黄莪胶囊联合非那雄胺治疗中老年前列腺增生症疗效观察
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摘要
目的探讨黄莪胶囊联合非那雄胺治疗中老年前列腺增生症的临床疗效。方法选取医院2015年6月至2017年9月收治的前列腺增生症患者100例,采用随机信封法分为观察组和对照组,各50例。对照组采用非那雄胺治疗,观察组在对照组基础上加用黄莪胶囊治疗,均治疗6周。结果治疗组总有效率为88.00%,显著高于对照组的60.00%(P <0.05);治疗后,两组患者国际前列腺症状评分(IPSS)、生活质量评分均显著降低(P <0.05),且观察组显著优于对照组(P <0.05);治疗后,两组患者前列腺体积显著小于治疗前(P <0.05),且观察组显著小于对照组(P <0.05);治疗后,两组患者最大尿流率显著高于治疗前(P <0.05),且观察组显著高于对照组(P <0.05);所有患者均未出现不良反应。结论黄莪胶囊联合非那雄胺治疗中老年前列腺增生症,可有效提高临床疗效,改善患者生活质量。
Objective To investigate the clinical effect of Huang'e Capsules combined with finasteride in the treatment of senile benign prostatic hyperplasia(BPH).Methods Totally 100 patients with BPH admitted to the hospital from June 2015 to September 2017 were selected and divided into the observation group and the control group by the random envelope method,50 cases in each group.The patients in the control group were treated with finasteride,on this basis,the patients in the observation group were treated with Huang'e Capsules.All the patients were treated for 6 weeks.Results The total effective rate of the treatment group was 88.00%,which was significantly higher than 60.00% of the control group(P < 0.05).After treatment,the International Prostate Symptom Score(IPSS) and the score of quality of life in the two groups were significantly reduced(P < 0.05),and those in the observation group were significantly better than those in the control group(P < 0.05).After treatment,the prostate volume of the two groups was significantly smaller than that before treatment(P < 0.05),and that of the observation group was significantly smaller than that of the control group(P < 0.05).After treatment,the maximum urine flow rate in the two groups was significantly higher than that before the treatment(P < 0.05),and that in the observation group was significantly higher than that in the control group(P < 0.05).No adverse reactions occurred in all patients.Conclusion Huang'e Capsules combined with finasteride in the treatment of senile BPH can effectively improve the clinical effect and improve the quality of life of patients.
Objective To investigate the clinical effect of Huang'e Capsules combined with finasteride in the treatment of senile benign prostatic hyperplasia(BPH).Methods Totally 100 patients with BPH admitted to the hospital from June 2015 to September 2017 were selected and divided into the observation group and the control group by the random envelope method,50 cases in each group.The patients in the control group were treated with finasteride,on this basis,the patients in the observation group were treated with Huang'e Capsules.All the patients were treated for 6 weeks.Results The total effective rate of the treatment group was 88.00%,which was significantly higher than 60.00% of the control group(P < 0.05).After treatment,the International Prostate Symptom Score(IPSS) and the score of quality of life in the two groups were significantly reduced(P < 0.05),and those in the observation group were significantly better than those in the control group(P < 0.05).After treatment,the prostate volume of the two groups was significantly smaller than that before treatment(P < 0.05),and that of the observation group was significantly smaller than that of the control group(P < 0.05).After treatment,the maximum urine flow rate in the two groups was significantly higher than that before the treatment(P < 0.05),and that in the observation group was significantly higher than that in the control group(P < 0.05).No adverse reactions occurred in all patients.Conclusion Huang'e Capsules combined with finasteride in the treatment of senile BPH can effectively improve the clinical effect and improve the quality of life of patients.
引文
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[13]邱阳,胡海地,胡冰青,等.二氢睾酮通过下调LOX-1的表达抑制J774.1细胞向泡沫细胞转化[J].中华医学杂志,2016,96(42):3403-3407.
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[15]陈朝辉,刘东莲,王美,等.老年良性前列腺增生病人用药依从性及影响因素的横断面调查研究[J].蚌埠医学院学报,2017,42(3):405-408.
[16]贾玉玲,崇立明,李雷,等.雄激素对雌激素引发去势雄性SD大鼠前列腺炎症及炎症因子的抑制作用[J].中国药理学与毒理学杂志,2017,31(6):568-573.
[17]郑入文,蒋静,宁艳哲,等.中医对良性前列腺增生的认识及治疗现状[J].世界中医药,2017,12(8):1974-1978.
[18]陈立,王小琴.肾藏精理论源流探析[J].中国中西医结合肾病杂志,2016,17(9):839-841.
[19]胡季强,王如伟,吴华铃,等.黄莪胶囊的药物用途:CN104547910A[P].2015-04-29.
[2]李拔森,王良.良性前列腺增生介入治疗的现状和进展[J].影像诊断与介入放射学,2017,26(3):230-235.
[3]汪洋,杨丽,孔东波,等.短期大剂量爱普列特联合坦洛新治疗前列腺增生症并尿潴留54例临床观察[J].中国药业,2018,27(8):77-79.
[4]KIM EH,LARSON JA,ANDRIOLE GL.Management of Benign Prostatic Hyperplasia[J].Annual Review of Medicine,2016,67(67):137.
[5]NORSTRM MM,RDESTAD E,SUNDBERG B,et al.Progression of benign prostatic hyperplasia is associated with pro-inflammatory mediators and chronic activation of prostate-infiltrating lymphocytes[J].Oncotarget,2016,7(17):23581.
[6]赵凡,张春和,李焱风.中医药治疗良性前列腺增生症临床研究近况[J].辽宁中医药大学学报,2016,18(6):64-67.
[7]中国中西医结合学会男科专业委员会.良性前列腺增生中西医结合诊疗指南(试行版)[J].中华男科学杂志,2017,23(3):280-285.
[8]彭伟,吴海霞,桂定文,等.评价经尿道前列腺双极等离子电切术与前列腺电切术治疗良性前列腺增生的临床效果及其安全性[J].中国性科学,2017,26(5):24-27.
[9]赖传进.前列腺增生患者症状与焦虑程度相关关系的研究[D].重庆:重庆医科大学,2010.
[10]王存选.前列腺增生症的中医诊断和疗效标准设想[J].辽宁中医杂志,1998,10(6):19-20
[11]MANSOOREH E,TAHERE K,TAHERE M,et al.Evaluation of survivin expression in prostate specimens of patients with prostate adenocarcinoma and benign prostate hyperplasia underwent transurethral resection of the prostate or prostatectomy[J].Springerplus,2016,5(1):1-6.
[12]ELSHAL AM,MEKKAWY R,LAYMON M,et al.Holmium laser enucleation of the prostate for treatment for large-sized benign prostate hyperplasia;is it a realistic endourologic alternative in developing country?[J].World Journal of Urology,2016,34(3):399-405.
[13]邱阳,胡海地,胡冰青,等.二氢睾酮通过下调LOX-1的表达抑制J774.1细胞向泡沫细胞转化[J].中华医学杂志,2016,96(42):3403-3407.
[14]杨华,贾洪涛,司敏.良性前列腺增生的外科治疗进展[J].中国老年保健医学,2017,15(3):61-63.
[15]陈朝辉,刘东莲,王美,等.老年良性前列腺增生病人用药依从性及影响因素的横断面调查研究[J].蚌埠医学院学报,2017,42(3):405-408.
[16]贾玉玲,崇立明,李雷,等.雄激素对雌激素引发去势雄性SD大鼠前列腺炎症及炎症因子的抑制作用[J].中国药理学与毒理学杂志,2017,31(6):568-573.
[17]郑入文,蒋静,宁艳哲,等.中医对良性前列腺增生的认识及治疗现状[J].世界中医药,2017,12(8):1974-1978.
[18]陈立,王小琴.肾藏精理论源流探析[J].中国中西医结合肾病杂志,2016,17(9):839-841.
[19]胡季强,王如伟,吴华铃,等.黄莪胶囊的药物用途:CN104547910A[P].2015-04-29.