发育性髋关节脱位软骨发育不良的分子机制研究进展
|
摘要
发育性髋关节脱位常伴有髋关节软骨发育不良,其分子机制尚不明确。细胞凋亡是由多基因调控、多因子参与的细胞自主死亡过程,发展过程精细,呈多样性。近年来,细胞凋亡与发育性髋关节脱位软骨发育不良的关系受到了广泛关注。JAK1/STAT1信号通路与Bcl-2家族、Caspase家族之间在软骨细胞凋亡过程中的关系密切,为揭示发育性髋关节脱位中软骨发育不良的相关研究带来了新思路。
Developmental dysplasia of the hip(DDH) is often accompanied by hip articular cartilage degeneration, and its molecular mechanism is still unclear. Apoptosis is a process of autonomic death caused by multi-gene regulation and multi-factor participation. In recent years, the relationship between apoptosis and developmental dysplasia of the hip articular cartilage has received extensive attention. In the process of the apoptosis of chondrocytes,the JAK1/STAT1 signaling pathway is closely related to the Bcl-2 family and the Caspase family, which brings new ideas for the study of cartilage degeneration in DDH.
Developmental dysplasia of the hip(DDH) is often accompanied by hip articular cartilage degeneration, and its molecular mechanism is still unclear. Apoptosis is a process of autonomic death caused by multi-gene regulation and multi-factor participation. In recent years, the relationship between apoptosis and developmental dysplasia of the hip articular cartilage has received extensive attention. In the process of the apoptosis of chondrocytes,the JAK1/STAT1 signaling pathway is closely related to the Bcl-2 family and the Caspase family, which brings new ideas for the study of cartilage degeneration in DDH.
引文
[1]Jacobsen S,Sonne-Holm S,Soballe K,et al.Hip dysplasia and osteoarthritis:a survey of 4,151 subjects from the Osteoarthrosis Substudy of the Copenhagen City Heart Study[J].Acta Orthop,2005;76(2):149-58
[2] Wynne-Davies R.Acetabular dysplasia and familial joint laxity:two etiological factors in congenital dislocation of the hip.A review of 589 patients and their families[J].J Bone Joint Surg Br,1970;52(4):704
[3]边红飞,韦宜山.发育性髋关节脱位的病理与细胞凋亡的研究进展[J].内蒙古医学院学报,2012;34(S1):211-215
[4]王炳海,韦宜山,丁良甲,等.发育性髋关节脱位早期髋臼软骨细胞凋亡的实验研究[J].中国矫形外科杂志,2013;21(17):1755-1760
[5]Mutijima E,De Maertelaer V,Deprez M,et al.The apoptosis of osteoblasts and osteocytes in femoral head osteonecrosis:its specicity and its distribution[J].Clin.Rheumatol,2014;33(12):1791-1795
[6]Chang J,Wang W,Zhang H,et al.The dual role of autophagy in chondrocyte responses in the pathogenesis of articular cartilage degeneration in osteoarthritis[J].Int J Mol Med,2013;32(6):1311-1318
[7]Grogan SP,D'Lima DD.Joint aging and chondrocyte cell death[J].Int J Clin Rheumtol,2010;5(2):199-214
[8]Iannone F,Lapadula G.The pathophysiology of osteoarthritis[J].Aging Clin Exp Res,2003;15(5):364-372
[9]Chen Y,Klionsky DJ.The regulation of autophagy unanswered questions[J].J Cell Sci,2011;124(2):161-170
[10]Karaliotas GI,Mavridis K,Scorilas A,et al.Quantitative analysis of the mRNA expression levels of BCL2 and BAX genes in human osteoarthritis and normal articular cartilage:An investigation into their differential expression[J].Mol Med Rep,2015;12(3):4514-4521
[11]Martel-Pelletier J,Boileau C,Pelletier JP,et al.Cartilage in normal and osteoarthritis conditions[J].Best Pract Res Clin Rheumatol,2008;22(2):351-384
[12]Cengic T,Trkulja V,Pavelic SK,et al.Association of TGFB1 29C/T and IL6 -572G/C polymorphisms with developmental hip dysplasia:a case–control study in adults with severe osteoarthritis[J].Int Orthop,2015;39(4):793-798
[13]G Regis,L Icardi,L Conti,et al.IL-6,but not IFN-c,triggers apoptosis and inhibits in vivo growth of human malignant T cells on STAT3 silencing[J].Leukemia,2009;23(11):2102-2108
[14]王炳海,韦宜山,丁良甲,等.发育性髋关节脱位早期髋臼软骨细胞凋亡与Bcl-2、Bax表达的相关性研究[J].实用医学杂志,2013;29(20):3301-3303
[15]熊飞,韦宜山.发育性髋关节脱位早期髋臼软骨细胞凋亡的实验研究[J].世界最新医学信息文摘,2017;17(83):33-34
[16]丁良甲,韦宜山,王炳海,等.发育性髋脱位早期髋臼软骨细胞凋亡与Caspase-3、Bcl-2表达的相关性研究[J].浙江临床医学,2014;16(2):175-178
[17]Ding LJ,Wei YSH,Liu YL,et al.Correlation of acetabular chondrocyte apoptosis with caspase-3 and Bcl-2 expression in developmental dislocations of the hip[J].Genetics and Molecular Research,2016;15(3)
[18]Wei YSH,Li DH,Liu WL,et al.Altered Chondrocyte Apoptosis Status in Developmental Hip Dysplasia in Rabbits[J].Balkan Med J,2016;33(6):639-644
[19]Martinou JC.Apoptosis.Key to the mitochondrial gate[J].Nature,1999;399(6735):411-412
[20] Pacher P,Hajnóczky G.Propagation of the apoptotic signal by mitochondrial waves[J].The EMBO Journal,2001;20(15):4107-4121
[21]Gupta R,Ghosh S.Putative roles of mitochondrial Voltage-Dependent Anion Channel,Bcl-2 family proteins and c-Jun N-terminal Kinases in ischemic stroke associated apoptosis[J].Biochim Open,2017;4(6):47-55
[22]Rosse T,Olivi er R,M onney L,et al.Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c[J].Nature,1998;391(6666):496-499
[23]Guo B,Zhai D,Cabezas E,et al.Humanin peptide suppresses apoptosis by interfering with Bax activation[J].Nature,2003;423(6938):456-461
[24]Korsmeyer SJ,Shutter JR,Veis DJ,et al..Bcl-2/BAX:a rheostat that regulates an anti-oxidant pathway and cell death[J].Semin.Cancer Biol,1993;4(6):327-332
[25]Oltvai ZN,Korsmeyer SJ.Checkpoints of dueling dimers foil death wishes[J].Cell,1994;79(2):189-192
[26]Kim HA,Lee YJ,Seong SC,et al.Apoptotic chondrocyte death in human osteoarthritis[J].J.Rheumatol,2000;27(2):455-462
[27]Hu J,Huang G,Huang S,et al.Control genes of chondrocyte apoptosis in osteoarthritic articular cartilage[J].Zhonghua Wai Ke Za Zhi,2000;38(4):266-268
[28]Wang SJ,Guo X,Chen JH,et al.Mechanism of chondrocyte apoptosis in Kashin-Beck disease and primary osteoarthritis:a comparative study[J].Nan Fang Yi Ke Da Xue Xue Bao,2006;26(7):927-930
[29]Kohler T,Schill C,Deininger MW,et al.High Bad and BAX mRNA expression correlate with negative outcome in acute myeloid leukemia (AMl)[J].Leukemia,2002;16(1):22-29
[30]Tallman MS,Gilliland DG,Rowe JM.Drug therapy for acute myeloid leukemia[J].Blood,2005;106(4):1154-1163
[31]Bustamante J,Nutt L,Orrenius S,et al.Arsenic stimulates release of cyto chrome c from isolated mitochondria via induction of mitochondrial permeability transition[J].Toxicol.Appl.Pharmacol,2005;207(2):110-116
[32]Kim H.S,Lee M.S.STAT1 as a key modulator of cell death[J].Cell Signal,2007;19(3):454-465
[33]Siegrist S,Kettiger H,Fasler-Kan E,et al.Selective stimulation of the JAK/STAT signaling pathway by silica nanoparticles in human endothelial cells[J].Toxicol In Vitro,2017;42:308-318
[34]Goropevsek A,Holcar M,Avcin T.The Role of STAT Signaling Pathways in the Pathogenesis of Systemic Lupus Erythematosus[J].Clin Rev Allergy Immunol,2017;52(2):164-181
[35]Walter Liszewski,David Gram Naym,Edyta Biskup,et al.Psoralen with ultraviolet A-induced apoptosis of cutaneous lymphoma cell lines is augmented by type I interferons via the JAK1-STAT1 pathway[J].Photodermatol Photoimmunol Photomed,2017;33(3):164-171
[36]Seif F,Khoshmirsafa M,Aazami H,et al.The role JAK-STAT signaling pathway and its regulators in the fate of The helper cells[J].Cell Commun.Signal,2017;15(1):23
[37]韦宜山,刘万林,丁良甲,等.发育性髋脱位髋臼软骨细胞病理学改变的实验研究[J].内蒙古医学院学报,2012;34(06):447-452
[38]Kang SJ,Wang S,Hara H,et al.Dual role of caspase-11 in mediating activation of caspase-1 and caspase-3 under pathological conditions[J].J.Cell Biol,2000;149(3):613-622
[39]Peng M,Wang Y,Qiang L,et al.Interleukin-35 Inhibits TNF-α-Induced Osteoclastogenesis and Promotes Apoptosis Shifting the Activation From TNF Receptor-Associated Death Domain (TRADD)-TRAF2 to TRADD-Fas-Associated Death Domain by JAK1/STAT1[J].Front Immunol,2018;01417
[40]Stephanou A,Scarabelli TM,Brar BK,et al.Induction of apoptosis and Fas receptor/Fas ligand expression by ischemia/reperfusion in cardiac myocytes requires serine 727 of the STAT-1 transcription factor but not tyrosine 701[J].J.Biol.Chem,2001;276(30):28340-28347
[41]Yao QH,Jian JL,Simon K.Thrombin Inhibits Tumor Cell Growth in Association with Up-regulation of p21waf/cip1 and Caspases via a p53-independent,STAT-1-dependent Pathway[J].THE JOURNAL OF BIOLOGICAL CHEMISTRY,2000;275(9):6462–6468
[42]Adamaki M,Tsotra M,Vlahopoulos S,et al.STAT transcript levels in childhood acute lymphoblastic leukemia:STAT1,and STAT3 transcript correlations[J].Leuk Res,2015;39(11):1285-1291
[43]Iriana G A,Gerardo A M,Agueda F D,et al.Oral administration of the p38 MAPK inhibitor,UR13870,inhibits affective pain behavior after spinal cordinjury[J].Pain,2014;155(10):2188-2198
[44]K Suk,I Chang,Y H Kim,et al.Interferon g (IFNg) and Tumor Necrosis Factor a Synergism in ME-180 Cervical Cancer Cell Apoptosis and Necrosis[J].J.Biol.Chem,2001;276(16):13153-13159
[45] Feng Z,Zheng W,Tang Q,et al.Fludarabine inhibits STAT1-mediated up-regulation of caspase-3 expression in dexamethasone-induced osteoblasts apoptosis and slows the progression of steroid-induced avascular necrosis of the femoral head in rats[J].Apoptosis,2017;22(8):1001-1012
[46] Meissl K,Macho -Maschler S,Müller M,et al.The good and the bad faces of STAT1 in solid tumours[J].Cytokine,2017;Jan;89:12-20
[47] Haneji T.Roles of PKR in differentiation and apoptosis of bone-related cells[J].Anat Sci Int,2017;92(3):313-319
[48] Yan W,Hua G,Feng S,et al.The effect of miR-146a on STAT1 expression and apoptosis in acute lymphoblastic leukemia Jurkat cells[J].Oncol Let,2017;13(1):151-154
[49] Chaudhuri A,Yang B,Gendelman HE,et al.STAT1 signaling modulates HIV-1-induced inflammatory responses and leukocyte transmigration across the blood-brain barrier[J].Blood,2008;111(4):2062-2072
[2] Wynne-Davies R.Acetabular dysplasia and familial joint laxity:two etiological factors in congenital dislocation of the hip.A review of 589 patients and their families[J].J Bone Joint Surg Br,1970;52(4):704
[3]边红飞,韦宜山.发育性髋关节脱位的病理与细胞凋亡的研究进展[J].内蒙古医学院学报,2012;34(S1):211-215
[4]王炳海,韦宜山,丁良甲,等.发育性髋关节脱位早期髋臼软骨细胞凋亡的实验研究[J].中国矫形外科杂志,2013;21(17):1755-1760
[5]Mutijima E,De Maertelaer V,Deprez M,et al.The apoptosis of osteoblasts and osteocytes in femoral head osteonecrosis:its specicity and its distribution[J].Clin.Rheumatol,2014;33(12):1791-1795
[6]Chang J,Wang W,Zhang H,et al.The dual role of autophagy in chondrocyte responses in the pathogenesis of articular cartilage degeneration in osteoarthritis[J].Int J Mol Med,2013;32(6):1311-1318
[7]Grogan SP,D'Lima DD.Joint aging and chondrocyte cell death[J].Int J Clin Rheumtol,2010;5(2):199-214
[8]Iannone F,Lapadula G.The pathophysiology of osteoarthritis[J].Aging Clin Exp Res,2003;15(5):364-372
[9]Chen Y,Klionsky DJ.The regulation of autophagy unanswered questions[J].J Cell Sci,2011;124(2):161-170
[10]Karaliotas GI,Mavridis K,Scorilas A,et al.Quantitative analysis of the mRNA expression levels of BCL2 and BAX genes in human osteoarthritis and normal articular cartilage:An investigation into their differential expression[J].Mol Med Rep,2015;12(3):4514-4521
[11]Martel-Pelletier J,Boileau C,Pelletier JP,et al.Cartilage in normal and osteoarthritis conditions[J].Best Pract Res Clin Rheumatol,2008;22(2):351-384
[12]Cengic T,Trkulja V,Pavelic SK,et al.Association of TGFB1 29C/T and IL6 -572G/C polymorphisms with developmental hip dysplasia:a case–control study in adults with severe osteoarthritis[J].Int Orthop,2015;39(4):793-798
[13]G Regis,L Icardi,L Conti,et al.IL-6,but not IFN-c,triggers apoptosis and inhibits in vivo growth of human malignant T cells on STAT3 silencing[J].Leukemia,2009;23(11):2102-2108
[14]王炳海,韦宜山,丁良甲,等.发育性髋关节脱位早期髋臼软骨细胞凋亡与Bcl-2、Bax表达的相关性研究[J].实用医学杂志,2013;29(20):3301-3303
[15]熊飞,韦宜山.发育性髋关节脱位早期髋臼软骨细胞凋亡的实验研究[J].世界最新医学信息文摘,2017;17(83):33-34
[16]丁良甲,韦宜山,王炳海,等.发育性髋脱位早期髋臼软骨细胞凋亡与Caspase-3、Bcl-2表达的相关性研究[J].浙江临床医学,2014;16(2):175-178
[17]Ding LJ,Wei YSH,Liu YL,et al.Correlation of acetabular chondrocyte apoptosis with caspase-3 and Bcl-2 expression in developmental dislocations of the hip[J].Genetics and Molecular Research,2016;15(3)
[18]Wei YSH,Li DH,Liu WL,et al.Altered Chondrocyte Apoptosis Status in Developmental Hip Dysplasia in Rabbits[J].Balkan Med J,2016;33(6):639-644
[19]Martinou JC.Apoptosis.Key to the mitochondrial gate[J].Nature,1999;399(6735):411-412
[20] Pacher P,Hajnóczky G.Propagation of the apoptotic signal by mitochondrial waves[J].The EMBO Journal,2001;20(15):4107-4121
[21]Gupta R,Ghosh S.Putative roles of mitochondrial Voltage-Dependent Anion Channel,Bcl-2 family proteins and c-Jun N-terminal Kinases in ischemic stroke associated apoptosis[J].Biochim Open,2017;4(6):47-55
[22]Rosse T,Olivi er R,M onney L,et al.Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c[J].Nature,1998;391(6666):496-499
[23]Guo B,Zhai D,Cabezas E,et al.Humanin peptide suppresses apoptosis by interfering with Bax activation[J].Nature,2003;423(6938):456-461
[24]Korsmeyer SJ,Shutter JR,Veis DJ,et al..Bcl-2/BAX:a rheostat that regulates an anti-oxidant pathway and cell death[J].Semin.Cancer Biol,1993;4(6):327-332
[25]Oltvai ZN,Korsmeyer SJ.Checkpoints of dueling dimers foil death wishes[J].Cell,1994;79(2):189-192
[26]Kim HA,Lee YJ,Seong SC,et al.Apoptotic chondrocyte death in human osteoarthritis[J].J.Rheumatol,2000;27(2):455-462
[27]Hu J,Huang G,Huang S,et al.Control genes of chondrocyte apoptosis in osteoarthritic articular cartilage[J].Zhonghua Wai Ke Za Zhi,2000;38(4):266-268
[28]Wang SJ,Guo X,Chen JH,et al.Mechanism of chondrocyte apoptosis in Kashin-Beck disease and primary osteoarthritis:a comparative study[J].Nan Fang Yi Ke Da Xue Xue Bao,2006;26(7):927-930
[29]Kohler T,Schill C,Deininger MW,et al.High Bad and BAX mRNA expression correlate with negative outcome in acute myeloid leukemia (AMl)[J].Leukemia,2002;16(1):22-29
[30]Tallman MS,Gilliland DG,Rowe JM.Drug therapy for acute myeloid leukemia[J].Blood,2005;106(4):1154-1163
[31]Bustamante J,Nutt L,Orrenius S,et al.Arsenic stimulates release of cyto chrome c from isolated mitochondria via induction of mitochondrial permeability transition[J].Toxicol.Appl.Pharmacol,2005;207(2):110-116
[32]Kim H.S,Lee M.S.STAT1 as a key modulator of cell death[J].Cell Signal,2007;19(3):454-465
[33]Siegrist S,Kettiger H,Fasler-Kan E,et al.Selective stimulation of the JAK/STAT signaling pathway by silica nanoparticles in human endothelial cells[J].Toxicol In Vitro,2017;42:308-318
[34]Goropevsek A,Holcar M,Avcin T.The Role of STAT Signaling Pathways in the Pathogenesis of Systemic Lupus Erythematosus[J].Clin Rev Allergy Immunol,2017;52(2):164-181
[35]Walter Liszewski,David Gram Naym,Edyta Biskup,et al.Psoralen with ultraviolet A-induced apoptosis of cutaneous lymphoma cell lines is augmented by type I interferons via the JAK1-STAT1 pathway[J].Photodermatol Photoimmunol Photomed,2017;33(3):164-171
[36]Seif F,Khoshmirsafa M,Aazami H,et al.The role JAK-STAT signaling pathway and its regulators in the fate of The helper cells[J].Cell Commun.Signal,2017;15(1):23
[37]韦宜山,刘万林,丁良甲,等.发育性髋脱位髋臼软骨细胞病理学改变的实验研究[J].内蒙古医学院学报,2012;34(06):447-452
[38]Kang SJ,Wang S,Hara H,et al.Dual role of caspase-11 in mediating activation of caspase-1 and caspase-3 under pathological conditions[J].J.Cell Biol,2000;149(3):613-622
[39]Peng M,Wang Y,Qiang L,et al.Interleukin-35 Inhibits TNF-α-Induced Osteoclastogenesis and Promotes Apoptosis Shifting the Activation From TNF Receptor-Associated Death Domain (TRADD)-TRAF2 to TRADD-Fas-Associated Death Domain by JAK1/STAT1[J].Front Immunol,2018;01417
[40]Stephanou A,Scarabelli TM,Brar BK,et al.Induction of apoptosis and Fas receptor/Fas ligand expression by ischemia/reperfusion in cardiac myocytes requires serine 727 of the STAT-1 transcription factor but not tyrosine 701[J].J.Biol.Chem,2001;276(30):28340-28347
[41]Yao QH,Jian JL,Simon K.Thrombin Inhibits Tumor Cell Growth in Association with Up-regulation of p21waf/cip1 and Caspases via a p53-independent,STAT-1-dependent Pathway[J].THE JOURNAL OF BIOLOGICAL CHEMISTRY,2000;275(9):6462–6468
[42]Adamaki M,Tsotra M,Vlahopoulos S,et al.STAT transcript levels in childhood acute lymphoblastic leukemia:STAT1,and STAT3 transcript correlations[J].Leuk Res,2015;39(11):1285-1291
[43]Iriana G A,Gerardo A M,Agueda F D,et al.Oral administration of the p38 MAPK inhibitor,UR13870,inhibits affective pain behavior after spinal cordinjury[J].Pain,2014;155(10):2188-2198
[44]K Suk,I Chang,Y H Kim,et al.Interferon g (IFNg) and Tumor Necrosis Factor a Synergism in ME-180 Cervical Cancer Cell Apoptosis and Necrosis[J].J.Biol.Chem,2001;276(16):13153-13159
[45] Feng Z,Zheng W,Tang Q,et al.Fludarabine inhibits STAT1-mediated up-regulation of caspase-3 expression in dexamethasone-induced osteoblasts apoptosis and slows the progression of steroid-induced avascular necrosis of the femoral head in rats[J].Apoptosis,2017;22(8):1001-1012
[46] Meissl K,Macho -Maschler S,Müller M,et al.The good and the bad faces of STAT1 in solid tumours[J].Cytokine,2017;Jan;89:12-20
[47] Haneji T.Roles of PKR in differentiation and apoptosis of bone-related cells[J].Anat Sci Int,2017;92(3):313-319
[48] Yan W,Hua G,Feng S,et al.The effect of miR-146a on STAT1 expression and apoptosis in acute lymphoblastic leukemia Jurkat cells[J].Oncol Let,2017;13(1):151-154
[49] Chaudhuri A,Yang B,Gendelman HE,et al.STAT1 signaling modulates HIV-1-induced inflammatory responses and leukocyte transmigration across the blood-brain barrier[J].Blood,2008;111(4):2062-2072