近十年法医毒物分析和法医毒理学研究热点统计分析
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摘要
借助Bicomb 2.0软件及SPSS 19.0软件对近十年国内外法医毒物分析和法医毒理学的研究热点进行分析,结果表明国内研究热点可以分为5类:分类1为毒品和精神活性物质的提取方法和样品稳定性研究;分类2为镇静催眠药的代谢和死后分布研究;分类3为农药的快速检测方法开发;分类4为分析方法的完善和标准化研究;分类5为新型毒物"γ-羟基丁酸"和"合成大麻素"的检测方法研究。国际研究热点分为6类:分类1为传统精神活性物质、乙醇和样品稳定性的研究;分类2为芬太尼的分析研究;分类3为氰化物的检测和毒理学研究;分类4为新型精神活性物质的检测图库建立和分析方法开发;分类5为镇静催眠药的研究;分类6为丁烷及其引起的猝死案例的研究。同时,对近十年国际合作法医毒物学研究进行了网络可视化分析。
Bicomb 2.0 software and SPSS 19.0 software were used to analyze the research hotspots of forensic toxicology and forensic toxicology in the past ten years. The results showed that domestic research hotspots can be divided into 5 categories. Category 1 is about the extraction and detection methods of drugs and psychoactive substances;Category 2 is the in vivo metabolism and mortal re-distribution studies of sedative hypnotics; Category 3 is focused on the rapid detection methods of pesticides; Category 4 is the standardization and improvements of methods; Category 5 is the research on the detection methods of "gamma-hydroxybutyric acid" and "synthetic cannabinoids." International research hotspots are divided into 6 categories: Category 1 includes researches on traditional psychoactive substances, ethanol,and sample stability; Category 2 is the analyses of fentanyl; Category 3 is the toxicology studies of cyanide; Category 4 includes the establishments of test libraries and analytical methods for novel drugs and psychoactive substances; Category5 is the study of sedative hypnotics; Category 6 is the study of sudden death cases caused by butane. At the same time, we have conducted a network visualization analysis of international cooperation in forensic toxicology in the last decade.
Bicomb 2.0 software and SPSS 19.0 software were used to analyze the research hotspots of forensic toxicology and forensic toxicology in the past ten years. The results showed that domestic research hotspots can be divided into 5 categories. Category 1 is about the extraction and detection methods of drugs and psychoactive substances;Category 2 is the in vivo metabolism and mortal re-distribution studies of sedative hypnotics; Category 3 is focused on the rapid detection methods of pesticides; Category 4 is the standardization and improvements of methods; Category 5 is the research on the detection methods of "gamma-hydroxybutyric acid" and "synthetic cannabinoids." International research hotspots are divided into 6 categories: Category 1 includes researches on traditional psychoactive substances, ethanol,and sample stability; Category 2 is the analyses of fentanyl; Category 3 is the toxicology studies of cyanide; Category 4 includes the establishments of test libraries and analytical methods for novel drugs and psychoactive substances; Category5 is the study of sedative hypnotics; Category 6 is the study of sudden death cases caused by butane. At the same time, we have conducted a network visualization analysis of international cooperation in forensic toxicology in the last decade.
引文
[1]廖林川.法医毒物分析[M].北京:人民卫生出版社,2016.
[2]刘良.法医毒理学[M].北京:人民卫生出版社,2016.
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[6]向平,卜俊,乔正,等.甲基苯丙胺滥用与司来吉兰服用的区分:尿液中甲基苯丙胺和苯丙胺的手性分析[J].法医学杂志,2017,33(6):599-603.
[7]张琳,王朝虹,李虹,等.不同前处理方法对全血中12种毒品成分检测结果的影响[J].中国法医学杂志,2015,30(5):463-467.
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[11]徐恩宇,袁慧雅,高利娜,等.生物检材中乌头碱的LC-MS/MS快速分析[J].中国法医学杂志,2017,32(4):393-396.
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[14]Cappelle D,Neels H,De S K,et al.Ethyl glucuronide in keratinous matrices as biomarker of alcohol use:Acorrelation study between hair and nails[J].Forensic Sci Int,2017,279:187-191.
[15]Chatterton CN,Scottham M.The distribution and redistribution of fentanyl&norfentanyl in post mortem samples.[J].Forensic Sci Int,2017,284:146-152.
[16]Akhgari M,Baghdadi F,Kadkhodaei A.Cyanide poisoning related deaths,a four-year experience and review of the literature[J].Aust J Forensic Sci,2015,48(2):186-194.
[17]Chaudhary MT,Sarwar M,Tahir AM,et al.Rapid and economical colorimetric detection of cyanide in blood using vitamin B12[J].Aust J Forensic Sci,2016,48(1):42-49.
[18]Andresen‐Streichert H,Iwersen‐Bergmann S,Mueller A,et al.Attempted Drug‐facilitated Sexual AssaultXylazine Intoxication in a Child[J].J Forensic Sci,2016,62(1):270.
[19]Véronique AMD,Yvan GPD,Fran?ois CMD,et al.Death from butane inhalation abuse in teenagers:two new case studies and review of the literature[J].J Forensic Sci,2018,63(1):330-335.
[20]Bork T,Celbis O,Petekkaya S,et al.Sudden death in relation to inhaling lighter fluid in adolescents[J].Rom JLeg Med,2017,25(4):379-383.
[2]刘良.法医毒理学[M].北京:人民卫生出版社,2016.
[3]曾立波,胡小龙,张玉荣,等.特异性可卡因核酸适体测试条的研制[J].中国法医学杂志,2014,29(5):424-426.
[4]胡刚,陈连康,胡小龙,等.巴比妥单克隆抗体制备及其免疫学特性鉴定[J].中国法医学杂志,2013,28(3):177-180.
[5]仲利静,林宽,张蕾萍,等.唾液、尿液中甲基苯丙胺浓度分布及初筛情况分析[J].中国法医学杂志,2018,33(1):26-30.
[6]向平,卜俊,乔正,等.甲基苯丙胺滥用与司来吉兰服用的区分:尿液中甲基苯丙胺和苯丙胺的手性分析[J].法医学杂志,2017,33(6):599-603.
[7]张琳,王朝虹,李虹,等.不同前处理方法对全血中12种毒品成分检测结果的影响[J].中国法医学杂志,2015,30(5):463-467.
[8]朱治国,罗洁,徐健君.大体积水系中微量农药的固相萃取柱选择[J].中国法医学杂志,2016,31(6):605-606.
[9]李文海,蔺大伟,孙红雷,等.快速溶剂萃取-气相色谱-质谱联用法分析血液中的农药[J].法医学杂志,2014,V30(6):463-465.
[10]刘俊亭,高利娜,王春媛.百草枯类似物的合成及其还原产物GC/MS确认[J].中国法医学杂志,2013,28(5):371-373.
[11]徐恩宇,袁慧雅,高利娜,等.生物检材中乌头碱的LC-MS/MS快速分析[J].中国法医学杂志,2017,32(4):393-396.
[12]Wang X,Johansen SS,Nielsen M,et al.Hair analysis in toxicological investigation of drug-facilitated crimes in Denmark over a 8-year period[J].Forensic Sci Int,2018,285,E1-E12.
[13]Baillif-Couniou V,Bartoli C,Sastre C,et al.Repeated attempted homicide by administration of drugs documented by hair analysis[J].J Forensic Leg Med,2018,54:82-86.
[14]Cappelle D,Neels H,De S K,et al.Ethyl glucuronide in keratinous matrices as biomarker of alcohol use:Acorrelation study between hair and nails[J].Forensic Sci Int,2017,279:187-191.
[15]Chatterton CN,Scottham M.The distribution and redistribution of fentanyl&norfentanyl in post mortem samples.[J].Forensic Sci Int,2017,284:146-152.
[16]Akhgari M,Baghdadi F,Kadkhodaei A.Cyanide poisoning related deaths,a four-year experience and review of the literature[J].Aust J Forensic Sci,2015,48(2):186-194.
[17]Chaudhary MT,Sarwar M,Tahir AM,et al.Rapid and economical colorimetric detection of cyanide in blood using vitamin B12[J].Aust J Forensic Sci,2016,48(1):42-49.
[18]Andresen‐Streichert H,Iwersen‐Bergmann S,Mueller A,et al.Attempted Drug‐facilitated Sexual AssaultXylazine Intoxication in a Child[J].J Forensic Sci,2016,62(1):270.
[19]Véronique AMD,Yvan GPD,Fran?ois CMD,et al.Death from butane inhalation abuse in teenagers:two new case studies and review of the literature[J].J Forensic Sci,2018,63(1):330-335.
[20]Bork T,Celbis O,Petekkaya S,et al.Sudden death in relation to inhaling lighter fluid in adolescents[J].Rom JLeg Med,2017,25(4):379-383.