多巴胺β-羟化酶及多位酶催化动力学的研究现状
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摘要
职业性危害因素可对人的神经系统产生影响,诱发多种神经性疾病及心脑血管疾病。多巴胺β-羟化酶是人体内多巴胺系统的重要酶之一,调节体内多巴胺代谢活动。随着近年来对多巴胺β-羟化酶的结构研究不断深入,有关酶催化动力学的研究也备受关注。该文从多巴胺β-羟化酶结构为基点,探讨多位酶催化动力学在职业卫生领域的潜在应用,以期为未来职业卫生领域的疾病防治研究工作提供依据。
Occupational hazards have an impact on the human nervous system, inducing a variety of neurological diseases and cardiovascular and cerebrovascular diseases. Dopamine β-hydroxylase is one of the most important enzymes used in the body's dopamine system and regulates dopamine metabolism in the body. With the deepening of the research on the structure of dopamine β-hydroxylase in recent years, more and more attention focuses on the research of enzyme catalytic kinetics. On the basis of the structure of dopamine β-hydroxylase, the article summarizes the potential applications of multi-enzyme catalytic kinetics in occupational health, to lay a theoretical foundation for future research on disease prevention and control in occupational health.
Occupational hazards have an impact on the human nervous system, inducing a variety of neurological diseases and cardiovascular and cerebrovascular diseases. Dopamine β-hydroxylase is one of the most important enzymes used in the body's dopamine system and regulates dopamine metabolism in the body. With the deepening of the research on the structure of dopamine β-hydroxylase in recent years, more and more attention focuses on the research of enzyme catalytic kinetics. On the basis of the structure of dopamine β-hydroxylase, the article summarizes the potential applications of multi-enzyme catalytic kinetics in occupational health, to lay a theoretical foundation for future research on disease prevention and control in occupational health.
引文
[1]李斌,肖经纬,王海华,等.苯乙烯对大鼠不同脑区多巴胺递质含量及单胺氧化酶活性的影响[J].卫生研究,2006,5(4):399-402.
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[7]高磊,关明杰,侯雪.多巴胺羟化酶基因与环境交互作用对儿童注意缺陷多动障碍的影响[J].中国学校卫生,2016,37(9):1377-1379.
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[12]余维华,孙善全,汪克建,等.脑外伤后大鼠脊髓内去甲肾上腺素能神经元变化的研究[J].中华危重病急救医学,2007,19(6):349-352.
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[14]VENDELBOE TV,HARRIS P,ZHAO Y,et al.The crystal structure of human dopamineβ-hydroxylase at 2.9魡resolution[J].Sci Adv,2016,2(4):e1500980.
[15]谢小虎.多巴胺β-羟化酶基因多态性与海洛因依赖的相关性分析[D].宁波大学,2010.
[16]NTEI A,MEHRET Y,TORBJORN L.Kinetic studies on the activation of dopamine beta-monooxygenase by copper and vanadium ions[J].FEBS J,1998,257(3):622-629.
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[18]WASILEWSKA E,STANOSZ S,BARGIEL Z.Serum dopamine beta-hydroxylase activity in women occupationally exposed to carbon disulphide[J].Ind Health,1989,27(2):89-93.
[19]MARIA B,FILIPA S,MARCO N,et al.Characterization of the interaction of the novel antihypertensive etamicastat with human dopamineβ-hydroxylase:Comparison with nepicastat[J].Eur J Pharmacol,2015,751(7147):50-58.
[20]CHUNG-JUNG T,ANTONIO DEL S,RUTH N.Protein allostery,signal transmission and dynamics:a classification scheme of allosteric mechanisms[J].Mol Biosyst,2009,5(3):207-216.
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[22]SUSAN J,ANTOINE M,JANET T.Protein domain interfaces:characterization and comparison with oligomeric protein interfaces[J].Protein Eng,2000,13(13):77-82.
[23]SARAH M,HERNAN G,ROB P.Statistical mechanics of MonodWyman-Changeux[J].J Mol Biol,2013,425(9):1433-1460.
[24]TAJALLI ILM C,MASIHUZ Z,MOHSIN VAHID K,et al.A mechanistic insight into protein-ligand interaction,folding,misfolding,aggregation and inhibition of protein aggregates:An overview[J/OL].Int JBiol Macromol,2017,106:1115-1129.[2018-02-23].http://xueshu.baidu.com/s?wd=paperuri%3A%28d26e69ca6154d299fd815691af2ab43%29&filter=sc_long_sign&tn=SE_xueshusource_2kduw22v&sc_vurl=http%3A%2F%2Feuropepmc.org%2Fabstract%2FMED2F28890370&ie=utf-8&sc_us=2640296400751066249.DOI:10.1016/j.ijbiomac.2017.07.185.
[25]BEATA WK,TOMASZ G,AGNIESZKA B.Part-of-the-sites binding and reactivity in the homooligomeric enzymes-facts and artifacts[J/OL].Arch Biochem Biophys,2018,642:31-45.[2018-02-23].http://xueshu.baidu.com/s?wd=paperuri%3A%28cbc4ff4982791576269939b465ecd105%29&filter=sc_long_sign&tn=SE_xueshusource_2kduw22v&sc_vurl=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F29408402&ie=utf-8&sc_us=664703964259701907.DOI:10.1016/j.abb.2018.01.011.
[26]JACQUE M,JEFFRIES W,JEAN-PIERRE C.On the nature of allosteric transitions:a plausible model[J].J Mol Biol,1965,12(1):88-118.
[27]HONGQIANG L,SHUHUA C,HUAMING Z.Fractal mechanisms for the allosteric effects of proteins and enzymes[J].Biophys J,1990,58(5):1313-1320.
[28]EILEEN J.Morpheeins-a new structural paradigm for allosteric regulation[J].Trends Biochem Sci,2005,30(9):490-497.
[29]JAGADEESH S,CHETAN G.Solution of the Michaelis-Menten equation using the decomposition method[J].Math Biosci Eng,2017,6(1):173-188.
[30]GOODHART PJ,DEWOLF WE,KRUSE LI.Mechanism-based inactivation of dopamine beta-hydroxylase by p-cresol and related alkylphenols[J].Biochemistry,1987,26(9):2576-2583.
[31]TREVOR S,EILEEN J.Dynamic dissociating homo-oligomers and the control of protein function[J].Arch Biochem Biophys,2012,519(2):131-143.
[2]陈雯雯,邵华.多巴胺β-羟化酶基因多态性与电焊工神经功能异常易感性的关系[J].中华劳动卫生职业病杂志,2010,28(9):656-659.
[3]马云,李君,汤宜朗.精神分裂症认知功能损害与多巴胺β-羟化酶关系研究进展[J].精神医学杂志,2014,27(5):384-387.
[4]开标.多巴胺与去甲肾上腺素治疗感染性休克的疗效及安全性分析[J].医学理论与实践,2016,29(1):37-38.
[5]CHARLES R,JAN J.Metabolic pathways of dopamine and norepinephrine in rabbit brain in vitro[J].J Pharmacol Exp Ther,1967,157(3):493-502.
[6]孔岳南,谢惠君.多巴胺系统基因和帕金森病的相关性[J].中国组织工程研究,2003,7(19):2730-2731.
[7]高磊,关明杰,侯雪.多巴胺羟化酶基因与环境交互作用对儿童注意缺陷多动障碍的影响[J].中国学校卫生,2016,37(9):1377-1379.
[8]胡玉伟,陈冉,杨治峰,等.叔丁基对苯二酚对大鼠急性矽尘暴露的保护效果和机制[J].中华劳动卫生职业病杂志,2017,35(10):721-726.
[9]STEFAN O,WALTER R.Encyclopedia of Molecular Pharmacology[M].Berlin:Springer,2008:1219-1222.
[10]刘林林,孙宝胜,杨巍,等.改良的紫外荧光光度计法检测小鼠血清中多巴胺β-羟化酶活性的方法[J].吉林大学学报(医学版),2003,29(3):370-371.
[11]阮国洪,邬春华,郑力行,等.高效液相色谱法测定多巴胺-β-羟化酶活性[J].复旦学报(医学版),2009,36(3):354-357.
[12]余维华,孙善全,汪克建,等.脑外伤后大鼠脊髓内去甲肾上腺素能神经元变化的研究[J].中华危重病急救医学,2007,19(6):349-352.
[13]ELLEN F.W,MARK J.K,WALTER L.Dopamine-betahydroxylase:a tetrameric glycoprotein[J].Proceedings of the National Academy of Sciences of the United States of America,1973,70(8):2253-2255.
[14]VENDELBOE TV,HARRIS P,ZHAO Y,et al.The crystal structure of human dopamineβ-hydroxylase at 2.9魡resolution[J].Sci Adv,2016,2(4):e1500980.
[15]谢小虎.多巴胺β-羟化酶基因多态性与海洛因依赖的相关性分析[D].宁波大学,2010.
[16]NTEI A,MEHRET Y,TORBJORN L.Kinetic studies on the activation of dopamine beta-monooxygenase by copper and vanadium ions[J].FEBS J,1998,257(3):622-629.
[17]阮国洪,邬春华,郑力行,等.乐果对大鼠纹状体和血清中多巴胺β-羟化酶活性的影响[J].复旦学报(医学版),2011,38(3):194-197.
[18]WASILEWSKA E,STANOSZ S,BARGIEL Z.Serum dopamine beta-hydroxylase activity in women occupationally exposed to carbon disulphide[J].Ind Health,1989,27(2):89-93.
[19]MARIA B,FILIPA S,MARCO N,et al.Characterization of the interaction of the novel antihypertensive etamicastat with human dopamineβ-hydroxylase:Comparison with nepicastat[J].Eur J Pharmacol,2015,751(7147):50-58.
[20]CHUNG-JUNG T,ANTONIO DEL S,RUTH N.Protein allostery,signal transmission and dynamics:a classification scheme of allosteric mechanisms[J].Mol Biosyst,2009,5(3):207-216.
[21]ROBERT C.Introduction to Protein Structure[J].Q Rev.Biol,1999,2(3):1-16.
[22]SUSAN J,ANTOINE M,JANET T.Protein domain interfaces:characterization and comparison with oligomeric protein interfaces[J].Protein Eng,2000,13(13):77-82.
[23]SARAH M,HERNAN G,ROB P.Statistical mechanics of MonodWyman-Changeux[J].J Mol Biol,2013,425(9):1433-1460.
[24]TAJALLI ILM C,MASIHUZ Z,MOHSIN VAHID K,et al.A mechanistic insight into protein-ligand interaction,folding,misfolding,aggregation and inhibition of protein aggregates:An overview[J/OL].Int JBiol Macromol,2017,106:1115-1129.[2018-02-23].http://xueshu.baidu.com/s?wd=paperuri%3A%28d26e69ca6154d299fd815691af2ab43%29&filter=sc_long_sign&tn=SE_xueshusource_2kduw22v&sc_vurl=http%3A%2F%2Feuropepmc.org%2Fabstract%2FMED2F28890370&ie=utf-8&sc_us=2640296400751066249.DOI:10.1016/j.ijbiomac.2017.07.185.
[25]BEATA WK,TOMASZ G,AGNIESZKA B.Part-of-the-sites binding and reactivity in the homooligomeric enzymes-facts and artifacts[J/OL].Arch Biochem Biophys,2018,642:31-45.[2018-02-23].http://xueshu.baidu.com/s?wd=paperuri%3A%28cbc4ff4982791576269939b465ecd105%29&filter=sc_long_sign&tn=SE_xueshusource_2kduw22v&sc_vurl=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F29408402&ie=utf-8&sc_us=664703964259701907.DOI:10.1016/j.abb.2018.01.011.
[26]JACQUE M,JEFFRIES W,JEAN-PIERRE C.On the nature of allosteric transitions:a plausible model[J].J Mol Biol,1965,12(1):88-118.
[27]HONGQIANG L,SHUHUA C,HUAMING Z.Fractal mechanisms for the allosteric effects of proteins and enzymes[J].Biophys J,1990,58(5):1313-1320.
[28]EILEEN J.Morpheeins-a new structural paradigm for allosteric regulation[J].Trends Biochem Sci,2005,30(9):490-497.
[29]JAGADEESH S,CHETAN G.Solution of the Michaelis-Menten equation using the decomposition method[J].Math Biosci Eng,2017,6(1):173-188.
[30]GOODHART PJ,DEWOLF WE,KRUSE LI.Mechanism-based inactivation of dopamine beta-hydroxylase by p-cresol and related alkylphenols[J].Biochemistry,1987,26(9):2576-2583.
[31]TREVOR S,EILEEN J.Dynamic dissociating homo-oligomers and the control of protein function[J].Arch Biochem Biophys,2012,519(2):131-143.