双氯芬酸钠利多卡因在驻香港部队官兵肛门疾病术后镇痛中的应用效果研究
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摘要
目的:探讨驻香港部队官兵肛门疾病术后使用双氯芬酸钠利多卡因镇痛的临床疗效。方法:选取2012-01-01~2017-12-31我院治疗的肛门疾病术后患者136例,随机分为2组:观察组76例,采用双氯芬酸钠利多卡因注射液2ml肌肉注射镇痛;对照组60例,采用盐酸哌替啶100mg+枸橼酸芬太尼0.3g,8ml/h持续静脉泵入6~8h镇痛。比较2组疗效及不良反应发生率。结果:观察组术后24h切口处疼痛均可耐受。对照组术后12h出现切口处疼痛,36例疼痛难忍,给予加强治疗。观察组显效率和总有效率均明显高于对照组(P<0.01)。观察组不良反应发生率明显低于对照组(P<0.01)。结论:双氯芬酸钠利多卡因注射液在肛门疾病术后镇痛中的效果优于盐酸哌替啶+枸橼酸芬太尼,且单一用药安全性高、疗效可靠,值得临床推广应用。
Objective:To investigate the clinical analgesic effect of diclofenac sodium and lidocaine in postperative analgesia of anus diseases in Hong Kong troops.Methods:A total of136 patients with anus disease after operation who were treated in our hospital from January2012 to December 2017 were selected,and were randomly divided into two groups:76 cases in the observation group,who were treated with diclofenac sodium and lidocaine hydrochloride injection 2 ml muscle injection,and 60 cases in the control group,who were treated with piperidine hydrochloride 100 mg plus citric acid fentanyl 0.3 g,8 ml/h pump for 6-8 hours.The clinical effect and incidence of adverse reactions were compared.Results:Observation group had mild but no severe incision pain in 24 hours after operation.Control group had mild incision pain in 12 hours after operation,and 36 patients suffered from severe pain.The efficiency rate and total effective rate in observation group were higher than those in control group(P<0.01).The incidence of adverse reactions in observation group were lower than that in control group(P<0.01).Conclusion:The analgesic effect of intramuscular injection of diclofenac sodium and lidocaine hydrochloride after the surgery of anus disease is better than that of piperidine hydrochloride and fentanyl citrate,the single medication has high satisfactory and reliable curative effect,it is worthy of clinical promotion and application.
Objective:To investigate the clinical analgesic effect of diclofenac sodium and lidocaine in postperative analgesia of anus diseases in Hong Kong troops.Methods:A total of136 patients with anus disease after operation who were treated in our hospital from January2012 to December 2017 were selected,and were randomly divided into two groups:76 cases in the observation group,who were treated with diclofenac sodium and lidocaine hydrochloride injection 2 ml muscle injection,and 60 cases in the control group,who were treated with piperidine hydrochloride 100 mg plus citric acid fentanyl 0.3 g,8 ml/h pump for 6-8 hours.The clinical effect and incidence of adverse reactions were compared.Results:Observation group had mild but no severe incision pain in 24 hours after operation.Control group had mild incision pain in 12 hours after operation,and 36 patients suffered from severe pain.The efficiency rate and total effective rate in observation group were higher than those in control group(P<0.01).The incidence of adverse reactions in observation group were lower than that in control group(P<0.01).Conclusion:The analgesic effect of intramuscular injection of diclofenac sodium and lidocaine hydrochloride after the surgery of anus disease is better than that of piperidine hydrochloride and fentanyl citrate,the single medication has high satisfactory and reliable curative effect,it is worthy of clinical promotion and application.
引文
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[6]任鹏涛,张苑,阎庆辉,等.双氯芬酸钠利多卡因合用止痛剂治疗疼痛的疗效研究[J].中国现代医学杂志,2017,27(23):91-94.
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[9]武江文,司惠芳.双氯芬酸钠联合应用对肛肠手术后患者的镇痛效应及术后并发症影响[J].医学信息,2014,27(12):448-449.
[10]黄伟波,张禄芳.双氯芬酸钠栓纳肛联合肛周亚甲蓝注射在肛肠病术后镇痛效果的临床观察[J].北方药学,2017,14(10):87-88.
[11]任鹏涛,张苑,阎庆辉,等.双氯芬酸钠利多卡因合用止痛剂治疗疼痛的疗效研究[J].中国现代医学杂志,2017,27(23):91-94.
[12]莫国威,覃兴尤,陈梓杰,等.双氯芬酸钠利多卡因联合长效止痛剂用于肛肠病术后疼痛的临床研究[J].中国医学创新,2013,10(13):37-38.
[13]钟辉云,刘锦.注射用双氯芬酸钠利多卡因不良反应分析与防范[J].医学信息,2015,28(23):188.
[14]边薇,俞凯,骆玉璇.哌替啶联合利多卡因在腹膜透析置管术中效果的观察[J].浙江临床医学,2015,17(4):643-645.
[15]韦剑决.哌替啶联合利多卡因用于人工流产术麻醉200例临床观察[J].吉林医学,2011,32(19):3960-3961.
[16]刘华耀.双氯芬酸钠利多卡因注射液治疗肾绞痛临床观察[J].基层医学论坛,2012,16(28):3699-3700.
[2]马磊,刘广余,张丹丹.3%地卡因蜂蜜对肛肠术后患者行肛管创面换药的效果观察[J].山东医药,2012,52(46):75-76.
[3]黄履芳.电子生物疼痛贴与腰俞穴配合治疗肛肠术后疼痛的应用效果[J].中国实用医药,2017,12(5):109-111.
[4]任宝书.超前平衡镇痛法在中医肛肠挂线治疗中的应用研究[J].实用中西医结合临床,2017,17(9):65-66.
[5]吴泽伟.硬膜外不同浓度罗哌卡因用于肛肠科术后多模式镇痛的观察[J].现代诊断与治疗,2017,28(12):2195-2197.
[6]任鹏涛,张苑,阎庆辉,等.双氯芬酸钠利多卡因合用止痛剂治疗疼痛的疗效研究[J].中国现代医学杂志,2017,27(23):91-94.
[7]闫亚东,吕长武.肛肠术后应用双氯芬酸钠栓镇痛效果观察[J].中国现代药物应用,2010,4(5):25-26.
[8]闵春明,冉小燕,张树志.双氯芬酸钠栓用于肛肠病术后无痛换药效果观察[J].现代中西医结合杂志,2011,20(31):3954-3955.
[9]武江文,司惠芳.双氯芬酸钠联合应用对肛肠手术后患者的镇痛效应及术后并发症影响[J].医学信息,2014,27(12):448-449.
[10]黄伟波,张禄芳.双氯芬酸钠栓纳肛联合肛周亚甲蓝注射在肛肠病术后镇痛效果的临床观察[J].北方药学,2017,14(10):87-88.
[11]任鹏涛,张苑,阎庆辉,等.双氯芬酸钠利多卡因合用止痛剂治疗疼痛的疗效研究[J].中国现代医学杂志,2017,27(23):91-94.
[12]莫国威,覃兴尤,陈梓杰,等.双氯芬酸钠利多卡因联合长效止痛剂用于肛肠病术后疼痛的临床研究[J].中国医学创新,2013,10(13):37-38.
[13]钟辉云,刘锦.注射用双氯芬酸钠利多卡因不良反应分析与防范[J].医学信息,2015,28(23):188.
[14]边薇,俞凯,骆玉璇.哌替啶联合利多卡因在腹膜透析置管术中效果的观察[J].浙江临床医学,2015,17(4):643-645.
[15]韦剑决.哌替啶联合利多卡因用于人工流产术麻醉200例临床观察[J].吉林医学,2011,32(19):3960-3961.
[16]刘华耀.双氯芬酸钠利多卡因注射液治疗肾绞痛临床观察[J].基层医学论坛,2012,16(28):3699-3700.