老年男性摄盐量与骨转换标志物和骨密度的关系
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摘要
目的:调查老年男性摄盐量与骨转换标志物和骨密度的关系。方法:调查512例70～95岁的老年男性摄盐量的情况,根据日摄盐量分为高盐饮食组(≥5克)和低盐饮食组(<5克),并进行骨转换标志物[包括I型胶原C-末端肽交联(CTX)、I型原胶原N-端前肽(P1NP)和骨钙素(OC)]和骨密度[包括股骨颈骨密度(FNBMD)、总髋部骨密度(THBMD)、腰椎1-4骨密度(LSBMD)]的检测,分析摄盐量与骨转换标志物、骨密度的关系。结果:与低盐饮食组相比,高盐饮食组血清CTX水平较高(0. 37±0. 18 ng/ml VS 0. 33±0. 17ng/ml,P <0. 05),FNBMD(0. 79±0. 13g/cm~2VS 0. 82±0. 14g/cm~2,P <0. 05)和THBMD(0. 88±0. 13g/cm~2VS 0. 92±0. 14g/cm~2,P <0. 05)较低,而在血清P1NP、OC和LSBMD上2组之间没有差异(P> 0. 05)。结论:高盐饮食可能会升高老年男性的骨转换水平,加快骨的丢失。
[Objective] To explore the relationship between salt intake,and serum bone turnover markers( BTMs) and bone mineral density( BMD) in men aged 70 and over. [Method]A total of 512 men aged 70-95 years were enrolled in this study,and grouped into high salt intake group( 152 cases,daily salt intake≥5 g) and lowsalt intake group( 360 cases,daily salt intake < 5 g). The levels of serum BTMs[included C-terminal telopeptide of type 1 collagen( CTX),procollagen type 1 N-peptide( P1 NP),and osteocalcin( OC) ]and BMD[included femoral neck bone mineral density( FNBMD),total hip bone mineral density( THBMD) and lumbar spine bone mineral density( LSBMD) ]were detected and compared between two groups. [Result]The levels of serum CTX in high salt intake group were significantly higher than lowsalt intake group( 0. 37 ± 0. 18 ng/ml VS 0. 33 ± 0. 17 ng/ml,P < 0. 05),FNBMD( 0. 79 ± 0. 13 g/cm~2 VS0. 82 ± 0. 14 g/cm~2,P < 0. 05) and THBMD( 0. 88 ± 0. 13 g/cm~2 VS 0. 92 ± 0. 14 g/cm~2,P < 0. 05) in high salt intake group were significantly lower than lowsalt intake group. There was no difference between the two groups on serum P1 NP,OC and LSBMD( all P > 0. 05). [Conclusion] High salt intake probably increases the level of BTMs,which can speed up bone loss.
[Objective] To explore the relationship between salt intake,and serum bone turnover markers( BTMs) and bone mineral density( BMD) in men aged 70 and over. [Method]A total of 512 men aged 70-95 years were enrolled in this study,and grouped into high salt intake group( 152 cases,daily salt intake≥5 g) and lowsalt intake group( 360 cases,daily salt intake < 5 g). The levels of serum BTMs[included C-terminal telopeptide of type 1 collagen( CTX),procollagen type 1 N-peptide( P1 NP),and osteocalcin( OC) ]and BMD[included femoral neck bone mineral density( FNBMD),total hip bone mineral density( THBMD) and lumbar spine bone mineral density( LSBMD) ]were detected and compared between two groups. [Result]The levels of serum CTX in high salt intake group were significantly higher than lowsalt intake group( 0. 37 ± 0. 18 ng/ml VS 0. 33 ± 0. 17 ng/ml,P < 0. 05),FNBMD( 0. 79 ± 0. 13 g/cm~2 VS0. 82 ± 0. 14 g/cm~2,P < 0. 05) and THBMD( 0. 88 ± 0. 13 g/cm~2 VS 0. 92 ± 0. 14 g/cm~2,P < 0. 05) in high salt intake group were significantly lower than lowsalt intake group. There was no difference between the two groups on serum P1 NP,OC and LSBMD( all P > 0. 05). [Conclusion] High salt intake probably increases the level of BTMs,which can speed up bone loss.
引文
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[8]杨俊贤,李青南.高钠摄入与骨质疏松的关系[J].中华骨质疏松和骨矿盐疾病杂志,2017,10(3):306-309.
[9]Park Y,Kwon SJ,Ha YC. Association between urinary sodi-um excretion and bone health in male and female adults[J]. Ann Nutr Metab,2016,68(3):189-196.
[2]孙丹,边平达,江萍,等.老年人腕部骨折发生率的调查分析[J].浙江医学教育,2018,17(6):60-62.
[3]汪桔仙.舒适护理在骨折术后疼痛患者中的应用[J].浙江医学教育,2016,15(3):38-40.
[4]Wu L,Luthringer BJC,Feyerabend F,et al. Increased levelsof sodium chloride directly increase osteoclastic differentia-tion and resorption in mice and men[J]. Osteoporos Int,2017,28(11):3215-3228.
[5]宋安洋.慢性阻塞性肺疾病与骨质疏松[J].中国骨质疏松杂志,2015,21(8):1018-1020.
[6]边平达,应奇峰,李秀央,等. 80岁以上高龄老人骨密度与骨转换标志物的相关性研究[J].中华内分泌代谢杂志,2014,30(3):206-209.
[7]Fatahi S,Namazi N,Larijani B,et al. The association of diet-ary and urinary sodium with bone mineral density and risk ofosteoporosis:a systematic reviewand meta-analysis[J]. JAm Coll Nutr,2018,37(6):522-532.
[8]杨俊贤,李青南.高钠摄入与骨质疏松的关系[J].中华骨质疏松和骨矿盐疾病杂志,2017,10(3):306-309.
[9]Park Y,Kwon SJ,Ha YC. Association between urinary sodi-um excretion and bone health in male and female adults[J]. Ann Nutr Metab,2016,68(3):189-196.