多力玛结合人绒毛膜促性腺激素治疗黄体功能不全引起先兆流产的疗效
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摘要
目的探讨多力玛结合人绒毛膜促性腺激素治疗黄体功能不全引起先兆流产的疗效。方法随机选取2014年5月至2017年5月西安高新医院诊治的黄体功能不全引起先兆流产的106例患者为研究对象。依据治疗方法将这些患者分为多力玛结合人绒毛膜促性腺激素治疗组(结合治疗组,53例)和单独人绒毛膜促性腺激素治疗组(单独治疗组,53例)两组,对两组患者的HCG、E2、P水平、临床疗效、不良反应发生情况进行统计分析。结果两组患者治疗后6周、7周、8周、9周的HCG、E2、P水平均逐渐提升,差异具有统计学意义(P<0.05);治疗后8周结合治疗组患者的P水平显著低于单独治疗组,差异具有统计学意义(P<0.05)。结合治疗组患者治疗的总有效率94.3%(50/53)显著高于单独治疗组73.6%(39/53),差异具有统计学意义(P<0.05),但两组患者的不良反应发生率22.6%(12/53)、18.9%(10/53)之间的差异无统计学意义(P>0.05)。结论多力玛结合人绒毛膜促性腺激素治疗黄体功能不全引起先兆流产的疗效较人绒毛膜促性腺激素治疗显著。
Objective To investigate the efficacy of turinal combined with human chorionic gonadotropin(HCG) in the treatment of threatened abortioncaused byluteal insufficiency. Methods 106 patients with threatened abortioncaused byluteal insufficiency from May 2014 to May 2017 in Xi′an Gaoxin Hospital were randomly selected and divided into combined treatment group(n=53) andsingle treatment group(n=53).The combined treatment group received turinal combined with HCG while the signal treatment group received HCG alone. The HCG, E2, P levels, clinical efficacy and incidences of adverse reactions in the two groups were statistically analyzed. Results The HCG, E2 and P levels in the two groups increased gradually at 6 weeks, 7 weeks, 8 weeks and 9 weeks after treatment, with statisticallysignificant differences(P<0.05). The P level of combined treatment group was significantly lower than that of single treatment group at 8 weeks after treatment, with statisticallysignificantdifferences(P<0.05). The total effective rate of combined treatment group(94.3%, 50/53) was significantly higher than that of single treatment group(73.6%, 39/53), with statisticallysignificant difference(P<0.05), but the difference in incidence of adverse reactions between the two groups was not statisticallysignificant(22.6%, 12/53 vs 18.9%, 10/53)(P>0.05). Conclusions Turinal combined with HCG is of more significant effect in the treatment of threatened abortioncaused byluteal insufficiency than single HCG treatment.
Objective To investigate the efficacy of turinal combined with human chorionic gonadotropin(HCG) in the treatment of threatened abortioncaused byluteal insufficiency. Methods 106 patients with threatened abortioncaused byluteal insufficiency from May 2014 to May 2017 in Xi′an Gaoxin Hospital were randomly selected and divided into combined treatment group(n=53) andsingle treatment group(n=53).The combined treatment group received turinal combined with HCG while the signal treatment group received HCG alone. The HCG, E2, P levels, clinical efficacy and incidences of adverse reactions in the two groups were statistically analyzed. Results The HCG, E2 and P levels in the two groups increased gradually at 6 weeks, 7 weeks, 8 weeks and 9 weeks after treatment, with statisticallysignificant differences(P<0.05). The P level of combined treatment group was significantly lower than that of single treatment group at 8 weeks after treatment, with statisticallysignificantdifferences(P<0.05). The total effective rate of combined treatment group(94.3%, 50/53) was significantly higher than that of single treatment group(73.6%, 39/53), with statisticallysignificant difference(P<0.05), but the difference in incidence of adverse reactions between the two groups was not statisticallysignificant(22.6%, 12/53 vs 18.9%, 10/53)(P>0.05). Conclusions Turinal combined with HCG is of more significant effect in the treatment of threatened abortioncaused byluteal insufficiency than single HCG treatment.
引文
[1] 程艳丽,骆海哲,赵爱国,等.黄体酮治疗黄体功能不全所致先兆流产的疗效观察[J].实用妇科内分泌电子杂志,2016,3(5):30-31.
[2] 范建美,杨永连.大剂量绒毛膜促性腺激素治疗黄体功能不全引起先兆流产的效果[J].国际医药卫生导报,2013,19(17):2706-2708.
[3] 张红艳.舒适护理在妊娠黄体功能不足引起先兆流产的应用及效果[J].河南大学学报(医学版),2013,11(4):282-284.
[4] 余艳.比较两种不同方式治疗黄体功能不全先兆流产的疗效及其血清孕酮值与治疗结局的相关性[J].临床和实验医学杂志,2016,15(8):791-793.
[5] 张锦文,吴晓丽,杨英,等.地屈孕酮治疗先兆流产患者血清PIBF的表达分析[J].热带医学杂志,2016,16(11):1393-1396.
[6] 李燕,何焕群,赵正云,等.大剂量绒毛膜促性腺激素治疗黄体功能不全致先兆流产[J].当代医学,2014,20(10):90-90,91.
[7] 杜敏,许可可,周明,等.多力玛联合hCG治疗先兆流产临床研究[J].中国妇幼保健,2007,22(14):1891-1892.
[8] 陈晓慧.黄体酮治疗黄体功能不全所致先兆流产的效果分析[J].中国保健营养,2017,27(15):212-213.
[9] 孙燕.大剂量绒毛膜促性腺激素配伍天然黄体酮针治疗先兆流产的临床疗效观察[J].中国优生与遗传杂志,2008,16(1):80-81.
[10] 王红蕾.地屈孕酮治疗先兆流产的临床应用探究[J].中外医疗,2014,11(35):148-150.
[11] 董智力,王国纬,南燕燕,等.地屈孕酮用于先兆流产保胎治疗的临床效果观察[J].中国现代药物应用,2012,6(5):14-15.
[12] 林春霞.天然黄体酮针配伍绒毛膜促性腺激素治疗先兆流产临床观察[J].临床合理用药杂志,2014,7(13):20-21.
[13] 何桃风,刘云,吴建华,等.地屈孕酮与黄体酮治疗先兆流产疗效观察[J].中外医疗,2012,31(21):101.
[14] 岳来凤,宋末兰,陈莉,等.生殖激素水平测定对早期先兆流产妊娠预后的判断价值[J].中国性科学,2016,25(6):111-114.
[15] 聂敦利,张雷,齐小雪,等.微量元素水平同不良妊娠结局的相关性研究[J].中国性科学,2016,25(6):106-108.
[16] Liu Y,Zhang Y,Huang J,et al.Meta-analysis comparing the safety of laparoscopic and open surgical approaches for suspected adnexal mass during the second trimester[J].Int J Gynaecol Obstet,2017,136(3):272-279.
[17] Yu J,Luo Y,Yang X,et al.Effects of perinatal exposure to nonylphenol on delivery outcomes of pregnant rats and inflammatory hepatic injury in newborn rats[J].Braz J Med Biol Res,2016,49(12):5647-5648.
[18] Park C,Kang MY,Kim D,et al.Prevalence of abortion and adverse pregnancy outcomes among working women in Korea:A cross-sectional study[J].PLoS One,2017,12(8):182341-182342.
[2] 范建美,杨永连.大剂量绒毛膜促性腺激素治疗黄体功能不全引起先兆流产的效果[J].国际医药卫生导报,2013,19(17):2706-2708.
[3] 张红艳.舒适护理在妊娠黄体功能不足引起先兆流产的应用及效果[J].河南大学学报(医学版),2013,11(4):282-284.
[4] 余艳.比较两种不同方式治疗黄体功能不全先兆流产的疗效及其血清孕酮值与治疗结局的相关性[J].临床和实验医学杂志,2016,15(8):791-793.
[5] 张锦文,吴晓丽,杨英,等.地屈孕酮治疗先兆流产患者血清PIBF的表达分析[J].热带医学杂志,2016,16(11):1393-1396.
[6] 李燕,何焕群,赵正云,等.大剂量绒毛膜促性腺激素治疗黄体功能不全致先兆流产[J].当代医学,2014,20(10):90-90,91.
[7] 杜敏,许可可,周明,等.多力玛联合hCG治疗先兆流产临床研究[J].中国妇幼保健,2007,22(14):1891-1892.
[8] 陈晓慧.黄体酮治疗黄体功能不全所致先兆流产的效果分析[J].中国保健营养,2017,27(15):212-213.
[9] 孙燕.大剂量绒毛膜促性腺激素配伍天然黄体酮针治疗先兆流产的临床疗效观察[J].中国优生与遗传杂志,2008,16(1):80-81.
[10] 王红蕾.地屈孕酮治疗先兆流产的临床应用探究[J].中外医疗,2014,11(35):148-150.
[11] 董智力,王国纬,南燕燕,等.地屈孕酮用于先兆流产保胎治疗的临床效果观察[J].中国现代药物应用,2012,6(5):14-15.
[12] 林春霞.天然黄体酮针配伍绒毛膜促性腺激素治疗先兆流产临床观察[J].临床合理用药杂志,2014,7(13):20-21.
[13] 何桃风,刘云,吴建华,等.地屈孕酮与黄体酮治疗先兆流产疗效观察[J].中外医疗,2012,31(21):101.
[14] 岳来凤,宋末兰,陈莉,等.生殖激素水平测定对早期先兆流产妊娠预后的判断价值[J].中国性科学,2016,25(6):111-114.
[15] 聂敦利,张雷,齐小雪,等.微量元素水平同不良妊娠结局的相关性研究[J].中国性科学,2016,25(6):106-108.
[16] Liu Y,Zhang Y,Huang J,et al.Meta-analysis comparing the safety of laparoscopic and open surgical approaches for suspected adnexal mass during the second trimester[J].Int J Gynaecol Obstet,2017,136(3):272-279.
[17] Yu J,Luo Y,Yang X,et al.Effects of perinatal exposure to nonylphenol on delivery outcomes of pregnant rats and inflammatory hepatic injury in newborn rats[J].Braz J Med Biol Res,2016,49(12):5647-5648.
[18] Park C,Kang MY,Kim D,et al.Prevalence of abortion and adverse pregnancy outcomes among working women in Korea:A cross-sectional study[J].PLoS One,2017,12(8):182341-182342.