血浆D-二聚体测定在结核性胸腔积液中诊治价值的相关研究
摘要
目的探讨血浆D-二聚体在结核性胸腔积液(Tuberculous pleural effusion,TPE)中的诊断价值。方法选取60例结核性胸腔积液患者(观察组)及60例非结核性胸积液患者(对照组)为研究对象,分析血浆D-二聚体在结核性胸腔积液中诊治价值,利用ROC曲线探讨血浆D-二聚体诊断结核性胸腔积液的最佳临界值。结果观察组患者血浆D-二聚体水平显著高于对照组,差异有统计学意义(P<0.05);将血浆D-二聚体水平的临界值定为4.65mg/L,其敏感度和特异度分别为90.0%和80.0%。结论结核性胸腔积液血浆D-二聚体水平高于非结核性胸腔积液患者;血浆D-二聚体水平的临界值定为4.65mg/L时对结核性胸腔积液的诊断价值最大。
引文
[1]黄彩芝,莫丽亚,张新萍,等.重症肺炎患儿血浆纤维蛋白单体与D-二聚体水平分析[J].实用预防医学,2016,23(9):1065-1068.
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[14]陶雪芳,杨金荣,任迎,等.结核性胸腔积液中D-二聚体测定及意义[J]浙江医学,2011,31(12):1651-1656.
[15]刘书娟,卢瑞琦,张利萍,等.CRP、ADA和D-二聚体在包裹性胸腔积液鉴别诊断中的应用价值[J].河北医药,2017,39(10):1546-1548.
[16]刘国威,叶静,孔伟利,等.结核病患者纤维蛋白原及D-二聚体水平临床分析[J].中国城乡企业卫生,2016,7:104-105.
[17]田金平.肺结核病凝血指标检测的变化分析[J].疾病监测与控制杂志,2014,12(8):778-779.
[18]Y.SHEN,T.YANG,L.JIA,et al.A potential role for D-dimer in the diagnosis of tuberculous pleural effusion[J].European Review for Medica and Pharmacological Sciences,2013,17:201-205.
[19]张永刚,李海明,张华茹.结核性胸腔积液胸液中D-二聚体对胸膜肥厚及粘连形成的影响[J].中国实用医刊,2013,409(12):100-101.
[20]李海明,张华茹.结核性胸腔积液胸液中纤维蛋白原含量对胸膜及粘连形成的影响[J].中华防痨杂志,2004.26(4):215-219.
[2]吕友堤,陈平,徐敏.测定胸液中D-二聚体含量的临床意义[J].湖南医科大学学报,2000,25(1):71-72.
[3]高亮,郑建,欧勤芳,等.胸腔积液糖类抗原125和腺苷脱氨酶含量检测对渗出性胸膜炎的诊断价值[J].山西医药杂志,2015,44(6):622-623.
[4]H ASANEEN NA,Z AKI ME,S HALABY HM,et al.Polymerase chain reaction of pleural biopsy is a rapid and sensitive method for the diagnosis of tuberculous pleural effusion[J].Chest,2003,124:2105-2111.
[5]M C G RATH EE,A NDERSON PB.Diagnostic tests for tuberculous pleural effusion[J].Eur J Clin Microbiol Infect Dis,2010,29:1187-1193.
[6]L IGHT RW.Update on tuberculous pleural effusion[J].Respirology,2010,15451-458.
[7]V AZ MA,V ARGAS FS,M ARINHO FC,et al.Does the evaluation of coagulation factors contribute to etiological diagnosis of pleural effusions?[J]Clinics(Sao Paulo),2009,64:891-895.
[8]LU XG,MAO JS,T ONG JF,et al.Fibrinolytic characteristics and their significance in malignant,tuberculous and cirrhotic pleural and ascitic fluids[J].Int J Lab Hematol,2007,29:132-138.
[9]张小萍,陈振华,刘彬彬,等.肺结核合并不同肺部疾病住院患者血浆D-二聚体和纤维蛋白原检测的临床意义[J].实用预防医学,2017,24(10):1255-1258.
[10]谢敏,王曾礼.慢性阻塞性肺病的血栓前状态[J].中华内科杂志,1998,37(9):616-617.
[11]Aahikair AS,Agarwal N,lwakuma T.Metastatic Potential of tumorinitiating cell in solid tumors[J].F ront Biosci,2011,16(7):620-621.
[12]Satoh H,Kamma H,Ogata T,et al.Local production of plasminogen activator inhibitor-I in carcinomatous pleuritis[J].Acta Oncologica,1994,33:710-711.
[13]L U YD,C HEN P,X U M.Detection of D-dimer in pleural effusion[J]Hunan Yi Ke Da Xue Xue Bao,2000,28:71-72.
[14]陶雪芳,杨金荣,任迎,等.结核性胸腔积液中D-二聚体测定及意义[J]浙江医学,2011,31(12):1651-1656.
[15]刘书娟,卢瑞琦,张利萍,等.CRP、ADA和D-二聚体在包裹性胸腔积液鉴别诊断中的应用价值[J].河北医药,2017,39(10):1546-1548.
[16]刘国威,叶静,孔伟利,等.结核病患者纤维蛋白原及D-二聚体水平临床分析[J].中国城乡企业卫生,2016,7:104-105.
[17]田金平.肺结核病凝血指标检测的变化分析[J].疾病监测与控制杂志,2014,12(8):778-779.
[18]Y.SHEN,T.YANG,L.JIA,et al.A potential role for D-dimer in the diagnosis of tuberculous pleural effusion[J].European Review for Medica and Pharmacological Sciences,2013,17:201-205.
[19]张永刚,李海明,张华茹.结核性胸腔积液胸液中D-二聚体对胸膜肥厚及粘连形成的影响[J].中国实用医刊,2013,409(12):100-101.
[20]李海明,张华茹.结核性胸腔积液胸液中纤维蛋白原含量对胸膜及粘连形成的影响[J].中华防痨杂志,2004.26(4):215-219.