清金化痰汤联合常规疗法治疗慢性阻塞性肺疾病急性加重期临床研究
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摘要
目的:观察清金化痰汤联合常规疗法治疗慢性阻塞性肺疾病(COPD)急性加重期患者的临床效果。方法:将110例痰热壅肺型COPD急性加重期患者纳入研究,通过随机数字表法分为联合组和对照组各55例。2组均应用常规西医疗法治疗,联合组加服清金化痰汤,治疗1周后对比2组的疗效,观察治疗前后2组患者肺功能指标[第1秒用力呼气容积(FEV_1)、用力肺活量(FVC)及第1秒用力呼气容积占用力肺活量比值(FEV_1/FVC)]与炎性指标[C-反应蛋白(CRP)、白细胞介素-6 (IL-6)、降钙素(PCT)]的变化。结果:治疗后,联合组总有效率94.55%,高于对照组的81.82%,差异有统计学意义(P <0.05)。2组FEV_1、FVC及FEV_1/FVC均较治疗前升高,联合组3项指标值均高于对照组,差异均有统计学意义(P <0.05)。2组CRP、PCT及IL-6水平均较治疗前降低,联合组3项指标值均低于对照组,差异均有统计学意义(P <0.05)。2组患者在治疗过程中均未发生严重不良反应。结论:以清金化痰汤联合常规西医疗法治疗痰热蕴肺型COPD急性加重期患者效果确切,能够有效缓解患者的症状,促进肺功能改善,且安全性高。
Objective:To observe the clinical effect of Qingjin huatan tang combined with routine therapy for chronic obstructive pulmonary disease(COPD) with acute exacerbation. Methods:110 patients with COPD with acute exacerbation of phlegm-heat stagnating the lung type were included in the study and were divided into the combination group and the control group with 55 cases in each group by random number table method. Both groups were treated with routine western medicine,and the combination group was additionally treated with Qingjin Huatan tang. After one week of treatment,the curative effect of the two groups were compared. Observed the lung function indexes including forced expiratory volume in one second(FEV_1),forced lung capacity(FVC) and the ratio of forced expiratory volume in one second to forced vital capacity(FEV_1/FVC),and the changes of inflammatory indexes including C-reactive protein(CRP),interleukin-6(IL-6) and plasma calcitonin(PCT) before and after treatment in the two groups. Results:After treatment,the total effective rate of the combination group was 94.55%,which was higher than that of 81.82% in the control group,the difference being significant(P < 0.05). The values of FEV_1,FVC and FEV_1/FVC in the two groups were increased when compared with those before treatment,and the values of three indexes in the combination group were higher than those in the control group,differences being significance(P < 0.05). The levels of CRP,PCT and IL-6 in the two groups were decreased when compared with those before treatment,and the three indexes in the combination group were lower than those in the control group,differences being significance(P < 0.05). There was no serious adverse reaction during the treatment in both groups. Conclusion:The combination of Qingjin Huatan tang and routine western medicine has a definite effect on patients with COPD of phlegm-heat stagnating the lung type with acute exacerbation. It can effectively relieve the symptoms and promote the improvement of lung function with high safety.
Objective:To observe the clinical effect of Qingjin huatan tang combined with routine therapy for chronic obstructive pulmonary disease(COPD) with acute exacerbation. Methods:110 patients with COPD with acute exacerbation of phlegm-heat stagnating the lung type were included in the study and were divided into the combination group and the control group with 55 cases in each group by random number table method. Both groups were treated with routine western medicine,and the combination group was additionally treated with Qingjin Huatan tang. After one week of treatment,the curative effect of the two groups were compared. Observed the lung function indexes including forced expiratory volume in one second(FEV_1),forced lung capacity(FVC) and the ratio of forced expiratory volume in one second to forced vital capacity(FEV_1/FVC),and the changes of inflammatory indexes including C-reactive protein(CRP),interleukin-6(IL-6) and plasma calcitonin(PCT) before and after treatment in the two groups. Results:After treatment,the total effective rate of the combination group was 94.55%,which was higher than that of 81.82% in the control group,the difference being significant(P < 0.05). The values of FEV_1,FVC and FEV_1/FVC in the two groups were increased when compared with those before treatment,and the values of three indexes in the combination group were higher than those in the control group,differences being significance(P < 0.05). The levels of CRP,PCT and IL-6 in the two groups were decreased when compared with those before treatment,and the three indexes in the combination group were lower than those in the control group,differences being significance(P < 0.05). There was no serious adverse reaction during the treatment in both groups. Conclusion:The combination of Qingjin Huatan tang and routine western medicine has a definite effect on patients with COPD of phlegm-heat stagnating the lung type with acute exacerbation. It can effectively relieve the symptoms and promote the improvement of lung function with high safety.
引文
[1]李皓如.中西医结合慢性阻塞性肺疾病急性加重期临床效果评价[J].中医临床研究,2017,9(28):73-74.
[2]中华医学会呼吸病学分会.慢性阻塞性肺疾病诊治指南(2014)[J].中国医学前沿杂志,2014,6(2):67-79.
[3]蔡绪明,张军城,曹利平.曹氏加味清金化痰汤联合沙美特罗替卡松粉吸入剂治疗慢性阻塞性肺疾病稳定期临床疗效[J].陕西中医,2016,37(6):655-657.
[4]杜建超,冯淬灵,葛东宇,等.清金化痰汤对慢性阻塞性肺疾病急性加重期模型大鼠肺组织Foxp3和RORγt表达的影响[J].北京中医药大学学报, 2016, 39(12):1006-1012.
[5] Cafarella PA,Effing TW,Usmani ZA,et al.Treatments foranxiety and depression in patients with chronic obstructivepulmonary disease:a literature review[J].Respirology,2012,17(4):627.
[6]陈小燕,黄冬娥.清金化痰汤联合西药治疗慢性阻塞性肺疾病急性加重期随机平行对照研究[J].实用中医内科杂志,2015,29(8):115-117.
[7]姜芊竹,陈会君.清金化痰汤联合西药治疗慢性阻塞性肺疾病急性加重期(痰热郁肺型)临床疗效观察[J].四川中医,2017,35(2):84-86.
[2]中华医学会呼吸病学分会.慢性阻塞性肺疾病诊治指南(2014)[J].中国医学前沿杂志,2014,6(2):67-79.
[3]蔡绪明,张军城,曹利平.曹氏加味清金化痰汤联合沙美特罗替卡松粉吸入剂治疗慢性阻塞性肺疾病稳定期临床疗效[J].陕西中医,2016,37(6):655-657.
[4]杜建超,冯淬灵,葛东宇,等.清金化痰汤对慢性阻塞性肺疾病急性加重期模型大鼠肺组织Foxp3和RORγt表达的影响[J].北京中医药大学学报, 2016, 39(12):1006-1012.
[5] Cafarella PA,Effing TW,Usmani ZA,et al.Treatments foranxiety and depression in patients with chronic obstructivepulmonary disease:a literature review[J].Respirology,2012,17(4):627.
[6]陈小燕,黄冬娥.清金化痰汤联合西药治疗慢性阻塞性肺疾病急性加重期随机平行对照研究[J].实用中医内科杂志,2015,29(8):115-117.
[7]姜芊竹,陈会君.清金化痰汤联合西药治疗慢性阻塞性肺疾病急性加重期(痰热郁肺型)临床疗效观察[J].四川中医,2017,35(2):84-86.