幽门螺杆菌感染与民族、体质指数、血脂、颈部血管斑块形成的关系
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摘要
目的了解幽门螺杆菌(Hp)感染与民族、年龄、体质指数(BMI)、血脂、颈部血管斑块形成的关系。方法收集2012年1月至2016年12月的在新疆医科大学第一附属医院住院的810例患者,根据13C-尿素呼气试验(UBT)或14C-UBT结果将研究对象分为Hp(+)组及Hp(-)组。分析Hp感染与性别、民族、年龄、BMI、血脂、颈部血管斑块形成是否存在联系。结果单因素分析结果显示Hp(+)组的少数民族、BMI≥25 kg/m2、甘油三酯>1.7 mmol/L和颈部血管形成斑块的比例大于Hp(-)组,差异有统计学意义(P<0.05,P<0.01)。将上述标作自变量再进行多因素Logistic回归分析结果显示,少数民族(P=0.000,OR=3.468,95%CI:2.396~5.019)、BMI≥25 kg/m2(P=0.020,OR=1.426,95%CI:1.058~1.922)、甘油三酯>1.7 mmol/L(P=0.026,OR=1.424,95%CI:1.042~1.944)、颈部血管斑块形成(P=0.027,OR=1.467,95%CI:1.045~2.060)是Hp感染的独立危险因素。结论 Hp感染在少数民族中易发,BMI升高、甘油三酯升高、颈部血管斑块形成是Hp感染的独立危险因素。
Objective To explore the correlation between Helicobacter pylori(Hp) infection and the patient' s ethnicity,age,body mass index(BMI),blood fat and neck vascular plaque formation. Methods A total of 810 patients hospitalized in the first hospital of Xinjiang medical university from January 2012 to December 2016 were selected and divided into Hp(+) group and Hp(-) group according to the results of13 C-urea breath test(UBT) or14 C-UBT. The associations of Hp infection with the patient' s ethnicity,age,BMI,blood fat and neck vascular plaque formation were analyzed. Results Univariate analysis showed that the proportions of minorities,BMI≥25 kg/m2,triglyceride > 1. 7 mmol/L and neck plaque in Hp(+) group were significantly larger than those in Hp(-) group(P < 0. 05,P < 0. 01). Multiple factor Logistic regression analysis showed that the national minority(P = 0. 000,OR = 3. 468,95% CI: 2. 396-5. 019),BMI≥25 kg/m2(P = 0. 020,OR = 1. 426,95% CI: 1. 058-1. 922),triglyceride > 1. 7 mmol/L(P = 0. 026,OR = 1. 424,95% CI: 1. 042-1. 944) and the formation of neck vascular plaque formation(P = 0. 027,OR = 1. 467,95% CI: 1. 045-2. 060) were the independent risk factors of Hp infection. Conclusion Hp infection is prone to occur in ethnic minorities,and the increasing of BMI and TG level and the formation of neck vascular plaque formation are the independent risk factors for Hp infection.
Objective To explore the correlation between Helicobacter pylori(Hp) infection and the patient' s ethnicity,age,body mass index(BMI),blood fat and neck vascular plaque formation. Methods A total of 810 patients hospitalized in the first hospital of Xinjiang medical university from January 2012 to December 2016 were selected and divided into Hp(+) group and Hp(-) group according to the results of13 C-urea breath test(UBT) or14 C-UBT. The associations of Hp infection with the patient' s ethnicity,age,BMI,blood fat and neck vascular plaque formation were analyzed. Results Univariate analysis showed that the proportions of minorities,BMI≥25 kg/m2,triglyceride > 1. 7 mmol/L and neck plaque in Hp(+) group were significantly larger than those in Hp(-) group(P < 0. 05,P < 0. 01). Multiple factor Logistic regression analysis showed that the national minority(P = 0. 000,OR = 3. 468,95% CI: 2. 396-5. 019),BMI≥25 kg/m2(P = 0. 020,OR = 1. 426,95% CI: 1. 058-1. 922),triglyceride > 1. 7 mmol/L(P = 0. 026,OR = 1. 424,95% CI: 1. 042-1. 944) and the formation of neck vascular plaque formation(P = 0. 027,OR = 1. 467,95% CI: 1. 045-2. 060) were the independent risk factors of Hp infection. Conclusion Hp infection is prone to occur in ethnic minorities,and the increasing of BMI and TG level and the formation of neck vascular plaque formation are the independent risk factors for Hp infection.
引文
[1]朱锦涛,魏哲威,周志军,等.幽门螺杆菌对胃癌患者预后的影响[J].热带医学杂志,2017,17(5):578-582.
[2]丁绍祥.脂质代谢失调作为慢性应激原致动脉粥样硬化的发病机制[J].中国老年学杂志,2011,31(11):2154-2157.
[3]吴士.2003年欧洲高血压治疗指南的内容简介[J].国外医学(心血管疾病分册),2003,30(4):199-205.
[4]胡伏莲.幽门螺杆菌感染诊疗指南[M].北京:人民卫生出版社,2006.
[5]Khalifa MM,Sharaf RR,Aziz RK.Helicobacter pylori:a poor man's gut pathogen[J].Gut Pathog,2010,2(1):2.
[6]Gasbarrini G,Racco S,Franceschi F,et al.Helicobacter pylori infection:from gastric to systemic disease[J].Recenti Prog Med,2010,101(1):27-33.
[7]刘兵荣,肖瑾,陈伟,等.幽门螺杆菌感染与脑梗死患者颈动脉粥样硬化斑块稳定性的关系[J].中国脑血管病杂志,2013,10(5):264-267.
[8]Vizzardi E,Bonadei I,Piovanelli B,et al.Helicobacter pylori and ischemic heart disease[J].Panminerva Med,2011,53(3):193-202.
[9]Akbas HS,Basyigit S,Suleymanlar I,et al.The assessment of carotid intima media thickness and serum paraoxonase-1 activity in Helicobacter pylori positive subjects[J].Lipids Health Dis,2010,9:92.
[10]李燕,李玉东,李纲,等.幽门螺杆菌感染对冠心病患者血清指标的影响[J].中华医院感染学杂志,2014,24(3):662-664.
[11]Kattan OM,Kasravi FB,Elford EL,et al.Apolipoprotein E-mediated immune regulation in sepsis[J].J Immunol,2008,181(2):1399-1408.
[12]Gen R,Demir M,Ataseven H.Effect of Helicobacter pylori eradication on insulin resistance,serum lipids and low-grade inflammation[J].South Med J,2010,103(3):190-196.
[13]Polyzos SA,Kountouras J,Zavos C,et al.The association between Helicobacter pylori infection and insulin resistance:a systematic review[J].Helicobacter,2011,16(2):79-88.
[14]Papamichael KX,Papaioannou G,Karga H,et al.Helicobacter pylori infection and endocrine disorders:is there a link?[J].World J Gastroenterol,2009,15(22):2701-2707.
[15]宋珏,冉利梅,华玉淑,等.幽门螺杆菌感染与体质量指数、血脂、尿酸的相关性分析[J].中国临床保健杂志,2015,18(2):160-163.
[16]刘玲梅,罗雁,刘会领,等.幽门螺杆菌感染对动脉粥样硬化的影响[J].中华医院感染学杂志,2013,23(9):2072-2073,2076.
[17]朱伟群,张萍萍,孙涛,等.幽门螺杆菌感染与动脉粥样硬化的关系及危险因素研究[J].中华医院感染学杂志,2017,27(15):3460-3463.
[18]卢晓旭,卢学锋,邱敬涛,等.Hp感染与超声检测颈动脉粥样硬化程度和MMP-9及内脂素的相关性研究[J].中华医院感染学杂志,2016,26(22):5141-5143.
[19]陈晶,付娟,刘娜,等.幽门螺杆菌感染对冠心病患者相关指标及颈动脉硬化的影响[J].中华医院感染学杂志,2016,26(13):2972-2974.
[20]DavìG,Neri M,Falco A,et al.Helicobacter pylori infection causes persistent platelet activation in vivo through enhanced lipid peroxidation[J].Arterioscler Thromb Vasc Biol,2005,25(1):246-251.
[2]丁绍祥.脂质代谢失调作为慢性应激原致动脉粥样硬化的发病机制[J].中国老年学杂志,2011,31(11):2154-2157.
[3]吴士.2003年欧洲高血压治疗指南的内容简介[J].国外医学(心血管疾病分册),2003,30(4):199-205.
[4]胡伏莲.幽门螺杆菌感染诊疗指南[M].北京:人民卫生出版社,2006.
[5]Khalifa MM,Sharaf RR,Aziz RK.Helicobacter pylori:a poor man's gut pathogen[J].Gut Pathog,2010,2(1):2.
[6]Gasbarrini G,Racco S,Franceschi F,et al.Helicobacter pylori infection:from gastric to systemic disease[J].Recenti Prog Med,2010,101(1):27-33.
[7]刘兵荣,肖瑾,陈伟,等.幽门螺杆菌感染与脑梗死患者颈动脉粥样硬化斑块稳定性的关系[J].中国脑血管病杂志,2013,10(5):264-267.
[8]Vizzardi E,Bonadei I,Piovanelli B,et al.Helicobacter pylori and ischemic heart disease[J].Panminerva Med,2011,53(3):193-202.
[9]Akbas HS,Basyigit S,Suleymanlar I,et al.The assessment of carotid intima media thickness and serum paraoxonase-1 activity in Helicobacter pylori positive subjects[J].Lipids Health Dis,2010,9:92.
[10]李燕,李玉东,李纲,等.幽门螺杆菌感染对冠心病患者血清指标的影响[J].中华医院感染学杂志,2014,24(3):662-664.
[11]Kattan OM,Kasravi FB,Elford EL,et al.Apolipoprotein E-mediated immune regulation in sepsis[J].J Immunol,2008,181(2):1399-1408.
[12]Gen R,Demir M,Ataseven H.Effect of Helicobacter pylori eradication on insulin resistance,serum lipids and low-grade inflammation[J].South Med J,2010,103(3):190-196.
[13]Polyzos SA,Kountouras J,Zavos C,et al.The association between Helicobacter pylori infection and insulin resistance:a systematic review[J].Helicobacter,2011,16(2):79-88.
[14]Papamichael KX,Papaioannou G,Karga H,et al.Helicobacter pylori infection and endocrine disorders:is there a link?[J].World J Gastroenterol,2009,15(22):2701-2707.
[15]宋珏,冉利梅,华玉淑,等.幽门螺杆菌感染与体质量指数、血脂、尿酸的相关性分析[J].中国临床保健杂志,2015,18(2):160-163.
[16]刘玲梅,罗雁,刘会领,等.幽门螺杆菌感染对动脉粥样硬化的影响[J].中华医院感染学杂志,2013,23(9):2072-2073,2076.
[17]朱伟群,张萍萍,孙涛,等.幽门螺杆菌感染与动脉粥样硬化的关系及危险因素研究[J].中华医院感染学杂志,2017,27(15):3460-3463.
[18]卢晓旭,卢学锋,邱敬涛,等.Hp感染与超声检测颈动脉粥样硬化程度和MMP-9及内脂素的相关性研究[J].中华医院感染学杂志,2016,26(22):5141-5143.
[19]陈晶,付娟,刘娜,等.幽门螺杆菌感染对冠心病患者相关指标及颈动脉硬化的影响[J].中华医院感染学杂志,2016,26(13):2972-2974.
[20]DavìG,Neri M,Falco A,et al.Helicobacter pylori infection causes persistent platelet activation in vivo through enhanced lipid peroxidation[J].Arterioscler Thromb Vasc Biol,2005,25(1):246-251.