生物检材中甲基苯丙胺分析方法研究进展
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摘要
甲基苯丙胺(MAM)是国内、外药物滥用最为广泛且因此,发展快速、准确的MAM检测方法对法医学研究、打击犯罪等方面都有重要的意义。本文对近年来国内外有关在生物检材中进行甲基苯丙胺测定的薄层色谱法、气相色谱法、高效液相色谱法、毛细管电泳法、免疫分析法等方法进行了归纳和综述,并提出了甲基苯丙胺分析方法的发展方向。
Methamphetamine is one of the most widely used and harmful drugs in the world. Therefore, it is important to develop fast and accurate MAM detection methods for forensic medicine and prevention of crime. This paper generalized the methods for the determination of methamphetamine in bio-materials at home and abroad in recent years, including the thin layer chromatography(TLC), gas chromatography(GC), high performance liquid chromatography(HPLC), capillary electrophoresis(CE) and immunoassay(IA) etc, and put forward the development direction of methamphetamine detection.
Methamphetamine is one of the most widely used and harmful drugs in the world. Therefore, it is important to develop fast and accurate MAM detection methods for forensic medicine and prevention of crime. This paper generalized the methods for the determination of methamphetamine in bio-materials at home and abroad in recent years, including the thin layer chromatography(TLC), gas chromatography(GC), high performance liquid chromatography(HPLC), capillary electrophoresis(CE) and immunoassay(IA) etc, and put forward the development direction of methamphetamine detection.
引文
[1]李桢,胡早秀,刘清,等.甲基苯丙胺体内藏毒致急性中毒死亡法医学检验及其毒品危害[J].中国药物依赖性杂志,2005,14(6):453-456.
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[9]陈朝阳,王玉瑾.薄层色谱扫描法检测血浆中苯丙胺与3,4-亚甲基二氧基甲基苯丙胺[J].山西医科大学学报,2003,34(2):99-100.
[10]李雯佳,廖林川,陈礼莉,等.GC法检测血液和尿液中甲基苯丙胺和咖啡因[J].中国法医学杂志,2009,24(1):11-14.
[11]郭鹏,许晓宇,谢文林.响应面法优化-固相萃取-气相色谱法测定尿液中甲基苯丙胺[J].理化检验:化学分册,2013,49(10):1205-1205.
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[13]Pujadas M,Pichini S,Poudevida S,et al.Development and validation of a gas chromatography-mass spectrometry assay for hair analysis of amphetamine,methamphetamine and methylenedioxy derivatives[J].J.Chromatogr B,2003,798(2):249-255.
[14]Al-Dirbashi O,Kuroda N,Nakashima K,et al.HPLCwith fluorescence detection of methamphetamine and amphetamine in segmentally analyzed human hair[J].Analyst,1999,124(4):493-497.
[15]张小婷,刘娟,杜晖玲,等.超高效液相色谱法(UPLC)同时筛选检测吗啡等7种常见毒品[J].刑事技术,2008(6):11-12+18
[16]王伟,乔湜,张文芳,等.液-质联用法对人血浆中吗啡类,氯胺酮和苯丙胺类9种毒品的定性定量检测[J].中国运动医学杂志,2017,36(7):622-627.
[17]王朝虹,张琳,赵蒙,等.超高效液相色谱-MS/MS法测定血中11种苯丙胺类物质[J].中国法医学杂志,2015,30(3):260-264.
[18]吴国萍,相秉仁.近红外光谱技术应用于摇头丸中MDMA,MA无损定量分析的研究[J].分析测试学报,2007,26(5):698-701.
[19]Weng S,Dong R,Zhu Z,et al.Dynamic surface-enhanced Raman spectroscopy and Chemometric methods for fast detection and intelligent identification of methamphetamine and 3,4-Methylenedioxy methamphetamine in human urine[J].Spectrochim Acta A Mol Biomol Spectrosc,2018,189:1-7.
[20]Weinberger R,Lurie I S.Micellar electrokinetic capillary chromatography of illicit drug substances[J].Anal Chem,1991,63(8):823-827.
[21]王燕燕,孟品佳.唾液中苯丙胺类毒品的毛细管区带电泳在线富集检测[J].分析测试学报,2008,27(5):463-466.
[22]江静,刘一兵,周棱,等.甲基苯丙胺免疫层析测试条的研制[J].同位素,2004,17(2):79-83.
[23]陈明山,吉琼梅,赵芳,等.甲基苯丙胺稀土荧光试纸条的研制[J].中国法医学杂志,2013,28(4):272-274.
[24]张雪娜,钟新文,钟岩.运用电化学方法快速检测冰毒的研究[J].赤峰学院学报(自然科学版),2015,31(19):27-29.
[25]Bartlett C A,Taylor S,Fernandez C,et al.Disposable screen printed sensor for the electrochemical detection of methamphetamine in undiluted saliva[J].Chem Cent J,2016,10(1):3-3.
[26]Arenas L F,Ebarvia B S,Sevilla F B.Enantioselective piezoelectric quartz crystal sensor for d-methamphetamine based on a molecularly imprinted polymer[J].Anal Bioanal Chem,2010,397(7):3155-3158.
[27]Han C,Shang Z,Zhang H,et al.Detection of hidden drugs with a molecularly imprinted electrochemiluminescence sensor[J].Anal Methods,2013,5(21):6064-6070.
[2]高卫民,宛洋,毛瑞明,等.甲基苯丙胺的中毒机制及中毒死亡法医学鉴定[J].法医学杂志,2012,28(2):126-129.
[3]Sull T J,Chass G A,Varro A,et al.A comparative conformational analysis of selected central nervous system stimulants[J].J Mol Struct,2003,623(1):51-62.
[4]李继印,刘青青,任国印,等.甲基苯丙胺检测方法的研究进展[J].河南科技大学学报(医学版),2016,34(3):236-240.
[5]胡文兵,谭锐.甲基苯丙胺检测方法研究进展[J].中国科技信息,2016(19):68-69.
[6]徐泽琼,李喜青,刘煜,等.HPLC-MS/MS测定水中甲基苯丙胺和苯丙胺的手性比例[A].中国化学会、国家自然科学基金委员会.中国化学会第二届全国质谱分析学术报告会会议摘要集[C].中国化学会、国家自然科学基金委员会:2015:1.
[7]李宏森,黄克建,林翠梧,等.顶空固相微萃取与气质联用快速检测尿液中苯丙胺、甲基苯丙胺、MDA和MDMA[J].广西大学学报(自然科学版),2007(3):266-269.
[8]黄建华,陈雪岚.利用胶体金层析法快速检测尿样中的甲基苯丙胺[J].南昌高专学报,2009,24(1):166-168.
[9]陈朝阳,王玉瑾.薄层色谱扫描法检测血浆中苯丙胺与3,4-亚甲基二氧基甲基苯丙胺[J].山西医科大学学报,2003,34(2):99-100.
[10]李雯佳,廖林川,陈礼莉,等.GC法检测血液和尿液中甲基苯丙胺和咖啡因[J].中国法医学杂志,2009,24(1):11-14.
[11]郭鹏,许晓宇,谢文林.响应面法优化-固相萃取-气相色谱法测定尿液中甲基苯丙胺[J].理化检验:化学分册,2013,49(10):1205-1205.
[12]Jurado C,Gimenez M P,Soriano T,et al.Rapid analysis of amphetamine,methamphetamine,MDA,and MDMA in urine using solid-phase microextraction,direct on-fiber derivatization,and analysis by GC-MS[J].J Anal Toxicol,2000,24(1):11-16.
[13]Pujadas M,Pichini S,Poudevida S,et al.Development and validation of a gas chromatography-mass spectrometry assay for hair analysis of amphetamine,methamphetamine and methylenedioxy derivatives[J].J.Chromatogr B,2003,798(2):249-255.
[14]Al-Dirbashi O,Kuroda N,Nakashima K,et al.HPLCwith fluorescence detection of methamphetamine and amphetamine in segmentally analyzed human hair[J].Analyst,1999,124(4):493-497.
[15]张小婷,刘娟,杜晖玲,等.超高效液相色谱法(UPLC)同时筛选检测吗啡等7种常见毒品[J].刑事技术,2008(6):11-12+18
[16]王伟,乔湜,张文芳,等.液-质联用法对人血浆中吗啡类,氯胺酮和苯丙胺类9种毒品的定性定量检测[J].中国运动医学杂志,2017,36(7):622-627.
[17]王朝虹,张琳,赵蒙,等.超高效液相色谱-MS/MS法测定血中11种苯丙胺类物质[J].中国法医学杂志,2015,30(3):260-264.
[18]吴国萍,相秉仁.近红外光谱技术应用于摇头丸中MDMA,MA无损定量分析的研究[J].分析测试学报,2007,26(5):698-701.
[19]Weng S,Dong R,Zhu Z,et al.Dynamic surface-enhanced Raman spectroscopy and Chemometric methods for fast detection and intelligent identification of methamphetamine and 3,4-Methylenedioxy methamphetamine in human urine[J].Spectrochim Acta A Mol Biomol Spectrosc,2018,189:1-7.
[20]Weinberger R,Lurie I S.Micellar electrokinetic capillary chromatography of illicit drug substances[J].Anal Chem,1991,63(8):823-827.
[21]王燕燕,孟品佳.唾液中苯丙胺类毒品的毛细管区带电泳在线富集检测[J].分析测试学报,2008,27(5):463-466.
[22]江静,刘一兵,周棱,等.甲基苯丙胺免疫层析测试条的研制[J].同位素,2004,17(2):79-83.
[23]陈明山,吉琼梅,赵芳,等.甲基苯丙胺稀土荧光试纸条的研制[J].中国法医学杂志,2013,28(4):272-274.
[24]张雪娜,钟新文,钟岩.运用电化学方法快速检测冰毒的研究[J].赤峰学院学报(自然科学版),2015,31(19):27-29.
[25]Bartlett C A,Taylor S,Fernandez C,et al.Disposable screen printed sensor for the electrochemical detection of methamphetamine in undiluted saliva[J].Chem Cent J,2016,10(1):3-3.
[26]Arenas L F,Ebarvia B S,Sevilla F B.Enantioselective piezoelectric quartz crystal sensor for d-methamphetamine based on a molecularly imprinted polymer[J].Anal Bioanal Chem,2010,397(7):3155-3158.
[27]Han C,Shang Z,Zhang H,et al.Detection of hidden drugs with a molecularly imprinted electrochemiluminescence sensor[J].Anal Methods,2013,5(21):6064-6070.