雪菊化学成分分析、提取、鉴定及其生物活性研究进展
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摘要
对目前国内外在雪菊(Coreopsis tinctoria)的有效化学成分分析、提取、鉴定及其生物活性等方面的研究进展进行综述,并提出一些建议,旨在为雪菊的深入研究和开发利用提供参考。
Kunlun chrysanthemum(Coreopsis tinctoria), which is found in the high altitude mountain area of Xinjiang, China, is reported to exhibit a broad spectrum of biological activities including hypolipidemic, hypoglycemic, antihypertensive and anti-oxidant effects. In this review, we summarize the recent progresses in the analysis, extraction and characterization and biological activities of chemical substances of Coreopsis tinctoria, with the aim to lay the ground for further study of its biological functions and development into functional foods.
Kunlun chrysanthemum(Coreopsis tinctoria), which is found in the high altitude mountain area of Xinjiang, China, is reported to exhibit a broad spectrum of biological activities including hypolipidemic, hypoglycemic, antihypertensive and anti-oxidant effects. In this review, we summarize the recent progresses in the analysis, extraction and characterization and biological activities of chemical substances of Coreopsis tinctoria, with the aim to lay the ground for further study of its biological functions and development into functional foods.
引文
[1]张媛,木合布力·阿不力孜,李志远.金鸡菊属药用植物研究进展[J].中国中药杂志,2013,38(16):2633-2638.
[2]李冬明.昆仑雪菊的药学研究进展[J].浙江中医杂志,2012,47(10):776-777.
[3]ZHANG Yuan,SHI Shepo,ZHAO Mingbo,et al.Coreosides A-D,C14-polyacetylene glycosides from the capitula of Coreopsis tinctoria and its anti-infl ammatory activity against COX-2[J].Fitoterapia,2013,87:93-97.
[4]梁淑红,庞市宾,刘晓燕,等.金鸡菊提取物降血脂作用的研究[J].中国实验方剂学杂志,2010(8):234-235.
[5]梁淑红,庞市宾,刘晓燕,等.金鸡菊提取物降血脂作用的动物实验研究[J].农垦医学,2009,31(6):495-498.
[6]崔康康,姬凤彩,王志琴,等.新疆昆仑雪菊水提液对大鼠血压的影响[J].畜牧兽医科技信息,2013(7):17-19.
[7]梁淑红,哈木拉提,庞市宾,等.金鸡菊提取物降血压化学成分实验研究[J].时珍国医国药,2012,21(7):1619-1621.
[8]曹燕,庞市宾,徐磊,等.金鸡菊提取物对血管环舒张作用的探讨[J].农垦医学,2011,33(2):148-152.
[9]明婷,孙玉华,胡梦颖,等.金鸡菊提取物降压及体内抗氧化作用的研究[J].中国实验方剂学杂志,2012,18(10):249-252.
[10]张淑鹏,李琳琳,王丽凤,等.昆仑雪菊提取物对α-葡萄糖苷酶的抑制作用[J].现代生物医学进展,2011,11(6):1055-1058.
[11]张燕,李琳琳,王丽凤,等.新疆昆仑雪菊5种提取物对α-葡萄糖苷酶活性的影响[J].中国实验方剂学杂志,2011,17(7):166-169.
[12]明婷,庞市宾,刘晓燕,等.金鸡菊提取物对微循环及抗凝血作用的实验研究[J].农垦医学,2012,34(1):17-19.
[13]曹燕,庞市宾,徐磊,等.金鸡菊提取物体外抗氧化活性[J].中国实验方剂学杂志,2011,17(12):144-147.
[14]鲁晓翔.黄酮类化合物抗氧化作用机制研究进展[J].食品研究与开发,2012,33(3):220-224.
[15]沈维治,邹宇晓,刘凡,等.顶空固相微萃取气质联用分析比较雪菊与市售菊花的挥发性成分[J].热带作物学报,2013,34(4):771-776.
[16]张彦丽,韩艳春,阿依吐伦·斯马义.GC-MS对昆仑雪菊挥发油成分的研究[J].新疆医科大学学报,2010,33(11):1299-1300.
[17]张彦丽,阿布都热合曼·合力力,阿依吐伦·斯马义.苯酚-硫酸法测定维吾尔药昆仑雪菊多糖含量的研究[J].药物分析杂志,2010(11):2205-2207.
[18]木合布力·阿布力孜,张兰,张敏.昆仑雪菊中氨基酸的含量分析[J].医药导报,2011,30(4):431-432.
[19]张彦丽,韩艳春,阿依吐伦·斯马义.分光光度法测定维吾尔药昆仑雪菊中总皂苷的含量[J].西北药学杂志,2011,26(2):87-88.
[20]西力扎提·阿布来提,古海妮萨·麦合木提,哈力旦·阿布力米提,等.超声微波协同萃取维药雪菊中总黄酮工艺研究[J].广州化工,2013,41(7):75-77.
[21]张燕,景兆均,毛新民.新疆昆仑雪菊化学成分的初步定性研究[J].新疆医科大学学报,2010,33(6):628-630.
[22]买买提·艾买提,赵文惠,木合布力·阿布力孜,等.反相高效液相色谱法测定昆仑雪菊中绿原酸的含量[J].新疆医科大学学报,2011,34(12):1370-1372.
[23]张彦丽,王艳,李新霞,等.高效液相色谱法测定昆仑雪菊中绿原酸和黄芩苷的含量[J].中国实验方剂学杂志,2012,18(4):107-109.
[24]热阳古·阿布拉,夏娜,木尼热·阿不都克里木,等.昆仑雪菊总黄酮的提取及含量测定[J].喀什师范学院学报,2013,34(3):45-47.
[25]王艳,张彦丽.分光光度法测定新疆昆仑雪菊中总黄酮的含量[J].新疆医科大学学报,2011,34(8):817-819.
[26]买买提·艾买提,木合布力·阿布力孜,孟磊.新疆昆仑雪菊水溶性总黄酮的含量测定[J].海峡药学,2010,22(10):56-58.
[27]景玉霞,兰卫.不同产地昆仑雪菊总黄酮含量测定[J].新疆中医药,2012,30(5):62-64.
[28]孙自增,毕肯·阿不都克力木,张彦丽.不同产地雪菊化学成分含量测定及模式识别研究[J].中国实验方剂学志,2012,18(24):174-178.
[29]黎耀东,闫素雅,李晓瑾,等.昆仑雪菊的红外光谱产地鉴别[J].现代仪器,2012,18(6):71-73.
[30]沈维治,邹宇晓,刘凡,等.雪菊与市售菊花活性成分的比较研究[J].热带作物学报,2012,33(12):2284-2287.
[31]兰卫,赵保胜,李玉清,等.昆仑雪菊中多种成分的含量测定[J].中国实验方剂学杂志,2012,18(10):101-103.
[32]WALLE T.Absorption and metabolism of flavonoids[J].Free Radical Biology&Medicine,2004,36(7):829-837.
[33]QURESHI I.Following the flavonoids:a close look at flavonoids shows their multiple actions against dementia[J].Nutritional Outlook,2013,16(7):32-39.
[34]CHUN O K,CHUNG S J,SONG W O.Estimated dietary flavonoid intake and major food sources of US adults[J].The Journal of Nutrition,2007,137(5):1244-1252.
[35]LOPEZ-LAZARO M.Flavonoids as anticancer agents:structureactivity relationship study[J].Current Medicinal Chemistry-AntiCancer Agents,2002,2(6):691-714.
[36]GOSSLAU A,LI S,HO C T,et al.The importance of natural product characterization in studies of their anti-inflammatory activity[J].Molecular Nutrition&Food Research,2011,55(1):74-82.
[37]赵军,孙玉华,徐芳,等.昆仑雪菊黄酮类成分研究[J].天然产物研究与开发,2013,25(1):50-52.
[38]郑大成,木合布力·阿布力孜,阿依努尔·吐鲁洪,等.昆仑雪菊水溶性黄酮的制备及初步鉴定[J].亚太传统医药,2010,6(10):18-20.
[39]吴瑛,王秀芳,袁守亮.响应面分析昆仑雪菊水溶性黄酮类化合物的提取工艺[J].食品科学,2013,34(6):129-133.
[40]赵文杰,敬思群.响应面法回流提取新疆昆仑雪菊原花青素工艺优化[J].食品科技,2013(4):214-219.
[41]张彦丽,丁海燕,王艳.超声-微波协同萃取法提取昆仑雪菊中总黄酮的研究[J].广州化工,2012,39(21):57-59.
[42]张媛,屠鹏飞.两色金鸡菊头状花序的化学成分研究[J].中国中药杂志,2012,37(23):3581-3584.
[43]ZHANG Yuan,SHI Shepo,ZHAO Minbo,et al.A novel chalcone from Coreopsis tinctoria Nutt[J].Biochemical Systematics and Ecology,2006,34(10):766-769.
[44]SHIMOKORIYAMA M.Anthochlor pigments of Coreopsis tinctoria[J].Journal of the American Chemical Society,1957,79(1):214-220.
[45]HARBORNE J B,GEISSMAN T A.Anthochlor pigments.XII.Maritimein and marein[J].Journal of the American Chemical Society,1956,78(4):829-832.
[46]SUN Y H,ZHAO J,JIN H T,et al.Vasorelaxant effects of the extracts and some flavonoids from the buds of Coreopsis tinctoria[J].Pharmaceutical Biology,2013,51(9):1158-1164.
[47]ABDUREYIM A,ABLIZ M,SULTAN A,et al.Phenolic compounds from the flowers of Coreopsis tinctoria[J].Chemistry of Natural Compounds,2013,48(6):1085-1086.
[48]CRISAN CC,CACLINESCU I,ZALARU C,et al.Techniques for extraction polyphenols from Coreopsis tinctorial Nutt.fruits[J].UPB Science Bulletin B,2013,75(4):169-178.
[49]潘英,李宁,倪慧,等.金鸡菊属植物化学成分和药理活性研究进展[J].现代药物与临床,2012,27(5):512-518.
[50]沙爱龙,吴瑛,盛海燕,等.昆仑雪菊黄酮对衰老模型小鼠脑及脏器指数的影响[J].动物医学进展,2013(7):66-68.
[51]DIAS T,BRONZE M R,HOUGHTON P J,et al.The flavonoid-rich fraction of Coreopsis tinctoria promotes glucose tolerance regain through pancreatic function recovery in streptozotocin-induced glucose-intolerant rats[J].Journal of Ethnopharmacology,2010,132(2):483-490.
[52]DIAS T,MOTA-FILIPE H,LIU B,et al.Recovery of oral glucose tolerance by Wistar rats after treatment with Coreopsis tinctoriainfusion[J].Phytotherapy Research,2010,24(5):699-705.
[53]INGUK H,HYUNYOUNG K,KEUMIL J,et al.Biological activities of Coreopsis tinctoria Nutt.flower extracts[J].Korean Journal of Horticultural Science&Technology,2010,28(5):857-863.
[54]LIU Y,ZHANG Y,LIU X M,et al.Interactions between thrombin and natural products of Coreopsis tinctoria Nutt and Cistanche deserticola Ma in capillary zone electrophoresis[J].Journal of Pharmaceutical Sciences,2006,15(1):38-44.
[2]李冬明.昆仑雪菊的药学研究进展[J].浙江中医杂志,2012,47(10):776-777.
[3]ZHANG Yuan,SHI Shepo,ZHAO Mingbo,et al.Coreosides A-D,C14-polyacetylene glycosides from the capitula of Coreopsis tinctoria and its anti-infl ammatory activity against COX-2[J].Fitoterapia,2013,87:93-97.
[4]梁淑红,庞市宾,刘晓燕,等.金鸡菊提取物降血脂作用的研究[J].中国实验方剂学杂志,2010(8):234-235.
[5]梁淑红,庞市宾,刘晓燕,等.金鸡菊提取物降血脂作用的动物实验研究[J].农垦医学,2009,31(6):495-498.
[6]崔康康,姬凤彩,王志琴,等.新疆昆仑雪菊水提液对大鼠血压的影响[J].畜牧兽医科技信息,2013(7):17-19.
[7]梁淑红,哈木拉提,庞市宾,等.金鸡菊提取物降血压化学成分实验研究[J].时珍国医国药,2012,21(7):1619-1621.
[8]曹燕,庞市宾,徐磊,等.金鸡菊提取物对血管环舒张作用的探讨[J].农垦医学,2011,33(2):148-152.
[9]明婷,孙玉华,胡梦颖,等.金鸡菊提取物降压及体内抗氧化作用的研究[J].中国实验方剂学杂志,2012,18(10):249-252.
[10]张淑鹏,李琳琳,王丽凤,等.昆仑雪菊提取物对α-葡萄糖苷酶的抑制作用[J].现代生物医学进展,2011,11(6):1055-1058.
[11]张燕,李琳琳,王丽凤,等.新疆昆仑雪菊5种提取物对α-葡萄糖苷酶活性的影响[J].中国实验方剂学杂志,2011,17(7):166-169.
[12]明婷,庞市宾,刘晓燕,等.金鸡菊提取物对微循环及抗凝血作用的实验研究[J].农垦医学,2012,34(1):17-19.
[13]曹燕,庞市宾,徐磊,等.金鸡菊提取物体外抗氧化活性[J].中国实验方剂学杂志,2011,17(12):144-147.
[14]鲁晓翔.黄酮类化合物抗氧化作用机制研究进展[J].食品研究与开发,2012,33(3):220-224.
[15]沈维治,邹宇晓,刘凡,等.顶空固相微萃取气质联用分析比较雪菊与市售菊花的挥发性成分[J].热带作物学报,2013,34(4):771-776.
[16]张彦丽,韩艳春,阿依吐伦·斯马义.GC-MS对昆仑雪菊挥发油成分的研究[J].新疆医科大学学报,2010,33(11):1299-1300.
[17]张彦丽,阿布都热合曼·合力力,阿依吐伦·斯马义.苯酚-硫酸法测定维吾尔药昆仑雪菊多糖含量的研究[J].药物分析杂志,2010(11):2205-2207.
[18]木合布力·阿布力孜,张兰,张敏.昆仑雪菊中氨基酸的含量分析[J].医药导报,2011,30(4):431-432.
[19]张彦丽,韩艳春,阿依吐伦·斯马义.分光光度法测定维吾尔药昆仑雪菊中总皂苷的含量[J].西北药学杂志,2011,26(2):87-88.
[20]西力扎提·阿布来提,古海妮萨·麦合木提,哈力旦·阿布力米提,等.超声微波协同萃取维药雪菊中总黄酮工艺研究[J].广州化工,2013,41(7):75-77.
[21]张燕,景兆均,毛新民.新疆昆仑雪菊化学成分的初步定性研究[J].新疆医科大学学报,2010,33(6):628-630.
[22]买买提·艾买提,赵文惠,木合布力·阿布力孜,等.反相高效液相色谱法测定昆仑雪菊中绿原酸的含量[J].新疆医科大学学报,2011,34(12):1370-1372.
[23]张彦丽,王艳,李新霞,等.高效液相色谱法测定昆仑雪菊中绿原酸和黄芩苷的含量[J].中国实验方剂学杂志,2012,18(4):107-109.
[24]热阳古·阿布拉,夏娜,木尼热·阿不都克里木,等.昆仑雪菊总黄酮的提取及含量测定[J].喀什师范学院学报,2013,34(3):45-47.
[25]王艳,张彦丽.分光光度法测定新疆昆仑雪菊中总黄酮的含量[J].新疆医科大学学报,2011,34(8):817-819.
[26]买买提·艾买提,木合布力·阿布力孜,孟磊.新疆昆仑雪菊水溶性总黄酮的含量测定[J].海峡药学,2010,22(10):56-58.
[27]景玉霞,兰卫.不同产地昆仑雪菊总黄酮含量测定[J].新疆中医药,2012,30(5):62-64.
[28]孙自增,毕肯·阿不都克力木,张彦丽.不同产地雪菊化学成分含量测定及模式识别研究[J].中国实验方剂学志,2012,18(24):174-178.
[29]黎耀东,闫素雅,李晓瑾,等.昆仑雪菊的红外光谱产地鉴别[J].现代仪器,2012,18(6):71-73.
[30]沈维治,邹宇晓,刘凡,等.雪菊与市售菊花活性成分的比较研究[J].热带作物学报,2012,33(12):2284-2287.
[31]兰卫,赵保胜,李玉清,等.昆仑雪菊中多种成分的含量测定[J].中国实验方剂学杂志,2012,18(10):101-103.
[32]WALLE T.Absorption and metabolism of flavonoids[J].Free Radical Biology&Medicine,2004,36(7):829-837.
[33]QURESHI I.Following the flavonoids:a close look at flavonoids shows their multiple actions against dementia[J].Nutritional Outlook,2013,16(7):32-39.
[34]CHUN O K,CHUNG S J,SONG W O.Estimated dietary flavonoid intake and major food sources of US adults[J].The Journal of Nutrition,2007,137(5):1244-1252.
[35]LOPEZ-LAZARO M.Flavonoids as anticancer agents:structureactivity relationship study[J].Current Medicinal Chemistry-AntiCancer Agents,2002,2(6):691-714.
[36]GOSSLAU A,LI S,HO C T,et al.The importance of natural product characterization in studies of their anti-inflammatory activity[J].Molecular Nutrition&Food Research,2011,55(1):74-82.
[37]赵军,孙玉华,徐芳,等.昆仑雪菊黄酮类成分研究[J].天然产物研究与开发,2013,25(1):50-52.
[38]郑大成,木合布力·阿布力孜,阿依努尔·吐鲁洪,等.昆仑雪菊水溶性黄酮的制备及初步鉴定[J].亚太传统医药,2010,6(10):18-20.
[39]吴瑛,王秀芳,袁守亮.响应面分析昆仑雪菊水溶性黄酮类化合物的提取工艺[J].食品科学,2013,34(6):129-133.
[40]赵文杰,敬思群.响应面法回流提取新疆昆仑雪菊原花青素工艺优化[J].食品科技,2013(4):214-219.
[41]张彦丽,丁海燕,王艳.超声-微波协同萃取法提取昆仑雪菊中总黄酮的研究[J].广州化工,2012,39(21):57-59.
[42]张媛,屠鹏飞.两色金鸡菊头状花序的化学成分研究[J].中国中药杂志,2012,37(23):3581-3584.
[43]ZHANG Yuan,SHI Shepo,ZHAO Minbo,et al.A novel chalcone from Coreopsis tinctoria Nutt[J].Biochemical Systematics and Ecology,2006,34(10):766-769.
[44]SHIMOKORIYAMA M.Anthochlor pigments of Coreopsis tinctoria[J].Journal of the American Chemical Society,1957,79(1):214-220.
[45]HARBORNE J B,GEISSMAN T A.Anthochlor pigments.XII.Maritimein and marein[J].Journal of the American Chemical Society,1956,78(4):829-832.
[46]SUN Y H,ZHAO J,JIN H T,et al.Vasorelaxant effects of the extracts and some flavonoids from the buds of Coreopsis tinctoria[J].Pharmaceutical Biology,2013,51(9):1158-1164.
[47]ABDUREYIM A,ABLIZ M,SULTAN A,et al.Phenolic compounds from the flowers of Coreopsis tinctoria[J].Chemistry of Natural Compounds,2013,48(6):1085-1086.
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