性激素比值预测特发性少精子症愈后的意义
|
摘要
目的通过分析不同疗效组间促卵泡生成素(FSH)与促黄体生成素(LH)的比值和睾酮(T)与LH的比值有无区别,探讨性激素内部比值对他莫昔芬治疗特发性少精子症疗效有无临床预测意义。方法筛选出性激素单项指标均在正常范围,经过他莫昔芬治疗呈现不同疗效的特发性少精子症患者131例,分为3组:治愈组49例、改善组36例、无效组46例。回顾性分析各组治疗前性激素内部比值水平(FSH/LH和T/LH)及单项指标有无区别。结果治愈组、有效组、无效组3组的FSH/LH比值分别为(1.163±0.409)、(1.478±0.524)、(1.930±0.558),3组比较差异有统计学意义(P <0.05),任意两组间经LSD-t检验差异有统计学意义(P <0.05);治愈组、有效组、无效组3组的T/LH比值分别为(3.931±1.432)、(3.438±1.583)、(3.165±1.522),3组比较差异有统计学意义(P <0.05),其中治愈组和无效组间比较差异有统计学意义(P <0.05);单项指标FSH 3组比较差异有统计学意义(P <0.05),但3组间LH和T指标比较差异无统计学意义(P>0.05),仅LH值治愈组和无效组比较差异有统计学意义(P <0.05)。结论与性激素单项检测指标比较,内部比值(FSH/LH和T/LH)对他莫昔芬治疗特发性少精子症的愈后判断更有临床意义。
Objective To investigate the effect of sex hormone internal ratio(FSH/LH and T/LH) in patients with idiopathic oligospermia post treatment of Tamoxifen. Methods A total of 131 idiopathic spermatozoa patients were involved and divided into three groups according to curative effects: full cure group(n = 49), partial cure group(n = 36) and no-response group(n = 46). Results The FSH/LH ratio in full cure group, effective group, and no-response group was(1.163 ± 0.409),(1.478 ± 0.524), and(1.930 ± 0.558), respectively. Statistically significant difference in FSH/LH ratio was identified in two groups. The T/LH ratio in full cure group, effective group, and noresponse group was(3.931 ± 1.432,(3.438 ± 1.583), and(3.165 ± 1.522), respectively. Significant difference in T/LH was identified between full cure group and no-response group. Concentrations of FSH were statistically significant different among three groups while only concentration of LH was obviously different between full cure group and no-response group. Conclusions The internal rates of sex hormones(FSH/LH and T/LH) may be used as predictive markers in predicting the efficacy of Tamoxifen citrate in treatment of idiopathic oligospermia.
Objective To investigate the effect of sex hormone internal ratio(FSH/LH and T/LH) in patients with idiopathic oligospermia post treatment of Tamoxifen. Methods A total of 131 idiopathic spermatozoa patients were involved and divided into three groups according to curative effects: full cure group(n = 49), partial cure group(n = 36) and no-response group(n = 46). Results The FSH/LH ratio in full cure group, effective group, and no-response group was(1.163 ± 0.409),(1.478 ± 0.524), and(1.930 ± 0.558), respectively. Statistically significant difference in FSH/LH ratio was identified in two groups. The T/LH ratio in full cure group, effective group, and noresponse group was(3.931 ± 1.432,(3.438 ± 1.583), and(3.165 ± 1.522), respectively. Significant difference in T/LH was identified between full cure group and no-response group. Concentrations of FSH were statistically significant different among three groups while only concentration of LH was obviously different between full cure group and no-response group. Conclusions The internal rates of sex hormones(FSH/LH and T/LH) may be used as predictive markers in predicting the efficacy of Tamoxifen citrate in treatment of idiopathic oligospermia.
引文
[1]ELSHEIKH M G,HOSNY M B,ELSHENOUFY A,et al.Combination of vitamin E and clomiphene citrate in treating patients with idiopathic oligoasthenozoospermia:A prospective,randomized trial[J].Andrology,2015,3(5):864-867.
[2]GUO L,JING J,FENG Y M,et al.Tamoxifen is a potent antioxidant modulator for sperm quality in patients with idiopathic oligoasthenospermia[J].Int Urol Nephrol,2015,47(9):1463-1469.
[3]VANDER BILT F E,HENDRIKSZ T R,VANDER MEIJDEN W A,et al.Outcome in patients with idiopathic retroperitoneal fibrosis treated with corticosteroid or tamoxifen monotherapy[J].Clin Kidney J,2016,9(2):184-191.
[4]World Health Organization.WHO laboratory manual for the examination and processing of human semen[M].5th ed.Geneva:World Health Organization,2010:7-113.
[5]俞旭君,张培海,娄腾涛,等.中药、中西药联合与西药治疗男性少弱精子症疗效比较的系统评价[J].中国男科学杂志,2015,29(12):45-50.
[6]WDOWIAK A,RACZKIEWICZ D,STASIAK M,et al.Levels of FSH,LH and testosterone,and sperm DNA fragmentation[J].Neuro Endocrinol Lett,2014,35(1):73-79.
[7]PARADISI R,NATALI F,FABBRI R,et al.Evidence for a stimulatory role of high doses of recombinant human folliclestimulating hormone in the treatment of male-factor infertility[J].Andrologia,2014,46(9):1067-1072.
[8]TRABADO S,LAMOTHE S,MAIONE L,et al.Congenital hypogonadotropic hypogonadism and kallmann syndrome as models for studying hormonal regulation of human testicular endocrine functions[J].Ann Endocrinol,2014,75(2):79-87.
[9]O'SHAUGHNESSY P J.Hormonal control of germ cell development and spermatogenesis[J].Semin Cell Dev Biol,2014,29(4):55-65.
[10]袁启龙,陆杉,卢兴宏,等.男性血清FSH/LH及T/LH比值与精子主要参数相关性分析[J].临床检验杂志,2015,33(3):197-199.
[11]WEI T C,HUANG W J,LIN A T,et al.The role of hormones on semen parameters in patients with idiopathic or varicocele-related oligoasthenoteratozoospermia(OAT)syndrome[J].J Chin Med Assoc,2013,76(11):624-628.
[12]ANDREONE L,AMBAO V,PELLIZZARI E H,et al.Role of FSH glycan structure in the regulation of Sertoli cell inhibin production[J].Reproduction,2017,154(5):711-721.
[13]SHIRAISHI K,MATSUYAMA H.Gonadotoropin actions on spermatogenesis and hormonal therapies for spermatogenic disorders[J].Endocr J,2017,64(2):123-131.
[14]J?RGENSEN N,JOENSEN U N,TOPPARI J,et al.Compensated reduction in Leydig cell function is associated with lower semen quality variables:a study of 8182 European young men[J].Hum Repro,2016,31(5):947-957.
[15]BABURSKI A Z,SOKANOVIC S J,BJELIC M M,et al.Circadian rhythm of the Leydig cells endocrine function is attenuated during aging[J].Exp Gerontol,2016,73(1):5-13.
[16]WELLS R 1,KENNY A L,DUCKETT R,et al.Elucidation of the role of LH and FSH during neonatal testicular development and growth in the boar[J].Anim Reprod Sci,2013,137(1-2):74-81.
[17]VITKU J,KOLATOROVA L,HAMPL R.Occurrence and reproductive roles of hormones in seminal plasma[J].Basic Clin Androl,2017,27:19.
[18]BOONYARANGKUL A,VINAYANUVATTIKHUN N,CHIAMCHANYA C,et al.Comparative study of the effects of tamoxifen citrate and folate on semen quality of the infertile male with semen abnormality[J].J Med Assoc Tha,2015,98(11):1057-1063.
[2]GUO L,JING J,FENG Y M,et al.Tamoxifen is a potent antioxidant modulator for sperm quality in patients with idiopathic oligoasthenospermia[J].Int Urol Nephrol,2015,47(9):1463-1469.
[3]VANDER BILT F E,HENDRIKSZ T R,VANDER MEIJDEN W A,et al.Outcome in patients with idiopathic retroperitoneal fibrosis treated with corticosteroid or tamoxifen monotherapy[J].Clin Kidney J,2016,9(2):184-191.
[4]World Health Organization.WHO laboratory manual for the examination and processing of human semen[M].5th ed.Geneva:World Health Organization,2010:7-113.
[5]俞旭君,张培海,娄腾涛,等.中药、中西药联合与西药治疗男性少弱精子症疗效比较的系统评价[J].中国男科学杂志,2015,29(12):45-50.
[6]WDOWIAK A,RACZKIEWICZ D,STASIAK M,et al.Levels of FSH,LH and testosterone,and sperm DNA fragmentation[J].Neuro Endocrinol Lett,2014,35(1):73-79.
[7]PARADISI R,NATALI F,FABBRI R,et al.Evidence for a stimulatory role of high doses of recombinant human folliclestimulating hormone in the treatment of male-factor infertility[J].Andrologia,2014,46(9):1067-1072.
[8]TRABADO S,LAMOTHE S,MAIONE L,et al.Congenital hypogonadotropic hypogonadism and kallmann syndrome as models for studying hormonal regulation of human testicular endocrine functions[J].Ann Endocrinol,2014,75(2):79-87.
[9]O'SHAUGHNESSY P J.Hormonal control of germ cell development and spermatogenesis[J].Semin Cell Dev Biol,2014,29(4):55-65.
[10]袁启龙,陆杉,卢兴宏,等.男性血清FSH/LH及T/LH比值与精子主要参数相关性分析[J].临床检验杂志,2015,33(3):197-199.
[11]WEI T C,HUANG W J,LIN A T,et al.The role of hormones on semen parameters in patients with idiopathic or varicocele-related oligoasthenoteratozoospermia(OAT)syndrome[J].J Chin Med Assoc,2013,76(11):624-628.
[12]ANDREONE L,AMBAO V,PELLIZZARI E H,et al.Role of FSH glycan structure in the regulation of Sertoli cell inhibin production[J].Reproduction,2017,154(5):711-721.
[13]SHIRAISHI K,MATSUYAMA H.Gonadotoropin actions on spermatogenesis and hormonal therapies for spermatogenic disorders[J].Endocr J,2017,64(2):123-131.
[14]J?RGENSEN N,JOENSEN U N,TOPPARI J,et al.Compensated reduction in Leydig cell function is associated with lower semen quality variables:a study of 8182 European young men[J].Hum Repro,2016,31(5):947-957.
[15]BABURSKI A Z,SOKANOVIC S J,BJELIC M M,et al.Circadian rhythm of the Leydig cells endocrine function is attenuated during aging[J].Exp Gerontol,2016,73(1):5-13.
[16]WELLS R 1,KENNY A L,DUCKETT R,et al.Elucidation of the role of LH and FSH during neonatal testicular development and growth in the boar[J].Anim Reprod Sci,2013,137(1-2):74-81.
[17]VITKU J,KOLATOROVA L,HAMPL R.Occurrence and reproductive roles of hormones in seminal plasma[J].Basic Clin Androl,2017,27:19.
[18]BOONYARANGKUL A,VINAYANUVATTIKHUN N,CHIAMCHANYA C,et al.Comparative study of the effects of tamoxifen citrate and folate on semen quality of the infertile male with semen abnormality[J].J Med Assoc Tha,2015,98(11):1057-1063.