医学院学报,2014,31(12):1045-1047.
[5]冯婷,梁衍,金刚.腹膜透析患者透出液糖类抗原125浓度变化的观察[J].临床肾脏病杂志,2016,16(7):408-411.
[6]蔡汝超.黄芪注射液对腹膜透析患者透出液CA125影响的临床观察[J].内蒙古中医药,2014,33(34):29.
[7]张小鹿,张丹,王怡.川芎嗪注射液对腹膜透析大鼠腹膜功能及相关蛋白的影响[J].中国中西医结合肾病杂志,2014,15(9):762-766.
[8]沈翊,梁晓平.川芎嗪注射液改善腹膜超滤功能及腹膜纤维化的疗效观察[J].湖南中医杂志,2015,31(1):48-50.
[9]郭林,赵晓光,贺小霞.慢性肾功能不全腹膜透析患者透出液CA125检测的临床意义[J].新乡医学院学报,2014,31(12):1045-1047.
[10]滕兰波,常明,刘书馨,等.不同钙离子浓度透析液对腹膜组织损伤及腹腔炎症标志的影响[J].中国血液净化,2016,15(10):554-558.
[11]李娟,郭志勇,赖学莉,等.腹腔内应用低分子肝素可以提高腹膜透析患者的透析效能[J].中国中西医结合肾病杂志,2015,16(5):430-432.
[12]李卫巍,单炜薇,孙铸兴,等.HMG-Co A还原酶抑制剂对腹膜透析患者腹膜纤维化的影响[J].吉林医学,2016,37(10):2419-2421.