重组人血管内皮抑制素注射液联合化疗治疗老年晚期非小细胞肺癌的效果观察
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摘要
目的探讨重组人血管内皮抑制素注射液联合化疗治疗老年晚期非小细胞肺癌的临床效果。方法选择患者80例,分为两组,每组各40例,对照组化疗方案:多西他塞75 mg/m2联合吉西他滨1000 mg/m2,观察组在对照组的基础上使用重组人血管内皮抑制素注射液,比较两组患者治疗前后的生活质量KPS评分,并统计两组的近期疗效。结果治疗后观察组的生活质量KPS评分显著高于对照组(P<0.05),观察组的有效率为35.0%,显著高于对照组的10.0%(P<0.05)。结论重组人血管内皮抑制素注射液联合化疗应用于晚期非小细胞肺癌患者,能显著提高患者的生活质量,延长生存时间,值得临床推广。
Objective To explore the effect of recombinant human endostatin injection combination with chemstherapy treatment for elderly patients with advanced non-small cell lung cancer. Methods 80 patients were divided into two groups,each group of 40 cases,the control group were used chemotherapy as:docetaxel 75 mg/m2and gemcitabine1000 mg/m2,the observation group were used recombinant human endostatin injection combination with chemotherapy based on the control group,then quality of life with KPS before and after treatment and recent statistical effect in the two groups were compared. Results After treatment,the quality of life in the observation group with KPS score was significantly higher than control group(P<0.05),the efficiency of the observation group was 35.0%,it was significantly higher than 10.0% of control group(P<0.05). Conclusion The effect of recombinant human endostatin injection combination with chemotherapy for elderly patients with advanced non-small cell lung cancer can significantly improve the quality of life and prolong survival time,so it is worthy of promotion.
Objective To explore the effect of recombinant human endostatin injection combination with chemstherapy treatment for elderly patients with advanced non-small cell lung cancer. Methods 80 patients were divided into two groups,each group of 40 cases,the control group were used chemotherapy as:docetaxel 75 mg/m2and gemcitabine1000 mg/m2,the observation group were used recombinant human endostatin injection combination with chemotherapy based on the control group,then quality of life with KPS before and after treatment and recent statistical effect in the two groups were compared. Results After treatment,the quality of life in the observation group with KPS score was significantly higher than control group(P<0.05),the efficiency of the observation group was 35.0%,it was significantly higher than 10.0% of control group(P<0.05). Conclusion The effect of recombinant human endostatin injection combination with chemotherapy for elderly patients with advanced non-small cell lung cancer can significantly improve the quality of life and prolong survival time,so it is worthy of promotion.
引文
[1]王玲,朱小霞,陈颖琦.恩度动静脉联合应用配合介入治疗中晚期非小细胞肺癌患者的护理[J].中国实用护理杂志,2011,27(30):37-38.
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[3]余婷婷,徐细明,陈彪.恩度联合GP方案治疗晚期非小细胞肺癌疗效及安全性的Meta分析[J].中华临床医师杂志,2013,7(9):3943-3946.
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[6]陈群,石琴,谢强,等.重组人血管内皮抑素注射液联合单药治疗老年晚期非小细胞肺癌的临床观察[J].中国老年学杂志,2012,32(5):900-902.
[7]秦海峰,高红军.重组人血管内皮抑制素(恩度)治疗非小细胞肺癌研究进展[J].军事医学,2011,35(7):553-560.
[8]杨润祥,任宏轩,庄莉,等.重组人血管内皮抑素联合TP方案治疗晚期非小细胞肺癌的临床研究[J].临床肿瘤学杂志,2010,15(5):453-456.
[9]魏启宏,丁惠珍,陶玉坚,等.重组人血管内皮抑素联合GP方案治疗晚期非小细胞肺癌近期疗效观察[J].实用临床医药杂志,2010,14(1):36-38.
[10]刘维,哈敏文,殷南昌,等.恩度联合顺铂胸腔内注射治疗非小细胞肺癌恶性胸腔积液临床研究[J].山东医药,2010,50(8):79-80.
[11]洪英财,王正,朱美琴,等.恩度联合化疗药物治疗晚期非小细胞肺癌疗效观察[J].海南医学,2011,22(6):29-30.
[12]赵培革.恩度联合顺铂治疗晚期非小细胞肺癌临床分析[J].中国医药科学,2013,3(20):47-48.
[2]刘少平,钱文军,茅卫东.恩度对晚期非小细胞肺癌患者血清VEGF和bFGF的影响[J].郑州大学学报(医学版),2013,48(1):144-146.
[3]余婷婷,徐细明,陈彪.恩度联合GP方案治疗晚期非小细胞肺癌疗效及安全性的Meta分析[J].中华临床医师杂志,2013,7(9):3943-3946.
[4]文锋,王伟,尚立群,等.恩度联合NP方案治疗非小细胞肺癌临床疗效观察[J].实用临床医药杂志,2011,15(13):79-80.
[5]戴永美,崔同建,刘振华,等.重组人血管内皮抑制素联合含铂方案治疗晚期非小细胞肺癌的临床观察[J].临床肿瘤学杂志,2012,17(11):1036-1039.
[6]陈群,石琴,谢强,等.重组人血管内皮抑素注射液联合单药治疗老年晚期非小细胞肺癌的临床观察[J].中国老年学杂志,2012,32(5):900-902.
[7]秦海峰,高红军.重组人血管内皮抑制素(恩度)治疗非小细胞肺癌研究进展[J].军事医学,2011,35(7):553-560.
[8]杨润祥,任宏轩,庄莉,等.重组人血管内皮抑素联合TP方案治疗晚期非小细胞肺癌的临床研究[J].临床肿瘤学杂志,2010,15(5):453-456.
[9]魏启宏,丁惠珍,陶玉坚,等.重组人血管内皮抑素联合GP方案治疗晚期非小细胞肺癌近期疗效观察[J].实用临床医药杂志,2010,14(1):36-38.
[10]刘维,哈敏文,殷南昌,等.恩度联合顺铂胸腔内注射治疗非小细胞肺癌恶性胸腔积液临床研究[J].山东医药,2010,50(8):79-80.
[11]洪英财,王正,朱美琴,等.恩度联合化疗药物治疗晚期非小细胞肺癌疗效观察[J].海南医学,2011,22(6):29-30.
[12]赵培革.恩度联合顺铂治疗晚期非小细胞肺癌临床分析[J].中国医药科学,2013,3(20):47-48.