针刺深浅与系统生物学
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摘要
目的:从系统生物学角度探讨针刺深浅对机体的影响。方法:概述针刺深浅的概念、意义,并简述系统生物学的概念、内涵,分析针刺深浅与系统生物学的关系及针刺深浅对机体的作用。结果:在系统生物学的基础上,从多个系统,如神经调节系统、皮肤免疫系统、筋膜系统等来论述针刺深浅对机体的作用及其主要的作用机制。结论:在系统生物学的角度探讨针刺深浅的不同影响,不仅对探讨经典针灸深浅理论具有重要意义,也是对研究系统生物学提供了新思路,对于现代针灸学和生命科学的发展都具有深刻的意义。
Objective: To study the effects of deep needling and shallow needling on the body from the aspect the systems biology. Methods: The article summarizes the concept and significance of needling depth, introduces the definition and content of system biology briefly, and analyses the relationship between needling depth and systems biology as well as the effect of needling depth on the body. Results: On the basis of the systems biology, the effects of needling depth on the body and the main mechanism were discussed from multiple aspects, such as neuromodulation, skin immune system, and fascia system. Conclusions: Studying the effects of needling depth on mechanism based on systems biology is not only of great significance to discuss the depth theory of classic acupuncture and moxibustion, but also a new entry point to study the signification of needling depth, but also provided a starting point for systems biology research, which will have a profound influence on acupuncture as well as the development of life sciences.
Objective: To study the effects of deep needling and shallow needling on the body from the aspect the systems biology. Methods: The article summarizes the concept and significance of needling depth, introduces the definition and content of system biology briefly, and analyses the relationship between needling depth and systems biology as well as the effect of needling depth on the body. Results: On the basis of the systems biology, the effects of needling depth on the body and the main mechanism were discussed from multiple aspects, such as neuromodulation, skin immune system, and fascia system. Conclusions: Studying the effects of needling depth on mechanism based on systems biology is not only of great significance to discuss the depth theory of classic acupuncture and moxibustion, but also a new entry point to study the signification of needling depth, but also provided a starting point for systems biology research, which will have a profound influence on acupuncture as well as the development of life sciences.
引文
1杨永清,尹磊淼,徐玉东,等.系统生物学与针灸学.上海针灸杂志,2009, 28(10):616-619.
2 刘力,李晓陵,王丰,等.基于fMRI技术对针刺作用机制的研究展望.中医药信息, 2014, 31(1):80-83.
3 Weston A D, Hood L. System’s biology, proteomics, and the future of health care:toward predictive, preventative, and personalized medicine.J Proteome Res, 2004, 3(2):179-196.
4 Hood L, Heath J R, Phelps M E, et al. System‘s biology and new technologies enable predictive and preventative medicine. Science, 2004,306(5696):640-643.
5 凌建维.谈谈针刺的“深浅在志”.中华中医药杂志, 2014, 29(3):792-794.
6 潘友灿,付丹丹,许能贵.合谷穴针刺深浅与疗效关系的探讨.中国中医基础医学杂志, 2018, 24(3):367-369.
7 盛灿若.针刺深浅与疗效的关系.江苏中医药, 1962, 7:6-7.
8 雷龙鸣,曾湘玲,林正,等.王泽涛教授论《内经》与《难经》针刺深浅学术思想.中华中医药学刊, 2003, 21(6):858-858.
9 田艳鹏.穴位深浅探析.上海中医药大学学报, 2017, 31(2):13-15.
10 吴聪生.针刺水沟穴配合主动运动治疗急性腰扭伤96例.中医临床研究, 2016, 8(4):42-43.
11 冉维正.《内经》皮部理论的研究.北京:北京中医药大学硕士学位论文, 2013.
12 张思彬,付于.付于皮部浅刺学术思想及经验介绍.辽宁中医杂志,2015, 42(10):1862-1863.
13 吴鲁辉.皮下浅刺法的文献研究.济南:山东中医药大学硕士学位论文, 2012.
14 邓雪皎,卢春霞,付静,等.论针刺深浅之皮”.中医杂志, 2018, 59(6):482-485.
15 陈超,姚丽芬.对针刺深度的思考.中国针灸, 2015, 35(1):81-86.
16 田艳鹏.穴位深浅探析.上海中医药大学学报, 2017, 31(2):13-15.
17 宋添添,崔庆华.系统生物学在医学研究中的应用.中国医学前沿杂志(电子版), 2013, 5(5):20-26.
18 谢忠伟,李普民,王进.乳腺癌细胞中microRNA作用机制的系统生物学分析.中国卫生标准管理, 2018(14):135-137.
19 徐强,王长亮,李胜.系统生物学——一生命科学的新领域.中国医药导报, 2008, 5(26):20-22.
20 孙安会,袁肇凯,夏世靖,等.中医证候系统生物学研究的现状和展望.中华中医药杂志, 2016, 31(1):200-204.
21 李宏伟,贾孟辉,黑晓英,等.试论以“浅刺”代“深刺”的新针刺观.河北中医, 2017, 39(2):277-280.
22 王志福,俞向梅,陶静.腕踝针镇痛实验机制及fMRI应用概况.中国民族民间医药, 2016, 25(24):50-52.
23 尹韬,倪金霞,朱文增.耳周三穴深刺与浅刺治疗主观性耳鸣:随机对照研究.中国针灸, 2015, 35(10):1015-1019.
24 刘玉丽,李野,任路,等.深刺“环跳”穴对大鼠损伤坐骨神经的修复作用.针刺研究, 2014, 39(2):93-99.
25 都鹏飞,范刚启.浅谈针刺的层次.中医药通报, 2014, 13(6):51-53.
26 李雪青,石志敏.论针刺之深浅.中国针灸, 2015, 35(9):913-916.
27 杨惠,张何骄子,王祥,等.针灸调节皮肤局部免疫功能及其机理的研究进展.辽宁中医杂志, 2017, 44(2):433-435.
28 楼方舟,王宏林.皮肤免疫系统功能性研究进展.生命科学, 2016, 28(2):268-274.
29 余文英,黄明愉,吴倩雯,等.捏脊疗法激活皮肤免疫探讨.福建中医药, 2018, 49(3):86-89.
30 景中坤,邱玲.浅刺针法治疗带状疱疹后遗神经痛机制探讨.河南中医, 2018, 38(4):619-622.
31 Wierzbicka J M,?mijewski M A, Antoniewicz J, et al. Differentiation of Keratinocytes Modulates Expression of Epidermal Elements of the Cutaneous Analog of Hypothalamus-Pituitary-Adrenal Axis. Journal of Cellular Physiology, 2017, 232(1):154–166.
32 李琛妮,付于.皮部浅刺法治疗眼肌型重症肌无力.河南中医, 2018,38(3):458-460.
33 王春雷,吴金鹏,王军,等.筋膜学说解读中医经络实质及针灸作用机制.中国中医基础医学杂志, 2008, 14(4):312-314.
34 白宇,原林,黄泳,等.经络的解剖学发现——筋膜学新理论.世界科学技术-中医药现代化, 2010, 12(1):20-24.
35 杨江霞,符仲华.浅析浮针的理论与临床研究.西部中医药, 2015, 28(6):156-158.
36 湛志婧,苏美意,康健,等.浮针疗法结合温针灸治疗腰背肌筋膜炎临床研究.辽宁中医杂志, 2016,(12):2624-2627.
37 林玉芳,沈卫东,陆欣玲,等.《内经》对针刺深浅的论述.上海针灸杂志, 2015, 34(7):682-685.
2 刘力,李晓陵,王丰,等.基于fMRI技术对针刺作用机制的研究展望.中医药信息, 2014, 31(1):80-83.
3 Weston A D, Hood L. System’s biology, proteomics, and the future of health care:toward predictive, preventative, and personalized medicine.J Proteome Res, 2004, 3(2):179-196.
4 Hood L, Heath J R, Phelps M E, et al. System‘s biology and new technologies enable predictive and preventative medicine. Science, 2004,306(5696):640-643.
5 凌建维.谈谈针刺的“深浅在志”.中华中医药杂志, 2014, 29(3):792-794.
6 潘友灿,付丹丹,许能贵.合谷穴针刺深浅与疗效关系的探讨.中国中医基础医学杂志, 2018, 24(3):367-369.
7 盛灿若.针刺深浅与疗效的关系.江苏中医药, 1962, 7:6-7.
8 雷龙鸣,曾湘玲,林正,等.王泽涛教授论《内经》与《难经》针刺深浅学术思想.中华中医药学刊, 2003, 21(6):858-858.
9 田艳鹏.穴位深浅探析.上海中医药大学学报, 2017, 31(2):13-15.
10 吴聪生.针刺水沟穴配合主动运动治疗急性腰扭伤96例.中医临床研究, 2016, 8(4):42-43.
11 冉维正.《内经》皮部理论的研究.北京:北京中医药大学硕士学位论文, 2013.
12 张思彬,付于.付于皮部浅刺学术思想及经验介绍.辽宁中医杂志,2015, 42(10):1862-1863.
13 吴鲁辉.皮下浅刺法的文献研究.济南:山东中医药大学硕士学位论文, 2012.
14 邓雪皎,卢春霞,付静,等.论针刺深浅之皮”.中医杂志, 2018, 59(6):482-485.
15 陈超,姚丽芬.对针刺深度的思考.中国针灸, 2015, 35(1):81-86.
16 田艳鹏.穴位深浅探析.上海中医药大学学报, 2017, 31(2):13-15.
17 宋添添,崔庆华.系统生物学在医学研究中的应用.中国医学前沿杂志(电子版), 2013, 5(5):20-26.
18 谢忠伟,李普民,王进.乳腺癌细胞中microRNA作用机制的系统生物学分析.中国卫生标准管理, 2018(14):135-137.
19 徐强,王长亮,李胜.系统生物学——一生命科学的新领域.中国医药导报, 2008, 5(26):20-22.
20 孙安会,袁肇凯,夏世靖,等.中医证候系统生物学研究的现状和展望.中华中医药杂志, 2016, 31(1):200-204.
21 李宏伟,贾孟辉,黑晓英,等.试论以“浅刺”代“深刺”的新针刺观.河北中医, 2017, 39(2):277-280.
22 王志福,俞向梅,陶静.腕踝针镇痛实验机制及fMRI应用概况.中国民族民间医药, 2016, 25(24):50-52.
23 尹韬,倪金霞,朱文增.耳周三穴深刺与浅刺治疗主观性耳鸣:随机对照研究.中国针灸, 2015, 35(10):1015-1019.
24 刘玉丽,李野,任路,等.深刺“环跳”穴对大鼠损伤坐骨神经的修复作用.针刺研究, 2014, 39(2):93-99.
25 都鹏飞,范刚启.浅谈针刺的层次.中医药通报, 2014, 13(6):51-53.
26 李雪青,石志敏.论针刺之深浅.中国针灸, 2015, 35(9):913-916.
27 杨惠,张何骄子,王祥,等.针灸调节皮肤局部免疫功能及其机理的研究进展.辽宁中医杂志, 2017, 44(2):433-435.
28 楼方舟,王宏林.皮肤免疫系统功能性研究进展.生命科学, 2016, 28(2):268-274.
29 余文英,黄明愉,吴倩雯,等.捏脊疗法激活皮肤免疫探讨.福建中医药, 2018, 49(3):86-89.
30 景中坤,邱玲.浅刺针法治疗带状疱疹后遗神经痛机制探讨.河南中医, 2018, 38(4):619-622.
31 Wierzbicka J M,?mijewski M A, Antoniewicz J, et al. Differentiation of Keratinocytes Modulates Expression of Epidermal Elements of the Cutaneous Analog of Hypothalamus-Pituitary-Adrenal Axis. Journal of Cellular Physiology, 2017, 232(1):154–166.
32 李琛妮,付于.皮部浅刺法治疗眼肌型重症肌无力.河南中医, 2018,38(3):458-460.
33 王春雷,吴金鹏,王军,等.筋膜学说解读中医经络实质及针灸作用机制.中国中医基础医学杂志, 2008, 14(4):312-314.
34 白宇,原林,黄泳,等.经络的解剖学发现——筋膜学新理论.世界科学技术-中医药现代化, 2010, 12(1):20-24.
35 杨江霞,符仲华.浅析浮针的理论与临床研究.西部中医药, 2015, 28(6):156-158.
36 湛志婧,苏美意,康健,等.浮针疗法结合温针灸治疗腰背肌筋膜炎临床研究.辽宁中医杂志, 2016,(12):2624-2627.
37 林玉芳,沈卫东,陆欣玲,等.《内经》对针刺深浅的论述.上海针灸杂志, 2015, 34(7):682-685.