维医异常黏液质型阳痿患者肝功指标和血脂改变的研究
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摘要
目的探讨肝功能和脂代谢改变与异常黏液质型阳痿的关系。方法选取国际勃起功能指数5项(IIEF-5)评分<22分的阳痿患者112例,在维医辨证分型的基础上分为异常黏液质型阳痿组(46例)和非异常黏液质型阳痿组(66例),并选取正常对照组28例,检测肝功指标及血脂7项。结果 (1)肝功指标:异常黏液质型阳痿组中碱性磷酸酶(ALP)、胆碱酯酶(ChE)、总胆红素(TBILI)和间接胆红素(IBILI)较正常对照组显著降低(P<0.05)。异常黏液质型阳痿组总蛋白(TP)与白蛋白(ALB)较正常对照组和非异常黏液质型阳痿组均显著降低(P<0.05)。异常黏液质型阳痿组L-γ-谷氨酰胺转移酶(L-γ-GGT)和总胆汁酸(TBA)较正常对照组与非异常黏液质型阳痿组均显著升高(P<0.05)。(2)血脂谱变化:异常黏液质型阳痿组甘油三酯(TG)较正常对照组显著升高(P<0.05)。异常黏液质型阳痿组极低密度脂蛋白胆固醇(VLDL-C)较正常对照组和非异常黏液质型阳痿组显著升高(P<0.05)。结论肝功能和脂肪代谢异常可能与维医异常黏液质型阳痿病证的发生、发展有关。
Objective To evaluate the relationship between liver function and lipid metabolism and abnormal mucinous impotence.Methods A total of 112 male impotence disease patients(IIEF-5scores<22)were divided into impotence group with abnormal phlegmatic syndrome and impotence group without abnormal phlegmatic syndrome according to Uyghur medicine,and 28 healthy males as the normal control group.Hepatic biochemical indexes and serum lipid levels were detected.Results(1)Changes of hepatic biochemical indexes:ALP,ChE,TBILI,DBILI and IBILI levels in impotence group with abnormal phlegmatic syndrome were significantly decreased compared to normal control group(P <0.05).TP and ALB levels in impotence group with abnormal phlegmatic syndrome were significantly decreased compared to both the normal control group and impotence group without abnormal phlegmatic syndrome(P <0.05).L-γ-GGT and TBA levels were significantly increased in impotence group with abnormal phlegmatic syndrome compared to both the normal control group and impotence group without abnormal phlegmatic syndrome(P <0.05).(2)Serum lipid change:TG level was significantly increased in impotence group with abnormal phlegmatic syndrome compared to the normal control group(P <0.05),while VLDL-C level was significantly increased in impotence group with abnormal phlegmatic syndrome compared to both the normal control group and impotence group without abnormal phlegmatic syndrome(P <0.05).Conclusion Changes of hepatic biochemical indexes and serum lipid levels might be highly related to the initiation and development of impotence disease with abnormal phlegmatic syndrome.
Objective To evaluate the relationship between liver function and lipid metabolism and abnormal mucinous impotence.Methods A total of 112 male impotence disease patients(IIEF-5scores<22)were divided into impotence group with abnormal phlegmatic syndrome and impotence group without abnormal phlegmatic syndrome according to Uyghur medicine,and 28 healthy males as the normal control group.Hepatic biochemical indexes and serum lipid levels were detected.Results(1)Changes of hepatic biochemical indexes:ALP,ChE,TBILI,DBILI and IBILI levels in impotence group with abnormal phlegmatic syndrome were significantly decreased compared to normal control group(P <0.05).TP and ALB levels in impotence group with abnormal phlegmatic syndrome were significantly decreased compared to both the normal control group and impotence group without abnormal phlegmatic syndrome(P <0.05).L-γ-GGT and TBA levels were significantly increased in impotence group with abnormal phlegmatic syndrome compared to both the normal control group and impotence group without abnormal phlegmatic syndrome(P <0.05).(2)Serum lipid change:TG level was significantly increased in impotence group with abnormal phlegmatic syndrome compared to the normal control group(P <0.05),while VLDL-C level was significantly increased in impotence group with abnormal phlegmatic syndrome compared to both the normal control group and impotence group without abnormal phlegmatic syndrome(P <0.05).Conclusion Changes of hepatic biochemical indexes and serum lipid levels might be highly related to the initiation and development of impotence disease with abnormal phlegmatic syndrome.
引文
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[10]MULHALL J,TENOKEN P,BROCK G,et al.Obesity,dyslipidemias and erectile dysfunction:a report of a subcommittee of the sexual medicine society of North America[J].J Sex Med,2006,3(5):778-786.
[11]BRENTZOS G E,PARASKEVAS K I,MIKHAILIDIS D P.Dyslipidemia as a risk factor for erectile dysfunction[J].Curr Med Chem 2007,14(16):1765-1770.
[12]CAI Z,XI H,PAN Y,et al.Effect of testosterone deficiency on cholesterol metabolism in pigs fed a high-fat and high-cholesterol diet[J].Lipids Health Dis,2015,14(1):1-10.
[13]阿莱·巴合提汗,毛吾兰·买买提依明,张盼盼,等.异常黏液质证候大鼠甲状腺轴改变的研究[J].新疆医科大学学报,2016,39(5):538-541,545.
[2]张盼盼,刘新军,阿地力江·伊明,等.维医异常黏液质型阳痿病证大鼠模型血脂水平与肝功能相关指标的改变及其生物学意义[J].新疆医科大学学报,2014,37(8):968-973.
[3]AYTA I A,MCKINLAY J B,KRANE R J.The likely worldwide increase in erectile dysfunction between 1995and 2025and some possible policy consequence[J].BJU Int,1999,84(1):50-56.
[4]刘德风,姜辉,洪锴,等.近5年来中国11个城市门诊勃起功能障碍患者的流行病学变化[J].中华男科学杂志,2009,15(8):724-726.
[5]林一民,黄学梅,易琳,等.血清PA、ALB及TBA联合检测在肝病诊断中的应用价值[J].重庆医学,2011,40(34):3455-3457.
[6]PAOLICCHI A,EMDIN M,PASSINO C,et al.Beta-lipoprotein and LDL-associated serum gamma-glutamyl transferase in patients with coronary atherosclerosis[J].Atherosclerosis,2006,186(1):80-85.
[7]GUM E T,SWANSON R A,ALNO C.Human serum albumin and its N-terminal tetrapeptide(DAHK)block oxidantinduced neuronal death[J].Stroke,2004,35(2):590-594.
[8]张英霞,张云畅.白蛋白的功能及应用[J].海南大学学报自然科学版,2007,25(3):315-320.
[9]NEUZIL J,STOCKER R.Free and albumin-bound bilirubin are efficient co-antioxidants for alpha-tocopherol,inhibitingplasma and low density lipoprotein lipid peroxidation[J].J Biol Chem,1994,269(24):16712-16721.
[10]MULHALL J,TENOKEN P,BROCK G,et al.Obesity,dyslipidemias and erectile dysfunction:a report of a subcommittee of the sexual medicine society of North America[J].J Sex Med,2006,3(5):778-786.
[11]BRENTZOS G E,PARASKEVAS K I,MIKHAILIDIS D P.Dyslipidemia as a risk factor for erectile dysfunction[J].Curr Med Chem 2007,14(16):1765-1770.
[12]CAI Z,XI H,PAN Y,et al.Effect of testosterone deficiency on cholesterol metabolism in pigs fed a high-fat and high-cholesterol diet[J].Lipids Health Dis,2015,14(1):1-10.
[13]阿莱·巴合提汗,毛吾兰·买买提依明,张盼盼,等.异常黏液质证候大鼠甲状腺轴改变的研究[J].新疆医科大学学报,2016,39(5):538-541,545.