小剂量阿司匹林联合美托洛尔对老年心力衰竭患者抗血栓及心功能的影响效果分析
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摘要
目的研究小剂量阿司匹林与美托洛尔联合应用治疗老年心力衰竭的临床效果,并总结其对患者心功能的影响。方法选择该院2016年3月—2018年3月期间所收治的62例老年心力衰竭患者作为该次研究病例,按照随机数字表法将其分为研究组与对照组,每组患者31例,对照组患者单独应用美托洛尔治疗,研究组采取美托洛尔联合小剂量的阿司匹林,对比分析两组患者的心功能指标,治疗效果、观察两组患者血浆p-选择素以及D-二聚水平,脑利钠肽水平及用药安全性。结果治疗1周、2周、周和4周后,研究组的脑利钠肽水平指标显著低于对照组,研究组生活质量评分93.54%高于对照组63.52%(t=10.228 2,9.721 1,8.801 5,P<0.05),治疗后,研究组患者的D-二聚体水平(0.50±0.21)mg/L、血浆P-选择素(5.96±3.07)g/L、血管性假性血友病因子(135.38±23.41)%明显低于对照组的D-二聚体水平(0.73±0.13)mg/L、血浆P-选择素(17.59±4.87)g/L、血管性假性血友病因子(156.31±20.37)%(t=11.247 9,3.755 3,5.184 9,P<0.05),研究组LVEF与LVESV名下低于对照组,LVEDV显著高于对照组,组间差异有统计学意义(t=4.759 9,4.574 2,18.296 0,P<0.05)。结论小剂量阿司匹林联合美托洛尔治疗老年心力衰竭患者的效果明显,能够有效改善患者的心功能指标,提高生活质量评分,且安全性较高,值得临床应用探索。
Objective To study the clinical effect of low-dose aspirin combined with metoprolol in the treatment of senile heart failure, and to summarize its effect on cardiac function. Methods Sixty-two elderly patients with heart failure who were admitted to the hospital from March 2016 to March 2018 were enrolled in this study. They were divided into study group and control group according to random number table, 31 patients in each group. The patients in the control group were treated with metoprolol alone. The study group was treated with metoprolol combined with low-dose aspirin.The cardiac function of the two groups was compared. The therapeutic effect and the plasma p-selectin and D-of the two groups were observed. Dimerization level, brain natriuretic peptide level and medication safety were compared.Results After 1 week, 2 weeks,3 weeks and 4 weeks of treatment, the brain natriuretic peptide level of the study group was significantly lower than that of the control group. The quality of life score of the study group was 93.54% higher than that of the control group 63.52%,(t=10.228 2, 9.721 1, 8.801 5, P<0.05), after treatment, patients in the study group D-dimer level(0.50±0.21)mg/L, plasma P-selectin(5.96 ± 3.07)g/L, vascular pseudo Hemophilia factor(135.38±23.41)% was significantly lower than the D-dimer level of the control group(0.73 ±0.13) mg/L, plasma P-selectin(17.59±4.87)g/L, vascular leave Hemophilia factor(156.31±20.37)%(t=11.247 9, 3.755 3, 5.184 9, P<0.05), the study group was lower than the control group under LVEF and LVESV, LVEDV was significantly higher than the control group, there were significant statistics between the groups, with academic significance(t=4.759 9, 4.574 2, 18.296 0,P<0.05). Conclusion Low-dose aspirin combined with metoprolol is effective in the treatment of elderly patients with heart failure, which can effectively improve patients' cardiac function indicators and improve quality of life scores, with high safety, it is worth exploring for clinical application.
Objective To study the clinical effect of low-dose aspirin combined with metoprolol in the treatment of senile heart failure, and to summarize its effect on cardiac function. Methods Sixty-two elderly patients with heart failure who were admitted to the hospital from March 2016 to March 2018 were enrolled in this study. They were divided into study group and control group according to random number table, 31 patients in each group. The patients in the control group were treated with metoprolol alone. The study group was treated with metoprolol combined with low-dose aspirin.The cardiac function of the two groups was compared. The therapeutic effect and the plasma p-selectin and D-of the two groups were observed. Dimerization level, brain natriuretic peptide level and medication safety were compared.Results After 1 week, 2 weeks,3 weeks and 4 weeks of treatment, the brain natriuretic peptide level of the study group was significantly lower than that of the control group. The quality of life score of the study group was 93.54% higher than that of the control group 63.52%,(t=10.228 2, 9.721 1, 8.801 5, P<0.05), after treatment, patients in the study group D-dimer level(0.50±0.21)mg/L, plasma P-selectin(5.96 ± 3.07)g/L, vascular pseudo Hemophilia factor(135.38±23.41)% was significantly lower than the D-dimer level of the control group(0.73 ±0.13) mg/L, plasma P-selectin(17.59±4.87)g/L, vascular leave Hemophilia factor(156.31±20.37)%(t=11.247 9, 3.755 3, 5.184 9, P<0.05), the study group was lower than the control group under LVEF and LVESV, LVEDV was significantly higher than the control group, there were significant statistics between the groups, with academic significance(t=4.759 9, 4.574 2, 18.296 0,P<0.05). Conclusion Low-dose aspirin combined with metoprolol is effective in the treatment of elderly patients with heart failure, which can effectively improve patients' cardiac function indicators and improve quality of life scores, with high safety, it is worth exploring for clinical application.
引文
[1]王萍.小剂量阿司匹林结合美托洛尔对老年心力衰竭患者血液高凝及心功能的改善作用[J].现代医药卫生,2018(9):1404-1406.
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[4]胡霜,蔡莉,张川平.美托洛尔联合芪苈强心胶囊治疗慢性心力衰竭的疗效观察[J].重庆医学,2017(5):689-691.
[5]邓兵安,兰江.通脉养心丸联合阿司匹林、阿托伐他汀及美托洛尔治疗冠心病心绞痛的疗效观察[J].中国医院用药评价与分析,2018(4):514-516.
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[8]罗晓芳,蔡红专,戴正东.美托洛尔联合阿托伐他汀治疗心肌梗死的疗效观察[J].中国医院用药评价与分析,2016(5):620-621.
[9]王晓红,郭瑄,孙芳.美托洛尔联合阿司匹林治疗93例急性心肌梗死的临床效果[J].检验医学与临床,2017(17):2605-2607.
[10]钟江涛.美托洛尔联合曲美他嗪治疗冠心病心力衰竭的临床效果分析[J].吉林医学,2018(1):112-114.
[11]周利.观察小剂量阿司匹林结合美托洛尔对老年心衰患者血液高凝及心功能的改善作用[J].临床医药文献电子杂志,2017(66):13004-13005.
[12]李朝东.关于美托洛尔和依那普利、阿司匹林用于心功能不全患者治疗中的临床效果研究[J].医药前沿,2017(5):149-150.
[13]汪红艳,朱冬梅.胺碘酮联合琥珀酸美托洛尔治疗急性心力衰竭伴室性心律失常的疗效观察[J].中国医院用药评价与分析,2018(4):504-505,508.
[14]萧丽军,洪梅,赵文雪,等.卡维地洛和美托洛尔治疗老年慢性心力衰竭的效果分析[J].检验医学与临床,2017(24):3588-3589,3592.
[2]魏梅,刘永升,陈洁,等.螺内酯联合美托洛尔对老年慢性心力衰竭患者左室重构及心功能的影响[J].中国老年学杂志,2015(6):1509-1510.
[3]吴雷,耿国英,赵明虎.美托洛尔与比索洛尔治疗舒张性心力衰竭的疗效和安全性比较[J].中国药房,2016(18):2488-2490.
[4]胡霜,蔡莉,张川平.美托洛尔联合芪苈强心胶囊治疗慢性心力衰竭的疗效观察[J].重庆医学,2017(5):689-691.
[5]邓兵安,兰江.通脉养心丸联合阿司匹林、阿托伐他汀及美托洛尔治疗冠心病心绞痛的疗效观察[J].中国医院用药评价与分析,2018(4):514-516.
[6]王志华.左西孟旦致老年心力衰竭患者严重药物不良反应1例[J].岭南心血管病杂志,2017(6):770-772.
[7]傅颖.替格瑞洛和氯吡格雷对急诊介入治疗的STEMI患者炎症相关指标的影响[D].济南:山东大学,2016.
[8]罗晓芳,蔡红专,戴正东.美托洛尔联合阿托伐他汀治疗心肌梗死的疗效观察[J].中国医院用药评价与分析,2016(5):620-621.
[9]王晓红,郭瑄,孙芳.美托洛尔联合阿司匹林治疗93例急性心肌梗死的临床效果[J].检验医学与临床,2017(17):2605-2607.
[10]钟江涛.美托洛尔联合曲美他嗪治疗冠心病心力衰竭的临床效果分析[J].吉林医学,2018(1):112-114.
[11]周利.观察小剂量阿司匹林结合美托洛尔对老年心衰患者血液高凝及心功能的改善作用[J].临床医药文献电子杂志,2017(66):13004-13005.
[12]李朝东.关于美托洛尔和依那普利、阿司匹林用于心功能不全患者治疗中的临床效果研究[J].医药前沿,2017(5):149-150.
[13]汪红艳,朱冬梅.胺碘酮联合琥珀酸美托洛尔治疗急性心力衰竭伴室性心律失常的疗效观察[J].中国医院用药评价与分析,2018(4):504-505,508.
[14]萧丽军,洪梅,赵文雪,等.卡维地洛和美托洛尔治疗老年慢性心力衰竭的效果分析[J].检验医学与临床,2017(24):3588-3589,3592.