氢气在呼吸系统疾病模型中的应用及相关机制研究进展
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摘要
<正>氢气是密度最小且无色无味的气体,具有可燃性和一定还原性,曾被认为是一种生理性惰性气体。2007年Ohsawa等[1]提出氢气可选择性清除氧自由基,并在大鼠脑缺血再灌注模型中证实氢气的保护作用,开启了氢气医学研究和应用的新纪元。迄今研究已证实氢气对多个脏器缺血再灌注损伤、神经退行性疾病、骨关节疾病及呼吸系统疾病等具
引文
1 Ohsawa I, Ishikawa M, Takahashi K, et al. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med, 2007, 13(6):688-694.
2 Ohno K, Ito M, Ichihara M, et al. Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases. Oxid Med Cell Longev, 2012, 2012:353152.
3 Lin Y, Ohkawara B, Ito M, et al. Molecular hydrogen suppresses activated Wnt/β-catenin signaling. Sci Rep, 2016, 6:31986.
4 Ning YY, Shang Y, Huang HD, et al. Attenuation of cigarette smoke-induced airway mucus production by hydrogen-rich saline in rats. PLoS One, 2013, 8:e83429.
5 Liu X, Ma C, Wang X, et al. Hydrogen coadministration slows the development of COPD-like lung disease in a cigarette smokeinduced rat model. Int J Chron Obstruct Pulmon Dis, 2017, 12:1309-1324.
6 Suzuki Y, Sato T, Sugimoto M, et al. Hydrogen-rich pure water prevents cigarette smoke-induced pulmonary emphysema in SMP30 knockout mice. Biochem Biophys Res Commun, 2017,492(1):74-81.
7张宁,张景熙.吸入高浓度氢气对大鼠支气管哮喘的治疗作用.国际呼吸杂志,2015, 35(3):179-182.
8 Xiao M, Zhu T, Wang T, et al. Hydrogen-rich saline reduces airway remodeling via inactivation of NF-κB in a murine model of asthma.Eur Rev Med Pharmacol Sci,2013, 17(8):1033-1043.
9 Liu H, Liang X, Wang D, et al. Combination therapy with nitric oxide and molecular hydrogen in a murine model of acute lunginjury. Shock, 2015,43(5):504-511.
10 Xie K, Yu Y, Huang Y, et al. Molecular hydrogen ameliorates lipopolysaccharide-induced acute lung injury in mice through reducing inflammation and apoptosis. Shock, 2012, 37(5):548-555.
11 Qiu X, Li H, Tang H, et al. Hydrogen inhalation ameliorates lipopolysaccharide-induced acute lung injury in mice. Int Immunopharmacol, 2011, 11(12):2130-2137.
12 Zhang Y, Liu Y, Zhang J. Saturated hydrogen saline attenuates endotoxin-induced lung dysfunction. J Surg Res, 2015, 198(1):41-49.
13 Tao B, Liu L, Wang N, et al. Effects of hydrogen-rich saline on aquaporin 1, 5 in septic rat lungs. J Surg Res, 2016, 202(2):291-298.
14 Liu LD, Wu XY, Tao BD, et al. Protective effect and mechanism of hydrogen treatment on lung epithelial barrier dysfunction in rats with sepsis. Genet Mol Res, 2016,15(1):gmr. 15016050.
15 Wang K, Song X, Duan S, et al. Hydrogen-rich saline prevents the down regulation of claudin-5 protein in septic rat lung via the PI3K/Akt signaling pathway. Int J Clin Exp Med, 2017, 10(8):11717-11727.
16张红涛,刘玲玲,于洋,等.Rho/ROCK信号通路在氢气改善脓毒症小鼠急性肺损伤中的作用.中华危重病急救医学,2016, 28(5):401-406.
17边映雪,秦超,谢克亮,等.吸入氢气对脓毒症小鼠急性肺损伤时蛋白质组学的影响.中华麻醉学杂志,2017, 37(2):218-223.
18 Liu S, Liu K, Sun Q, et al. Consumption of hydrogen water reduces paraquat-induced acute lung injury in rats. J Biomed Biotechnol,2011,2011:305086.
19 Zhang HL, Liu YF, Luo XR, et al. Saturated hydrogen saline protects rats from acute lung injury induced by paraquat. World J Emerg Med, 2011, 2(2):149-153.
20 Ying Y, Xu H, Yao M, et al. Protective effect of hydrogen-saturated saline on acute lung injury induced by oleic acid in rats. J Orthop Surg Res, 2017,12:134.
21 Diao M, Zhang S, Wu L, et al. Hydrogen gas inhalation attenuates seawater instillation-induced acute lung injury via the Nrf2pathway in rabbits. Inflammation, 2016, 39(1):2029-2039.
22 Huang CS, Kawamura T, Lee S, et al. Hydrogen inhalation ameliorates ventilator-induced lung injury. Crit Care, 2010, 14(6):R234.
23 Huang CS, Kawamura T, Peng X, et al. Hydrogen inhalation reduced epithelial apoptosis in ventilator-induced lung injury via a mechanism involving nuclear factor-kappa B activation. Biochem Biophys Res Commun, 2011, 408(2):253-258.
24 Terasaki Y,Suzuki T, Tonaki K, et al. Molecular hydrogen attenuates gefitinib-induced exacerbation of naphthalene-evoked acute lung injury through a reduction in oxidative stress and inflammation. Lab Invest, 2019 Feb 1.[Epub ahead of print]
25刘琪,王大为,陈兴,等.氢气对吸入性损伤大鼠急性肺损伤的保护作用及量效研究.天津医科大学学报,2013, 19(6):445-448.
26 Fang Y, Fu XJ, Gu C, et al. Hydrogen-rich saline protects against acute lung injury induced by extensive burn in rat model. J Burn Care Res, 2011, 32(3):e82-e91.
27秦超,边映雪,冯甜甜,等.氢对烧伤小鼠肺损伤炎症反应时自噬的影响.中华麻醉学杂志,2018, 38(5):610-613.
28 Terasaki Y, Ohsawa I, Terasaki M, et al. Hydrogen therapy attenuates irradiation-induced lung damage by reducing oxidative stress. Am J Physiol Lung Cell Mol Physiol, 2011, 301(4):L415-L426.
29 Kawamura T, Wakabayashi N, Shigemura N, et al. Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo. Am J Physiol Lung Cell Mol Physiol, 2013, 304(10):L646-L656.
30 Sun Q, Han W, Hu H, et al. Hydrogen alleviates hyperoxic acute lung injury related endoplasmic reticulum stress in rats through upregulation of SIRT1. Free Radic Res, 2017, 51(6):622-632.
31 Kawamura T, Huang CS, Tochigi N, et al. Inhaled hydrogen gas therapy for prevention of lung transplant-induced ischemia/reperfusion injury in rats. Transplantation, 2010, 90(12):1344-1351.
32 Kawamura T, Huang CS, Peng X, et al. The effect of donor treatment with hydrogen on lung allograft function in rats.Surgery, 2011, 150(2):240-249.
33 Zhou H, Fu Z, Wei Y, et al. Hydrogen inhalation decreases lung graft injury in brain-dead donor rats. J Heart Lung Transplant,2013, 32(2):251-258.
34 Tanaka Y, Shigemura N, Kawamura T, et al. Profiling molecular changes induced by hydrogen treatment of lung allografts prior to procurement. Biochem Biophys Res Commun, 2012, 425(4):873-879.
35 Kohama K, Yamashita H, Aoyama-Ishikawa M, et al. Hydrogen inhalation protects against acute lung injury induced by hemorrhagic shock and resuscitation. Surgery, 2015, 158(2):399-407.
36 Choi J, Suk An E, Ban YH, et al. Hydrogen-enriched water eliminates fine particles from the lungs and blood by enhancing phagocytic activity. J Biomed Res, 2017.[Epub ahead of print]
37 Wang DC, Wang LF, Zhang Y, et al. Hydrogen gas inhibits lung cancer progression through targeting SMC3. Biomed Pharmacother, 2018.104:788-797.
38 Jiang Y, Liu G, Zhang L, et al. Therapeutic efficacy of hydrogenrich saline alone and in combination with PI3K inhibitor in nonsmall cell lung cancer. Mol Med Rep, 2018, 18(2):2182-2190.
39王东昌,赵云霞,赵志芳,等.氢气干预抑制非小细胞肺癌生长的作用及其机制研究..国际呼吸杂志,2018, 38(8):561-565.
40 Itoh T, Fujita Y, Ito M, et al. Molecular hydrogen suppresses FceRI-mediated signal transduction and prevents degranulation of mast. Biochem Biophys Res Commun, 2009, 389(4):651-656.
41 Ren JD, Ma J, Hou J, et al. Hydrogen-rich saline inhibits NLRP3inflammasome activation and attenuates experimental acute pancreatitis in mice. Mediators Inflamm, 2014, 2014:930894.
42 Sobue S, Yamai K, Ito M, et al. Simultaneous oral and inhalational intake of molecular hydrogen additively suppresses signaling pathways in rodents. Mol Cell Biochem, 2015,403(1-2):231-241.
43 Iuchi K, Imoto A, Kamimura N, et al. Molecular hydrogen regulates gene expression by modifying the free radical chain reaction-dependent generation of oxidized phospholipid mediators. Sci Rep, 2016, 6:18971.
44 Yoritaka A, Takanashi M, Hirayama M, et al. Pilot study of H_2therapy in Parkinson's disease:a randomized double-blind placebo-controlled trial. Mov Disord, 2013, 28(6):836-839.
45 Song G, Lin Q, Zhao H, et al. Hydrogen Activates ATP-binding cassette transporter Al-dependent efflux ex vivo and improves high-density lipoprotein function in patients with hypercholesterolemia:a double-blinded, randomized, and placebocontrolled trial. J Clin Endocrinol Metab, 2015, 100(7):2724-2733.
46 Ishibashi T, Sato B, Rikitake M, et al. Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis:an open-label pilot study. Med Gas Res, 2012, 2(1):27.
47 Nakao A, Toyoda Y, Sharma P, et al. Effectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic syndrome-an open label pilot study. J Clin Biochem Nutr, 2010,46(2):140-149.
48龚志晶,关继涛,任雪珠,等.氢气对环卫工人雾霾暴露肺保护性作用的研究.中华结核和呼吸杂志,2016, 39(12):916-923.
2 Ohno K, Ito M, Ichihara M, et al. Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases. Oxid Med Cell Longev, 2012, 2012:353152.
3 Lin Y, Ohkawara B, Ito M, et al. Molecular hydrogen suppresses activated Wnt/β-catenin signaling. Sci Rep, 2016, 6:31986.
4 Ning YY, Shang Y, Huang HD, et al. Attenuation of cigarette smoke-induced airway mucus production by hydrogen-rich saline in rats. PLoS One, 2013, 8:e83429.
5 Liu X, Ma C, Wang X, et al. Hydrogen coadministration slows the development of COPD-like lung disease in a cigarette smokeinduced rat model. Int J Chron Obstruct Pulmon Dis, 2017, 12:1309-1324.
6 Suzuki Y, Sato T, Sugimoto M, et al. Hydrogen-rich pure water prevents cigarette smoke-induced pulmonary emphysema in SMP30 knockout mice. Biochem Biophys Res Commun, 2017,492(1):74-81.
7张宁,张景熙.吸入高浓度氢气对大鼠支气管哮喘的治疗作用.国际呼吸杂志,2015, 35(3):179-182.
8 Xiao M, Zhu T, Wang T, et al. Hydrogen-rich saline reduces airway remodeling via inactivation of NF-κB in a murine model of asthma.Eur Rev Med Pharmacol Sci,2013, 17(8):1033-1043.
9 Liu H, Liang X, Wang D, et al. Combination therapy with nitric oxide and molecular hydrogen in a murine model of acute lunginjury. Shock, 2015,43(5):504-511.
10 Xie K, Yu Y, Huang Y, et al. Molecular hydrogen ameliorates lipopolysaccharide-induced acute lung injury in mice through reducing inflammation and apoptosis. Shock, 2012, 37(5):548-555.
11 Qiu X, Li H, Tang H, et al. Hydrogen inhalation ameliorates lipopolysaccharide-induced acute lung injury in mice. Int Immunopharmacol, 2011, 11(12):2130-2137.
12 Zhang Y, Liu Y, Zhang J. Saturated hydrogen saline attenuates endotoxin-induced lung dysfunction. J Surg Res, 2015, 198(1):41-49.
13 Tao B, Liu L, Wang N, et al. Effects of hydrogen-rich saline on aquaporin 1, 5 in septic rat lungs. J Surg Res, 2016, 202(2):291-298.
14 Liu LD, Wu XY, Tao BD, et al. Protective effect and mechanism of hydrogen treatment on lung epithelial barrier dysfunction in rats with sepsis. Genet Mol Res, 2016,15(1):gmr. 15016050.
15 Wang K, Song X, Duan S, et al. Hydrogen-rich saline prevents the down regulation of claudin-5 protein in septic rat lung via the PI3K/Akt signaling pathway. Int J Clin Exp Med, 2017, 10(8):11717-11727.
16张红涛,刘玲玲,于洋,等.Rho/ROCK信号通路在氢气改善脓毒症小鼠急性肺损伤中的作用.中华危重病急救医学,2016, 28(5):401-406.
17边映雪,秦超,谢克亮,等.吸入氢气对脓毒症小鼠急性肺损伤时蛋白质组学的影响.中华麻醉学杂志,2017, 37(2):218-223.
18 Liu S, Liu K, Sun Q, et al. Consumption of hydrogen water reduces paraquat-induced acute lung injury in rats. J Biomed Biotechnol,2011,2011:305086.
19 Zhang HL, Liu YF, Luo XR, et al. Saturated hydrogen saline protects rats from acute lung injury induced by paraquat. World J Emerg Med, 2011, 2(2):149-153.
20 Ying Y, Xu H, Yao M, et al. Protective effect of hydrogen-saturated saline on acute lung injury induced by oleic acid in rats. J Orthop Surg Res, 2017,12:134.
21 Diao M, Zhang S, Wu L, et al. Hydrogen gas inhalation attenuates seawater instillation-induced acute lung injury via the Nrf2pathway in rabbits. Inflammation, 2016, 39(1):2029-2039.
22 Huang CS, Kawamura T, Lee S, et al. Hydrogen inhalation ameliorates ventilator-induced lung injury. Crit Care, 2010, 14(6):R234.
23 Huang CS, Kawamura T, Peng X, et al. Hydrogen inhalation reduced epithelial apoptosis in ventilator-induced lung injury via a mechanism involving nuclear factor-kappa B activation. Biochem Biophys Res Commun, 2011, 408(2):253-258.
24 Terasaki Y,Suzuki T, Tonaki K, et al. Molecular hydrogen attenuates gefitinib-induced exacerbation of naphthalene-evoked acute lung injury through a reduction in oxidative stress and inflammation. Lab Invest, 2019 Feb 1.[Epub ahead of print]
25刘琪,王大为,陈兴,等.氢气对吸入性损伤大鼠急性肺损伤的保护作用及量效研究.天津医科大学学报,2013, 19(6):445-448.
26 Fang Y, Fu XJ, Gu C, et al. Hydrogen-rich saline protects against acute lung injury induced by extensive burn in rat model. J Burn Care Res, 2011, 32(3):e82-e91.
27秦超,边映雪,冯甜甜,等.氢对烧伤小鼠肺损伤炎症反应时自噬的影响.中华麻醉学杂志,2018, 38(5):610-613.
28 Terasaki Y, Ohsawa I, Terasaki M, et al. Hydrogen therapy attenuates irradiation-induced lung damage by reducing oxidative stress. Am J Physiol Lung Cell Mol Physiol, 2011, 301(4):L415-L426.
29 Kawamura T, Wakabayashi N, Shigemura N, et al. Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo. Am J Physiol Lung Cell Mol Physiol, 2013, 304(10):L646-L656.
30 Sun Q, Han W, Hu H, et al. Hydrogen alleviates hyperoxic acute lung injury related endoplasmic reticulum stress in rats through upregulation of SIRT1. Free Radic Res, 2017, 51(6):622-632.
31 Kawamura T, Huang CS, Tochigi N, et al. Inhaled hydrogen gas therapy for prevention of lung transplant-induced ischemia/reperfusion injury in rats. Transplantation, 2010, 90(12):1344-1351.
32 Kawamura T, Huang CS, Peng X, et al. The effect of donor treatment with hydrogen on lung allograft function in rats.Surgery, 2011, 150(2):240-249.
33 Zhou H, Fu Z, Wei Y, et al. Hydrogen inhalation decreases lung graft injury in brain-dead donor rats. J Heart Lung Transplant,2013, 32(2):251-258.
34 Tanaka Y, Shigemura N, Kawamura T, et al. Profiling molecular changes induced by hydrogen treatment of lung allografts prior to procurement. Biochem Biophys Res Commun, 2012, 425(4):873-879.
35 Kohama K, Yamashita H, Aoyama-Ishikawa M, et al. Hydrogen inhalation protects against acute lung injury induced by hemorrhagic shock and resuscitation. Surgery, 2015, 158(2):399-407.
36 Choi J, Suk An E, Ban YH, et al. Hydrogen-enriched water eliminates fine particles from the lungs and blood by enhancing phagocytic activity. J Biomed Res, 2017.[Epub ahead of print]
37 Wang DC, Wang LF, Zhang Y, et al. Hydrogen gas inhibits lung cancer progression through targeting SMC3. Biomed Pharmacother, 2018.104:788-797.
38 Jiang Y, Liu G, Zhang L, et al. Therapeutic efficacy of hydrogenrich saline alone and in combination with PI3K inhibitor in nonsmall cell lung cancer. Mol Med Rep, 2018, 18(2):2182-2190.
39王东昌,赵云霞,赵志芳,等.氢气干预抑制非小细胞肺癌生长的作用及其机制研究..国际呼吸杂志,2018, 38(8):561-565.
40 Itoh T, Fujita Y, Ito M, et al. Molecular hydrogen suppresses FceRI-mediated signal transduction and prevents degranulation of mast. Biochem Biophys Res Commun, 2009, 389(4):651-656.
41 Ren JD, Ma J, Hou J, et al. Hydrogen-rich saline inhibits NLRP3inflammasome activation and attenuates experimental acute pancreatitis in mice. Mediators Inflamm, 2014, 2014:930894.
42 Sobue S, Yamai K, Ito M, et al. Simultaneous oral and inhalational intake of molecular hydrogen additively suppresses signaling pathways in rodents. Mol Cell Biochem, 2015,403(1-2):231-241.
43 Iuchi K, Imoto A, Kamimura N, et al. Molecular hydrogen regulates gene expression by modifying the free radical chain reaction-dependent generation of oxidized phospholipid mediators. Sci Rep, 2016, 6:18971.
44 Yoritaka A, Takanashi M, Hirayama M, et al. Pilot study of H_2therapy in Parkinson's disease:a randomized double-blind placebo-controlled trial. Mov Disord, 2013, 28(6):836-839.
45 Song G, Lin Q, Zhao H, et al. Hydrogen Activates ATP-binding cassette transporter Al-dependent efflux ex vivo and improves high-density lipoprotein function in patients with hypercholesterolemia:a double-blinded, randomized, and placebocontrolled trial. J Clin Endocrinol Metab, 2015, 100(7):2724-2733.
46 Ishibashi T, Sato B, Rikitake M, et al. Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis:an open-label pilot study. Med Gas Res, 2012, 2(1):27.
47 Nakao A, Toyoda Y, Sharma P, et al. Effectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic syndrome-an open label pilot study. J Clin Biochem Nutr, 2010,46(2):140-149.
48龚志晶,关继涛,任雪珠,等.氢气对环卫工人雾霾暴露肺保护性作用的研究.中华结核和呼吸杂志,2016, 39(12):916-923.