血浆置换联合双重血浆分子吸附治疗妊娠期急性脂肪肝的效果观察
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摘要
目的探讨血浆置换(PE)与双重血浆分子吸附(DPMAS)联合治疗对妊娠期急性脂肪肝(AFLP)患者肝功能的影响。方法选择我院AFLP患者共46例,按照随机数字表法分成两组,每组23例。对照组采用单纯PE治疗,观察组采用PE联合DPMAS治疗。比较两组临床疗效及肝功能指标水平。结果治疗后观察组各肝功能指标水平均明显更优于对照组,且临床总有效率明显高于对照组,差异有统计学意义(P <0.05)。结论 PE与DPMAS联合治疗能有效改善AFLP患者临床症状及肝功能,疗效显著。
Objective To investigate the effect of PE combined with DPMAS on liver function in patients with AFLP during pregnancy. Methods 46 patients with AFLP admitted to our hospital were randomly divided into the control group(n =23, treated with PE alone) and the observation group(n =23, treated with PE combined with DPMAS). The clinical efficacy and liver function index levels between the two groups were compared. Results After treatment, the liver function index of the observation group was significantly better than the control group, and the total clinical effective rate of the observation group was significantly higher than that of the control group(P < 0.05). Conclusion The combination of PE and DPMAS can effectively improve the clinical symptoms and liver function of patients with AFLP. The curative effect is remarkable.
Objective To investigate the effect of PE combined with DPMAS on liver function in patients with AFLP during pregnancy. Methods 46 patients with AFLP admitted to our hospital were randomly divided into the control group(n =23, treated with PE alone) and the observation group(n =23, treated with PE combined with DPMAS). The clinical efficacy and liver function index levels between the two groups were compared. Results After treatment, the liver function index of the observation group was significantly better than the control group, and the total clinical effective rate of the observation group was significantly higher than that of the control group(P < 0.05). Conclusion The combination of PE and DPMAS can effectively improve the clinical symptoms and liver function of patients with AFLP. The curative effect is remarkable.
引文
[1]李佳宁,钟蕊,李侗曾.妊娠期急性脂肪肝38例临床分析[J].北京医学,2015,37(5):463-465.
[2]曾雅畅,陈悦.利用Child-Pugh改良评分法分析妊娠期急性脂肪肝的临床特点及预后[J].中国妇幼保健,2018,33(14):3137-3139.
[3]段志文,邓龑,武杨屏.胆红素吸附柱联合血液灌流器的吸附系统治疗高胆红素血症的效果[J].中国医药导报,2014,11(26):21-25.
[4]张宝文,阳学风,罗湘俊,等.双重血浆吸附、胆红素吸附及血浆置换治疗肝衰竭的疗效比较[J].中国现代医学杂志,2016,26(12):103-106.
[5]莫祖聪,熊滨,黄寨,等.小剂量血浆置换联合血浆灌流治疗妊娠期急性脂肪肝的疗效观察[J].右江医学,2015,43(6):691-693.
[6]孙爱华,温晓洲.妊娠急性脂肪肝的临床分析[J].临床检验杂志(电子版),2017,6(2):186-187.
[7]陈忱,何津,王红,等.妊娠期急性脂肪肝临床分析[J].中国妇幼保健,2017,32(6):1177-1180.
[8]赵桂芳.妊娠急性脂肪肝患者应用非生物型人工肝支持技术的疗效及不良反应观察[J].肝脏,2017,22(7):610-613.
[9]侯红瑛.血浆置换在妊娠期急性脂肪肝中的应用[J].中华产科急救电子杂志,2014,3(3):180-182.
[10]周芸.双重血浆分子吸附系统治疗早期肝衰竭的疗效及护理[J].检验医学与临床,2017,14(24):3590-3592.
[11]叶卫国,朱明丽.血浆置换联合双重血浆分子吸附系统治疗妊娠期急性脂肪肝剖宫产后的护理[J].护理与康复,2018,17(7):59-62.
[12]和鹰.血浆置换联合DPMAS与单纯血浆置换治疗重型肝炎不良反应对比分析[J].系统医学,2018,3(9):69-70,73.
[2]曾雅畅,陈悦.利用Child-Pugh改良评分法分析妊娠期急性脂肪肝的临床特点及预后[J].中国妇幼保健,2018,33(14):3137-3139.
[3]段志文,邓龑,武杨屏.胆红素吸附柱联合血液灌流器的吸附系统治疗高胆红素血症的效果[J].中国医药导报,2014,11(26):21-25.
[4]张宝文,阳学风,罗湘俊,等.双重血浆吸附、胆红素吸附及血浆置换治疗肝衰竭的疗效比较[J].中国现代医学杂志,2016,26(12):103-106.
[5]莫祖聪,熊滨,黄寨,等.小剂量血浆置换联合血浆灌流治疗妊娠期急性脂肪肝的疗效观察[J].右江医学,2015,43(6):691-693.
[6]孙爱华,温晓洲.妊娠急性脂肪肝的临床分析[J].临床检验杂志(电子版),2017,6(2):186-187.
[7]陈忱,何津,王红,等.妊娠期急性脂肪肝临床分析[J].中国妇幼保健,2017,32(6):1177-1180.
[8]赵桂芳.妊娠急性脂肪肝患者应用非生物型人工肝支持技术的疗效及不良反应观察[J].肝脏,2017,22(7):610-613.
[9]侯红瑛.血浆置换在妊娠期急性脂肪肝中的应用[J].中华产科急救电子杂志,2014,3(3):180-182.
[10]周芸.双重血浆分子吸附系统治疗早期肝衰竭的疗效及护理[J].检验医学与临床,2017,14(24):3590-3592.
[11]叶卫国,朱明丽.血浆置换联合双重血浆分子吸附系统治疗妊娠期急性脂肪肝剖宫产后的护理[J].护理与康复,2018,17(7):59-62.
[12]和鹰.血浆置换联合DPMAS与单纯血浆置换治疗重型肝炎不良反应对比分析[J].系统医学,2018,3(9):69-70,73.