RAAS基因与原发性高血压研究进展
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摘要
原发性高血压(essential hypertension,EH)是外在环境影响下内部调控基因的多态性扮演着重要角色。RASS是调节血压的最关键体液因素,调控机制涉及3个基因(AGT基因、ACE基因和ATR基因)的表达产物,基因编码蛋白产物通过调控信号途径保持血压正常生理水平。针对3个相关基因的一系列研究有助于从其遗传本质入手对其治疗、预后、预防和抗高血压药物个体化用药等方面找到依据。
Essential hypertension(EH) is in environmental factors(external), internal gene polymorphism plays an important role. RASS(Renin Angiotensin Aldosterone System)is one of the most important humoral factors in the regulation of blood pressure, 3 genes regulating the process involved are angiotensinogen gene AGT, angiotensin converting enzyme ACE gene and angiotensin II receptor ATR gene. The above genes coding protein products play a direct role in the contraction of arterial hypertension/essential hypertension. A series of studies on 3 related genes will be helpful to find the basis for the treatment, prognosis, prevention and individual administration of antihypertensive drugs.
Essential hypertension(EH) is in environmental factors(external), internal gene polymorphism plays an important role. RASS(Renin Angiotensin Aldosterone System)is one of the most important humoral factors in the regulation of blood pressure, 3 genes regulating the process involved are angiotensinogen gene AGT, angiotensin converting enzyme ACE gene and angiotensin II receptor ATR gene. The above genes coding protein products play a direct role in the contraction of arterial hypertension/essential hypertension. A series of studies on 3 related genes will be helpful to find the basis for the treatment, prognosis, prevention and individual administration of antihypertensive drugs.
引文
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[2] Gatti1 RR, Santos PS, Sena AA, et al. The interaction of AGT and NOS3 gene polymorphisms with conventional risk factors increases predisposition to hypertension[J]. Renin Angiotensin Aldosterone Syst, 2014,14(4): 360-368.
[3] Singh D, Jajodia A, Kaur H, et al. Gender specific association of RAS gene polymorphism with essential hypertension: acase-control study[J]. Biomed Res Int, 2014, 4 (17): 1-16.
[4] Gunda P, Nagalingam S, Tirunilai P. Role of tagged SNPs of the AGT gene in causing susceptibility to essential hypertension[J]. Clinical & Experimental Hypertension, 2016, 38(6):520.
[5] Jiali Y,Wenru T,Yinan C,et al. Angiotensinogen T174M and m235T Variants and Hypertension in the Hani and Yi Minority Groups of China [J].Biochemical Genetics, 2009, 47(5):344-350.
[6] Angelidis G, Samara M, Papathanassiou M, et al. Impact of renin-angiotensin-aldosterone system polymorphisms on myocardial perfusion: Correlations with myocardial single photon emission computed tomography-derived parameters[J]. Journal of Nuclear Cardiology Official Publication of the American Society of Nuclear Cardiology, 2018(4).
[7] 朱旭明,郁昊达,孙伟峰,等。血管紧张素原基因T174M多态性与原发性高血压相关性的Meta分析[J]. 实用医学杂志,2014, 29(4):639-641.
[8] 汪莉,周雪梅,吴传云,等,血管紧张素原基因7位点间交互作用对原发性高血压的影响[J].中华高血压杂志,2015,23(7):667-670.
[9] Petkeviciene J,Klumbiene J,Simonyte S,et al. Physical behavioural and genetic predictors of adult hypertension:the findings of the Kaunas cardiovascular risk cohort study[J]. PLoS One . 2014, 9(10):e100974.
[10] Shanmuganathan R, Kumaresan R, Giri P. Prevalence of angiotensin converting enzyme (ACE) gene insertion/deletion polymorphism in South Indian population with hypertension and chronic kidney disease[J]. Journal of Postgraduate Medicine. 2015, 61(4), 230-234.
[11] Sun F, He N, Zhang K, et al. Association of ACE gene A2350G and I/D polymorphisms with essential hypertension in the northernmost province of China[J]. Clinical & Experimental Hypertension, 2017, 40(1):1-7.
[12] Vir SN,Panneer D, Reena G. Angiotensin-converting enzyme (ACE) gene insertion/deletion polymorphism is not a risk factor for hypertension in SLE nephritis[J]. Clinical Rheumatology, 2015,34(9):1545-1549.
[13] Manisha P,Pallabi P, Surendran ,et al. Aldosterone synthase C-344T, angiotensin II type 1 receptor A1166C and 11-hydroxysteroid dehydrogenase G534A gene polymorphisms and essential hypertension in the population of Odisha, India[J]. Journal of Genetics,2015,94(2):363-363.
[14] Lozinski SE.Prediction of effectiveness of antihypertensive treatment in patients with consideration of the role of polymorphisms of angiotensin receptors ATR1[J]. Kardiologiia ,2013,53 (11): 49-54.
[15] Shahin, Dima S, et al. The A1166C polymorphism of the AT1R gene is associated with an early onset of hypertension and high waist circumference in Jordanian males attending the Jordan University Hospital [J]. Clinical & Experimental Hypertension, 2014,36(5) :333-339.
[16] Nirupama D, Karunakara P, Velaga L,et al. Renin angiotensin aldosterone system (RAAS) gene polymorphism in CABG patients: a translational study [J].Indian Journal of Thoracic and Cardiovascular Surgery,2013,29(1):5-9.
[17] Yang W,Qi Y,Fu J. Genetic signals of high-altitude adaptation in amphibians: a comparative transcriptome analysis [J]. BMC Genetics,2016,17:134.
[18] Tong J, Wang Y, Yuan J, et al. Effect of Interaction Between Noise and A1166C Site of AT1R Gene Polymorphism on Essential Hypertension in an Iron and Steel Enterprise Workers.[J]. Journal of Occupational & Environmental Medicine, 2017, 59(4):412.
[2] Gatti1 RR, Santos PS, Sena AA, et al. The interaction of AGT and NOS3 gene polymorphisms with conventional risk factors increases predisposition to hypertension[J]. Renin Angiotensin Aldosterone Syst, 2014,14(4): 360-368.
[3] Singh D, Jajodia A, Kaur H, et al. Gender specific association of RAS gene polymorphism with essential hypertension: acase-control study[J]. Biomed Res Int, 2014, 4 (17): 1-16.
[4] Gunda P, Nagalingam S, Tirunilai P. Role of tagged SNPs of the AGT gene in causing susceptibility to essential hypertension[J]. Clinical & Experimental Hypertension, 2016, 38(6):520.
[5] Jiali Y,Wenru T,Yinan C,et al. Angiotensinogen T174M and m235T Variants and Hypertension in the Hani and Yi Minority Groups of China [J].Biochemical Genetics, 2009, 47(5):344-350.
[6] Angelidis G, Samara M, Papathanassiou M, et al. Impact of renin-angiotensin-aldosterone system polymorphisms on myocardial perfusion: Correlations with myocardial single photon emission computed tomography-derived parameters[J]. Journal of Nuclear Cardiology Official Publication of the American Society of Nuclear Cardiology, 2018(4).
[7] 朱旭明,郁昊达,孙伟峰,等。血管紧张素原基因T174M多态性与原发性高血压相关性的Meta分析[J]. 实用医学杂志,2014, 29(4):639-641.
[8] 汪莉,周雪梅,吴传云,等,血管紧张素原基因7位点间交互作用对原发性高血压的影响[J].中华高血压杂志,2015,23(7):667-670.
[9] Petkeviciene J,Klumbiene J,Simonyte S,et al. Physical behavioural and genetic predictors of adult hypertension:the findings of the Kaunas cardiovascular risk cohort study[J]. PLoS One . 2014, 9(10):e100974.
[10] Shanmuganathan R, Kumaresan R, Giri P. Prevalence of angiotensin converting enzyme (ACE) gene insertion/deletion polymorphism in South Indian population with hypertension and chronic kidney disease[J]. Journal of Postgraduate Medicine. 2015, 61(4), 230-234.
[11] Sun F, He N, Zhang K, et al. Association of ACE gene A2350G and I/D polymorphisms with essential hypertension in the northernmost province of China[J]. Clinical & Experimental Hypertension, 2017, 40(1):1-7.
[12] Vir SN,Panneer D, Reena G. Angiotensin-converting enzyme (ACE) gene insertion/deletion polymorphism is not a risk factor for hypertension in SLE nephritis[J]. Clinical Rheumatology, 2015,34(9):1545-1549.
[13] Manisha P,Pallabi P, Surendran ,et al. Aldosterone synthase C-344T, angiotensin II type 1 receptor A1166C and 11-hydroxysteroid dehydrogenase G534A gene polymorphisms and essential hypertension in the population of Odisha, India[J]. Journal of Genetics,2015,94(2):363-363.
[14] Lozinski SE.Prediction of effectiveness of antihypertensive treatment in patients with consideration of the role of polymorphisms of angiotensin receptors ATR1[J]. Kardiologiia ,2013,53 (11): 49-54.
[15] Shahin, Dima S, et al. The A1166C polymorphism of the AT1R gene is associated with an early onset of hypertension and high waist circumference in Jordanian males attending the Jordan University Hospital [J]. Clinical & Experimental Hypertension, 2014,36(5) :333-339.
[16] Nirupama D, Karunakara P, Velaga L,et al. Renin angiotensin aldosterone system (RAAS) gene polymorphism in CABG patients: a translational study [J].Indian Journal of Thoracic and Cardiovascular Surgery,2013,29(1):5-9.
[17] Yang W,Qi Y,Fu J. Genetic signals of high-altitude adaptation in amphibians: a comparative transcriptome analysis [J]. BMC Genetics,2016,17:134.
[18] Tong J, Wang Y, Yuan J, et al. Effect of Interaction Between Noise and A1166C Site of AT1R Gene Polymorphism on Essential Hypertension in an Iron and Steel Enterprise Workers.[J]. Journal of Occupational & Environmental Medicine, 2017, 59(4):412.