药食两用中药-芡实的研究进展
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摘要
芡实为睡莲科植物芡的干燥成熟种仁,既是一种传统中药材,也是一种常用的食品材料。芡实含有多种化学成分,并具有较强的药理作用,临床上常用于治疗多种肾脏疾病、慢性肠炎以及中风后遗症。近年来,以芡实为原料的食品开发逐渐成为研究热点。本文主要对芡实的化学成分、药理活性、临床应用以及食品开发等方面的研究进行综述,旨在为其在食品和医药领域的进一步深入研究与开发利用提供参考。
Euryale ferox seeds, the dried mature kernel of E.ferox Salisb., has the concomitant function of both traditional Chinese medicine and foodstuff. E.e ferox seedsis rich in chemical constituents, and has various strong pharmacological activities. Currently, it is used to treat some diseases such as various kidney diseases, chronic enteritis and sequelae of stroke. In recent years, the development of E. ferox seeds as the food stuffs has gradually become a research hotspot. This paper made a review focus on the chemical constituents, pharmacological activity, clinical application and food development of E. ferox.seeds. The aim was to provide the theoretical support and reference for the further study of E. ferox seeds in the pharmaceutical and food fields.
Euryale ferox seeds, the dried mature kernel of E.ferox Salisb., has the concomitant function of both traditional Chinese medicine and foodstuff. E.e ferox seedsis rich in chemical constituents, and has various strong pharmacological activities. Currently, it is used to treat some diseases such as various kidney diseases, chronic enteritis and sequelae of stroke. In recent years, the development of E. ferox seeds as the food stuffs has gradually become a research hotspot. This paper made a review focus on the chemical constituents, pharmacological activity, clinical application and food development of E. ferox.seeds. The aim was to provide the theoretical support and reference for the further study of E. ferox seeds in the pharmaceutical and food fields.
引文
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[4]吴仰风.芡实种子发育及其淀粉特性的初步研究[D].扬州:扬州大学,2007.
[5]丁利君,任乃林,张木生,等.火焰原子吸收法测定潮州芡实中的矿质元素[J].微量元素与健康研究,2004,21(6):28-29.
[6]王红,吴启南,伍城颖,等.不同产地芡实中无机元素微波消解-ICP-OES法分析[J].中药材,2015,38(1):29-35.
[7]俞乐,袁伟超,周子杰,等.不同产地芡实种仁中蛋白质与淀粉组分差异性研究[J].广东农业科学,2014,41(24):28-32.
[8]Zhang S,Cheng H,Dong J.Amino-acid and mineral composition of the seeds of Euryale ferox[J]. Chemistry of natural compounds,2011,47(3):490-491.
[9]张汆,张国权,郑建梅,等.安徽芡实营养特性分析[J].中国食品添加剂,2010,(2):206-209.
[10]陈蓉,吴启南,沈蓓.不同产地芡实氨基酸组成分析与营养价值评价[J].食品科学,2011,32(15):239-244.
[11]陈静,陈志宏,张汆,等.不同品种芡实种仁蛋白质亚基组成及氨基酸分析[J].食品工业科技,2017,38(8):98-102.
[12]李湘利,刘静,梁宝东,等.微波辅助碱溶酸沉法提取芡实蛋白的工艺优化及其抗氧化性[J].食品工业科技, 2017,38(24):206-211.
[13]王红,吴启南,伍城颖,等.高效液相色谱法测定芡实中不同构型维生素E的含量[J].食品工业科技,2014,35(8):74-78.
[14]姑丽巴哈尔·艾合买提,阿依古丽·塔西.气质联用法测定芡实中脂肪酸[J].现代农业科技,2018,(3):251,255.
[15]Zhao H R,Zhao S X,Sun C Q,et al.Glucosylsterols in extracts of Euryale ferox identified by high resolution NMR and mass spectrometry[J]. Journal of lipid research, 1989,30(10):1633-1637.
[16]李成良,陈学好,李良俊,等.芡实黄酮类物质的提取及抗氧化性研究[J].长江蔬菜,2010,(14):57-61.
[17]Song C W,Wang S M,Zhou L L,et al.Isolation and identification of compounds responsible for antioxidant capacity of Euryale ferox seeds[J].Journal of agricultural&food chemistry,2011,59(4):1199-1204.
[18]李美红,杨雪琼,万直剑,等.芡实的化学成分[J].中国天然药物,2007,5(1):24-26.
[19]王优,赖宜生,张奕华.环肽类化合物的合成与生物活性研究进展[J].药学进展,2008,32(10):440-446.
[20]董高超.一种呋喃类倍半木脂素的合成研究[D].青岛:青岛科技大学,2017.
[21]丛悦,王艳,郭敬功,等.功劳木中脑苷脂类成分的研究[J].中成药,2011,33(11):1936-1938.
[22]赵守训,史玉俊.芡实中的新脑苷脂类化合物[J].中草药,1994,(11):594.
[23]Row L C,HO J C,Chen C M.Cerebrosides and tocopherol trimers from the seeds of Euryale ferox[J]. Journal of natural products,2007,70(7):1214-1217.
[24]Zhang C.In vitro antioxidant properties of Euryale ferox,seed shell extracts and their preservation effects on pork sausages[J]. Journal of food processing&preservation, 2015,39(6):1172-1182.
[25]Liu Y,Wei S,Liao M.Optimization of ultrasonic extraction of phenolic compounds from Euryale ferox seed shells using response surface methodology[J].Industrial crops&products,2013,49(4):837-843.
[26]Han Z, Luo J,Kong L Y.Two new tocopherol polymers from the seeds of Euryale ferox[J].Journal of asian natural products research,2012,14(8):743-747.
[27]Sun H L,Zhang Y Q,Xie X Y,et al.Studies on chemical constituents from seeds of Euryale ferox[J]. Journal of Chinese medical material,2014,37(11):2019.
[28]张晓云,王书源,董英.南、北芡实提取物的抗氧化活性比较及其GC-MS分析[J].中国粮油学报,2012,27(6):31-35.
[29]Wu C Y,Wang H,He X X,et al.The hypoglycemic and antioxidant effects of polysaccharides from the petioles and pedicels of Euryale ferox Salisb on alloxan-induced hyperglycemic mice[J].Food&Function,2017,8(10):3803-3813.
[30]Yuan H,Meng S,Wang G,et al.Hypoglycemic effect of triterpenoid-rich extracts from Euryale ferox shell on normal and streptozotocin-diabetic mice[J]. Pakistan journal of pharmaceutical sciences,2014,27(4):859-864.
[31]Ahmd D,Sharma M,Kumar V,et al.2-hydroxybetulinic acid3-caprylate:an active principle from Euryale ferox Salisb.seeds with antidiabetic,antioxidant,pancreas&hepatoprotective potential in streptozotocin induced diabetic rats[J].Journal of food science&technology,2015,52(9):5427-5441.
[32]Ahmed D,Kumar V,Verma A,et al.Antidiabetic,antioxidant,antihyperlipidemic effect of extract of Euryale ferox salisb.with enhanced histopathology of pancreas,liver and kidney in streptozotocin induced diabetic rats[J].Springerplus,2015,4(1):315.
[33]Wang X,Cheng Y,Chen X,et al.Comparison of natural and synthetic-tocopherol in rat plasma by HPLC and Euryale ferox seed as a source of natural-tocopherol[J].Asian journal of chemistry,2014,26(16):5279-5282.
[34]Wu C,Wang X,Wang H,et al.Extraction optimization, isolation, preliminary structural characterization and antioxidant activities of the cell wall polysaccharides in the petioles and pedicels of Chinese herbal medicine Qian(Euryale ferox Salisb.)[J]. International journal of biological macromolecules,2014,64(2):458-467.
[35]刘志国,赵文亚.芡实多糖对小鼠抗运功性疲劳作用的研究[J].中国农学通报,2012,28(21):269-271.
[36]Wu C,Chen R,Wang X S,et al.Antioxidant and anti-fatigue activities of phenolic extract from the seed coat of Euryale ferox Salisb.and identification of three phenolic compounds by LCESI-MS/MS[J].Molecules,2013,18(9):11003-11021.
[37]Lee M R,Kim J H,Son E S, et al..Protective effect of extracts from Euryale ferox against glutamate-induced cytotoxicity in neuronal cells[J]. Natural product sciences, 2009,15(3):162-166.
[38]Das S,Rayhauddhu,Maulik N,et al.The effect of Euryale ferox(Makhana),an herb of aquatic origin,on myocardial ischemic reperfusion injury[J].Molecular&cellular biochemistry,2006,289(1-2):55-63.
[39]平橹,孙艳艳,方敬爱,等.芡实对糖尿病肾病大鼠肾组织MMP-9、TIMP-1及CollagenⅣ表达的影响[J].中国中西医结合肾病杂志,2015,(7):583-586.
[40]Baek S H, Nam i J,Kwak H S,et al.Cellular anti-melanogenic effects of a Euryale ferox seed extract ethyl acetate fraction via the lysosomal degradation machinery[J]. International journal of molecular sciences,2015,16(5):9217-9235.
[41]李湘利,刘静,燕伟,等.芡实多糖的抗氧化性及抑菌特性[J].食品与发酵工业,2014,40(11):104-108.
[42]倪炼.黄芪芡实治疗肺肾气虚型早期糖尿病肾病30例观察[J].浙江中医杂志,2013,48(2):92-93.
[43]白海涛,滕安琪,李励,等.芡实合剂联合黄葵胶囊治疗慢性肾炎蛋白尿30例疗效观察[J].武警后勤学院学报:医学版,2011,20(9):731-732.
[44]王婉钢,张晓平,古青,等.芡实对中风后遗症康复的影响[J].湖北中医杂志,2010,32(2):16-17.
[45]刘琳,刘洋洋,占颖,等.芡实的化学成分,药理作用及临床应用研究进展[J].中华中医药杂志,2015,(2):477-479.
[46]予辑.药食同源原料目录[J].口腔护理用品工业,2017,27(6):24-28.
[47]薛立英,高丽,秦雪梅,等.药食同源中药抗衰老研究进展[J].中国药理学与毒理学杂志,2016,38(10):302-309.
[48]郭玲玲,付天祎.芡实食品开发研究进展[J].农业科技与装备,2017,(9):61-62.
[49]薛峰,孙锦杨,刘琪,等.芡实精深加工研究进展[J].食品工业科技,2016,37(11):390-394.
[50]贾小丽,孙艳辉,董艺凝,等.芡实保健八宝粥的研制[J].粮食与食品业,2017,24(5):30-34.
[2]徐旭,刘娴,李良俊.芡实研究进展[J].长江蔬菜, 2017,(18):62-68.
[3]Zhao L,Huang J,Man J,et al.Physicochemical properties of Euryale ferox kernel starches from two different regions[J].International journal of food properties,2016,19(2):289-299.
[4]吴仰风.芡实种子发育及其淀粉特性的初步研究[D].扬州:扬州大学,2007.
[5]丁利君,任乃林,张木生,等.火焰原子吸收法测定潮州芡实中的矿质元素[J].微量元素与健康研究,2004,21(6):28-29.
[6]王红,吴启南,伍城颖,等.不同产地芡实中无机元素微波消解-ICP-OES法分析[J].中药材,2015,38(1):29-35.
[7]俞乐,袁伟超,周子杰,等.不同产地芡实种仁中蛋白质与淀粉组分差异性研究[J].广东农业科学,2014,41(24):28-32.
[8]Zhang S,Cheng H,Dong J.Amino-acid and mineral composition of the seeds of Euryale ferox[J]. Chemistry of natural compounds,2011,47(3):490-491.
[9]张汆,张国权,郑建梅,等.安徽芡实营养特性分析[J].中国食品添加剂,2010,(2):206-209.
[10]陈蓉,吴启南,沈蓓.不同产地芡实氨基酸组成分析与营养价值评价[J].食品科学,2011,32(15):239-244.
[11]陈静,陈志宏,张汆,等.不同品种芡实种仁蛋白质亚基组成及氨基酸分析[J].食品工业科技,2017,38(8):98-102.
[12]李湘利,刘静,梁宝东,等.微波辅助碱溶酸沉法提取芡实蛋白的工艺优化及其抗氧化性[J].食品工业科技, 2017,38(24):206-211.
[13]王红,吴启南,伍城颖,等.高效液相色谱法测定芡实中不同构型维生素E的含量[J].食品工业科技,2014,35(8):74-78.
[14]姑丽巴哈尔·艾合买提,阿依古丽·塔西.气质联用法测定芡实中脂肪酸[J].现代农业科技,2018,(3):251,255.
[15]Zhao H R,Zhao S X,Sun C Q,et al.Glucosylsterols in extracts of Euryale ferox identified by high resolution NMR and mass spectrometry[J]. Journal of lipid research, 1989,30(10):1633-1637.
[16]李成良,陈学好,李良俊,等.芡实黄酮类物质的提取及抗氧化性研究[J].长江蔬菜,2010,(14):57-61.
[17]Song C W,Wang S M,Zhou L L,et al.Isolation and identification of compounds responsible for antioxidant capacity of Euryale ferox seeds[J].Journal of agricultural&food chemistry,2011,59(4):1199-1204.
[18]李美红,杨雪琼,万直剑,等.芡实的化学成分[J].中国天然药物,2007,5(1):24-26.
[19]王优,赖宜生,张奕华.环肽类化合物的合成与生物活性研究进展[J].药学进展,2008,32(10):440-446.
[20]董高超.一种呋喃类倍半木脂素的合成研究[D].青岛:青岛科技大学,2017.
[21]丛悦,王艳,郭敬功,等.功劳木中脑苷脂类成分的研究[J].中成药,2011,33(11):1936-1938.
[22]赵守训,史玉俊.芡实中的新脑苷脂类化合物[J].中草药,1994,(11):594.
[23]Row L C,HO J C,Chen C M.Cerebrosides and tocopherol trimers from the seeds of Euryale ferox[J]. Journal of natural products,2007,70(7):1214-1217.
[24]Zhang C.In vitro antioxidant properties of Euryale ferox,seed shell extracts and their preservation effects on pork sausages[J]. Journal of food processing&preservation, 2015,39(6):1172-1182.
[25]Liu Y,Wei S,Liao M.Optimization of ultrasonic extraction of phenolic compounds from Euryale ferox seed shells using response surface methodology[J].Industrial crops&products,2013,49(4):837-843.
[26]Han Z, Luo J,Kong L Y.Two new tocopherol polymers from the seeds of Euryale ferox[J].Journal of asian natural products research,2012,14(8):743-747.
[27]Sun H L,Zhang Y Q,Xie X Y,et al.Studies on chemical constituents from seeds of Euryale ferox[J]. Journal of Chinese medical material,2014,37(11):2019.
[28]张晓云,王书源,董英.南、北芡实提取物的抗氧化活性比较及其GC-MS分析[J].中国粮油学报,2012,27(6):31-35.
[29]Wu C Y,Wang H,He X X,et al.The hypoglycemic and antioxidant effects of polysaccharides from the petioles and pedicels of Euryale ferox Salisb on alloxan-induced hyperglycemic mice[J].Food&Function,2017,8(10):3803-3813.
[30]Yuan H,Meng S,Wang G,et al.Hypoglycemic effect of triterpenoid-rich extracts from Euryale ferox shell on normal and streptozotocin-diabetic mice[J]. Pakistan journal of pharmaceutical sciences,2014,27(4):859-864.
[31]Ahmd D,Sharma M,Kumar V,et al.2-hydroxybetulinic acid3-caprylate:an active principle from Euryale ferox Salisb.seeds with antidiabetic,antioxidant,pancreas&hepatoprotective potential in streptozotocin induced diabetic rats[J].Journal of food science&technology,2015,52(9):5427-5441.
[32]Ahmed D,Kumar V,Verma A,et al.Antidiabetic,antioxidant,antihyperlipidemic effect of extract of Euryale ferox salisb.with enhanced histopathology of pancreas,liver and kidney in streptozotocin induced diabetic rats[J].Springerplus,2015,4(1):315.
[33]Wang X,Cheng Y,Chen X,et al.Comparison of natural and synthetic-tocopherol in rat plasma by HPLC and Euryale ferox seed as a source of natural-tocopherol[J].Asian journal of chemistry,2014,26(16):5279-5282.
[34]Wu C,Wang X,Wang H,et al.Extraction optimization, isolation, preliminary structural characterization and antioxidant activities of the cell wall polysaccharides in the petioles and pedicels of Chinese herbal medicine Qian(Euryale ferox Salisb.)[J]. International journal of biological macromolecules,2014,64(2):458-467.
[35]刘志国,赵文亚.芡实多糖对小鼠抗运功性疲劳作用的研究[J].中国农学通报,2012,28(21):269-271.
[36]Wu C,Chen R,Wang X S,et al.Antioxidant and anti-fatigue activities of phenolic extract from the seed coat of Euryale ferox Salisb.and identification of three phenolic compounds by LCESI-MS/MS[J].Molecules,2013,18(9):11003-11021.
[37]Lee M R,Kim J H,Son E S, et al..Protective effect of extracts from Euryale ferox against glutamate-induced cytotoxicity in neuronal cells[J]. Natural product sciences, 2009,15(3):162-166.
[38]Das S,Rayhauddhu,Maulik N,et al.The effect of Euryale ferox(Makhana),an herb of aquatic origin,on myocardial ischemic reperfusion injury[J].Molecular&cellular biochemistry,2006,289(1-2):55-63.
[39]平橹,孙艳艳,方敬爱,等.芡实对糖尿病肾病大鼠肾组织MMP-9、TIMP-1及CollagenⅣ表达的影响[J].中国中西医结合肾病杂志,2015,(7):583-586.
[40]Baek S H, Nam i J,Kwak H S,et al.Cellular anti-melanogenic effects of a Euryale ferox seed extract ethyl acetate fraction via the lysosomal degradation machinery[J]. International journal of molecular sciences,2015,16(5):9217-9235.
[41]李湘利,刘静,燕伟,等.芡实多糖的抗氧化性及抑菌特性[J].食品与发酵工业,2014,40(11):104-108.
[42]倪炼.黄芪芡实治疗肺肾气虚型早期糖尿病肾病30例观察[J].浙江中医杂志,2013,48(2):92-93.
[43]白海涛,滕安琪,李励,等.芡实合剂联合黄葵胶囊治疗慢性肾炎蛋白尿30例疗效观察[J].武警后勤学院学报:医学版,2011,20(9):731-732.
[44]王婉钢,张晓平,古青,等.芡实对中风后遗症康复的影响[J].湖北中医杂志,2010,32(2):16-17.
[45]刘琳,刘洋洋,占颖,等.芡实的化学成分,药理作用及临床应用研究进展[J].中华中医药杂志,2015,(2):477-479.
[46]予辑.药食同源原料目录[J].口腔护理用品工业,2017,27(6):24-28.
[47]薛立英,高丽,秦雪梅,等.药食同源中药抗衰老研究进展[J].中国药理学与毒理学杂志,2016,38(10):302-309.
[48]郭玲玲,付天祎.芡实食品开发研究进展[J].农业科技与装备,2017,(9):61-62.
[49]薛峰,孙锦杨,刘琪,等.芡实精深加工研究进展[J].食品工业科技,2016,37(11):390-394.
[50]贾小丽,孙艳辉,董艺凝,等.芡实保健八宝粥的研制[J].粮食与食品业,2017,24(5):30-34.