阿西美辛微囊的制备与质量评价
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摘要
目的:研究阿西美辛微囊的制备工艺,并对其进行质量评价。方法:以海藻酸钠和壳聚糖为囊材,采用机械乳化法制备阿西美辛微囊,并对微囊的外观形态、粒径、包封率、载药量和体外释放度进行研究。结果:海藻酸钠和壳聚糖的用量均为3%,所制得微囊外观形态圆整,大小均匀,粒径为60~70μm的微囊占76.40%,包封率为73.57%,载药量23.54%,24h累积释放度93.61%。结论:所制备的阿西美辛微囊工艺简单、可靠,具有缓释效果。
Objective:To study the preparation technologyof acemetacin microcapsules, and their quality evalution. Methods:Sodium alginate and chitosan were used as capsule materials and the acemetacin microcapsules were prepared by a mechanical emulsification method,Its appearance、particle size、encapsulation efficiency、drug loading and release degree in vitro were studied. Results:The dosage of sodium alginate and chitosan were 3% respectively,the prepared microcapsules spherical with smooth surface,the size of uniform,and the particle size distribution was 76.40% in 60 ~70μm,the average encapsulation efficacy was 73.57%,the average drug loading was23.54%,and the accumulated release amount is 93.61% in 24 h.Conclusion:To prepare acemetacin microcapsules is simple and reliable,microcapsules could provide some controlled-release effect.
Objective:To study the preparation technologyof acemetacin microcapsules, and their quality evalution. Methods:Sodium alginate and chitosan were used as capsule materials and the acemetacin microcapsules were prepared by a mechanical emulsification method,Its appearance、particle size、encapsulation efficiency、drug loading and release degree in vitro were studied. Results:The dosage of sodium alginate and chitosan were 3% respectively,the prepared microcapsules spherical with smooth surface,the size of uniform,and the particle size distribution was 76.40% in 60 ~70μm,the average encapsulation efficacy was 73.57%,the average drug loading was23.54%,and the accumulated release amount is 93.61% in 24 h.Conclusion:To prepare acemetacin microcapsules is simple and reliable,microcapsules could provide some controlled-release effect.
引文
[1]刘振华,金英,李忠思.HPLC法测定兔血浆中阿西美辛和吲哚美辛的浓度[J].河北医学,2014,20(3):353-355.
[2]李忠思,王玉平,刘振华.阿西美辛分散片的制备及其溶出度评价[J].中国药房,2011,22(1):39-41.
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[6]何荣军,杨爽,孙培龙,等.海藻酸钠/壳聚糖微胶囊的制备及其应用研究进展[J].食品与机械,2010,26(2):166-173.
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[9]程亮,韩腾飞,李莎莎,等.盐酸青藤碱微囊的制备及其质量评价[J].中草药,2012,43(5):880-884.
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[11]史同瑞,刘宇,苏永福,等.壳聚糖-海藻酸钠微囊形成机理及制备方法研究进展[J].上海畜牧兽医通讯,2015,5(5):11-13.
[12]阮心明,范春雷.青蒿油一壳聚糖缓释微囊的制备与质量评价[J].浙江中医药大学学报,2014,38(9):1098-1102.
[13]董自亮,卢君蓉,高飞,等.芍药苷微囊的制备及其体外释药研究[J].中草药,2013,44(13):1756-1760.
[2]李忠思,王玉平,刘振华.阿西美辛分散片的制备及其溶出度评价[J].中国药房,2011,22(1):39-41.
[3]Sansone F,Picerno P,Mencherini T,et al.Flavonoid microparticles by spray drying:Influence of enhancers of the dissolution rate on properties and stability[J].J Food Eng,2011,103(2):188-196.
[4]胡荣,罗先钦,励娜,等.丹参酮缓释微囊的制备工艺研究[J].中草药,2012,43(11):2173-2176.
[5]李忠思,张玲,王竹君,等.HPLC法测定阿西美辛分散片的含量[J].中国药房,2011,22(9):839-841.
[6]何荣军,杨爽,孙培龙,等.海藻酸钠/壳聚糖微胶囊的制备及其应用研究进展[J].食品与机械,2010,26(2):166-173.
[7]张艽,杨晓艳.盐酸小檗碱微囊口腔崩解片的制备与质量评价[J].中南药学,2014,12(5):1-5.
[8]国家药典委员会.中华人民共和国药典:四部[S].2015版,北京:中国医药科技出版社,2015:121-123.
[9]程亮,韩腾飞,李莎莎,等.盐酸青藤碱微囊的制备及其质量评价[J].中草药,2012,43(5):880-884.
[10]严春临,张季,张丹参,等.大黄酚微囊药代动力学研究[J].时珍国医国药,2011,22(5):1127-1129.
[11]史同瑞,刘宇,苏永福,等.壳聚糖-海藻酸钠微囊形成机理及制备方法研究进展[J].上海畜牧兽医通讯,2015,5(5):11-13.
[12]阮心明,范春雷.青蒿油一壳聚糖缓释微囊的制备与质量评价[J].浙江中医药大学学报,2014,38(9):1098-1102.
[13]董自亮,卢君蓉,高飞,等.芍药苷微囊的制备及其体外释药研究[J].中草药,2013,44(13):1756-1760.