氧化应激致精子DNA碎片化异常相关机制的研究进展
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摘要
男性精子DNA碎片化(sperm DNA fragment,SDF)异常与不育,流产及后代发育不良之间的密切关系被越来越多的研究证实。氧化应激,染色质组装异常以及细胞凋亡是目前认为导致SDF的主要机制。其中,氧化应激在SDF异常发生的整个过程居主要地位。
It has been confirmed by more and more researches that sperm DNA fragment(SDF) is closely related to infertility, miscarriage, dysplasia of offspring.The main mechanism currently recognizedleading to SDF include oxidative stress disorders, abnormal chromatin assembly and apoptosis, where oxidative stress disorders play the major role.
It has been confirmed by more and more researches that sperm DNA fragment(SDF) is closely related to infertility, miscarriage, dysplasia of offspring.The main mechanism currently recognizedleading to SDF include oxidative stress disorders, abnormal chromatin assembly and apoptosis, where oxidative stress disorders play the major role.
引文
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[9] 胡启蒙.哺乳动物精子超激活运动研究进展[J].生命科学,2017,29(11):1185-1191.
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[15] Houston BJ,Nixon B,King BV et al.The effects of radiofrequency electromagnetic radiation on sperm function[J].Reproduction,2016,152(6):R263-R276.
[16] De Iuliis GN,Thomson LK,Mitchell LA,et al.DNA damage in human spermatozoa is highly correlated with the efficiency of chromatin remodeling and the formation of 8-hydroxy-2′-deoxyguanosine,a marker of oxidative stress[J].Biol Reprod,2009,81(3):517-524.
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[18] Muratori M,Marchiani S,Maggi M,et al.Origin and biological significance of DNA fragmentation in human spermatozoa[J].Front Biosci,2006,11(1):1491-1499.
[19] Moazamian R,Polhemus A,Connaughton H,et al.Oxidative stress and human spermatozoa:diagnostic and functional significance of aldehydes generated as a result of lipid peroxidation[J].Mol Hum Reprod,2015,21(6):502-515.
[20] Ollero M,Gil-Guzman E,Lopez MC,et al.Characterization of subsets of human spermatozoa at different stages of maturation:implications in the diagnosis and treatment of male infertility[J].Hum.Reprod,2001,16(9):1912-1921.
[21] Atig F,Raffa M,Ali HB,et al.Altered antioxidant status and increased lipid per-oxidation in seminal plasma of tunisian infertile men[J].Int J Biol Sci ,2012,8(1):139-149.
[22] Aktan G,Dogru-Abbasoglu S,Kucukgergin C,et al.Mystery of idiopathic male infertility:Is oxidative stress an actual risk? [J].Fertil Steril,2013,99(5):1211-1215.
[23] ?uczaj W,Skrzydlewska E.DNA damage caused by lipid peroxidation products[J] .Cell Mol Biol Lett,2003,8(2):391-413.
[24] Lord T,Aitken RJ.Fertilization stimulates 8-hydroxy-2′-deoxyguanosine repair and antioxidant activity to prevent mutagenesis in the embryo[J].Dev Biol ,2015,406(1):1-13.
[25] Badouard C,Menezo Y,Panteix G,et al.Determination of new types of DNA lesions in human sperm[J].Zygote ,2008,16(1):9-13.
[26] Sakkas D,Alvarez JG.Sperm DNA fragmentation:Mechanisms of origin,impact on reproductive outcome,and analysis[J].Fertil Steril,2010,93(4):1027-1036.
[27] Smith TB,Dun MD,Smith ND,et al.2013.The presence of a truncated base excision repair pathway in human spermatozoa that is mediated by OGG1[J].J Cell Sci ,2013,126:1488-1497.
[28] Shukla KK,Mahdi AA,Rajender S.Apoptosis,spermatogenesis and male infertility[J].Front Biosci (Elite Ed),2012,1(4):746-754.
[29] Aitken RJ,Koppers AJ.Apoptosis and DNA damage in human spermatozoa[J].Asian J Androl,2011(1):36-42.
[30] 马淇,刘垒,陈佺.活性氧、线粒体通透性转换与细胞凋亡[J].生物物理学报,2012,28(7):523-536.
[31] Treulen F,UribeP P,Boguen R,et al.Mitochondrial outer membrane permeabilization increases reactive oxygen species production and decreases mean sperm velocity but is not associated with DNA fragmentation in human sperm[J].Mol Hum Reprod,2016,22(2):83-92.
[2] Smit M,Dohle GR,Hop WC,et al.Clinica I correIates of the biologica I variation of sperm DNA fragmentation in infertile men attending an andrology outpatient clinic[J].Int J Androl,2007,30(1):48-55.
[3] Zandieh Z,Vatannejad A,Doosti M,et al.Comparing reactive oxygen species and DNA fragmentation in semen samples of unexplained infertile and healthy fertile men[J] .Ir J Med Sci,2018,187(3):657-662.
[4] Ohno M,Sakumi K ,Fukumura R,et al.8-oxoguanine causes spontaneous de novo germline mutations in mice[J].Sci Rep,2014,15(4):4689-4693.
[5] Agarwal A,Virk G,Ong C,et al.Effect of oxidative stress on male reproduction[J] .World J Mens Health,2014,32(1):1-17.
[6] Aitken RJ.Reactive oxygen species as mediators of sperm capacitation and pathological damage[J].Mol Reprod.Dev,2017,84(10):1039-1052.
[7] Sharma RK,Agarwal A.Role of reactive oxygen species in male infertility[J].Urology,1996,48(6):835-850.
[8] Vizel R,Hillman P,Ickowicz D,et al.AKAP3 degradation in sperm capacitation is regulated by its tyrosine phosphorylation[J].Biochim Biophys Acta,2015,1850(9):1912-1920.
[9] 胡启蒙.哺乳动物精子超激活运动研究进展[J].生命科学,2017,29(11):1185-1191.
[10] Wright C,MilneS,Leeson H.Sperm DNA damage caused by oxidative stress:modifiable clinical,lifestyle and nutritional factors in male infertility[J].Reprod Biomed Online,2014,28(6):684-703.
[11] Aitken RJ,Gibb Z,Baker MA,et al.Causes and consequences of oxidative stress in spermatozoa[J].Reprod Fertil Dev,2016,28(1-2): 1-10.
[12] Aboulmaouahib S,Madkour A,Kaarouch I, et al.Impact of alcohol and cigarette smoking consumption in male fertility potential:Looks at lipid peroxidation,enzymatic antioxidant activities and sperm DNA damage[J].Andrologia,2017:e12926-e12926.
[13] Schulte RT,Ohl DM,Smith GD.Sperm DNA damage in male infertility:Etiologies,assays,and outcomes[J].J Assist Reprod Genet,2010,27(1):3-12.
[14] Bj?rndahl L,Kvist U.Structure of chromatin in spermatozoa[J].Adv Exp Med Biol,2014,791:1-11.
[15] Houston BJ,Nixon B,King BV et al.The effects of radiofrequency electromagnetic radiation on sperm function[J].Reproduction,2016,152(6):R263-R276.
[16] De Iuliis GN,Thomson LK,Mitchell LA,et al.DNA damage in human spermatozoa is highly correlated with the efficiency of chromatin remodeling and the formation of 8-hydroxy-2′-deoxyguanosine,a marker of oxidative stress[J].Biol Reprod,2009,81(3):517-524.
[17] Sakkas D,Seli E,Manicardi GC,et al.The presence of abnormal spermatozoa in the ejaculate:Did apoptosis fail?[J].Hum Fertil (Camb),2004,7(2):99-103.
[18] Muratori M,Marchiani S,Maggi M,et al.Origin and biological significance of DNA fragmentation in human spermatozoa[J].Front Biosci,2006,11(1):1491-1499.
[19] Moazamian R,Polhemus A,Connaughton H,et al.Oxidative stress and human spermatozoa:diagnostic and functional significance of aldehydes generated as a result of lipid peroxidation[J].Mol Hum Reprod,2015,21(6):502-515.
[20] Ollero M,Gil-Guzman E,Lopez MC,et al.Characterization of subsets of human spermatozoa at different stages of maturation:implications in the diagnosis and treatment of male infertility[J].Hum.Reprod,2001,16(9):1912-1921.
[21] Atig F,Raffa M,Ali HB,et al.Altered antioxidant status and increased lipid per-oxidation in seminal plasma of tunisian infertile men[J].Int J Biol Sci ,2012,8(1):139-149.
[22] Aktan G,Dogru-Abbasoglu S,Kucukgergin C,et al.Mystery of idiopathic male infertility:Is oxidative stress an actual risk? [J].Fertil Steril,2013,99(5):1211-1215.
[23] ?uczaj W,Skrzydlewska E.DNA damage caused by lipid peroxidation products[J] .Cell Mol Biol Lett,2003,8(2):391-413.
[24] Lord T,Aitken RJ.Fertilization stimulates 8-hydroxy-2′-deoxyguanosine repair and antioxidant activity to prevent mutagenesis in the embryo[J].Dev Biol ,2015,406(1):1-13.
[25] Badouard C,Menezo Y,Panteix G,et al.Determination of new types of DNA lesions in human sperm[J].Zygote ,2008,16(1):9-13.
[26] Sakkas D,Alvarez JG.Sperm DNA fragmentation:Mechanisms of origin,impact on reproductive outcome,and analysis[J].Fertil Steril,2010,93(4):1027-1036.
[27] Smith TB,Dun MD,Smith ND,et al.2013.The presence of a truncated base excision repair pathway in human spermatozoa that is mediated by OGG1[J].J Cell Sci ,2013,126:1488-1497.
[28] Shukla KK,Mahdi AA,Rajender S.Apoptosis,spermatogenesis and male infertility[J].Front Biosci (Elite Ed),2012,1(4):746-754.
[29] Aitken RJ,Koppers AJ.Apoptosis and DNA damage in human spermatozoa[J].Asian J Androl,2011(1):36-42.
[30] 马淇,刘垒,陈佺.活性氧、线粒体通透性转换与细胞凋亡[J].生物物理学报,2012,28(7):523-536.
[31] Treulen F,UribeP P,Boguen R,et al.Mitochondrial outer membrane permeabilization increases reactive oxygen species production and decreases mean sperm velocity but is not associated with DNA fragmentation in human sperm[J].Mol Hum Reprod,2016,22(2):83-92.