华卟啉钠的抗肿瘤作用研究进展
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摘要
光动力疗法(PDT)是肿瘤治疗的新策略,其关键因素包括光敏剂和匹配的光源。作为新一代高纯度光敏剂,华卟啉钠(DVDMS)具有活性成分明确、含量高、有效剂量低、治疗后避光时间短等特点,安全性也较好。随着其声敏性的发现,DVDMS介导的声动力治疗进一步拓展了其研究和应用范围。研究表明DVDMS有望用于抗肿瘤、抗菌、治疗银屑病、开发治疗诊断试剂等,具有较好的开发和应用前景。本文将对华卟啉钠的抗肿瘤活性及其机制的研究进展进行综述。
Photodynamic therapy(PDT) is a new oncotherapy method. Photosensitizer and matched-light are the key elements of PDT. As a next generation photosensitizers of high purity, sinoporphyrin sodium(DVDMS) has the characteristics of clear structure and high content, low effective dose, short time avoiding light after treatment and good safety. Due to the discovery of ultrasonic sensitivity of DVDMS, great progresses have been made on the research and application of DVDMSmediated sonodynamic therapy. Research suggests that DVDMS has potentials to be used for anti-tumor, anti-bacterial, treatment of psoriasis, development of therapeutic diagnostic reagents and so on. This review sums up the anti-tumor activities and mechanisms of DVDMS.
Photodynamic therapy(PDT) is a new oncotherapy method. Photosensitizer and matched-light are the key elements of PDT. As a next generation photosensitizers of high purity, sinoporphyrin sodium(DVDMS) has the characteristics of clear structure and high content, low effective dose, short time avoiding light after treatment and good safety. Due to the discovery of ultrasonic sensitivity of DVDMS, great progresses have been made on the research and application of DVDMSmediated sonodynamic therapy. Research suggests that DVDMS has potentials to be used for anti-tumor, anti-bacterial, treatment of psoriasis, development of therapeutic diagnostic reagents and so on. This review sums up the anti-tumor activities and mechanisms of DVDMS.
引文
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[12]SHI R,LI C,JIANG Z,LI W,WANG A,WEI J.Preclinical study of antineoplastic sinoporphyrin sodiumPDT via in vitro and in vivo models[J/OL].Molecules,2017,22:112.doi:10.3390/molecules22010112.
[13]WANG X,HU J,WANG P,ZHANG S,LIU Y,XIONGW,et al.Analysis of the in vivo and in vitro effects of photodynamic therapy on breast cancer by using a sensitizer,sinoporphyrin sodium[J].Theranostics,2015,5:772-786.
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[15]WU L,WANG X,LIU Q,WINGNANG LEUNG A,WANG P,XU C.Sinoporphyrin sodium mediated photodynamic therapy inhibits the migration associated with collapse of F-actin filaments cytoskeleton in MDA-MB-231 cells[J].Photodiagnosis Photodyn Ther,2016,13:58-65.
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[17]HU J,WANG X,LIU Q,ZHANG K,XIONG W,XU C,et al.Antitumor effect of sinoporphyrin sodium-mediated photodynamic therapy on human esophageal cancer Eca-109 cells[J].Photochem Photobiol,2014,90:1404-1412.
[18]吕海燕.新型光敏剂以醚键结合的卟啉二聚体盐(DVDMS-2)的初步临床前研究[D].厦门:厦门大学,2012.
[19]姜智换,史蕤,李超,王爱平.华卟啉钠介导的光动力疗法在体外和体内对肿瘤生长的抑制作用[J].癌变·畸变·突变,2013,25:163-167.
[20]CHUNG C,KIM Y K,SHIN D,RYOO S R,HONG BH,MIN D H.Biomedical applications of graphene and graphene oxide[J].Acc Chem Res,2013,46:2211-2224.
[21]HUANG C,CHU C C,ZHANG J,GAO H Y,LIU G.First Sino-German Symposium on“Singlet molecular oxygen and photodynamic effects”:antitumor effect of sinoporphyrin sodium loaded graphene oxide on human liver cancer HepG2 cells[J].Photon Lasers Med,2015,4:365-368.
[22]YAN X,NIU G,LIN J,JIN A J,HU H,TANG Y,et al.Enhanced fluorescence imaging guided photodynamic therapy of sinoporphyrin sodium loaded graphene oxide[J].Biomaterials,2015,42:94-102.
[23]YAN X,HU H,LIN J,JIN A J,NIU G,ZHANG S,et al.Optical and photoacoustic dual-modality imaging guided synergistic photodynamic/photothermal therapies[J].Nanoscale,2015,7:2520-2526.
[24]Y U M I TA N,N I S H I G A K I R,U M E M U R A K,UMEMURA S.Hematoporphyrin as a sensitizer of celldamaging effect of ultrasound[J].Jpn J Cancer Res,1989,80:219-222.
[25]XIONG W,WANG P,HU J,JIA Y,WU L,CHEN X,et al.A new sensitizer DVDMS combined with multiple focused ultrasound treatments:an effective antitumor strategy[J/OL].Sci Rep,2015,5:17485.doi:10.1038/srep17485.
[26]WANG H,WANG P,LI L,ZHANG K,WANG X,LIU Q.Microbubbles enhance the antitumor effects of sinoporphyrin sodium mediated sonodynamic therapy both in vitro and in vivo[J].Int J Biol Sci,2015,11:1401-1409.
[27]LIU Y,WANG P,LIU Q,WANG X.Sinoporphyrin sodium triggered sono-photodynamic effects on breast cancer both in vitro and in vivo[J].Ultrason Sonochem,2016,31:437-448.
[28]李晖,谢树森.采用X射线间接激励光敏剂的光动力学疗法新设想[J].中国激光医学杂志,1997,6:63-65.
[29]李晓龙.初步探究华卟啉钠的放疗增敏作用[D].石家庄:河北医科大学,2016.
[2]方起程.癌症光动力治疗和新抗癌光敏剂华卟啉钠[J].中国新药杂志,2014,23:1540-1545.
[3]方起程,杨栋.以醚键结合的卟啉二聚体盐及其制造方法:CN102030765B[P].2012-08-29.
[4]LI C F,ZHANG K,WANG P,HU J M,LIU Q H,WANG X B.Sonodynamic antitumor effect of a novel sonosensitizer on S180 solid tumor[J].Biopharm Drug Dispos,2014,35:50-59.
[5]HU J,WANG X,ZHANG K,WANG P,SU X,LI Y,et al.Sinoporphyrin sodium:a novel sensitizer in sonodynamic therapy[J].Anticancer Drugs,2014,25:174-182.
[6]WANG X,WANG H,ZHANG S,WANG P,ZHANGK,LIU Q.Sinoporphyrin sodium,a novel sensitizer,triggers mitochondrial-dependent apoptosis in ECA-109cells via production of reactive oxygen species[J].Int JNanomedicine,2014,9:3077-3090.
[7]刘汉清,张晶旋,魏金峰,靳洪涛,王爱平.华卟啉钠光动力疗法对细胞异常增殖影响的体内、外实验研究[J].中国皮肤性病学杂志,2016,30:20-24.
[8]刘汉清,姜智焕,吴文涛,魏金峰,靳洪涛,王爱平.华卟啉钠的光漂白性质研究[J].癌变·畸变·突变,2016,28:81-90.
[9]MAI B,WANG X,LIU Q,LEUNG A W,WANG X,XU C,et al.The antibacterial effect of sinoporphyrin sodium photodynamic therapy on Staphylococcus aureus planktonic and biofilm cultures[J].Lasers Surg Med,2016,48:400-408.
[10]LIN N,LI C,WANG Z,ZHANG J,YE X,GAO W,et al.A safety study of a novel photosensitizer,sinoporphyrin sodium,for photodynamic therapy in Beagle dogs[J].Photochem Photobiol Sci,2015,14:815-832.
[11]SHI R,LIN X,ZHANG J,JIN H,WANG A,WEI J.Safety evaluation of repeated intravenous infusion of sinoporphyrin with and without PDT in rats[J].Photochem Photobiol Sci,2016,15:1366-1376.
[12]SHI R,LI C,JIANG Z,LI W,WANG A,WEI J.Preclinical study of antineoplastic sinoporphyrin sodiumPDT via in vitro and in vivo models[J/OL].Molecules,2017,22:112.doi:10.3390/molecules22010112.
[13]WANG X,HU J,WANG P,ZHANG S,LIU Y,XIONGW,et al.Analysis of the in vivo and in vitro effects of photodynamic therapy on breast cancer by using a sensitizer,sinoporphyrin sodium[J].Theranostics,2015,5:772-786.
[14]胡建敏.新型光敏剂华卟啉钠介导的光动力疗法对小鼠乳腺癌抗肿瘤效应研究[D].西安:陕西师范大学,2015.
[15]WU L,WANG X,LIU Q,WINGNANG LEUNG A,WANG P,XU C.Sinoporphyrin sodium mediated photodynamic therapy inhibits the migration associated with collapse of F-actin filaments cytoskeleton in MDA-MB-231 cells[J].Photodiagnosis Photodyn Ther,2016,13:58-65.
[16]XIONG W,WANG X,HU J,LIU Y,LIU Q,WANGP.Comparative study of two kinds of repeated photodynamic therapy strategies in breast cancer by using a sensitizer,sinoporphyrin sodium[J].J Photochem Photobiol B,2016,160:299-305.
[17]HU J,WANG X,LIU Q,ZHANG K,XIONG W,XU C,et al.Antitumor effect of sinoporphyrin sodium-mediated photodynamic therapy on human esophageal cancer Eca-109 cells[J].Photochem Photobiol,2014,90:1404-1412.
[18]吕海燕.新型光敏剂以醚键结合的卟啉二聚体盐(DVDMS-2)的初步临床前研究[D].厦门:厦门大学,2012.
[19]姜智换,史蕤,李超,王爱平.华卟啉钠介导的光动力疗法在体外和体内对肿瘤生长的抑制作用[J].癌变·畸变·突变,2013,25:163-167.
[20]CHUNG C,KIM Y K,SHIN D,RYOO S R,HONG BH,MIN D H.Biomedical applications of graphene and graphene oxide[J].Acc Chem Res,2013,46:2211-2224.
[21]HUANG C,CHU C C,ZHANG J,GAO H Y,LIU G.First Sino-German Symposium on“Singlet molecular oxygen and photodynamic effects”:antitumor effect of sinoporphyrin sodium loaded graphene oxide on human liver cancer HepG2 cells[J].Photon Lasers Med,2015,4:365-368.
[22]YAN X,NIU G,LIN J,JIN A J,HU H,TANG Y,et al.Enhanced fluorescence imaging guided photodynamic therapy of sinoporphyrin sodium loaded graphene oxide[J].Biomaterials,2015,42:94-102.
[23]YAN X,HU H,LIN J,JIN A J,NIU G,ZHANG S,et al.Optical and photoacoustic dual-modality imaging guided synergistic photodynamic/photothermal therapies[J].Nanoscale,2015,7:2520-2526.
[24]Y U M I TA N,N I S H I G A K I R,U M E M U R A K,UMEMURA S.Hematoporphyrin as a sensitizer of celldamaging effect of ultrasound[J].Jpn J Cancer Res,1989,80:219-222.
[25]XIONG W,WANG P,HU J,JIA Y,WU L,CHEN X,et al.A new sensitizer DVDMS combined with multiple focused ultrasound treatments:an effective antitumor strategy[J/OL].Sci Rep,2015,5:17485.doi:10.1038/srep17485.
[26]WANG H,WANG P,LI L,ZHANG K,WANG X,LIU Q.Microbubbles enhance the antitumor effects of sinoporphyrin sodium mediated sonodynamic therapy both in vitro and in vivo[J].Int J Biol Sci,2015,11:1401-1409.
[27]LIU Y,WANG P,LIU Q,WANG X.Sinoporphyrin sodium triggered sono-photodynamic effects on breast cancer both in vitro and in vivo[J].Ultrason Sonochem,2016,31:437-448.
[28]李晖,谢树森.采用X射线间接激励光敏剂的光动力学疗法新设想[J].中国激光医学杂志,1997,6:63-65.
[29]李晓龙.初步探究华卟啉钠的放疗增敏作用[D].石家庄:河北医科大学,2016.