慢性阻塞性肺疾病合并肺心病与hs-CRP、NT-proBNP相关性分析
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摘要
目的研究并探讨慢性阻塞性肺疾病合并肺心病与hs-CRP、NT-pro BNP的相关性。方法于2014年1月1日至2015年8月1日,选取50例健康体检者进行研究,将其设置为A组;另选取60例COPD合并肺心病代偿期患者、40例COPD合并肺心病失代偿期患者,将其设置为B1组、B2组。抽取三组受检者的空腹静脉血,对hs-CRP、NT-pro BNP水平进行测定,对比A组和B组的hs-CRP、NT-pro BNP水平,并对比B1组和B2组的hs-CRP、NT-pro BNP水平,计算COPD合并肺心病与hs-CRP、NT-pro BNP水平的相关性系数。结果与A组相比,B组的hs-CRP、NT-pro BNP水平均明显增高(P<0.05)。与B1组相比,B2组的hs-CRP、NT-pro BNP水平均明显增高(P<0.05)。hs-CRP、NT-pro BNP水平与COPD合并肺心病均密切相关(P<0.05)。结论慢性阻塞性肺疾病合并肺心病的发生、发展与hs-CRP、NT-pro BNP水平密切相关,hs-CRP、NT-pro BNP水平变化情况可作为慢性阻塞性肺疾病合并肺心病临床诊断和病情评估的重要指标。
Objective To study the relationship between chronic obstructive pulmonary disease complicated with pulmonary heart disease and hs-CRP,NT-pro BNP. Methods In January 1st 2014 ~ August 1st 2015,50 cases of healthy physical examination were selected as A group; another 60 cases of COPD combined with pulmonary heart disease compensation,40 patients with COPD and pulmonary heart disease in patients with loss of compensation,were set to B1 group,B2 group. Fasting venous blood samples were taken from three groups,and the levels of hs-CRP and NT-pro BNP were determined,compared with hs-CRP group and B group,the levels of A and NT-pro BNP,and compared the NT-pro BNP and hs-CRP levels in group B1 and group B2,calculated the correlation coefficient between COPD and hs-CRP,NT-pro BNP. Results Compared with the A group,the hs-CRP and NT-pro BNP in the B group were significantly higher( P < 0. 05).Compared with the B1 group, the hs-CRP and NT-pro BNP water in the B2 group were significantly higher( P < 0. 05). The levels of hs-CRP and NT-pro BNP were closely related to COPD and pulmonary heart disease( P < 0. 05). Conclusions Chronic obstructive pulmonary disease combined with pulmonary heart disease occurrence,development and hs CRP and NT pro BNP levels are closely related,hs CRP and NT pro BNP levels can be used as an important indicator of chronic obstructive pulmonary disease combined with pulmonary heart disease clinical diagnosis and assessment of disease.
Objective To study the relationship between chronic obstructive pulmonary disease complicated with pulmonary heart disease and hs-CRP,NT-pro BNP. Methods In January 1st 2014 ~ August 1st 2015,50 cases of healthy physical examination were selected as A group; another 60 cases of COPD combined with pulmonary heart disease compensation,40 patients with COPD and pulmonary heart disease in patients with loss of compensation,were set to B1 group,B2 group. Fasting venous blood samples were taken from three groups,and the levels of hs-CRP and NT-pro BNP were determined,compared with hs-CRP group and B group,the levels of A and NT-pro BNP,and compared the NT-pro BNP and hs-CRP levels in group B1 and group B2,calculated the correlation coefficient between COPD and hs-CRP,NT-pro BNP. Results Compared with the A group,the hs-CRP and NT-pro BNP in the B group were significantly higher( P < 0. 05).Compared with the B1 group, the hs-CRP and NT-pro BNP water in the B2 group were significantly higher( P < 0. 05). The levels of hs-CRP and NT-pro BNP were closely related to COPD and pulmonary heart disease( P < 0. 05). Conclusions Chronic obstructive pulmonary disease combined with pulmonary heart disease occurrence,development and hs CRP and NT pro BNP levels are closely related,hs CRP and NT pro BNP levels can be used as an important indicator of chronic obstructive pulmonary disease combined with pulmonary heart disease clinical diagnosis and assessment of disease.
引文
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[9]黄耀宁,莫晓能.慢性肺源性心脏病患者超敏C-反应蛋白和N末端B型利钠肽原检测的临床意义[J].新医学,2013,44(5):311-313.
[10]杨侠,李雅莉,冯向莉,等.慢性肺心病患者hs-CRP与NTpro BNP的检测及临床意义[J].陕西医学杂志,2012,41(9):1223-1225.
[2]Lee MHS,Chang CL,Davies AR,et al.Cardiac dysfunction and N-terminal pro-B-type natriuretic peptide in exacerbations of chronic obstructive pulmonary disease[J].Internal medicine journal,2013,43(5):595-598.
[3]吕侯强,谢轩,杨丛丽,等.血浆NT-pro BNP、hs-CRP水平与COPD急性加重期合并肺心病心力衰竭及治疗的相关性分析[J].临床合理用药杂志,2014,7(28):73-74.
[4]肖祖华,钟德福,欧次高,等.慢性阻塞性肺疾病并肺心病患者与hs-CRP、NT-pro BNP相关性研究[J].医学检验与临床,2015,26(2):27-29.
[5]陆霓虹,杨蕤,杨继群,等.COPD并肺心病心力衰竭hs-CRP、BNP检测临床意义分析[J].临床肺科杂志,2013,18(2):278-279.
[6]伏攀,李春碧.超敏C反应蛋白和脑钠肽检测在慢性阻塞性肺疾病并发肺心病中的临床意义[J].实用临床医药杂志,2015,19(1):29-31,48.
[7]宫姝宁,朴商,王玉红,等.N-端脑钠肽前体测定对慢性阻塞性肺疾病及肺心病患者右心功能的评估价值[CD].中华肺部疾病杂志(电子版),2014,7(2):66-67.
[8]牛华,方浩徽,王云,等.N-末端脑钠肽前体在AECOPD合并肺心病诊治中的价值[J].临床肺科杂志,2014,19(9):1594-1596.
[9]黄耀宁,莫晓能.慢性肺源性心脏病患者超敏C-反应蛋白和N末端B型利钠肽原检测的临床意义[J].新医学,2013,44(5):311-313.
[10]杨侠,李雅莉,冯向莉,等.慢性肺心病患者hs-CRP与NTpro BNP的检测及临床意义[J].陕西医学杂志,2012,41(9):1223-1225.