摘要
目的研究小剂量阿司匹林与美托洛尔联合应用治疗老年心力衰竭的临床效果,并总结其对患者心功能的影响。方法选择该院2016年3月—2018年3月期间所收治的62例老年心力衰竭患者作为该次研究病例,按照随机数字表法将其分为研究组与对照组,每组患者31例,对照组患者单独应用美托洛尔治疗,研究组采取美托洛尔联合小剂量的阿司匹林,对比分析两组患者的心功能指标,治疗效果、观察两组患者血浆p-选择素以及D-二聚水平,脑利钠肽水平及用药安全性。结果治疗1周、2周、周和4周后,研究组的脑利钠肽水平指标显著低于对照组,研究组生活质量评分93.54%高于对照组63.52%(t=10.228 2,9.721 1,8.801 5,P<0.05),治疗后,研究组患者的D-二聚体水平(0.50±0.21)mg/L、血浆P-选择素(5.96±3.07)g/L、血管性假性血友病因子(135.38±23.41)%明显低于对照组的D-二聚体水平(0.73±0.13)mg/L、血浆P-选择素(17.59±4.87)g/L、血管性假性血友病因子(156.31±20.37)%(t=11.247 9,3.755 3,5.184 9,P<0.05),研究组LVEF与LVESV名下低于对照组,LVEDV显著高于对照组,组间差异有统计学意义(t=4.759 9,4.574 2,18.296 0,P<0.05)。结论小剂量阿司匹林联合美托洛尔治疗老年心力衰竭患者的效果明显,能够有效改善患者的心功能指标,提高生活质量评分,且安全性较高,值得临床应用探索。
Objective To study the clinical effect of low-dose aspirin combined with metoprolol in the treatment of senile heart failure, and to summarize its effect on cardiac function. Methods Sixty-two elderly patients with heart failure who were admitted to the hospital from March 2016 to March 2018 were enrolled in this study. They were divided into study group and control group according to random number table, 31 patients in each group. The patients in the control group were treated with metoprolol alone. The study group was treated with metoprolol combined with low-dose aspirin.The cardiac function of the two groups was compared. The therapeutic effect and the plasma p-selectin and D-of the two groups were observed. Dimerization level, brain natriuretic peptide level and medication safety were compared.Results After 1 week, 2 weeks,3 weeks and 4 weeks of treatment, the brain natriuretic peptide level of the study group was significantly lower than that of the control group. The quality of life score of the study group was 93.54% higher than that of the control group 63.52%,(t=10.228 2, 9.721 1, 8.801 5, P<0.05), after treatment, patients in the study group D-dimer level(0.50±0.21)mg/L, plasma P-selectin(5.96 ± 3.07)g/L, vascular pseudo Hemophilia factor(135.38±23.41)% was significantly lower than the D-dimer level of the control group(0.73 ±0.13) mg/L, plasma P-selectin(17.59±4.87)g/L, vascular leave Hemophilia factor(156.31±20.37)%(t=11.247 9, 3.755 3, 5.184 9, P<0.05), the study group was lower than the control group under LVEF and LVESV, LVEDV was significantly higher than the control group, there were significant statistics between the groups, with academic significance(t=4.759 9, 4.574 2, 18.296 0,P<0.05). Conclusion Low-dose aspirin combined with metoprolol is effective in the treatment of elderly patients with heart failure, which can effectively improve patients' cardiac function indicators and improve quality of life scores, with high safety, it is worth exploring for clinical application.
引文
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