持续和间歇低氧运动对肥胖大鼠体重及相关代谢指标的影响
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摘要
在常氧和低氧(常氧安静组、间歇常氧运动组、持续常氧运动组、低氧安静组、间歇低氧运动组和持续低氧运动组)环境中,建立肥胖造模SD大鼠暴露和水槽游泳运动方案。游泳训练持续8周,每周5d,每天定时称测大鼠24h内饲料消耗量;训练结束后处死大鼠,测定体重、体长及内脏脂肪重,并采血检测血脂、血糖、胰岛素和瘦素。结果表明:常氧运动后肥胖大鼠摄食量增加,而与其相对的低氧运动大鼠摄食量却减少;常氧和低氧运动对肥胖大鼠均有很好的减重作用,低氧运动较常氧运动作用更加明显,而以持续低氧运动效果最佳;常氧、低氧运动和单纯低氧均引起肥胖大鼠胆固醇、三酰甘油、低密度脂蛋白、血糖和胰岛素降低或呈降低趋势,而高密度脂蛋白和瘦素升高或呈升高趋势;大鼠内脏脂肪积累与体重变化一致。
To study the effect of continuous and intermittent hypoxic exercise on body composition,blood lipids,glucose,insulin and leptin in obese rats,the obese model rats were randomly divided into 6groups:normoxic sedentary exposure,intermittent normoxic exercise,continuous normoxic exercise,hypoxic sedentary exposure,intermittent hypoxic exercise and continuous hypoxic exercise.Under normoxic and hypoxic conditions,rats were exposed and trained by swimming exercise for 8weeks,5days per week.Diet consumption of rats was measured every day.After training,body weight and stem length of rats were measured.Their blood and visceral fat were collected.Blood lipids,glucose,insulin and leptin were determined.Normoxic exercise increased diet of obese rats,but hypoxic exercise decreased it.Normoxic and hypoxic exercise had weight relief for obese rats.Comparing with normoxic exercise,hypoxic exercise showed more significant effect.Continuous hypoxic exercise was most significant in all groups.Normoxic exercise,hypoxic exercise and hypoxic condition decreased blood TC,TG,LDL-C,glucose and insulin in rats or showed trend,increased HDL-C and leptin or showed trend.Hypoxic exercise improved blood lipids and glucose metabolism,decreased body weight of rats.Continuous normoxic exercise was better than intermittent normoxic exercise.
To study the effect of continuous and intermittent hypoxic exercise on body composition,blood lipids,glucose,insulin and leptin in obese rats,the obese model rats were randomly divided into 6groups:normoxic sedentary exposure,intermittent normoxic exercise,continuous normoxic exercise,hypoxic sedentary exposure,intermittent hypoxic exercise and continuous hypoxic exercise.Under normoxic and hypoxic conditions,rats were exposed and trained by swimming exercise for 8weeks,5days per week.Diet consumption of rats was measured every day.After training,body weight and stem length of rats were measured.Their blood and visceral fat were collected.Blood lipids,glucose,insulin and leptin were determined.Normoxic exercise increased diet of obese rats,but hypoxic exercise decreased it.Normoxic and hypoxic exercise had weight relief for obese rats.Comparing with normoxic exercise,hypoxic exercise showed more significant effect.Continuous hypoxic exercise was most significant in all groups.Normoxic exercise,hypoxic exercise and hypoxic condition decreased blood TC,TG,LDL-C,glucose and insulin in rats or showed trend,increased HDL-C and leptin or showed trend.Hypoxic exercise improved blood lipids and glucose metabolism,decreased body weight of rats.Continuous normoxic exercise was better than intermittent normoxic exercise.
引文
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[14]王立靖,衣雪洁.耐力训练及限制饮食对单纯性肥胖大鼠脂肪合成的影响[J].北京体育大学学报,2008,31(9):1215-1218.
[2]王惠君,王志宏,李园,等.1993~2004年中国九省成人中心性肥胖流行趋势分析[J].中国食物与营养,2007(6):47-50.
[3]MURLASITS Z,CUTLIOP R G,GERONILLA K B,et al.Resistance trainingincrease heat shock protein levels in skeletal muscle of young and oldrats[J].Exp Gerontol,2006,41:398-406.
[4]赵健亚,王晓珂,刘天娥,等.水通道蛋白7、9在不同肥胖易感大鼠组织中差异表达[J].扬州大学学报(农业与生命科学版),2013,34(4):18-22.
[5]王宁琦,胡扬,官余凌,等.4周低氧运动结合饮食控制对肥胖青年体重、血脂及胰岛素抵抗的影响[J].中国运动医学杂志,2012,31(4):289-294.
[6]邱烈峰.低氧运动对营养性肥胖大鼠体脂代谢的影响及其机制分析[J].现代预防医学,2013,40(20):3833-3835.
[7]MELOV S,TARNOPOLSKY M A,BECKMAN K,et al.Resistanceexercise reverses aging in human skeletal muscle[J].PLoS ONE,2007,2(5):e465.
[8]邱烈峰,林文弢,翁锡全.间歇低氧运动对肥胖大鼠体成分的影响[J].山东体育学院学报,2008,24(7):41-44.
[9]KHALID S A,JEFFREY A P,SAMUEL B G.Effects of split exercise sessions on excess post exercise oxygen consumption and resting metabolic rate[J].Physiol,1998,23(5):433-443.
[10]ASTRUP A.The role of energy expenditure in the development of obesity[J].Int J Obesity,1998,22(3):S68.
[11]NI K,STEGER K,YANG H,et al.Expression and role of leptin under hypoxic conditions in human testis:organotypic in vitro culture experiment and clinical study on patients with varicocele[J].J Urol,2015,193(1):360-367.
[12]李旭辉,范晓梅,薛明明,等.16周有氧运动处方对肥胖初中生血浆瘦素水平和血脂代谢的影响[J].沈阳体育学院学报,2014,33(1):79-82.
[13]SONG W,KWAK H B,LAWLER J M.Exercise training attenuates age-induced changes in apoptotic signaling in rat skeletal muscle[J].Antioxid Redox Signal,2006,8(3/4):517-528.
[14]王立靖,衣雪洁.耐力训练及限制饮食对单纯性肥胖大鼠脂肪合成的影响[J].北京体育大学学报,2008,31(9):1215-1218.