腹腔镜下阑尾切除术和开腹阑尾切除术治疗穿孔性阑尾炎的效果及对氧化应激和炎症反应的影响
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摘要
目的:对比腹腔镜下阑尾切除术和开腹阑尾切除术治疗穿孔性阑尾炎的效果及对氧化应激和炎症反应的影响。方法:选取2016年5月-2018年6月笔者所在医院收治的185例穿孔性阑尾炎患者作为研究对象,按照手术方法分为试验组(95例)和对照组(90例),试验组采用腹腔镜下阑尾切除术,对照组采用开腹阑尾切除术;对比两组患者手术相关指标情况、术后患者氧化应激指标浓度、血清炎性细胞因子浓度。结果:试验组患者手术时间、术后体温正常时间、肛门排气时间、下床活动时间、住院时间均短于对照组(P<0.05),研究组置管引流率和切口感染率均低于对照组(P<0.05);术后试验组患者血浆SOD浓度高于对照组,MAD浓度明显低于对照组,血清炎性因子浓度低于对照组(P<0.05)。结论:腹腔镜下阑尾切除术相对开腹术恢复较快,创伤比较小,氧化应激反应及炎症反应减少,手术效果具有比较优势。
Objective:To compare the effects of laparoscopic appendectomy and laparotomy in the treatment of perforated appendicitis and its effects on oxidative stress and inflammatory response.Method:A total of 185 patients with perforated appendicitis were admitted to our hospital from May 2016 to 2018 June were selected as the research object.According to the surgical method,the experimental group(95 cases) and the control group(90 cases) in the experimental group were treated with laparoscopic appendectomy.Among them,the control group used laparotomy.The related indexes of the two groups,the concentration of oxidative stress index and the concentration of serum inflammatory cytokines in the patients after operation were compared.Result:The operation time,normal time of postoperative body temperature,anus exhaust time,bed activity time and the hospitalization time was shorter than those in the control group(P<0.05).Besides,the rate of catheterization drainage and the rate of incision infection in the study group were less than that in the control group(P<0.05).What's more,the plasma sod concentration was higher in the postoperative experimental group than in the control group,and the mad concentration was significantly lower than that in the control group,inflammatory factorsconcentration was lower than that of the control group(P<0.05).Conclusion:Laparoscopic appendectomy recovery is faster and the trauma is relatively small,and hence oxidative stress response is small and inflammatory response is reduced.Therefore,it is worth clinical application.
Objective:To compare the effects of laparoscopic appendectomy and laparotomy in the treatment of perforated appendicitis and its effects on oxidative stress and inflammatory response.Method:A total of 185 patients with perforated appendicitis were admitted to our hospital from May 2016 to 2018 June were selected as the research object.According to the surgical method,the experimental group(95 cases) and the control group(90 cases) in the experimental group were treated with laparoscopic appendectomy.Among them,the control group used laparotomy.The related indexes of the two groups,the concentration of oxidative stress index and the concentration of serum inflammatory cytokines in the patients after operation were compared.Result:The operation time,normal time of postoperative body temperature,anus exhaust time,bed activity time and the hospitalization time was shorter than those in the control group(P<0.05).Besides,the rate of catheterization drainage and the rate of incision infection in the study group were less than that in the control group(P<0.05).What's more,the plasma sod concentration was higher in the postoperative experimental group than in the control group,and the mad concentration was significantly lower than that in the control group,inflammatory factorsconcentration was lower than that of the control group(P<0.05).Conclusion:Laparoscopic appendectomy recovery is faster and the trauma is relatively small,and hence oxidative stress response is small and inflammatory response is reduced.Therefore,it is worth clinical application.
引文
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[9]吴荣斌.腹腔镜下阑尾切除术治疗穿孔性阑尾炎的临床效果及安全性分析[J].河南医学研究,2017,26(2):323-324.
[10]莫春林,朱沛劲.腹腔镜和开腹阑尾切除术治疗老年穿孔性阑尾炎的效果分析[J].临床医学工程,2017,24(1):15-16.
[11]虞卫.腹腔镜和开腹阑尾切除术在治疗穿孔性阑尾炎的临床疗效[J/OL].临床医药文献电子杂志,2016,3(47):9316,9318.
[12]利跑,易石坚,詹朝炎.腹腔镜手术与开腹阑尾切除术治疗穿孔性阑尾炎患者的疗效比较[J].中国药物经济学,2016,11(9):119-121.
[13]汤浩,孙键,吴登峰.腹腔镜下阑尾切除术与开腹阑尾切除术在穿孔性阑尾炎中的疗效及安全性分析[J].河北医药,2016,38(9):1318-1320.
[14]王立军.开腹手术和腹腔镜阑尾切除术治疗穿孔性阑尾炎患者的临床疗效[J].中国药物经济学,2016,11(1):101-102.
[15]袁春生,林庆国.腹腔镜和开腹阑尾切除术治疗穿孔性阑尾炎的效果比较[J].微创医学,2015,10(6):808-810.
[2]李晓欢,周鸿鲲,梅小平,等.腹腔镜下阑尾切除术治疗穿孔性阑尾炎的疗效及对围术期氧化应激和炎症反应的影响[J].中国普通外科杂志,2018,27(3):382-386.
[3]陈明军.腹腔镜阑尾切除术治疗急性坏疽穿孔性阑尾炎的效果观察[J].河南医学研究,2017,26(22):4120-4121.
[4]宁日旭.腹腔镜与开腹阑尾切除术治疗穿孔性阑尾炎的比较[J].中国医药指南,2017,15(30):148-149.
[5]牛泉方.腹腔镜下阑尾切除术治疗穿孔性阑尾炎的临床疗效及安全性分析[J].山西职工医学院学报,2017,27(4):32-34.
[6]赵红军,刘建洛.腹腔镜阑尾切除术治疗穿孔性阑尾炎的临床效果观察[J].河南医学研究,2017,26(18):3364-3366.
[7]孙建斌.腹腔镜下阑尾切除术治疗穿孔性阑尾炎的临床疗效及安全性分析[J].临床医学研究与实践,2017,2(19):53-54.
[8]赵宏升.腹腔镜与开腹阑尾切除术治疗急性穿孔性阑尾炎的疗效对比[J].临床医学研究与实践,2017,2(17):69-70.
[9]吴荣斌.腹腔镜下阑尾切除术治疗穿孔性阑尾炎的临床效果及安全性分析[J].河南医学研究,2017,26(2):323-324.
[10]莫春林,朱沛劲.腹腔镜和开腹阑尾切除术治疗老年穿孔性阑尾炎的效果分析[J].临床医学工程,2017,24(1):15-16.
[11]虞卫.腹腔镜和开腹阑尾切除术在治疗穿孔性阑尾炎的临床疗效[J/OL].临床医药文献电子杂志,2016,3(47):9316,9318.
[12]利跑,易石坚,詹朝炎.腹腔镜手术与开腹阑尾切除术治疗穿孔性阑尾炎患者的疗效比较[J].中国药物经济学,2016,11(9):119-121.
[13]汤浩,孙键,吴登峰.腹腔镜下阑尾切除术与开腹阑尾切除术在穿孔性阑尾炎中的疗效及安全性分析[J].河北医药,2016,38(9):1318-1320.
[14]王立军.开腹手术和腹腔镜阑尾切除术治疗穿孔性阑尾炎患者的临床疗效[J].中国药物经济学,2016,11(1):101-102.
[15]袁春生,林庆国.腹腔镜和开腹阑尾切除术治疗穿孔性阑尾炎的效果比较[J].微创医学,2015,10(6):808-810.