去甲斑蝥素抗肿瘤的研究进展
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摘要
去甲斑蝥素是一种新型人工合成的抗肿瘤药物,对肝癌、胃癌、食管癌等治疗都具有显著疗效,并且有升高白细胞的作用。其作用机制与促进肿瘤细胞凋亡、抑制肿瘤细胞增殖和肿瘤细胞侵袭、抑制肿瘤细胞DNA复制和影响细胞的有丝分裂等有关。本文将近年来去甲斑蝥素抗肿瘤的作用机制及前景进行综述。
引文
[1]汤华清,毕容,刘小河.斑蝥及斑蝥制剂的临床应用现状[J].中国民族民间药,2010(21):54-55.
[2]BO S,HE P J,SHAO C L.Norcantharidin induced DU145cell apoptosis through ROS-mediated mitochondrial dysfunction and energy depletion[J].PLo S One,2013,8(12):e84610.
[3]CHEN A W,TSENG Y S,LIN C C,et al.Norcantharidin induce apoptosis in human nasopharyngeal carcinoma through caspase and mitochondrial pathway[J].Environ Toxicol,2018,33(3):343-350.
[4]成浩,范跃祖.去甲斑蝥素对人胃癌SGC-7901细胞增殖的影响及其机制探讨[J].现代肿瘤医学,2008,16(4):527-530.
[5]赵良中,李强,冯宪敏,等.去甲斑蝥素抑制肺癌细胞增殖的体外研究[J].中国畜牧兽医,2010,37(6):155-157.
[6]WAN X Y,ZHAI X F,JIANG Y P,et al.Antimetastatic effects of norcantharidin on hepatocellular carcinoma cells by up-regulating FAM46C expression[J].Am J Transl Res,2017,9(1):155-166.
[7]范跃祖,傅锦业,赵泽明,等.去甲斑蝥素对人胆囊癌GBC-SD细胞系生长及侵袭的影响[J].中国中西医结合杂志,2004,24(6):180-183.
[8]CHEN Y J,SHIEH C J,TSAI T H,et al.Inhibitory effect of norcantharidin,a derivative compound from blister beetles,on tumor invasion and metastasis in CT26 colorectal adenocarcinoma cells[J].Anticancer Drugs,2005,16(3):293-299.
[9]李瑞婧,洪兴福,季媛媛,等.去甲斑蝥素诱导人卵巢癌SK-OV-3细胞发生有丝分裂期阻滞与凋亡[J].中国药理学与毒理学杂志,2013,27(2):180-186.
[10]FAN Y Z,FU J Y,ZHAO Z M,et al.Inhibitory effect of norcantharidin on the growth of human gallbladder carcinoma GBC-SD cells in vitro[J].Hepatobiliary Pancreat Dis Int,2007,6(1):72-80.
[11]BORLADO L R,MNDEZ J.CDC6:from DNA replication to cell cycle checkpoints and oncogenesis[J].Carcinogenesis,2008,29(2):237-243.
[12]李金龙,蔡于琛,胡志明,等.去甲斑蝥素对肿瘤细胞DNA复制起始蛋白Cdc6的抑制作用[J].南方医科大学学报,2010,30(8):1851-1853.
[13]周文丽,考军,范清玲.去甲斑蝥素片辅助治疗胃肠道癌肝转移30例临床观察[J].山东医药,2005,45(20):32-33.
[14]翁欣然,吴剑,李德和,等.去甲斑蝥素合三维适形放疗治疗消化道肿瘤后腹膜淋巴结转移24例[J].江西中医药,2009,40(6):39.
[15]郑英兰,史春雷,贺延新.去甲斑蝥素治疗肝癌的临床研究[J].河北医学,2005,11(9):820-821.
[16]尤燕华,刘玉平,李瑛,等.去甲斑蝥素通过抑制蛋白磷酸酶2Ac抗肾间质纤维化[J].中华肾脏病杂志,2014,30(4):293-298.
[17]叶琨,刘伏友,李瑛,等.去甲斑蝥素对蛋白超负荷肾病大鼠CTGF及NF-κBp65表达的影响[J].中国血液净化,2008,7(4):198-202.
[2]BO S,HE P J,SHAO C L.Norcantharidin induced DU145cell apoptosis through ROS-mediated mitochondrial dysfunction and energy depletion[J].PLo S One,2013,8(12):e84610.
[3]CHEN A W,TSENG Y S,LIN C C,et al.Norcantharidin induce apoptosis in human nasopharyngeal carcinoma through caspase and mitochondrial pathway[J].Environ Toxicol,2018,33(3):343-350.
[4]成浩,范跃祖.去甲斑蝥素对人胃癌SGC-7901细胞增殖的影响及其机制探讨[J].现代肿瘤医学,2008,16(4):527-530.
[5]赵良中,李强,冯宪敏,等.去甲斑蝥素抑制肺癌细胞增殖的体外研究[J].中国畜牧兽医,2010,37(6):155-157.
[6]WAN X Y,ZHAI X F,JIANG Y P,et al.Antimetastatic effects of norcantharidin on hepatocellular carcinoma cells by up-regulating FAM46C expression[J].Am J Transl Res,2017,9(1):155-166.
[7]范跃祖,傅锦业,赵泽明,等.去甲斑蝥素对人胆囊癌GBC-SD细胞系生长及侵袭的影响[J].中国中西医结合杂志,2004,24(6):180-183.
[8]CHEN Y J,SHIEH C J,TSAI T H,et al.Inhibitory effect of norcantharidin,a derivative compound from blister beetles,on tumor invasion and metastasis in CT26 colorectal adenocarcinoma cells[J].Anticancer Drugs,2005,16(3):293-299.
[9]李瑞婧,洪兴福,季媛媛,等.去甲斑蝥素诱导人卵巢癌SK-OV-3细胞发生有丝分裂期阻滞与凋亡[J].中国药理学与毒理学杂志,2013,27(2):180-186.
[10]FAN Y Z,FU J Y,ZHAO Z M,et al.Inhibitory effect of norcantharidin on the growth of human gallbladder carcinoma GBC-SD cells in vitro[J].Hepatobiliary Pancreat Dis Int,2007,6(1):72-80.
[11]BORLADO L R,MNDEZ J.CDC6:from DNA replication to cell cycle checkpoints and oncogenesis[J].Carcinogenesis,2008,29(2):237-243.
[12]李金龙,蔡于琛,胡志明,等.去甲斑蝥素对肿瘤细胞DNA复制起始蛋白Cdc6的抑制作用[J].南方医科大学学报,2010,30(8):1851-1853.
[13]周文丽,考军,范清玲.去甲斑蝥素片辅助治疗胃肠道癌肝转移30例临床观察[J].山东医药,2005,45(20):32-33.
[14]翁欣然,吴剑,李德和,等.去甲斑蝥素合三维适形放疗治疗消化道肿瘤后腹膜淋巴结转移24例[J].江西中医药,2009,40(6):39.
[15]郑英兰,史春雷,贺延新.去甲斑蝥素治疗肝癌的临床研究[J].河北医学,2005,11(9):820-821.
[16]尤燕华,刘玉平,李瑛,等.去甲斑蝥素通过抑制蛋白磷酸酶2Ac抗肾间质纤维化[J].中华肾脏病杂志,2014,30(4):293-298.
[17]叶琨,刘伏友,李瑛,等.去甲斑蝥素对蛋白超负荷肾病大鼠CTGF及NF-κBp65表达的影响[J].中国血液净化,2008,7(4):198-202.