BDNF和NMDAR在微波辐射对学习记忆影响中作用的研究进展
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摘要
随着微波技术的广泛应用,其潜在危害日益引起关注。中枢神经系统是微波辐射最敏感靶部位之一,海马是哺乳类动物完成学习记忆功能的关键结构,学习记忆能力障碍是微波辐射致海马损伤的重要表现形式。脑源性神经营养因子(BDNF)能促进突触可塑性、改变脑内神经元的形态、促进树突和轴突的生长,还参与学习记忆的机制和长时程增强效应。N-甲基-D-天冬氨酸受体(NMDAR)是一种兴奋性氨基酸特异性受体,可调节神经的存活、树突和轴突结构发育及突触可塑性,还能影响神经元回路的形成和学习记忆的过程。本文主要就BDNF和NMDAR在微波辐射对学习记忆的影响及其机制的研究进展进行综述,以期为今后的相关研究提供科学依据。
With the wide appliation of microwave technology,its potential harm to humans is becoming a concern. The central nervous system is one of the most sensitive parts to microwave radiation. The hippocampus is a key structure where mammals complete the function of learning and memory,and the damage to the learning and memory function is also the most significant effect of microwave radiation on the hippocampus. Brain derived neurotrophic factor( BDNF) can promote synaptic plasticity,change the configuration of neurons in the brain,and promote the growth of dendrites and axons. BDNF is also involved in the mechanism of learning and memory and enhances the effect of long-term potentiation( LTP). N-methyl-D-aspartate receptor( NMDAR) is an excitatory amino acid receptor with specificity,which can not only adjust the nerve survival,development and synaptic plasticity,but also influence the formation of neuronal circuits and the process of learning and memory.In this paper,we review the role of BDNF and NMDAR in microwave radiation effects on learning and memory and research progress in order to contribute to related research in the future.
With the wide appliation of microwave technology,its potential harm to humans is becoming a concern. The central nervous system is one of the most sensitive parts to microwave radiation. The hippocampus is a key structure where mammals complete the function of learning and memory,and the damage to the learning and memory function is also the most significant effect of microwave radiation on the hippocampus. Brain derived neurotrophic factor( BDNF) can promote synaptic plasticity,change the configuration of neurons in the brain,and promote the growth of dendrites and axons. BDNF is also involved in the mechanism of learning and memory and enhances the effect of long-term potentiation( LTP). N-methyl-D-aspartate receptor( NMDAR) is an excitatory amino acid receptor with specificity,which can not only adjust the nerve survival,development and synaptic plasticity,but also influence the formation of neuronal circuits and the process of learning and memory.In this paper,we review the role of BDNF and NMDAR in microwave radiation effects on learning and memory and research progress in order to contribute to related research in the future.
引文
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[22]ZUO H,LIN T,WANG D,et al.RKIP Regulates Neural Cell Apoptosis Induced by Exposure to Microwave Radiation Partly Through the MEK/ERK/CREB Pathway[J].Mol Neurobiol,2015,51(3):1520.
[23]王丽峰,彭瑞云,胡向军,等.微波辐射对PC12细胞突触素I表达的影响及其机制[J].细胞与分子免疫学杂志,2008,24(7):6559.
[2]WANG H,PENG R Y,ZHOU H M,et al.Impairment of long-term potentiation induction is essential for the disruption of spatial memory after microwave exposure[J].Int J Radiat Biol,2013,89(12):1100.
[3]王丽峰,彭瑞云,胡向军,等.微波辐射对大鼠大脑皮层和海马突触素Ⅰ及相关信号通路的影响[J].中华放射医学与防护,2008,23(10):1155.
[4]WANG H,PENG R,ZHAO L,et al.The relationship between NMDA receptors and microwave induced learning and memory impairment:A long-term observation on Wistar rats[J].Int J Radiat Biol,2015,91(3):262.
[5]NAKAZAWA K,QUIRK M C,CHITWOOD R A,et al.Requirement for hippocampal CA3 NMDA receptors in associative memory recall[J].Science,2002,297(5):2118.
[6]RONDI-REIG L,PETIT G H,TOBIN C,et al.Impaired sequential ego centfic and allocentric memories in force brain specific NMDA receptor knockout mice during an new task dissociating strategies of navigation[J].J Neum sci,2006,26(15):4071.
[7]MADRY C,MESIC I,BARTHOLOM US I,et al.Principal role of NR3 subunits in NR1/NR3 excitatory glycine receptor function[J].Biochem Biophys Res Commun,2007,354(1):102.
[8]KOLB J E,TRETTEL J,LEVINE E S.BDNF enhancement of postsynaptic NMDA receptors is blocked by ethanol[J].Synapse,2005,55(1):52.
[9]LIN S Y,WU K,LEVINE E S,et al.BDNF acutely increases tyrosine phosphorylation of the NMDA receptor subunit2B in cortical and hippocampal postsynaptic densities[J].Brain Res Mol Brain Res,1998,55(1):20.
[10]CROZIER R A,BLACK I B,PLUMMER M R.Blockade of NR2B-containing NMDA receptors prevents BDNF enhancement of glutamatergic transmission in hippocampal neurons[J].Learn Mem,1999,6(3):257.
[11]CALDEIRA M V,MELO C V,PEREIRA D B,et al.BDNF regulates the expression and traffic of NMDA receptors in cultured hippocampal neurons[J].Mol Cell Neurosci,2007,35(2):208.
[12]YOSHII A,CONSTANTINE-PATON M.BDNF induces transport of PSD-95 to dendrites through PI3K-AKT signaling after NMDA receptor activation[J].Nat Neurosci,2007,10(6):702.
[13]VANHOUTTE P,BADING H.Opposing roles of synaptic and extrasynaptic NMDA receptors in neuronal calcium signalling and BDNF gene regulation[J].Curr Opin Neurobiol,2003,13(3):366.
[14]ZHENG F,WANG H.NMDA-mediated and self-induced bdnf exon IV transcriptions are differentially regulated in cultured cortical neurons[J].Neurochem Int,2009,54(5-6):385.
[15]ZHOU Z,HONG E J,COHEN S,et al.Brain-specific phosphorylation of Me CP2 regulates activity-dependent Bdnf transcription,dendritic growth,and spine maturation[J].Neuron,2006,52(2):255.
[16]TIAN F,HU X Z,WU X,et al.Dynamic chromatin remodeling events in hippocampal neurons are associated with NMDA receptor-mediated activation of Bdnf gene promoter 1[J].J Neurochem,2009,109(5):1375.
[17]TIAN F,MARINI A M,Lipsky R H.NMDA receptor activation induces differential epigenetic modification of Bdnf promoters in hippocampal neurons[J].Amino Acids,2010,38(4):1067.
[18]乔思默,胡向军,王丽峰,等.微波辐射对大鼠海马结构和功能的影响及突触素Ⅰ在其中的作用[J].军事医学,2013,37(2):1260.
[19]XU S,NING W,XU Z,et al.Chronic exposure to GSM1800-MHz microwaves reduces excitatory synaptic activity in cultured hippocampal neurons[J].Neurosci Lett,2006,398(3):253.
[20]ZHAO L,YANG Y F,PENG R Y,et al.Upregulation of HIF-1αvia activation of ERK and PI3K pathway mediated protective response to microwave-induced mitochondrial injury in neuron-like cells[J].Mol Neurobiol,2014,50(3):1024.
[21]XIONG L,SUN C F,ZHANG J,et al.Microwave Exposure Impairs Synaptic Plasticity in the Rat Hippocampus and PC12 Cells through Over-activation of the NMDA Receptor Signaling Pathway[J].Biomed Environ Sci,2015,28(1):13.
[22]ZUO H,LIN T,WANG D,et al.RKIP Regulates Neural Cell Apoptosis Induced by Exposure to Microwave Radiation Partly Through the MEK/ERK/CREB Pathway[J].Mol Neurobiol,2015,51(3):1520.
[23]王丽峰,彭瑞云,胡向军,等.微波辐射对PC12细胞突触素I表达的影响及其机制[J].细胞与分子免疫学杂志,2008,24(7):6559.