丙戊酸钠联合用药疗效及不良反应文献分析
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摘要
目的通过对丙戊酸钠联合用药文献的综合整理分析,为临床联合用药提供可靠依据。方法检索2000年1月1日-2016年12月31日中国知网、万方、Pub Med等电子资源平台,搜索关键字"丙戊酸钠、联合、valproate and",选取符合本次研究入选标准的文献,回顾性研究不同联合药物与丙戊酸钠单药治疗的疗效及不良反应的信息,用统计学软件SPSS 16.0处理相关数据。结果本研究入选17篇共1 346例次的中文文献,分别包含丙戊酸钠联合拉莫三嗪、托吡酯、左乙拉西坦、卡马西平四种不同的抗癫痫药物。四种联合用药组分别与丙戊酸钠单药治疗组间的疗效及不良反应进行比较,发现各联合用药治疗组的总有效率优于丙戊酸钠单药治疗组,差异有统计学意义(P<0.05);且不良反应发生率略低或无变化。结论丙戊酸钠联合新型抗癫痫药物的疗效值得肯定,未发现有增加不良反应的发生。
Objective To analyse the valproate combinations comprehensively,it may provide reliable basis for clinical combination.Methods Retrieved from January 1st 2000 to December 31st 2016,the Chinese hownet and other electronic resources platform,it searched keywords "valproate","and",and met the study criteria for the selected literatures,with retrospective study different combinations of drugs with valproate monotherapy curative effect and adverse reaction of information,dealing with relevant data with statistics software SPSS 16.0.Results This study selected 17 articles,a total of 1346 cases of Chinese literature,containing valproate combined lamotrigine,topiramate,levetiracetam,carbamazepine four different kinds of antiepileptic drugs.The results were compared with the valproate treatment group and the adverse reactions in the valproate treatment group.The total effectiveness of the combined drug treatment group was better than that of valproate,and the difference was statistically significant(P<0.05).The incidence of adverse reactions was slightly lower or no change.Conclusion The effectiveness of valproate combined the new antiepileptic medicines is to be sure and there is no increase in adverse reactions.
Objective To analyse the valproate combinations comprehensively,it may provide reliable basis for clinical combination.Methods Retrieved from January 1st 2000 to December 31st 2016,the Chinese hownet and other electronic resources platform,it searched keywords "valproate","and",and met the study criteria for the selected literatures,with retrospective study different combinations of drugs with valproate monotherapy curative effect and adverse reaction of information,dealing with relevant data with statistics software SPSS 16.0.Results This study selected 17 articles,a total of 1346 cases of Chinese literature,containing valproate combined lamotrigine,topiramate,levetiracetam,carbamazepine four different kinds of antiepileptic drugs.The results were compared with the valproate treatment group and the adverse reactions in the valproate treatment group.The total effectiveness of the combined drug treatment group was better than that of valproate,and the difference was statistically significant(P<0.05).The incidence of adverse reactions was slightly lower or no change.Conclusion The effectiveness of valproate combined the new antiepileptic medicines is to be sure and there is no increase in adverse reactions.
引文
[1]张力.丙戊酸联合拉莫三嗪治疗癫痫的疗效性分析[J].中国医药指南,2015,13(18):14-16.
[2]孙建忠.丙戊酸钠联合拉莫三嗪治疗癫痫的疗效及安全性研究[J].中国处方药,2016,14(10):80-81.DOI:10.3969/j.issn.1671-945X.2016.10.058.
[3]孙志清,付庆喜,车峰远.丙戊酸钠联合拉莫三嗪治疗各型癫痫的疗效及安全性分析[J].中华高血压杂志,2015,23(2):232.
[4]吴珊珊,法艳梅.丙戊酸钠联合拉莫三嗪治疗癫痫效果观察[J].中国处方药,2016,14(10):73-74.DOI:10.3969/j.issn.1671-945X.2016.10.052.
[5]张华.拉莫三嗪联合丙戊酸钠治疗难治性癫痫部分性发作的临床研究[J].中国临床药理学杂志,2016,32(12):1085-1087.DOI:10.13699/j.cnki.1001-6821.2016.12.009.
[6]郭强,姚力.拉莫三嗪联合丙戊酸钠治疗脑卒中继发性癫痫的疗效分析[J].药物评价研究,2015,38(4):405-408.DOI:10.7501/j.issn.1674-6376.2015.04.013.
[7]温玉梅,刘秀娟,刘晓宇,等.拉莫三嗪联合丙戊酸治疗癫痫的临床疗效[J].海南医学院学报,2016,22(8):816-818.DOI:10.13210/j.cnki.jhmu.20160106.016.
[8]陈雄,张云志,杨庆雄,等.拉莫三嗪联合丙戊酸钠治疗儿童癫痫的临床效果观察[J].中国地方病防治杂志,2013,28(5):389-391.
[9]茶志芳.托吡酯联合丙戊酸钠治疗120例小儿癫痫的临床疗效分析[J].中外医疗,2013,32(6):129-131.DOI:10.3969/j.issn.1674-0742.2013.06.082.
[10]吴丽娟.托吡酯联合丙戊酸钠治疗小儿癫痫[J].社会医学杂志,2012,10(19):39-41.
[11]梁志安,张煜华.托吡酯联合丙戊酸钠治疗小儿癫痫的临床疗效观察[J].新医学,2012,43(2):82-84.DOI:10.3969/g.issn.0253-9802.2012.02.006.
[12]宋耀华.托吡酯联合丙戊酸钠治疗小儿癫痫的临床效果研究[J].中国当代医药,2016,23(10):144-146.
[13]熊光明.托吡酯联合丙戊酸钠治疗小儿癫痫效果观察[J].中国乡村医药杂志,2014,21(12):58-59.
[14]高宏亮.左乙拉西坦联合丙戊酸钠治疗全面性癫痫持续状态的疗效及对CKMB水平的影响[J].中国实用神经疾病杂志,2016,19(16):61-63.DOI:10.3969/j.issn.1673-5110.2016.16.034.
[15]田中臣.左乙拉西坦联合丙戊酸注射液治疗癫痫持续临床分析[J].中国继续医学教育,2016,8(15):129-130.DOI:10.3969/j.issn.1674-9308.2016.15.085.
[16]刘晓勇,钱心炜.卡马西平联合丙戊酸钠治疗继发性癫痫的疗效研究[J].黑龙江医药,2014,27(6):1349-1350.DOI:10.13190/j.jbupt.2014.06.036.
[17]蔡秀侠,宋昌鹏,牛艳花.卡马西平联合丙戊酸钠治疗早期癫痫的效果观察[J].中国实用神经疾病杂志,2015,18(7):101-102.DOI:10.3969/j.issn.1673-5110.2015.07.065.
[2]孙建忠.丙戊酸钠联合拉莫三嗪治疗癫痫的疗效及安全性研究[J].中国处方药,2016,14(10):80-81.DOI:10.3969/j.issn.1671-945X.2016.10.058.
[3]孙志清,付庆喜,车峰远.丙戊酸钠联合拉莫三嗪治疗各型癫痫的疗效及安全性分析[J].中华高血压杂志,2015,23(2):232.
[4]吴珊珊,法艳梅.丙戊酸钠联合拉莫三嗪治疗癫痫效果观察[J].中国处方药,2016,14(10):73-74.DOI:10.3969/j.issn.1671-945X.2016.10.052.
[5]张华.拉莫三嗪联合丙戊酸钠治疗难治性癫痫部分性发作的临床研究[J].中国临床药理学杂志,2016,32(12):1085-1087.DOI:10.13699/j.cnki.1001-6821.2016.12.009.
[6]郭强,姚力.拉莫三嗪联合丙戊酸钠治疗脑卒中继发性癫痫的疗效分析[J].药物评价研究,2015,38(4):405-408.DOI:10.7501/j.issn.1674-6376.2015.04.013.
[7]温玉梅,刘秀娟,刘晓宇,等.拉莫三嗪联合丙戊酸治疗癫痫的临床疗效[J].海南医学院学报,2016,22(8):816-818.DOI:10.13210/j.cnki.jhmu.20160106.016.
[8]陈雄,张云志,杨庆雄,等.拉莫三嗪联合丙戊酸钠治疗儿童癫痫的临床效果观察[J].中国地方病防治杂志,2013,28(5):389-391.
[9]茶志芳.托吡酯联合丙戊酸钠治疗120例小儿癫痫的临床疗效分析[J].中外医疗,2013,32(6):129-131.DOI:10.3969/j.issn.1674-0742.2013.06.082.
[10]吴丽娟.托吡酯联合丙戊酸钠治疗小儿癫痫[J].社会医学杂志,2012,10(19):39-41.
[11]梁志安,张煜华.托吡酯联合丙戊酸钠治疗小儿癫痫的临床疗效观察[J].新医学,2012,43(2):82-84.DOI:10.3969/g.issn.0253-9802.2012.02.006.
[12]宋耀华.托吡酯联合丙戊酸钠治疗小儿癫痫的临床效果研究[J].中国当代医药,2016,23(10):144-146.
[13]熊光明.托吡酯联合丙戊酸钠治疗小儿癫痫效果观察[J].中国乡村医药杂志,2014,21(12):58-59.
[14]高宏亮.左乙拉西坦联合丙戊酸钠治疗全面性癫痫持续状态的疗效及对CKMB水平的影响[J].中国实用神经疾病杂志,2016,19(16):61-63.DOI:10.3969/j.issn.1673-5110.2016.16.034.
[15]田中臣.左乙拉西坦联合丙戊酸注射液治疗癫痫持续临床分析[J].中国继续医学教育,2016,8(15):129-130.DOI:10.3969/j.issn.1674-9308.2016.15.085.
[16]刘晓勇,钱心炜.卡马西平联合丙戊酸钠治疗继发性癫痫的疗效研究[J].黑龙江医药,2014,27(6):1349-1350.DOI:10.13190/j.jbupt.2014.06.036.
[17]蔡秀侠,宋昌鹏,牛艳花.卡马西平联合丙戊酸钠治疗早期癫痫的效果观察[J].中国实用神经疾病杂志,2015,18(7):101-102.DOI:10.3969/j.issn.1673-5110.2015.07.065.