养阴清肺汤联合西药治疗老年慢性阻塞性肺气肿(阴虚燥热)随机平行对照研究
|
摘要
[目的]观察养阴清肺汤联合西药治疗老年慢性阻塞性肺气肿(阴虚燥热)疗效。[方法]使用随机平行对照方法,将90例住院患者按病志号抽签方法随机分为两组。对照组45例氨茶碱0.1~0.2g/次,3次/d;沙美特罗替卡松,2次/d,雾化吸入;左氧氟沙星0.5g/次,1次/d。治疗组45例养阴清肺汤(白芍、地黄~(生)各15g;牡丹皮、~(川)贝母、麦冬、玄参各10g;甘草8g;薄荷6g),热重加鱼腥草、胆南星;寒重加生姜;痰黏稠加白芥、紫苏子等;咯血丝痰加茜草根、泽兰,水煎500m L,1剂/d,2次/d;西药治疗同对照组。连续治疗15d为1疗程。观测临床症状、FEV_1、FEV_1/FVC、不良反应。治疗1疗程(15d),判定疗效。[结果]治疗组显效26例,有效16例,无效2例,总有效率93.33%;对照组显效21例,有效13例,无效11例,总有效率75.56%;治疗组疗效优于对照组(P<0.05)。FEV_1、FEV_1/FEV两组均有升高(P<0.05),治疗组升高多于对照组(P<0.05)。[结论]养阴清肺汤联合西药治疗老年慢性阻塞性肺气肿(阴虚燥热),疗效满意,无严重不良反应,值得推广。
[Objective] To observe the effect of Yangyin Qingfei decoction(养阴清肺汤) combined with western medicine in treating chronic obstructive pulmonary emphysema(Yinxu Zaore/阴虚燥热) in the elderly. [Methods] 90 cases of inpatients were randomly divided into two groups by random parallel control method. In the control group,45 cases of aminophylline 0.1~0.2 g/times,3 times/d; salmeterol and fluticasone,2 times/d,inhalation,levofloxacin 0.5 g/times,1 times/d. In the treatment group,45 cases of Yangyin Qingfei decoction(Baishao,Shengdihuang aeach15 g,Mudanpi,Chuanbei,Maidong,Xuanshen each 10 g,Gancao 8 g,Bohe 6 g),cold weight plus ginger,phlegm sticky with white mustard and perilla seed,hemoptysis and Rhizoma Rhizoma,zisan,500 m L,1/d,2/d,and 2 times/d; western medicine treated the same Take a photo. The continuous treatment of 15 d was 1 courses. Clinical symptoms,FEV_1,FEV_1/FVC and adverse reactions were observed. The 1 course of treatment(15 d) was treated and the curative effect was determined. [Results] 26 cases were found in the treatment group,16 cases were effective,2 cases were invalid,the total effective rate was 93.33%,the control group was 21 cases,13 cases were effective,11 cases were invalid and the total effective rate was 75.56%. The curative effect of the treatment group was better than the control group(P<0.05). The two groups of FEV_1 and FEV_1/FEV were increased(P<0.05),and the treatment group was higher than that of the control group(P<0.05). [Conclusion] Yangyin Qingfei decoction combined with western medicine in the treatment of senile chronic obstructive pulmonary emphysema(Yinxu Zaore) has satisfactory curative effect,no serious adverse reactions,and is worthy of promotion.
[Objective] To observe the effect of Yangyin Qingfei decoction(养阴清肺汤) combined with western medicine in treating chronic obstructive pulmonary emphysema(Yinxu Zaore/阴虚燥热) in the elderly. [Methods] 90 cases of inpatients were randomly divided into two groups by random parallel control method. In the control group,45 cases of aminophylline 0.1~0.2 g/times,3 times/d; salmeterol and fluticasone,2 times/d,inhalation,levofloxacin 0.5 g/times,1 times/d. In the treatment group,45 cases of Yangyin Qingfei decoction(Baishao,Shengdihuang aeach15 g,Mudanpi,Chuanbei,Maidong,Xuanshen each 10 g,Gancao 8 g,Bohe 6 g),cold weight plus ginger,phlegm sticky with white mustard and perilla seed,hemoptysis and Rhizoma Rhizoma,zisan,500 m L,1/d,2/d,and 2 times/d; western medicine treated the same Take a photo. The continuous treatment of 15 d was 1 courses. Clinical symptoms,FEV_1,FEV_1/FVC and adverse reactions were observed. The 1 course of treatment(15 d) was treated and the curative effect was determined. [Results] 26 cases were found in the treatment group,16 cases were effective,2 cases were invalid,the total effective rate was 93.33%,the control group was 21 cases,13 cases were effective,11 cases were invalid and the total effective rate was 75.56%. The curative effect of the treatment group was better than the control group(P<0.05). The two groups of FEV_1 and FEV_1/FEV were increased(P<0.05),and the treatment group was higher than that of the control group(P<0.05). [Conclusion] Yangyin Qingfei decoction combined with western medicine in the treatment of senile chronic obstructive pulmonary emphysema(Yinxu Zaore) has satisfactory curative effect,no serious adverse reactions,and is worthy of promotion.
引文
[1]李友林,郭亚红,倪健,等.阻塞性肺气肿的首诊症状与诊断[J].中国全科医学,2004,7(6):367-368.
[2]中华人民共和国卫生部.涉及人的生物医学研究伦理审查办法(试行)[S].(2007-03-26)[2015-06-01].http://www.moh.gov.cn/qjjys/s3581/200804/b9f1bfee4ab344ec892e68097296e2a8.shtml.
[3]范晓宇,林红,宋丽君,等.慢性阻塞性肺气肿的诊断与治疗[J].中外健康文摘,2012(36):418-419.
[4]周仲瑛.中医内科学[M].7版.北京:中国中医药出版社,2004:96-97.
[5]国家中医药管理局.中华人民共和国中医药行业标准·中医病证诊断疗效标准:ZYT001.1-94[S].南京:南京大学出版社,1994.
[6]郑灵,张劲农.阻塞性肺气肿损伤与抗损伤机制[J].国际呼吸杂志,2005,25(10):736-738.
[7]高宏敏.阻塞性肺气肿患者血液流变学检测的临床意义[J].中医学报,2008,23(5):66.
[8]陈丹庆.健康教育新模式对慢性阻塞性肺气肿患者心境状况和应对方式的影响[J].实用临床医药杂志,2017,21(8):179-181.
[9]卢琴华.雾化吸入舒利迭辅助治疗慢性阻塞性肺病的疗效与抗炎作用的临床观察[J].中国医药导报,2012,9(17):103-104.
[10]黎友伦,罗永艾.氨茶碱的药理作用与临床应用[J].医药导报,2005,24(9):807-809.
[11]苏舟.青霉素G和左氧氟沙星治疗肺炎链球菌肺炎疗效观察[J].临床合理用药杂志,2016,9(23):24-25.
[12]王洋.FEV1/FVC<70%与其正常值下限在老年人COPD诊断中意义的探讨[D].济南:山东大学,2012.
[13]邓中甲.方剂学[M].7版.北京:中国中医药出版社2010:211.
[14]高学敏.中药学[M].北京:中国中医药出版社,2007.
[15]李灵芝,常国良.养阴清肺汤对巨细胞病毒性肺炎模型小鼠的保护作用[J].中国药房,2015,26(16):2196-2198.
[2]中华人民共和国卫生部.涉及人的生物医学研究伦理审查办法(试行)[S].(2007-03-26)[2015-06-01].http://www.moh.gov.cn/qjjys/s3581/200804/b9f1bfee4ab344ec892e68097296e2a8.shtml.
[3]范晓宇,林红,宋丽君,等.慢性阻塞性肺气肿的诊断与治疗[J].中外健康文摘,2012(36):418-419.
[4]周仲瑛.中医内科学[M].7版.北京:中国中医药出版社,2004:96-97.
[5]国家中医药管理局.中华人民共和国中医药行业标准·中医病证诊断疗效标准:ZYT001.1-94[S].南京:南京大学出版社,1994.
[6]郑灵,张劲农.阻塞性肺气肿损伤与抗损伤机制[J].国际呼吸杂志,2005,25(10):736-738.
[7]高宏敏.阻塞性肺气肿患者血液流变学检测的临床意义[J].中医学报,2008,23(5):66.
[8]陈丹庆.健康教育新模式对慢性阻塞性肺气肿患者心境状况和应对方式的影响[J].实用临床医药杂志,2017,21(8):179-181.
[9]卢琴华.雾化吸入舒利迭辅助治疗慢性阻塞性肺病的疗效与抗炎作用的临床观察[J].中国医药导报,2012,9(17):103-104.
[10]黎友伦,罗永艾.氨茶碱的药理作用与临床应用[J].医药导报,2005,24(9):807-809.
[11]苏舟.青霉素G和左氧氟沙星治疗肺炎链球菌肺炎疗效观察[J].临床合理用药杂志,2016,9(23):24-25.
[12]王洋.FEV1/FVC<70%与其正常值下限在老年人COPD诊断中意义的探讨[D].济南:山东大学,2012.
[13]邓中甲.方剂学[M].7版.北京:中国中医药出版社2010:211.
[14]高学敏.中药学[M].北京:中国中医药出版社,2007.
[15]李灵芝,常国良.养阴清肺汤对巨细胞病毒性肺炎模型小鼠的保护作用[J].中国药房,2015,26(16):2196-2198.